Research graph
References from When tau goes electric: The first report of a positive correlation between tau burden and ex vivo hyperexcitability in human epileptic hippocampal slices. Local targets link to admitted publications; unresolved targets remain external evidence.
Assessment of tau phosphorylation and β-amyloid pathology in human drug-resistant epilepsy
10.1002/epi4.12744 · 2023 · External reference
Specific imbalance of excitatory/inhibitory signaling establishes seizure onset pattern in temporal lobe epilepsy
10.1152/jn.01128.2015 · 2016 · External reference
Alzheimer’s disease: a case study involving EEG-based fE/I ratio and pTau-181 protein analysis through nasal administration of Saraswata Ghrita
10.1177/25424823241306771 · 2024 · External reference
International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a task force report from the ILAE commission on diagnostic methods
10.1111/epi.12220 · 2013 · External reference
GABAB receptor outward currents are transiently disclosed by the convulsant 4-aminopyridine in vitro
10.1016/j.crneur.2023.100117 · 2023 · External reference
Coefficient of variation vs. mean interspike interval curves: what do they tell us about the brain?
10.1016/s0925-2312(01)00480-5 · 2001 · External reference
Sex differences in P-Tau217, tau aggregation, and cognitive decline
10.1001/jamaneurol.2025.5670 · 2026 · External reference
Epileptic prodromal Alzheimer’s disease, a retrospective study of 13 new cases: expanding the spectrum of Alzheimer’s disease to an epileptic variant?
10.3233/jad-150096 · 2016 · External reference
CSF in epileptic prodromal Alzheimer’s disease: no diagnostic contribution but a pathophysiological one
10.3389/fneur.2021.623777 · 2021 · External reference
Steroid hormones and their action in women’s brains: the importance of hormonal balance
10.3389/fpubh.2018.00141 · 2018 · External reference
The neuropathological diagnosis of Alzheimer’s disease
10.1186/s13024-019-0333-5 · 2019 · External reference
Unresolved reference
2005 · External reference
An ecosystems and vulnerable populations perspective on solastalgia and psychological distress after a wildfire
10.1007/s10393-015-1052-1 · 2015 · External reference
An organotypic brain slice preparation from adult patients with temporal lobe epilepsy
10.1016/j.jneumeth.2014.07.009 · 2014 · External reference
Exploring biomarkers of neurodegeneration in epilepsy: critical insights
10.1002/epd2.70023 · 2025 · External reference
Time-dependent phenotypical changes of microglia drive alterations in hippocampal synaptic transmission in acute slices
10.3389/fncel.2024.1456974 · 2024 · External reference
Amyloid deposition in adults with drug-resistant temporal lobe epilepsy
10.1111/epi.18142 · 2024 · External reference
Time series segmentation for recognition of epileptiform patterns recorded via microelectrode arrays in vitro
10.1371/journal.pone.0309550 · 2025 · External reference
Aging-related adaptations of metabotropic glutamate receptors within the CA3 region of the rat hippocampus
10.1016/j.neurobiolaging.2025.08.008 · 2025 · External reference
Calbindin-D28k deficiency mediates tau-driven hippocampal hyperexcitement and cognitive impairment
10.1186/s40035-026-00547-3 · 2026 · External reference
Cracking novel shared targets between epilepsy and Alzheimer’s disease: need of the hour
10.1515/revneuro-2017-0064 · 2018 · External reference
Early Alzheimer’s disease pathology in human cortex involves transient cell states
10.1016/j.cell.2023.08.005 · 2023 · External reference
Tau reduction prevents disease in a mouse model of Dravet syndrome
10.1002/ana.24230 · 2014 · External reference
Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy
10.1093/brain/awz381 · 2020 · External reference
EEG spectral analysis as a putative early prognostic biomarker in nondemented, amyloid positive subjects
10.1016/j.neurobiolaging.2017.05.017 · 2017 · External reference
Metabotropic glutamate receptors at the aged mossy fiber - CA3 synapse of the hippocampus
10.1016/j.neuroscience.2019.12.016 · 2021 · External reference
Cerebrospinal fluid biomarkers of Alzheimer’s disease correlate with electroencephalography parameters assessed by exact low-resolution electromagnetic tomography (eLORETA)
10.1177/1550059416662119 · 2017 · External reference
Screening of Aβ and phosphorylated tau status in the cerebrospinal fluid through machine learning analysis of portable electroencephalography data
10.1038/s41598-025-86449-2 · 2025 · External reference
