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References from TDP-43 and ALS - what's wrong with my membranes?. Local targets link to admitted publications; unresolved targets remain external evidence.
Defective cholesterol metabolism in amyotrophic lateral sclerosis
10.1194/jlr.p071639 · 2017 · External reference
Amyloid-like interactions within nucleoporin FG hydrogels
10.1073/pnas.0910163107 · 2010 · External reference
Plasma lipids as biomarkers for Alzheimer’s disease: a systematic review
2020 · External reference
Modeling the effects of lipid peroxidation during ferroptosis on membrane properties
10.1038/s41598-018-23408-0 · 2018 · External reference
Mechanics of nuclear membranes
10.1242/jcs.229245 · 2019 · External reference
Deciphering lipid dysregulation in ALS: from mechanisms to translational medicine
10.1186/s40035-022-00322-0 · 2022 · External reference
Mitochondrial membrane potential and compartmentalized signaling: Calcium, ROS, and beyond
10.1016/j.redox.2025.103859 · 2025 · External reference
Sigmar1’s molecular, cellular, and biological functions in regulating cellular pathophysiology
10.3389/fphys.2021.705575 · 2021 · External reference
Pathological sequelae associated with skeletal muscle atrophy and histopathology in G93A*SOD1 mice
10.3390/muscles2010006 · 2023 · External reference
Tilt: major factor in sterols’ ordering capability in membranes
10.1021/jp064931u · 2006 · External reference
Impaired nucleoporins are present in sporadic amyotrophic lateral sclerosis motor neurons that exhibit mislocalization of the 43-kDa TAR DNA-binding protein
10.3988/jcn.2019.15.1.62 · 2019 · External reference
Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons
10.1186/s13046-020-01824-3 · 2021 · External reference
Cyclodextrin derivatives in pharmaceutics
10.1615/critrevtherdrugcarriersyst.v12.i4.20 · 1995 · External reference
The role of intranuclear lipids
10.1016/j.biolcel.2004.05.004 · 2004 · External reference
Nuclear lipid microdomains regulate cell function
10.4161/cib.2.1.7376 · 2009 · External reference
Involvement of lipids in the pathogenesis of amyotrophic lateral sclerosis
2023 · External reference
Neuromuscular junction denervation and terminal Schwann cell loss in the hTDP-43 overexpression mouse model of amyotrophic lateral sclerosis
2023 · External reference
Oxidative stress-mediated lipid peroxidation-derived lipid aldehydes in the pathophysiology of neurodegenerative diseases
10.2174/011570159x342720241014164650 · 2025 · External reference
The ESCRT-III isoforms CHMP2A and CHMP2B display different effects on membranes upon polymerization
10.1186/s12915-021-00983-9 · 2021 · External reference
Heterogeneous distribution of filipin-sterol complexes in nuclear membranes
10.1016/0005-2736(81)90411-9 · 1981 · External reference
A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis
10.1002/ana.22534 · 2011 · External reference
A common functional allele of the Nogo receptor gene, reticulon 4 receptor (RTN4R), is associated with sporadic amyotrophic lateral sclerosis in a French population
10.3109/21678421.2015.1051988 · 2015 · External reference
Vesicle associated membrane protein B (VAPB) is decreased in ALS spinal cord
10.1016/j.neurobiolaging.2008.07.005 · 2010 · External reference
Grease in the nucleus: insights into the dynamic life of nuclear membranes
10.1007/s00232-022-00272-8 · 2023 · External reference
Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology
10.7554/elife.67587 · 2021 · External reference
Inactivation of liver X receptor β leads to adult-onset motor neuron degeneration in male mice
10.1073/pnas.0500634102 · 2005 · External reference
Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia
10.1038/s41593-020-0650-6 · 2020 · External reference
Lipid alterations in human frontal cortex in ALS-FTLD-TDP43 proteinopathy spectrum are partly related to peroxisome impairment
10.1111/nan.12681 · 2021 · External reference
Membrane cholesterol depletion in cortical neurons highlights altered NMDA receptor functionality in a mouse model of amyotrophic lateral sclerosis
10.1016/j.bbadis.2017.11.008 · 2018 · External reference
TDP43 proteinopathy is associated with aberrant DNA methylation in human amyotrophic lateral sclerosis
10.1111/nan.12625 · 2021 · External reference
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
10.1016/j.bbrc.2006.10.093 · 2006 · External reference
Iron homeostasis is altered in response to hypoxia and hypothermic preconditioning in brain glial cells
10.3906/sag-2003-41 · 2020 · External reference
