Research graph
References from circHIPK3 promotes pro-fibrotic epithelial reprogramming via the miR-29a-3p/SPARC axis with associated enhancement of TGF-β/SMAD signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy
10.7326/0003-4819-134-2-200101160-00015 · 2001 · External reference
Pathogenic mechanisms underlying idiopathic pulmonary fibrosis
10.1146/annurev-pathol-042320-030240 · 2022 · External reference
A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis
10.1056/nejmoa1402582 · 2014 · External reference
Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis
10.1056/nejmoa1402584 · 2014 · External reference
The role of TGF-beta in pulmonary fibrosis
1991 · External reference
The function of non-coding RNAs in idiopathic pulmonary fibrosis
10.1515/med-2021-0231 · 2021 · External reference
Circular RNAs are a large class of animal RNAs with regulatory potency
10.1038/nature11928 · 2013 · External reference
CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts
2017 · External reference
Circ_0000064 promotes high glucose-induced renal tubular epithelial cells injury to facilitate diabetic nephropathy progression through miR-532-3p/ROCK1 axis
10.1186/s12902-022-00968-x · 2022 · External reference
Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs
10.1038/ncomms11215 · 2016 · External reference
Inhibition of circHIPK3 prevents angiotensin II-induced cardiac fibrosis by sponging miR-29b-3p
10.1016/j.ijcard.2019.04.006 · 2019 · External reference
circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA
10.1038/s41419-019-1430-7 · 2019 · External reference
CircHIPK3 regulates pulmonary fibrosis by facilitating glycolysis in miR-30a-3p/FOXK2-dependent manner
10.7150/ijbs.57915 · 2021 · External reference
Exosomal circHIPK3 released from hypoxia-pretreated cardiomyocytes regulates oxidative damage in cardiac Microvascular endothelial cells via the miR-29a/IGF-1 pathway
10.1155/2019/7954657 · 2019 · External reference
Exosomal CircHIPK3 released from hypoxia-induced cardiomyocytes regulates cardiac angiogenesis after myocardial infarction
2020 · External reference
miR-29 is a major regulator of genes associated with pulmonary fibrosis
10.1165/rcmb.2010-0323oc · 2011 · External reference
Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis
10.1002/hep.23922 · 2011 · External reference
miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice
10.1038/mt.2012.36 · 2012 · External reference
SPARC suppresses apoptosis of idiopathic pulmonary fibrosis fibroblasts through constitutive activation of beta-catenin
10.1074/jbc.m109.025684 · 2010 · External reference
The SPARC protein: an overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease
10.1111/bph.13653 · 2017 · External reference
IL-17A deficiency mitigates bleomycin-induced complement activation during lung fibrosis
10.1096/fj.201700289r · 2017 · External reference
Highly selective Endothelin-1 receptor A inhibition prevents bleomycin-induced pulmonary inflammation and fibrosis in mice
10.1159/000481201 · 2018 · External reference
Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration
10.1186/s12964-023-01040-4 · 2023 · External reference
The bleomycin model of pulmonary fibrosis
10.1007/978-1-4939-7113-8_2 · 2017 · External reference
Reticulocalbin 3 deficiency in alveolar epithelium exacerbated bleomycin-induced pulmonary fibrosis
10.1165/rcmb.2017-0347oc · 2018 · External reference
Time and phenotype-dependent transcriptome analysis in AAV-TGFβ1 and Bleomycin-induced lung fibrosis models
10.1038/s41598-022-16344-7 · 2022 · External reference
Loss of PTEN induces lung fibrosis via alveolar epithelial cell senescence depending on NF-κB activation
10.1111/acel.12858 · 2019 · External reference
Idiopathic pulmonary fibrosis (an update) and progressive pulmonary fibrosis in adults: an Official ATS/ERS/JRS/ALAT Clinical Practice guideline
10.1164/rccm.202202-0399st · 2022 · External reference
The role of miR-29 family in TGF-β driven fibrosis in glaucomatous optic neuropathy
10.3390/ijms231810216 · 2022 · External reference
SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury
