Research graph
References from Glycan targeting can recruit anti-tumor immunologic functions by lymphatic endothelium. Local targets link to admitted publications; unresolved targets remain external evidence.
The lymphatic vasculature in the 21(st) century: novel functional roles in homeostasis and disease
10.1016/j.cell.2020.06.039 · 2020 · External reference
Lymphatic vessels in the age of cancer immunotherapy
10.1038/s41568-024-00681-y · 2024 · External reference
The lymphatic system in disease processes and cancer progression
10.1146/annurev-bioeng-112315-031200 · 2016 · External reference
Tumor-draining lymph nodes - friend or foe during immune checkpoint therapy?
10.1016/j.trecan.2025.04.008 · 2025 · External reference
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
2015 · External reference
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
2016 · External reference
Infiltration characteristics and regulatory mechanisms of CD8(+) T lymphocytes in solid tumors: spatial distribution, biological functions, and interactions with the immune microenvironment
10.3389/fimmu.2025.1661545 · 2025 · External reference
Shaping of peripheral T cell responses by lymphatic endothelial cells
2016 · External reference
Steady-state antigen scavenging, cross-presentation, and CD8+ T cell priming: a new role for lymphatic endothelial cells
10.4049/jimmunol.1302492 · 2014 · External reference
Lymphatic endothelial cells prime naïve CD8(+) T cells into memory cells under steady-state conditions
10.1038/s41467-019-14127-9 · 2020 · External reference
Tumor-associated lymphatic vessel features and immunomodulatory functions
10.3389/fimmu.2019.00720 · 2019 · External reference
Functional cellular anti-tumor mechanisms are augmented by genetic proteoglycan targeting
10.1016/j.neo.2019.11.003 · 2020 · External reference
Sialic acid ligands of CD28 suppress costimulation of T cells
10.1021/acscentsci.1c00525 · 2021 · External reference
Dendritic cells: a spot on sialic acid
10.3389/fimmu.2013.00491 · 2013 · External reference
Phenotypic and functional maturation of dendritic cells mediated by heparan sulfate
10.4049/jimmunol.165.3.1599 · 2000 · External reference
Glycan sulfation modulates dendritic cell biology and tumor growth
10.1016/j.neo.2016.04.004 · 2016 · External reference
Tumor-associated lymphatic vessels upregulate PDL1 to inhibit T-cell activation
10.3389/fimmu.2017.00066 · 2017 · External reference
Heparan sulfate proteoglycans
10.1101/cshperspect.a004952 · 2011 · External reference
Endogenous Nur77 is a specific indicator of antigen receptor signaling in Human T and B cells
10.4049/jimmunol.1601301 · 2017 · External reference
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation
10.1073/pnas.1413726111 · 2014 · External reference
A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis
10.1186/1476-4598-9-316 · 2010 · External reference
Antigen presentation by vascular cells
10.3389/fimmu.2017.01907 · 2017 · External reference
Modes of antigen presentation by lymph node stromal cells and their immunological implications
10.3389/fimmu.2015.00446 · 2015 · External reference
Pathways of MHC I cross-presentation of exogenous antigens
10.1016/j.smim.2023.101729 · 2023 · External reference
Naive T lymphocytes chemotax long distance to CCL21 but not to a source of bioactive S1P
10.1016/j.isci.2023.107695 · 2023 · External reference
Phase I trial of intratumoral injection of CCL21 gene-modified dendritic cells in lung cancer elicits tumor-specific immune responses and CD8(+) T-cell infiltration
10.1158/1078-0432.ccr-16-2821 · 2017 · External reference
Therapeutically increasing MHC-I expression potentiates immune checkpoint blockade
10.1158/2159-8290.cd-20-0812 · 2021 · External reference
Tumor-draining lymph nodes: at the crossroads of metastasis and immunity
10.1126/sciimmunol.abg3551 · 2021 · External reference
