Research graph
References from Cellular senescence is an early feature and therapeutic target in amyotrophic lateral sclerosis TDP-43Q331K mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology
10.1038/s43587-023-00519-6 · 2023 · External reference
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
10.1073/pnas.1222809110 · 2013 · External reference
Electrophysiological motor unit number estimation (MUNE) measuring compound muscle action potential (CMAP) in mouse hindlimb muscles
2015 · External reference
Human amyotrophic lateral sclerosis/motor neuron disease: the disease-associated microglial pathway is upregulated while APOE genotype governs risk and survival
10.1111/bpa.70019 · 2025 · External reference
The differential effect of Senolytics on SASP cytokine secretion and regulation of EMT by CAFs
10.3390/ijms25074031 · 2024 · External reference
Reference genes for normalization: a study of rat brain tissue
10.1002/syn.20496 · 2008 · External reference
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
10.1038/s41586-018-0543-y · 2018 · External reference
The specification of cortical subcerebral projection neurons depends on the direct repression of TBR1 by CTIP1/BCL11a
10.1523/jneurosci.0169-15.2015 · 2015 · External reference
Improving reproducibility of motor evoked potentials in mice
10.1016/j.jneumeth.2021.109444 · 2022 · External reference
Normalization strategy for selection of reference genes for RT-qPCR analysis in left ventricles of failing human hearts
10.1186/s12872-022-02614-9 · 2022 · External reference
Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinson’s disease
10.1016/j.celrep.2017.12.092 · 2018 · External reference
The senescence-associated secretory phenotype and age-related diseases
2020 · External reference
The extent and time course of motoneuron involvement in amyotrophic lateral sclerosis
10.1002/mus.880140506 · 1991 · External reference
Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS
10.1016/j.neurobiolaging.2014.09.020 · 2015 · External reference
Region-specific heterogeneity in neuronal nuclear morphology in young, aged and in Alzheimer’s disease mouse brains
10.3389/fcell.2023.1032504 · 2023 · External reference
Chronological and biological aging in amyotrophic lateral sclerosis and the potential of Senolytic therapies
10.3390/cells13110928 · 2024 · External reference
Characterizing microglia activation: a spatial statistics approach to maximize information extraction
10.1038/s41598-017-01747-8 · 2017 · External reference
Senolytic treatment diminishes microglia and decreases severity of experimental autoimmune encephalomyelitis
10.1186/s12974-024-03278-2 · 2024 · External reference
Mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex
10.1111/jnc.15214 · 2021 · External reference
Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy
10.1038/s43587-021-00044-4 · 2021 · External reference
Accelerated brain aging in amyotrophic lateral sclerosis and its prognostic associations: a cohort study
10.1186/s12916-026-04631-3 · 2026 · External reference
Elimination of senescent cells fails to attenuate disease progression in an ALS mouse model
10.1007/s10072-026-09023-2 · 2026 · External reference
Neurostereology protocol for unbiased quantification of neuronal injury and neurodegeneration
10.3389/fnagi.2015.00196 · 2015 · External reference
Biological aging processes underlying cognitive decline and neurodegenerative disease
10.1172/jci158453 · 2022 · External reference
Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial
10.1038/s41591-023-02543-w · 2023 · External reference
Microglial brain regionâ ‘dependent diversity and selective regional sensitivities to aging
10.1038/nn.4222 · 2016 · External reference
Comparisons of quantitative approaches for assessing microglial morphology reveal inconsistencies, ecological fallacy, and a need for standardization
10.1038/s41598-022-23091-2 · 2022 · External reference
Diversity of layer 5 projection neurons in the mouse motor cortex
2013 · External reference
Cortical hyperexcitability drives dying forward amyotrophic lateral sclerosis symptoms and pathology in mice
10.1016/j.pneurobio.2025.102809 · 2025 · External reference
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
10.1002/ana.21425 · 2008 · External reference
Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease
10.1016/j.stem.2022.11.010 · 2022 · External reference
Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of Dasatinib plus quercetin in individuals with diabetic kidney disease
10.1016/j.ebiom.2019.08.069 · 2019 · External reference
Huntington’s disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels
10.18632/aging.101005 · 2016 · External reference
Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age
10.1111/acel.13767 · 2023 · External reference
Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis
10.1186/1742-2094-11-94 · 2014 · External reference
The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies
10.1038/s12276-020-00513-7 · 2020 · External reference
Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response
10.1111/j.1474-9726.2012.00870.x · 2012 · External reference
Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study
10.1016/j.ebiom.2018.12.052 · 2019 · External reference
Fluorescence-based quantification of nucleocytoplasmic transport
10.1016/j.ymeth.2018.11.002 · 2019 · External reference
5-HT2C agonism as a neurotherapeutic for sarcopenia: preclinical proof of concept
10.1007/s11357-025-01519-7 · 2025 · External reference
Senolytic drugs: from discovery to translation
10.1111/joim.13141 · 2020 · External reference
Classification of microglial morphological phenotypes using machine learning
10.3389/fncel.2021.701673 · 2021 · External reference
SAMP8 mice as a model of age-related cognition decline with underlying mechanisms in Alzheimer’s disease
10.3233/jad-200063 · 2020 · External reference
Senolytic treatment induces oligodendrocyte dysfunction and demyelination in the corpus callosum
10.1073/pnas.2524897123 · 2026 · External reference
Amyotrophic lateral sclerosis: a clinical review
10.1111/ene.14393 · 2020 · External reference
Senolytics: a novel strategy for neuroprotection in als?
10.3390/ijms222112078 · 2021 · External reference
α-Motor neurons are spared from aging while their synaptic inputs degenerate in monkeys and mice
10.1111/acel.12726 · 2018 · External reference
Mutant superoxide dismutase 1-induced IL-1β accelerates ALS pathogenesis
10.1073/pnas.1002396107 · 2010 · External reference
Cortical hyperexcitability precedes lower motor neuron dysfunction in ALS
10.1016/j.clinph.2014.04.023 · 2015 · External reference
Cortical hyperexcitability evolves with disease progression in ALS
10.1002/acn3.51039 · 2020 · External reference
Neurofilament light-chain response during therapy with antisense oligonucleotide tofersen in SOD1-related ALS: treatment experience in clinical practice
10.1002/mus.27818 · 2023 · External reference
Serum neurofilament light chain in distinct phenotypes of amyotrophic lateral sclerosis: a longitudinal, multicenter study
10.1111/ene.16379 · 2024 · External reference
Microglia morphological changes in the motor cortex of hsod1g93a transgenic als mice
10.3390/brainsci11060807 · 2021 · External reference
Long-term Tofersen in SOD1 amyotrophic lateral sclerosis
2025 · External reference
Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS
10.1186/s40478-015-0212-4 · 2015 · External reference
Endogenous TDP-43 mislocalization in a novel knock-in mouse model reveals DNA repair impairment, inflammation, and neuronal senescence
10.1186/s40478-025-01962-9 · 2025 · External reference
NeuN, a neuronal specific nuclear protein in vertebrates
10.1242/dev.116.1.201 · 1992 · External reference
10.1038/s41586-021-03970-w
10.1038/s41586-021-03970-w · External reference
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies
10.1007/s00401-008-0477-9 · 2009 · External reference
Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis
10.1007/s00401-017-1708-8 · 2017 · External reference
Obesity-induced cellular senescence drives anxiety and impairs neurogenesis
10.1016/j.cmet.2018.12.008 · 2019 · External reference
Optimization and construct validity of approaches to preclinical grip strength testing
10.1002/jcsm.13300 · 2023 · External reference
Decoding the relationship between ageing and amyotrophic lateral sclerosis: a cellular perspective
10.1093/brain/awz360 · 2020 · External reference
Selection of candidate housekeeping genes for normalization in human postmortem brain samples
10.3390/ijms12095461 · 2011 · External reference
Chronic demyelination and myelin repair after spinal cord injury in mice: a potential link for glutamatergic axon activity
10.1002/glia.24382 · 2023 · External reference