10.1172/jci12939 · 2001 · External reference
Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice
10.1371/journal.pone.0054962 · 2013 · External reference
SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells
10.1002/jcb.20008 · 2004 · External reference
Secreted protein acidic and rich in cysteine (SPARC) is upregulated by transforming growth factor (TGF)-β and is required for TGF-β-induced hydrogen peroxide production in fibroblasts
10.1186/1755-1536-6-6 · 2013 · External reference
The role of SPARC in extracellular matrix assembly
10.1007/s12079-009-0062-6 · 2009 · External reference
Pten regulates collagen fibrillogenesis by fibroblasts through SPARC
10.1371/journal.pone.0245653 · 2021 · External reference
SPARC, a matricellular protein: at the crossroads of cell-matrix
10.1016/s0945-053x(00)00105-0 · 2000 · External reference
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
10.1038/nrd.2016.246 · 2017 · External reference
Insulin-like growth Factor-1 signaling in lung development and inflammatory lung diseases
2018 · External reference
Transcriptional profiling of insulin-like growth factor signaling components in embryonic lung development and idiopathic pulmonary fibrosis
10.3390/cells11121973 · 2022 · External reference
MicroRNA mimicry blocks pulmonary fibrosis
10.15252/emmm.201303604 · 2014 · External reference
A lung targeted miR-29 mimic as a therapy for pulmonary fibrosis
10.1016/j.ebiom.2022.104304 · 2022 · External reference
The multilayered complexity of ceRNA crosstalk and competition
10.1038/nature12986 · 2014 · External reference
Differential responses by human respiratory epithelial cell lines to respiratory syncytial virus reflect distinct patterns of infection control
10.1128/jvi.02202-17 · 2018 · External reference
MiR-29a-3p inhibits fibrosis of diabetic kidney disease in diabetic mice via downregulation of DNA methyl transferase 3A and 3B
10.4239/wjd.v16.i4.93630 · 2025 · External reference
Curcumin regulates pulmonary extracellular matrix remodeling and mitochondrial function to attenuate pulmonary fibrosis by regulating the miR-29a-3p/DNMT3A axis
10.1016/j.biopha.2024.116572 · 2024 · External reference
Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis
10.1002/hep.23922 · ExternalCitation · doi-reference
SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells
10.1002/jcb.20008 · ExternalCitation · doi-reference
The bleomycin model of pulmonary fibrosis
10.1007/978-1-4939-7113-8_2 · ExternalCitation · doi-reference
The role of SPARC in extracellular matrix assembly
10.1007/s12079-009-0062-6 · ExternalCitation · doi-reference
Curcumin regulates pulmonary extracellular matrix remodeling and mitochondrial function to attenuate pulmonary fibrosis by regulating the miR-29a-3p/DNMT3A axis
10.1016/j.biopha.2024.116572 · ExternalCitation · doi-reference
A lung targeted miR-29 mimic as a therapy for pulmonary fibrosis
10.1016/j.ebiom.2022.104304 · ExternalCitation · doi-reference
Inhibition of circHIPK3 prevents angiotensin II-induced cardiac fibrosis by sponging miR-29b-3p
10.1016/j.ijcard.2019.04.006 · ExternalCitation · doi-reference
SPARC, a matricellular protein: at the crossroads of cell-matrix
10.1016/s0945-053x(00)00105-0 · ExternalCitation · doi-reference
miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice
10.1038/mt.2012.36 · ExternalCitation · doi-reference
Circular RNAs are a large class of animal RNAs with regulatory potency
10.1038/nature11928 · ExternalCitation · doi-reference
The multilayered complexity of ceRNA crosstalk and competition
10.1038/nature12986 · ExternalCitation · doi-reference
Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs
10.1038/ncomms11215 · ExternalCitation · doi-reference
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
10.1038/nrd.2016.246 · ExternalCitation · doi-reference
circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA
10.1038/s41419-019-1430-7 · ExternalCitation · doi-reference
Time and phenotype-dependent transcriptome analysis in AAV-TGFβ1 and Bleomycin-induced lung fibrosis models