The 4-aminopyridine model of acute seizures in vitro elucidates efficacy of new antiepileptic drugs
10.3389/fnins.2019.00677 · 2019 · External reference
An in vitro seizure model from human hippocampal slices using multi-electrode arrays
10.1016/j.jneumeth.2014.09.010 · 2015 · External reference
Tauopathy and epilepsy comorbidities and underlying mechanisms
10.3389/fnagi.2022.903973 · 2022 · External reference
Critical state of energy metabolism in brain slices: the principal role of oxygen delivery and energy substrates in shaping neuronal activity
10.3389/fnene.2011.00009 · 2011 · External reference
Detection of interictal epileptiform discharges using signal envelope distribution modelling: application to epileptic and non-epileptic intracranial recordings
10.1007/s10548-014-0379-1 · 2015 · External reference
Stereological analysis of GluR2-immunoreactive hilar neurons in the pilocarpine model of temporal lobe epilepsy: correlation of cell loss with mossy fiber sprouting
10.1016/j.expneurol.2007.03.025 · 2007 · External reference
Human brain slices for epilepsy research: pitfalls, solutions and future challenges
10.1016/j.jneumeth.2015.09.021 · 2016 · External reference
Human brain slice cultures: translational applications and ethical considerations
10.26508/lsa.202403160 · 2025 · External reference
3-carene modulates baseline brain electrical activity without suppressing 4-aminopyridine-induced seizure events: an in vivo and in vitro electrophysiological study
10.1007/s11064-025-04595-5 · 2025 · External reference
Oscillations in the dentate gyrus as a tool for the performance of the hippocampal functions: healthy and epileptic brain
10.1016/j.pnpbp.2023.110759 · 2023 · External reference
A comprehensive review on the influence of menstrual cycle and pregnancy on epileptic seizures
2025 · External reference
Modulation of epileptiform activity by three subgroups of GABAergic interneurons in mouse somatosensory cortex
10.1016/j.eplepsyres.2022.106937 · 2022 · External reference
Association of seizure foci and location of tau and amyloid deposition and brain atrophy in patients with Alzheimer disease and seizures
10.1212/wnl.0000000000209920 · 2024 · External reference
Temporal lobe epileptiform activity following systemic administration of 4-aminopyridine in rats
10.1111/epi.12041 · 2013 · External reference
Interneurons spark seizure-like activity in the entorhinal cortex
10.1016/j.nbd.2015.12.011 · 2016 · External reference
Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies
10.1007/s00401-015-1507-z · 2016 · External reference
Low concentration dimethyl sulfoxide (DMSO) modulates epileptiform synchronization in the 4-aminopyridine in vitro model
10.1016/j.jneumeth.2024.110255 · 2024 · External reference
Interneurons, GABAA signaling and their presumptive role in catamenial epilepsy
10.1016/j.neubiorev.2025.106291 · 2025 · External reference
Influence of the estrous cycle on seizure activity in a model of mesial temporal lobe epilepsy
10.1016/j.expneurol.2025.115597 · 2026 · External reference
Interneuronal network activity at the onset of seizure-like events in entorhinal cortex slices
10.1523/jneurosci.3906-16.2017 · 2017 · External reference
Senile plaques in temporal lobe epilepsy
10.1007/bf00294177 · 1994 · External reference
Voltage-activated potassium channels in mammalian neurons and their block by novel pharmacological agents
10.1016/s0306-3623(97)00034-7 · 1998 · External reference
Precise spatial and temporal control of oxygen within in vitro brain slices via microfluidic gas channels
10.1371/journal.pone.0043309 · 2012 · External reference
Stereological methods reveal the robust size and stability of ectopic hilar granule cells after pilocarpine-induced status epilepticus in the adult rat
10.1111/j.1460-9568.2006.05101.x · 2006 · External reference
Unilateral hippocampal sclerosis with contralateral temporal scalp ictal onset
10.1111/j.0013-9580.2004.35703.x · 2004 · External reference
Differential effects of tau expression on seizures and epileptogenesis in a mouse model of temporal lobe epilepsy
10.3389/fnsys.2025.1693339 · 2025 · External reference
Epileptiform activity in brain organoids derived from patient with glucose transporter 1 deficiency syndrome
10.3389/fnins.2024.1498801 · 2024 · External reference
Characterizing concentration-dependent neural dynamics of 4-aminopyridine-induced epileptiform activity
10.4172/2472-0895.1000128 · 2018 · External reference
Is ‘burned-out hippocampus’ syndrome a distinct electro-clinical variant of MTLE-HS syndrome?