ALS monocyte-derived microglia-like cells reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression
10.1186/s12974-022-02421-1 · 2022 · External reference
Current senolytics: mode of action, efficacy and limitations, and their future
10.1016/j.mad.2023.111888 · 2024 · External reference
Pathologically mislocalised TDP-43 in upper motor neurons causes a die-forward spread of ALS-like pathogenic changes throughout the mouse corticomotor system
10.1016/j.pneurobio.2023.102449 · 2023 · External reference
Pharmacological targeting of senescence with Senolytics as a new therapeutic strategy for neurodegeneration
10.1124/molpharm.123.000803 · 2024 · External reference
Large Maf transcription factor family is a major regulator of fast type IIb myofiber determination
10.1016/j.celrep.2023.112289 · 2023 · External reference
A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis
10.1002/cne.20620 · 2005 · External reference
NIH image to ImageJ: 25 years of image analysis
10.1038/nmeth.2089 · 2012 · External reference
Muscle strength and size are associated with motor unit connectivity in aged mice
10.1016/j.neurobiolaging.2018.03.016 · 2018 · External reference
Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy
10.1038/s41593-018-0083-7 · 2018 · External reference
A novel automated morphological analysis of Iba1+ microglia using a deep learning assisted model
10.3389/fncel.2022.944875 · 2022 · External reference
Rostro-caudal specificity of corticospinal tract projections in mice
10.1093/cercor/bhaa338 · 2021 · External reference
The role of TDP-43 mislocalization in amyotrophic lateral sclerosis
10.1186/s13024-020-00397-1 · 2020 · External reference
A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers
10.1242/dmm.049059 · 2022 · External reference
Emergence of microglia bearing senescence markers during paralysis progression in a rat model of inherited ALS
2019 · External reference
C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9
10.1038/s41467-023-41603-0 · 2023 · External reference
Expression of p16 and p21 in the frontal association cortex of ALS/MND brains suggests neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease
10.1111/nan.12559 · 2020 · External reference
Age-related increase in the excitability of mouse layer V pyramidal neurons in the primary motor cortex is accompanied by an increased persistent inward current
10.1007/s11357-024-01405-8 · 2025 · External reference
Reduced cortico-muscular output is associated with intrinsic hypoexcitability and reduced persistent inward currents in motor cortex neurons of TDP-43Q331K ALS mice
2025 · External reference
Riluzole exerts central and peripheral modulating effects in amyotrophic lateral sclerosis
10.1093/brain/awt085 · 2013 · External reference
Senolytic therapy is neuroprotective and improves functional outcome long-term after traumatic brain injury in mice
2023 · External reference
Extensive phenotypic characterisation of a human TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis (ALS)
10.1038/s41598-021-96122-z · 2021 · External reference
Top-down laminar organization of the excitatory network in motor cortex
10.1038/nn2049 · 2008 · External reference
Introduction to stereology
2012 · External reference
Muscle contractility dysfunction precedes loss of motor unit connectivity in SOD1(G93A) mice
10.1002/mus.26365 · 2019 · External reference
Effects of tofersen treatment in patients with SOD1-ALS in a “real-world” setting – a 12-month multicenter cohort study from the German early access program
10.1016/j.eclinm.2024.102495 · 2024 · External reference
Senolytics improve physical function and increase lifespan in old age
10.1038/s41591-018-0092-9 · 2018 · External reference
Senescent-like blood lymphocytes and disease progression in amyotrophic lateral sclerosis
10.1212/nxi.0000000000200042 · 2023 · External reference
Quantifying microglia morphology from photomicrographs of immunohistochemistry prepared tissue using imagej
2018 · External reference
Shape descriptors of the “never resting” microglia in three different acute brain injury models in mice
10.1186/s40635-015-0039-0 · 2015 · External reference
Senolytic therapy alleviates aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
10.1038/s41593-019-0372-9 · 2019 · External reference
Steps towards standardized quantification of adult neurogenesis
2020 · External reference
Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology
10.1016/j.nbd.2025.106939 · 2025 · External reference
The achilles’ heel of senescent cells: from transcriptome to senolytic drugs
10.1111/acel.12344 · 2015 · External reference
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
10.1111/acel.12445 · 2016 · External reference
Cortical hyperexcitability evolves with disease progression in ALS
10.1002/acn3.51039 · ExternalCitation · doi-reference
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
10.1002/ana.21425 · ExternalCitation · doi-reference
A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis
10.1002/cne.20620 · ExternalCitation · doi-reference
Chronic demyelination and myelin repair after spinal cord injury in mice: a potential link for glutamatergic axon activity
10.1002/glia.24382 · ExternalCitation · doi-reference
Optimization and construct validity of approaches to preclinical grip strength testing
10.1002/jcsm.13300 · ExternalCitation · doi-reference
Muscle contractility dysfunction precedes loss of motor unit connectivity in SOD1(G93A) mice
10.1002/mus.26365 · ExternalCitation · doi-reference
Neurofilament light-chain response during therapy with antisense oligonucleotide tofersen in SOD1-related ALS: treatment experience in clinical practice
10.1002/mus.27818 · ExternalCitation · doi-reference
The extent and time course of motoneuron involvement in amyotrophic lateral sclerosis
10.1002/mus.880140506 · ExternalCitation · doi-reference
Reference genes for normalization: a study of rat brain tissue
10.1002/syn.20496 · ExternalCitation · doi-reference
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies
10.1007/s00401-008-0477-9 · ExternalCitation · doi-reference
Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis
10.1007/s00401-017-1708-8 · ExternalCitation · doi-reference
Elimination of senescent cells fails to attenuate disease progression in an ALS mouse model
10.1007/s10072-026-09023-2 · ExternalCitation · doi-reference
Age-related increase in the excitability of mouse layer V pyramidal neurons in the primary motor cortex is accompanied by an increased persistent inward current
10.1007/s11357-024-01405-8 · ExternalCitation · doi-reference
5-HT2C agonism as a neurotherapeutic for sarcopenia: preclinical proof of concept
10.1007/s11357-025-01519-7 · ExternalCitation · doi-reference
Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinson’s disease
10.1016/j.celrep.2017.12.092 · ExternalCitation · doi-reference
Large Maf transcription factor family is a major regulator of fast type IIb myofiber determination
10.1016/j.celrep.2023.112289 · ExternalCitation · doi-reference
Cortical hyperexcitability precedes lower motor neuron dysfunction in ALS
10.1016/j.clinph.2014.04.023 · ExternalCitation · doi-reference
Obesity-induced cellular senescence drives anxiety and impairs neurogenesis
10.1016/j.cmet.2018.12.008 · ExternalCitation · doi-reference
Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study
10.1016/j.ebiom.2018.12.052 · ExternalCitation · doi-reference
Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of Dasatinib plus quercetin in individuals with diabetic kidney disease
10.1016/j.ebiom.2019.08.069 · ExternalCitation · doi-reference
Effects of tofersen treatment in patients with SOD1-ALS in a “real-world” setting – a 12-month multicenter cohort study from the German early access program
10.1016/j.eclinm.2024.102495 · ExternalCitation · doi-reference
Improving reproducibility of motor evoked potentials in mice
10.1016/j.jneumeth.2021.109444 · ExternalCitation · doi-reference
Current senolytics: mode of action, efficacy and limitations, and their future
10.1016/j.mad.2023.111888 · ExternalCitation · doi-reference
Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology
10.1016/j.nbd.2025.106939 · ExternalCitation · doi-reference
Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS
10.1016/j.neurobiolaging.2014.09.020 · ExternalCitation · doi-reference
Muscle strength and size are associated with motor unit connectivity in aged mice
10.1016/j.neurobiolaging.2018.03.016 · ExternalCitation · doi-reference
Pathologically mislocalised TDP-43 in upper motor neurons causes a die-forward spread of ALS-like pathogenic changes throughout the mouse corticomotor system
10.1016/j.pneurobio.2023.102449 · ExternalCitation · doi-reference