10.1038/s41598-022-16344-7 · ExternalCitation · doi-reference
A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis
10.1056/nejmoa1402582 · ExternalCitation · doi-reference
Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis
10.1056/nejmoa1402584 · ExternalCitation · doi-reference
SPARC suppresses apoptosis of idiopathic pulmonary fibrosis fibroblasts through constitutive activation of beta-catenin
10.1074/jbc.m109.025684 · ExternalCitation · doi-reference
IL-17A deficiency mitigates bleomycin-induced complement activation during lung fibrosis
10.1096/fj.201700289r · ExternalCitation · doi-reference
Loss of PTEN induces lung fibrosis via alveolar epithelial cell senescence depending on NF-κB activation
10.1111/acel.12858 · ExternalCitation · doi-reference
The SPARC protein: an overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease
10.1111/bph.13653 · ExternalCitation · doi-reference
Differential responses by human respiratory epithelial cell lines to respiratory syncytial virus reflect distinct patterns of infection control
10.1128/jvi.02202-17 · ExternalCitation · doi-reference
Pathogenic mechanisms underlying idiopathic pulmonary fibrosis
10.1146/annurev-pathol-042320-030240 · ExternalCitation · doi-reference
Exosomal circHIPK3 released from hypoxia-pretreated cardiomyocytes regulates oxidative damage in cardiac Microvascular endothelial cells via the miR-29a/IGF-1 pathway
10.1155/2019/7954657 · ExternalCitation · doi-reference
Highly selective Endothelin-1 receptor A inhibition prevents bleomycin-induced pulmonary inflammation and fibrosis in mice
10.1159/000481201 · ExternalCitation · doi-reference
Idiopathic pulmonary fibrosis (an update) and progressive pulmonary fibrosis in adults: an Official ATS/ERS/JRS/ALAT Clinical Practice guideline
10.1164/rccm.202202-0399st · ExternalCitation · doi-reference
miR-29 is a major regulator of genes associated with pulmonary fibrosis
10.1165/rcmb.2010-0323oc · ExternalCitation · doi-reference
Reticulocalbin 3 deficiency in alveolar epithelium exacerbated bleomycin-induced pulmonary fibrosis
10.1165/rcmb.2017-0347oc · ExternalCitation · doi-reference
SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury
10.1172/jci12939 · ExternalCitation · doi-reference
Secreted protein acidic and rich in cysteine (SPARC) is upregulated by transforming growth factor (TGF)-β and is required for TGF-β-induced hydrogen peroxide production in fibroblasts
10.1186/1755-1536-6-6 · ExternalCitation · doi-reference
Circ_0000064 promotes high glucose-induced renal tubular epithelial cells injury to facilitate diabetic nephropathy progression through miR-532-3p/ROCK1 axis
10.1186/s12902-022-00968-x · ExternalCitation · doi-reference
Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration
10.1186/s12964-023-01040-4 · ExternalCitation · doi-reference
Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice
10.1371/journal.pone.0054962 · ExternalCitation · doi-reference
Pten regulates collagen fibrillogenesis by fibroblasts through SPARC
10.1371/journal.pone.0245653 · ExternalCitation · doi-reference
The function of non-coding RNAs in idiopathic pulmonary fibrosis
10.1515/med-2021-0231 · ExternalCitation · doi-reference
MicroRNA mimicry blocks pulmonary fibrosis
10.15252/emmm.201303604 · ExternalCitation · doi-reference
Transcriptional profiling of insulin-like growth factor signaling components in embryonic lung development and idiopathic pulmonary fibrosis
10.3390/cells11121973 · ExternalCitation · doi-reference
The role of miR-29 family in TGF-β driven fibrosis in glaucomatous optic neuropathy
10.3390/ijms231810216 · ExternalCitation · doi-reference
MiR-29a-3p inhibits fibrosis of diabetic kidney disease in diabetic mice via downregulation of DNA methyl transferase 3A and 3B
10.4239/wjd.v16.i4.93630 · ExternalCitation · doi-reference
CircHIPK3 regulates pulmonary fibrosis by facilitating glycolysis in miR-30a-3p/FOXK2-dependent manner
10.7150/ijbs.57915 · ExternalCitation · doi-reference
Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy
10.7326/0003-4819-134-2-200101160-00015 · ExternalCitation · doi-reference
