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References from Cosmc loss induces truncated O-glycosylation and accelerates Kras-driven pancreatic carcinogenesis. Local targets link to admitted publications; unresolved targets remain external evidence.
Current and projected incidence rates of pancreatic cancer in 43 countries: an analysis of the Cancer Incidence in Five Continents database
10.1136/bmjgast-2024-001544 · 2025 · External reference
Cancer statistics
2025 · External reference
Early detection of pancreatic cancer
10.1016/s2468-1253(19)30416-9 · 2020 · External reference
Early detection of pancreatic cancer: opportunities and challenges
10.1053/j.gastro.2019.01.259 · 2019 · External reference
Clinicogenomic landscape of pancreatic adenocarcinoma identifies KRAS mutant dosage as prognostic of overall survival
10.1038/s41591-024-03362-3 · 2025 · External reference
Whole genomes redefine the mutational landscape of pancreatic cancer
10.1038/nature14169 · 2015 · External reference
Characterization of the genomic landscape in large-scale Chinese patients with pancreatic cancer
10.1016/j.ebiom.2022.103897 · 2022 · External reference
KRAS mutation: the booster of pancreatic ductal adenocarcinoma transformation and progression
2023 · External reference
Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies
10.1038/s41392-025-02499-y · 2026 · External reference
COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer
10.1186/s12943-015-0386-1 · 2015 · External reference
Immature truncated O-glycophenotype of cancer directly induces oncogenic features
10.1073/pnas.1406619111 · 2014 · External reference
Protein glycosylation in cancer
10.1146/annurev-pathol-012414-040438 · 2015 · External reference
A mutant chaperone converts a wild-type protein into a tumor-specific antigen
10.1126/science.1129200 · 2006 · External reference
Cosmc is an essential chaperone for correct protein O-glycosylation
10.1073/pnas.0914004107 · 2010 · External reference
Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma
10.1038/s41598-025-86988-8 · 2025 · External reference
Tumor-associated antigens: tn antigen, sTn antigen, and T antigen
10.1111/tan.12900 · 2016 · External reference
The Cosmc connection to the tn antigen in cancer
10.3233/cbm-130375 · 2014 · External reference
Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice
10.1038/s12276-018-0157-3 · 2018 · External reference
Modeling pancreatic cancer in mice for experimental therapeutics
10.1016/j.bbcan.2021.188554 · 2021 · External reference
Genetically engineered mouse models of pancreatic cancer: unravelling tumour biology and progressing translational oncology
10.1136/gutjnl-2011-300756 · 2012 · External reference
Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues
10.1002/path.3017 · 2012 · External reference
Differences between KC and KPC pancreatic ductal adenocarcinoma mice models, in terms of their modeling biology and their clinical relevance
10.1016/j.pan.2019.11.006 · 2020 · External reference
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
10.1016/j.ccr.2005.04.023 · 2005 · External reference
Oncogenic KRAS signalling in pancreatic cancer
10.1038/bjc.2014.215 · 2014 · External reference
Pancreatic ductal adenocarcinoma and its precursor lesions: histopathology, cytopathology, and molecular pathology
10.1016/j.ajpath.2018.10.004 · 2019 · External reference
Disruption of C1galt1 gene promotes development and metastasis of pancreatic adenocarcinomas in mice
10.1053/j.gastro.2018.08.007 · 2018 · External reference
Lectin histochemistry for metastasizing and non-metastasizing cancer cells
10.1007/978-1-4939-6788-9_8 · 2017 · External reference
Tissue microarrays
10.1007/978-1-4939-3204-7_3 · 2016 · External reference
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
10.1038/ng1180 · 2003 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
Gene set knowledge discovery with Enrichr
10.1002/cpz1.90 · 2021 · External reference
g:profiler-interoperable web service for functional enrichment analysis and gene identifier mapping (2023 update)
10.1093/nar/gkad347 · 2023 · External reference
Glycosylation: mechanisms, biological functions and clinical implications
10.1038/s41392-024-01886-1 · 2024 · External reference
Altered glycosylation in pancreatic cancer and beyond
10.1084/jem.20211505 · 2022 · External reference
High core 1beta1,3-galactosyltransferase 1 expression is associated with poor prognosis and promotes cellular radioresistance in lung adenocarcinoma
10.1007/s00432-024-05745-y · 2024 · External reference
C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin alpha(v)
10.1038/s41388-020-01594-4 · 2021 · External reference
A comprehensive analysis of tn and STn antigen expression in esophageal adenocarcinoma
10.3390/cancers16020240 · 2024 · External reference
C1GalT1 expression reciprocally controls tumour cell-cell and tumour-macrophage interactions mediated by galectin-3 and MGL with double impact on cancer development and progression
10.1038/s41419-023-06082-7 · 2023 · External reference
CD301 and LSECtin glycan-binding receptors of innate immune cells serve as prognostic markers and potential predictors of immune response in breast cancer subtypes
10.1093/glycob/cwae003 · 2024 · External reference
Bioinformatic analysis of C1GALT1 in cancer: insights into prognosis, metastasis and therapeutic potential
2025 · External reference
Update on the role of C1GALT1 in cancer
10.3892/ol.2022.13217 · 2022 · External reference
Antibody-mediated blockade for galectin-3 binding protein in tumor secretome abrogates PDAC metastasis
10.1073/pnas.2119048119 · 2022 · External reference
The glycosylation landscape of pancreatic cancer
2019 · External reference
Nuclear Galectin-1 promotes KRAS-dependent activation of pancreatic cancer stellate cells
10.1073/pnas.2424051122 · 2025 · External reference
Reduction in O-glycome induces differentially glycosylated CD44 to promote stemness and metastasis in pancreatic cancer
10.1038/s41388-021-02047-2 · 2022 · External reference
GalNT2-mediated O-glycosylation affects pancreas development and function in mice
10.1038/s41598-024-80276-7 · 2024 · External reference
Truncated O-glycans promote epithelial-to-mesenchymal transition and stemness properties of pancreatic cancer cells
10.1111/jcmm.14572 · 2019 · External reference
Truncated O-GalNAc glycans impact on fundamental signaling pathways in pancreatic cancer
2021 · External reference
Overexpression of tn antigen induces chronic pancreatitis in mice
10.1038/s41598-025-96060-0 · 2025 · External reference