Cortical hyperexcitability drives dying forward amyotrophic lateral sclerosis symptoms and pathology in mice
10.1016/j.pneurobio.2025.102809 · ExternalCitation · doi-reference
Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease
10.1016/j.stem.2022.11.010 · ExternalCitation · doi-reference
Fluorescence-based quantification of nucleocytoplasmic transport
10.1016/j.ymeth.2018.11.002 · ExternalCitation · doi-reference
NIH image to ImageJ: 25 years of image analysis
10.1038/nmeth.2089 · ExternalCitation · doi-reference
Microglial brain regionâ ‘dependent diversity and selective regional sensitivities to aging
10.1038/nn.4222 · ExternalCitation · doi-reference
Top-down laminar organization of the excitatory network in motor cortex
10.1038/nn2049 · ExternalCitation · doi-reference
The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies
10.1038/s12276-020-00513-7 · ExternalCitation · doi-reference
C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9
10.1038/s41467-023-41603-0 · ExternalCitation · doi-reference
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
10.1038/s41586-018-0543-y · ExternalCitation · doi-reference
10.1038/s41586-021-03970-w
10.1038/s41586-021-03970-w · ExternalCitation · doi-reference
Senolytics improve physical function and increase lifespan in old age
10.1038/s41591-018-0092-9 · ExternalCitation · doi-reference
Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial
10.1038/s41591-023-02543-w · ExternalCitation · doi-reference
Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy
10.1038/s41593-018-0083-7 · ExternalCitation · doi-reference
Senolytic therapy alleviates aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
10.1038/s41593-019-0372-9 · ExternalCitation · doi-reference
Characterizing microglia activation: a spatial statistics approach to maximize information extraction
10.1038/s41598-017-01747-8 · ExternalCitation · doi-reference
Extensive phenotypic characterisation of a human TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis (ALS)
10.1038/s41598-021-96122-z · ExternalCitation · doi-reference
Comparisons of quantitative approaches for assessing microglial morphology reveal inconsistencies, ecological fallacy, and a need for standardization
10.1038/s41598-022-23091-2 · ExternalCitation · doi-reference
Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy
10.1038/s43587-021-00044-4 · ExternalCitation · doi-reference
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology
10.1038/s43587-023-00519-6 · ExternalCitation · doi-reference
Mutant superoxide dismutase 1-induced IL-1β accelerates ALS pathogenesis
10.1073/pnas.1002396107 · ExternalCitation · doi-reference
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
10.1073/pnas.1222809110 · ExternalCitation · doi-reference
Senolytic treatment induces oligodendrocyte dysfunction and demyelination in the corpus callosum
10.1073/pnas.2524897123 · ExternalCitation · doi-reference
Riluzole exerts central and peripheral modulating effects in amyotrophic lateral sclerosis
10.1093/brain/awt085 · ExternalCitation · doi-reference
Decoding the relationship between ageing and amyotrophic lateral sclerosis: a cellular perspective
10.1093/brain/awz360 · ExternalCitation · doi-reference
Rostro-caudal specificity of corticospinal tract projections in mice
10.1093/cercor/bhaa338 · ExternalCitation · doi-reference
The achilles’ heel of senescent cells: from transcriptome to senolytic drugs
10.1111/acel.12344 · ExternalCitation · doi-reference
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
10.1111/acel.12445 · ExternalCitation · doi-reference
α-Motor neurons are spared from aging while their synaptic inputs degenerate in monkeys and mice
10.1111/acel.12726 · ExternalCitation · doi-reference
Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age
10.1111/acel.13767 · ExternalCitation · doi-reference
Human amyotrophic lateral sclerosis/motor neuron disease: the disease-associated microglial pathway is upregulated while APOE genotype governs risk and survival
10.1111/bpa.70019 · ExternalCitation · doi-reference
Amyotrophic lateral sclerosis: a clinical review
10.1111/ene.14393 · ExternalCitation · doi-reference
Serum neurofilament light chain in distinct phenotypes of amyotrophic lateral sclerosis: a longitudinal, multicenter study
10.1111/ene.16379 · ExternalCitation · doi-reference
Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response