Early and persistent abnormal decoding by glial cells at the neuromuscular junction in an ALS model
10.1523/jneurosci.1379-14.2015 · 2015 · External reference
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
10.1073/pnas.1222809110 · 2013 · External reference
Heavy metal neurotoxicants induce ALS-linked TDP-43 pathology
10.1093/toxsci/kfy267 · 2019 · External reference
Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)
10.1074/jbc.m115.679043 · 2015 · External reference
Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection
10.1101/gad.194829.112 · 2012 · External reference
Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS
10.1007/s00401-011-0850-y · 2011 · External reference
TDP-43 regulates its mRNA levels through a negative feedback loop
10.1038/emboj.2010.310 · 2011 · External reference
Liver X receptor agonist GW3965 regulates synaptic function upon amyloid beta exposure in hippocampal neurons
10.1007/s12640-017-9845-3 · 2018 · External reference
Does membrane curvature elastic energy play a role in mediating oxidative stress in lipid membranes?
10.1016/j.freeradbiomed.2021.05.021 · 2021 · External reference
The triggering receptor expressed on myeloid cells 2 binds apolipoprotein E
10.1074/jbc.m115.677286 · 2015 · External reference
Therapeutic targeting of the oxidative stress generated by pathological molecular pathways in the neurodegenerative diseases, ALS and Huntington’s
10.1016/j.ejphar.2024.177187 · 2025 · External reference
Lipid peroxidation drives liquid–liquid phase separation and disrupts raft protein partitioning in biological membranes
10.1021/jacs.3c10132 · 2024 · External reference
Promoter DNA methylation regulates progranulin expression and is altered in FTLD
10.1186/2051-5960-1-16 · 2013 · External reference
Autophagy-mediated inflammatory cytokine secretion in sporadic als patient iPSC-derived astrocytes
10.1155/2022/6483582 · 2022 · External reference
Coupling lipid synthesis with nuclear envelope remodeling
10.1016/j.tibs.2021.08.009 · 2022 · External reference
Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis
10.1523/jneurosci.4988-09.2010 · 2010 · External reference
Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
10.3389/fcell.2023.1328875 · 2024 · External reference
SUN1 facilitates CHMP7 nuclear influx and injury cascades in sporadic amyotrophic lateral sclerosis
2023 · External reference
Juvenile ALS with basophilic inclusions is a FUS proteinopathy with FUS mutations
10.1212/wnl.0b013e3181ed9cde · 2010 · External reference
Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies
10.1016/s1474-4422(18)30394-6 · 2019 · External reference
Comparative study of structural and functional rearrangements in skeletal muscle mitochondria of SOD1-G93A transgenic mice at pre-, early-, and late-symptomatic stages of ALS progression
10.31083/fbl28260 · 2025 · External reference
Predominance of spliceosomal complex formation over polyadenylation site selection in TDP-43 autoregulation
10.1093/nar/gkt1343 · 2014 · External reference
Hakuna MAM-Tata: Investigating the role of mitochondrial-associated membranes in ALS
1869 · External reference
Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration
10.1093/brain/awv008 · 2015 · External reference
Longer disease progression milestone-free time in people with amyotrophic lateral sclerosis treated versus not treated with intravenous edaravone: results from an administrative claims analysis
10.57264/cer-2024-0007 · 2025 · External reference
Cytoplasmic localization of amyotrophic lateral sclerosis-related TDP-43 proteins modulates stress granule formation
10.1111/ejn.14762 · 2020 · External reference
Neuropathologic and biochemical changes during disease progression in liver X receptor β −/− mice, a model of adult neuron disease
10.1097/nen.0b013e3181df20e1 · 2010 · External reference
24(S),25-epoxycholesterol--a potential friend
10.1161/01.atv.0000148704.72481.28 · 2004 · External reference
Traumatic brain injury induces TDP-43 mislocalization and neurodegenerative effects in tissue distal to the primary injury site in a non-transgenic mouse
10.1186/s40478-023-01625-7 · 2023 · External reference
Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS
10.1038/s41598-017-17389-9 · 2017 · External reference
Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma membrane
10.1074/jbc.m111.283671 · 2011 · External reference
The aging astrocyte transcriptome from multiple regions of the mouse brain
10.1016/j.celrep.2017.12.039 · 2018 · External reference
