Research graph
References from SHANK3 regulates nuclear hnRNP K and oxidative stress-associated DNA damage signaling in neurons. Local targets link to admitted publications; unresolved targets remain external evidence.
ProSAP/Shank proteins – a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease
10.1046/j.1471-4159.2002.00931.x · 2002 · External reference
ProSAP/Shank proteins–a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease
10.1046/j.1471-4159.2002.00931.x · 2002 · External reference
C-terminal synaptic targeting elements for postsynaptic density proteins ProSAP1/Shank2 and ProSAP2/Shank3
10.1111/j.1471-4159.2004.02910.x · 2005 · External reference
hnRNP K: one protein multiple processes
10.1002/bies.20048 · 2004 · External reference
Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan-McDermid syndrome and autism
10.1186/s13229-020-00355-0 · 2020 · External reference
Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation
10.1080/15548627.2019.1589257 · 2019 · External reference
Phenotypic and functional analysis of SHANK3 stop mutations identified in individuals with ASD and/or ID
10.1186/s13229-015-0020-5 · 2015 · External reference
Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications
10.1186/s11689-021-09397-8 · 2021 · External reference
Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders
10.1038/ng1933 · 2007 · External reference
Mitochondrial dysfunction may explain symptom variation in Phelan-McDermid syndrome
10.1038/srep19544 · 2016 · External reference
hnRNP K is a haploinsufficient tumor suppressor that regulates proliferation and differentiation programs in hematologic malignancies
10.1016/j.ccell.2015.09.001 · 2015 · External reference
Unresolved reference
2023 · External reference
Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation
10.1038/emboj.2010.336 · 2011 · External reference
Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies
10.1016/j.tcb.2011.07.003 · 2011 · External reference
The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation
10.1016/j.expneurol.2013.12.015 · 2014 · External reference
Jacob, a synapto-nuclear protein messenger linking N-methyl-D-aspartate receptor activation to nuclear gene expression
10.3389/fnsyn.2021.787494 · 2021 · External reference
Shank3 is localized in axons and presynaptic specializations of developing hippocampal neurons and involved in the modulation of NMDA receptor levels at axon terminals
10.1111/jnc.13523 · 2016 · External reference
Truncating mutations in SHANK3 associated with global developmental delay interfere with nuclear β-catenin signaling
10.1111/jnc.15014 · 2020 · External reference
Selective localization of shanks to VGLUT1-positive excitatory synapses in the mouse hippocampus
10.3389/fncel.2016.00106 · 2016 · External reference
Regulated transport of signaling proteins from synapse to nucleus
10.1016/j.conb.2017.04.006 · 2017 · External reference
Disrupted extracellular matrix and cell cycle genes in autism-associated Shank3 deficiency are targeted by lithium
10.1038/s41380-023-02362-y · 2024 · External reference
Nucleocytoplasmic protein shuttling: the direct route in synapse-to-nucleus signaling
10.1016/j.tins.2009.04.001 · 2009 · External reference
Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons
10.1038/nn1867 · 2007 · External reference
Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development
10.1038/mp.2017.185 · 2018 · External reference
Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs
10.1073/pnas.0900604106 · 2009 · External reference
SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage
10.1038/emboj.2012.293 · 2012 · External reference
Homer1a regulates Shank3 expression and underlies behavioral vulnerability to stress in a model of Phelan-McDermid syndrome
10.1016/j.celrep.2021.110014 · 2021 · External reference
SHANK3 antibody validation: differential performance in Western blotting, immunocyto- and immunohistochemistry
10.3389/fnsyn.2022.890231 · 2022 · External reference
Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles
10.1126/scitranslmed.aaz3267 · 2020 · External reference
Shank3 related oligodendrocyte alterations in autism are restored by Erk pathway inhibition
10.1038/s41380-025-03333-1 · 2026 · External reference
Adult restoration of Shank3 expression rescues selective autistic-like phenotypes
10.1038/nature16971 · 2016 · External reference
SHANK proteins: roles at the synapse and in autism spectrum disorder
10.1038/nrn.2016.183 · 2017 · External reference
ATM-dependent phosphorylation of heterogeneous nuclear ribonucleoprotein K promotes p53 transcriptional activation in response to DNA damage
10.4161/cc.23592 · 2013 · External reference
Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin
10.1016/s0896-6273(00)80809-0 · 1999 · External reference
DNA damage-induced heterogeneous nuclear ribonucleoprotein K sumoylation regulates p53 transcriptional activation
10.1074/jbc.m112.390120 · 2012 · External reference
Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation
10.1038/sj.emboj.7601569 · 2007 · External reference
Heterogeneous nuclear ribonucleoprotein K interacts with Abi-1 at postsynaptic sites and modulates dendritic spine morphology
10.1371/journal.pone.0027045 · 2011 · External reference
The Shank family of scaffold proteins
10.1242/jcs.113.11.1851 · 2000 · External reference
Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses*
10.1074/jbc.m111.258384 · 2011 · External reference
Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice
10.1038/mp.2016.30 · 2017 · External reference
p53 in health and disease
10.1038/nrm2147 · 2007 · External reference
Blinded by the light: the growing complexity of p53
10.1016/j.cell.2009.04.037 · 2009 · External reference
The emerging roles of hnRNPK
10.1002/jcp.29186 · 2020 · External reference
Knockdown of hnRNPK leads to increased DNA damage after irradiation and reduces survival of tumor cells
10.1093/carcin/bgx006 · 2017 · External reference
Shank3 ameliorates neuronal injury after cerebral ischemia/reperfusion via inhibiting oxidative stress and inflammation
10.1016/j.redox.2023.102983 · 2024 · External reference