10.1111/j.1474-9726.2012.00870.x · ExternalCitation · doi-reference
Mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex
10.1111/jnc.15214 · ExternalCitation · doi-reference
Senolytic drugs: from discovery to translation
10.1111/joim.13141 · ExternalCitation · doi-reference
Expression of p16 and p21 in the frontal association cortex of ALS/MND brains suggests neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease
10.1111/nan.12559 · ExternalCitation · doi-reference
Pharmacological targeting of senescence with Senolytics as a new therapeutic strategy for neurodegeneration
10.1124/molpharm.123.000803 · ExternalCitation · doi-reference
Biological aging processes underlying cognitive decline and neurodegenerative disease
10.1172/jci158453 · ExternalCitation · doi-reference
Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis
10.1186/1742-2094-11-94 · ExternalCitation · doi-reference
Normalization strategy for selection of reference genes for RT-qPCR analysis in left ventricles of failing human hearts
10.1186/s12872-022-02614-9 · ExternalCitation · doi-reference
Accelerated brain aging in amyotrophic lateral sclerosis and its prognostic associations: a cohort study
10.1186/s12916-026-04631-3 · ExternalCitation · doi-reference
ALS monocyte-derived microglia-like cells reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression
10.1186/s12974-022-02421-1 · ExternalCitation · doi-reference
Senolytic treatment diminishes microglia and decreases severity of experimental autoimmune encephalomyelitis
10.1186/s12974-024-03278-2 · ExternalCitation · doi-reference
The role of TDP-43 mislocalization in amyotrophic lateral sclerosis
10.1186/s13024-020-00397-1 · ExternalCitation · doi-reference
Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS
10.1186/s40478-015-0212-4 · ExternalCitation · doi-reference
Endogenous TDP-43 mislocalization in a novel knock-in mouse model reveals DNA repair impairment, inflammation, and neuronal senescence
10.1186/s40478-025-01962-9 · ExternalCitation · doi-reference
Shape descriptors of the “never resting” microglia in three different acute brain injury models in mice
10.1186/s40635-015-0039-0 · ExternalCitation · doi-reference
Senescent-like blood lymphocytes and disease progression in amyotrophic lateral sclerosis
10.1212/nxi.0000000000200042 · ExternalCitation · doi-reference
NeuN, a neuronal specific nuclear protein in vertebrates
10.1242/dev.116.1.201 · ExternalCitation · doi-reference
A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers
10.1242/dmm.049059 · ExternalCitation · doi-reference
The specification of cortical subcerebral projection neurons depends on the direct repression of TBR1 by CTIP1/BCL11a
10.1523/jneurosci.0169-15.2015 · ExternalCitation · doi-reference
Huntington’s disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels
10.18632/aging.101005 · ExternalCitation · doi-reference
SAMP8 mice as a model of age-related cognition decline with underlying mechanisms in Alzheimer’s disease
10.3233/jad-200063 · ExternalCitation · doi-reference
Region-specific heterogeneity in neuronal nuclear morphology in young, aged and in Alzheimer’s disease mouse brains
10.3389/fcell.2023.1032504 · ExternalCitation · doi-reference
Neurostereology protocol for unbiased quantification of neuronal injury and neurodegeneration
10.3389/fnagi.2015.00196 · ExternalCitation · doi-reference
Classification of microglial morphological phenotypes using machine learning
10.3389/fncel.2021.701673 · ExternalCitation · doi-reference
A novel automated morphological analysis of Iba1+ microglia using a deep learning assisted model
10.3389/fncel.2022.944875 · ExternalCitation · doi-reference
Microglia morphological changes in the motor cortex of hsod1g93a transgenic als mice
10.3390/brainsci11060807 · ExternalCitation · doi-reference
Chronological and biological aging in amyotrophic lateral sclerosis and the potential of Senolytic therapies
10.3390/cells13110928 · ExternalCitation · doi-reference
Selection of candidate housekeeping genes for normalization in human postmortem brain samples
10.3390/ijms12095461 · ExternalCitation · doi-reference
Senolytics: a novel strategy for neuroprotection in als?
10.3390/ijms222112078 · ExternalCitation · doi-reference
The differential effect of Senolytics on SASP cytokine secretion and regulation of EMT by CAFs
10.3390/ijms25074031 · ExternalCitation · doi-reference