Abnormal upregulation of GPR17 receptor contributes to oligodendrocyte dysfunction in SOD1 G93A mice
10.3390/ijms21072395 · 2020 · External reference
Identification of the non-lysosomal glucosylceramidase as β-glucosidase 2
10.1074/jbc.m610544200 · 2007 · External reference
Lipid unsaturation properties govern the sensitivity of membranes to photoinduced oxidative stress
10.1016/j.bpj.2019.01.033 · 2019 · External reference
Ambroxol hydrochloride improves motor functions and extends survival in a mouse model of familial amyotrophic lateral sclerosis
10.3389/fphar.2019.00883 · 2019 · External reference
Amyotrophic lateral sclerosis and environmental factors
2016 · External reference
Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis
10.1007/s00401-016-1633-2 · 2017 · External reference
LEM2 is a novel MAN1-related inner nuclear membrane protein associated with A-type lamins
10.1242/jcs.02701 · 2005 · External reference
TDP-43 and inflammation: implications for amyotrophic lateral sclerosis and frontotemporal dementia
10.3390/ijms22157781 · 2021 · External reference
On the lipid dependence of bacterial mechanosensitive channel gating in situ
2024 · External reference
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
10.1038/s41586-022-04436-3 · 2022 · External reference
Endplate denervation correlates with Nogo-A muscle expression in amyotrophic lateral sclerosis patients
10.1002/acn3.179 · 2015 · External reference
Membrane lipid rafts are necessary for the maintenance of the (alpha)7 nicotinic acetylcholine receptor in somatic spines of ciliary neurons
10.1523/jneurosci.21-02-00504.2001 · 2001 · External reference
Cholesterol suppresses membrane leakage by decreasing water penetrability
10.1039/c8sm00644j · 2018 · External reference
Functional Significance of TDP-43 Mutations in Disease
10.1016/bs.adgen.2015.07.001 · 2015 · External reference
Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9
10.1074/jbc.m104236200 · 2001 · External reference
The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation
10.4161/rna.7.4.12205 · 2010 · External reference
Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping
10.1093/emboj/20.7.1774 · 2001 · External reference
Histone deacetylase inhibition regulates lipid homeostasis in a mouse model of amyotrophic lateral sclerosis
10.3390/ijms222011224 · 2021 · External reference
Interplay of the nuclear envelope with chromatin in physiology and pathology
10.1080/19491034.2020.1806661 · 2020 · External reference
STAT1 drives M1 microglia activation and neuroinflammation under hypoxia
10.1016/j.abb.2019.05.011 · 2019 · External reference
Lipid profile in human frontal cortex is sustained throughout healthy adult life span to decay at advanced ages
2018 · External reference
TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis
10.1001/jamaneurol.2013.6237 · 2014 · External reference
Incidence of amyotrophic lateral sclerosis in older adults
10.1002/mus.27652 · 2022 · External reference
Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression
10.1016/j.nbd.2021.105289 · 2021 · External reference
Specific lipid recognition is a general feature of CD300 and TREM molecules
10.1007/s00251-011-0562-4 · 2012 · External reference
TREM2 regulates microglial cell activation in response to demyelination in vivo
10.1007/s00401-015-1388-1 · 2015 · External reference
Increased autophagy reduces endoplasmic reticulum stress after neonatal hypoxia–ischemia: role of protein synthesis and autophagic pathways
10.1016/j.expneurol.2014.03.002 · 2014 · External reference
Melatonin reduces endoplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia–ischemia
10.1111/jpi.12156 · 2014 · External reference
Antioxidant alternatives in the treatment of amyotrophic lateral sclerosis: a comprehensive review
10.3389/fphys.2020.00063 · 2020 · External reference
TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons
10.1016/j.jsb.2009.06.006 · 2009 · External reference
Membrane lipid composition: effect on membrane and organelle structure, function and compartmentalization and therapeutic avenues
10.3390/ijms20092167 · 2019 · External reference
Quantitative assessment of the degradation of aggregated TDP-43 mediated by the ubiquitin proteasome system and macroautophagy
10.1096/fj.201700292rr · 2017 · External reference
Lipid microdomains in cell nucleus
10.1091/mbc.e08-05-0517 · 2008 · External reference
Endoplasmic reticulum stress and lipids in health and diseases
10.1016/j.plipres.2022.101198 · 2023 · External reference