10.1016/j.yebeh.2017.01.003 · 2017 · External reference
Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease
10.1007/s00401-013-1154-1 · 2013 · External reference
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer’s disease
10.1016/j.neuron.2007.07.025 · 2007 · External reference
Sex differences in in vivo tau neuropathology in a multiethnic sample of late middle-aged adults
10.1016/j.neurobiolaging.2021.03.007 · 2021 · External reference
Traveling theta waves along the entire septotemporal axis of the hippocampus
10.1016/j.neuron.2012.07.015 · 2012 · External reference
Microelectrode array scaled for human hippocampal slices
2026 · External reference
4-aminopyridine-induced epileptiform activity and a GABA-mediated long-lasting depolarization in the rat hippocampus
10.1523/jneurosci.12-01-00104.1992 · 1992 · External reference
Physiological release of endogenous tau is stimulated by neuronal activity
10.1038/embor.2013.15 · 2013 · External reference
Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy
10.1016/j.brainres.2015.11.007 · 2016 · External reference
Human organotypic brain slice culture: a novel framework for environmental research in neuro-oncology
10.26508/lsa.201900305 · 2019 · External reference
Long-term alteration of calcium homeostatic mechanisms in the pilocarpine model of temporal lobe epilepsy
10.1016/s0006-8993(01)02127-8 · 2001 · External reference
Effects of small conductance Ca2+-activated potassium channel agonists on SLEs in varied epilepsy models, from animal slices to pharmacoresistant human tissue
10.1002/jnr.70078 · 2025 · External reference
Molecular mechanisms of sex differences in epilepsy and seizure susceptibility in chemical, genetic and acquired epileptogenesis
10.1016/j.neulet.2021.135753 · 2021 · External reference
Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy
10.1038/s41598-018-25378-9 · 2018 · External reference
Losartan fails to suppress epileptiform activity in brain slices from resected tissues of patients with drug resistant epilepsy
10.1016/j.jns.2019.01.008 · 2019 · External reference
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated
10.1093/brain/awy146 · 2018 · External reference
Electrophysiological phenotype characterization of human iPSC-derived neuronal cell lines by means of high-density microelectrode arrays
2021 · External reference
Cellular expression of low-density lipoprotein receptor-related protein 1 and amyloid beta deposition in human and rat epileptogenic brain
10.1016/j.expneurol.2025.115149 · 2025 · External reference
Differential effects of levetiracetam on hippocampal CA1 synaptic plasticity and molecular changes in the dentate gyrus in epileptic rats
10.1016/j.neuint.2022.105378 · 2022 · External reference
Towards an understanding of the dentate gyrus hilus
10.1002/hipo.23677 · 2025 · External reference
Hilar mossy cells of the dentate gyrus: a historical perspective
10.3389/fncir.2012.00106 · 2013 · External reference
Human cerebrospinal fluid promotes long-term neuronal viability and network function in human neocortical organotypic brain slice cultures
10.1038/s41598-017-12527-9 · 2017 · External reference
Long-term adult human brain slice cultures as a model system to study human CNS circuitry and disease
10.7554/elife.48417 · 2019 · External reference
TAU ablation in excitatory neurons and postnatal TAU knockdown reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model
10.1126/scitranslmed.abm5527 · 2022 · External reference
Low prevalence of amyloid and tau pathology in drug-resistant temporal lobe epilepsy
10.1111/epi.17086 · 2021 · External reference
Tau deposition in young adults with drug-resistant focal epilepsy
10.1111/epi.16375 · 2019 · External reference
Sex differences in molecular signaling at inhibitory synapses in the hippocampus
10.1523/jneurosci.1067-15.2015 · 2015 · External reference
Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections
10.1093/brain/aww187 · 2016 · External reference
Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study
10.1093/brain/awr209 · 2011 · External reference
Temporal lobe epilepsy and Alzheimer’s disease: from preclinical to clinical evidence of a strong association
10.3233/adr-200286 · 2021 · External reference
Hyperphosphorylated tau in mesial temporal lobe epilepsy: a neuropathological and cognitive study
10.1007/s12035-022-03190-x · 2023 · External reference
Functional and anatomic correlates of two frequently observed temporal lobe seizure-onset patterns
10.1155/np.2000.49 · 2000 · External reference
Aging-related impairments of hippocampal mossy fibers synapses on CA3 pyramidal cells
10.1016/j.neurobiolaging.2016.09.010 · 2017 · External reference
Seizures and epileptiform activity in the early stages of Alzheimer disease
10.1001/jamaneurol.2013.136 · 2013 · External reference
Incidence and impact of subclinical epileptiform activity in Alzheimer’s disease
10.1002/ana.24794 · 2016 · External reference
Incubation with tau aggregates increases hippocampal circuit excitability and enhances long-term depression in acute mouse hippocampal slices
10.3389/fncir.2025.1596989 · 2025 · External reference
Prolonged life of human acute hippocampal slices from temporal lobe epilepsy surgery
10.1038/s41598-018-22554-9 · 2018 · External reference
Human cerebrospinal fluid induces neuronal excitability changes in resected human neocortical and hippocampal brain slices
10.3389/fnins.2020.00283 · 2020 · External reference
ILAE commission report. Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery
10.1046/j.1528-1157.2001.4220282.x · 2001 · External reference
Abolishing spontaneous epileptiform activity in human brain tissue through AMPA receptor inhibition
10.1002/acn3.51030 · 2020 · External reference
A grading system for mesial temporal pathology (hippocampal sclerosis) from anterior temporal lobectomy
10.1016/s0896-6974(05)80120-3 · 1992 · External reference
Rhythmic network activity in human brain slices: variability, mechanisms, and translational insights
10.3389/fnsyn.2026.1798456 · 2026 · External reference
Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats
10.1016/j.nbd.2007.08.013 · 2008 · External reference