Environmental signals on microglial function during brain development, neuroplasticity, and disease
10.3390/ijms21062111 · 2020 · External reference
Control of mammalian locomotion by ventral spinocerebellar tract neurons
10.1016/j.cell.2021.12.014 · 2022 · External reference
Disruption of The Ran system by cysteine oxidation of the nucleotide exchange factor RCC1
10.1128/mcb.01133-14 · 2015 · External reference
Alterations in lipid metabolism of spinal cord linked to amyotrophic lateral sclerosis
10.1038/s41598-019-48059-7 · 2019 · External reference
Endoplasmic reticulum pathology and stress response in neurons precede programmed necrosis after neonatal hypoxia-ischemia
10.1016/j.ijdevneu.2015.11.007 · 2016 · External reference
Aggregation of the nucleic acid–binding protein TDP-43 occurs via distinct routes that are coordinated with stress granule formation
10.1074/jbc.ra118.006351 · 2019 · External reference
Brain energy metabolism: astrocytes in neurodegenerative diseases
10.1111/cns.13982 · 2023 · External reference
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets
10.1038/s41392-023-01570-w · 2023 · External reference
Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation
10.1073/pnas.1800656115 · 2018 · External reference
Machine learning identified novel players in lipid metabolism, endosomal trafficking, and iron metabolism of the ALS spinal cord
2025 · External reference
Differential modulation of TREM2 protein during postnatal brain development in mice
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Epigenetic regulation of motor neuron cell death through DNA methylation
10.1523/jneurosci.1639-11.2011 · 2011 · External reference
Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy
10.1186/s13024-019-0310-z · 2019 · External reference
Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism
10.1073/pnas.1002176107 · 2010 · External reference
Lipid peroxidation contributes to age-related membrane rigidity
10.1016/0891-5849(94)00217-8 · 1995 · External reference
Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy
10.1038/s41374-019-0196-y · 2019 · External reference
TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
10.1038/s41593-017-0047-3 · 2018 · External reference
Autophagy and ALS: mechanistic insights and therapeutic implications
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Crystal structure of the metazoan Nup62•Nup58•Nup54 nucleoporin complex
10.1126/science.aac7420 · 2015 · External reference
Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis
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TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis
10.1007/s00401-020-02193-z · 2020 · External reference
Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology
10.1007/s00401-015-1475-3 · 2015 · External reference
Pericytes: unsung heroes in myelin repair after neonatal brain hypoxia
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Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking: oxidative stress regulates TDP-43
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Cyclodextrins as emerging therapeutic tools in the treatment of cholesterol-associated vascular and neurodegenerative diseases
10.3390/molecules21121748 · 2016 · External reference
Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions
10.1186/s13059-017-1185-3 · 2017 · External reference
Membrane charge drives the aggregation of TDP-43 pathological fragments
2025 · External reference
TDP-43 regulates β-adducin (Add2) transcript stability
10.1080/15476286.2014.996081 · 2014 · External reference
Sigma-1 receptor is a key genetic modulator in amyotrophic lateral sclerosis
2019 · External reference
SIGMAR1 confers innate resilience against neurodegeneration
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Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)
10.1371/journal.pone.0009872 · 2010 · External reference
The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei
10.1186/s40478-021-01228-0 · 2021 · External reference
G4C2 repeat RNA initiates a POM121-mediated reduction in specific nucleoporins in C9orf72 ALS/FTD
10.1016/j.neuron.2020.06.027 · 2020 · External reference
Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS
10.1126/scitranslmed.abe1923 · 2021 · External reference
The density of synapses and neurons in normal, mentally defective ageing human brains
10.1093/brain/98.1.81 · 1975 · External reference
Oxidative stress inhibits nuclear protein export by multiple mechanisms that target FG nucleoporins and Crm1
10.1091/mbc.e09-05-0397 · 2009 · External reference
Developmental origin of oligodendrocyte lineage cells determines response to demyelination and susceptibility to age-associated functional decline
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Oxidative stress in amyotrophic lateral sclerosis: pathophysiology and opportunities for pharmacological intervention
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Mitochondria: a promising convergent target for the treatment of amyotrophic lateral sclerosis
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TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS
10.7554/elife.59419 · 2020 · External reference
Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis
10.1002/ana.10312 · 2002 · External reference
Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells
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Long-term exposure to lead reduces antioxidant capacity and triggers motor neurons degeneration and demyelination in spinal cord of adult rats
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Chronic lead intoxication affects the myelin membrane status in the central nervous system of adult rats
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Myelin glycoproteins targeted by lead in the rodent model of prolonged exposure
10.1016/j.fct.2007.10.024 · 2008 · External reference
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The role of TDP-43 fragments in regular cellular functions and homeostatic failure
10.1016/j.nbd.2026.107349 · 2026 · External reference
Tanshinone I alleviates motor and cognitive impairments via suppressing oxidative stress in the neonatal rats after hypoxic-ischemic brain damage
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A neuronal Slit1-dependent program rescues oligodendrocyte differentiation and myelination under chronic hypoxic conditions
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Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells
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Allosteric modulation of ghrelin receptor signaling by lipids
10.1038/s41467-021-23756-y · 2021 · External reference
Molecular machineries shaping the mitochondrial inner membrane
10.1038/s41580-025-00854-z · 2025 · External reference
TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics
10.1016/j.neulet.2018.04.053 · 2018 · External reference
The unprecedented membrane deformation of the human nuclear envelope, in a magnetic field, indicates formation of nuclear membrane invaginations
10.1038/s41598-020-61746-0 · 2020 · External reference
The ESCRT protein CHMP2B acts as a diffusion barrier on reconstituted membrane necks
10.1242/jcs.217968 · 2019 · External reference
Changes in the oligodendrocyte progenitor cell proteome with ageing
10.1074/mcp.ra120.002102 · 2020 · External reference
CDNF rescues motor neurons in models of amyotrophic lateral sclerosis by targeting endoplasmic reticulum stress
10.1093/brain/awad087 · 2023 · External reference
The dynamic nature of the nuclear envelope
10.1016/j.cub.2018.01.073 · 2018 · External reference
VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis
10.1093/hmg/ddr559 · 2012 · External reference
Mitochondrial membrane lipids in the regulation of bioenergetic flux
10.1016/j.cmet.2024.07.024 · 2024 · External reference
Spatial memory formation induces recruitment of NMDA receptor and PSD-95 to synaptic lipid rafts
10.1111/j.1471-4159.2008.05523.x · 2008 · External reference
Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential
10.1186/s13024-025-00859-4 · 2025 · External reference
Nuclear envelope rupture and repair during cancer cell migration
10.1126/science.aad7297 · 2016 · External reference
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
10.1038/nature10353 · 2011 · External reference
CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1
10.1083/jcb.202103033 · 2022 · External reference
Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS
10.1038/s41598-018-32902-4 · 2018 · External reference
The Nup62 coiled-coil motif provides plasticity for triple-helix bundle formation
10.1021/acs.biochem.6b01050 · 2017 · External reference
Evidence for alterations in lipid profiles and biophysical properties of lipid rafts from spinal cord in sporadic amyotrophic lateral sclerosis
10.1007/s00109-024-02419-7 · 2024 · External reference
Crosstalk between hypoxia and ER stress response: a key regulator of macrophage polarization
10.3389/fimmu.2019.02951 · 2020 · External reference
Gene targeting of mouse Tardbp negatively affects Masp2 expression
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Neuropathology of Parkinson disease
10.1016/j.parkreldis.2017.07.033 · 2018 · External reference
Class I and II histone deacetylase expression is not altered in human amyotrophic lateral sclerosis: neuropathological and positron emission tomography molecular neuroimaging evidence
10.1002/mus.26620 · 2019 · External reference
Myelination generates aberrant ultrastructure that is resolved by microglia
10.1083/jcb.202204010 · 2023 · External reference
Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis
10.1073/pnas.1508767112 · 2015 · External reference
Neutral lipid cacostasis contributes to disease pathogenesis in amyotrophic lateral sclerosis
10.1523/jneurosci.1388-20.2020 · 2020 · External reference
Recognition of the TDP-43 nuclear localization signal by importin α1/β
10.1016/j.celrep.2022.111007 · 2022 · External reference
25-hydroxycholesterol effect on membrane structure and mechanical properties
10.3390/ijms22052574 · 2021 · External reference
Adenoviral-TMBIM6 vector attenuates ER stress - induced apoptosis in a neonatal hypoxic-ischemic rat model
10.1242/dmm.040352 · 2019 · External reference
The ALS-linked E102Q mutation in Sigma receptor-1 leads to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins
10.1038/cdd.2017.88 · 2017 · External reference
Shared mechanisms in physiological and pathological nucleoplasmic reticulum formation
10.1080/19491034.2016.1252893 · 2017 · External reference
Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export
10.1016/j.celrep.2022.111106 · 2022 · External reference
Risk factors of amyotrophic lateral sclerosis: a global meta-summary
10.3389/fnins.2023.1177431 · 2023 · External reference
Colocalization of sterol isomerase and sigma(1) receptor at endoplasmic reticulum and nuclear envelope level
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Men and mice: Relating their ages
10.1016/j.lfs.2015.10.025 · 2016 · External reference
Regulation of TDP-43 phosphorylation in aging and disease
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Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1
10.1038/s41598-018-25007-5 · 2018 · External reference
CDNF interacts with ER chaperones and requires UPR sensors to promote neuronal survival
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TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2
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Consequences of lead exposure, and it’s emerging role as an epigenetic modifier in the aging brain
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Mapping the electrostatic profiles of cellular membranes
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Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease
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Pridopidine modifies disease phenotype in a SOD1 mouse model of amyotrophic lateral sclerosis
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Autophagy and mitophagy in ALS
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Functional corticospinal projections are established prenatally in the human foetus permitting involvement in the development of spinal motor centres
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Effect of age on neocortical brain cells in 90+ year old human females--a cell counting study
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NF-κB is transported into the nucleus by importin α3 and importin α4
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Traffic jam at the nuclear pore: All roads lead to nucleocytoplasmic transport defects in ALS/FTD
10.1016/j.nbd.2020.104835 · 2020 · External reference
Risk factors for amyotrophic lateral sclerosis
2015 · External reference
Parkinson’s disease: proteinopathy or lipidopathy?
10.1038/s41531-019-0103-7 · 2020 · External reference
Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase
10.1016/j.neurobiolaging.2012.02.009 · 2012 · External reference
A VAPB mutant linked to amyotrophic lateral sclerosis generates a novel form of organized smooth endoplasmic reticulum
10.1096/fj.09-147850 · 2010 · External reference
HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations
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Undernutrition during development modulates endoplasmic reticulum stress genes in the hippocampus of juvenile rats: Involvement of oxidative stress
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