Research graph
References from Machine learning of sunitinib resistance genes reveals that SP5 regulates angiogenesis and sunitinib resistance in RCC via the VEGFA/AKT axis. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer statistics, 2023
2023 · External reference
2004 WHO classification of the renal tumors of the adults
10.1016/j.eururo.2005.11.035 · 2006 · External reference
Role of VHL gene mutation in human cancer
10.1200/jco.2004.05.061 · 2004 · External reference
Von Hippel-Lindau disease: insights into oxygen sensing, protein degradation, and cancer
10.1172/jci162480 · 2022 · External reference
Renal cell carcinoma
10.1016/s0140-6736(24)00917-6 · 2024 · External reference
Sunitinib resistance in renal cell carcinoma: from molecular mechanisms to predictive biomarkers
10.1016/j.drup.2023.100929 · 2023 · External reference
Correction: n6‑methyladenosine‑modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14‑dependent manner in renal cell carcinoma
2026 · External reference
Resistance to sunitinib in renal cell carcinoma: from molecular mechanisms to predictive markers and future perspectives
2015 · External reference
The proliferative Scissor(+) gene signature model uncovers the ISG15-KPNA2 axis as a critical driver of malignancy in ccRCC
10.1016/j.ijbiomac.2026.150812 · 2026 · External reference
Construction and multi-omics analysis of ccRCC mitochondrial related gene machine learning model and validate of key gene FKBP10
10.1016/j.intimp.2025.115527 · 2025 · External reference
Constructing and visualizing models using mime-based machine-learning framework
2025 · External reference
Mime: a flexible machine-learning framework to construct and visualize models for clinical characteristics prediction and feature selection
10.1016/j.csbj.2024.06.035 · 2024 · External reference
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
10.1038/s41467-019-09234-6 · 2019 · External reference
Maftools: efficient and comprehensive analysis of somatic variants in cancer
10.1101/gr.239244.118 · 2018 · External reference
Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade
10.1016/j.celrep.2016.12.019 · 2017 · External reference
Immune gene expression is associated with genomic aberrations in breast cancer
10.1158/0008-5472.can-16-3478 · 2017 · External reference
DHODH drives sunitinib resistance via a non-enzymatic mechanism by inhibiting TRIM28 ubiquitination and consequent VEGFA activation in RCC
10.1002/advs.76266 · 2026 · External reference
Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase
10.1038/nbt.1645 · 2010 · External reference
Differential effects of the new class III agent dofetilide on potassium currents in guinea pig cardiomyocytes
10.1097/00005344-199410000-00007 · 1994 · External reference
Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases
10.1074/jbc.273.20.12281 · 1998 · External reference
Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases
1990 · External reference
Effects of suramin on metastatic ability, proliferation, and production of urokinase-type plasminogen activator and plasminogen activator inhibitor type 2 in human renal cell carcinoma cell line SN12C-PM6
10.1007/bf00133616 · 1995 · External reference
Suramin blocks binding of interleukin-4 to its receptors on human tumor cells and interleukin-4-induced mitogenic response
1995 · External reference
Phase I/II trial of 5-fluorouracil and a noncytotoxic dose level of suramin in patients with metastatic renal cell carcinoma
10.3816/cgc.2008.n.012 · 2008 · External reference
Mechanisms of sunitinib resistance in renal cell carcinoma and associated opportunities for therapeutics
10.1111/bph.16252 · 2023 · External reference
Molecular and functional analysis of Sunitinib-resistance induction in Human renal cell carcinoma cells
10.3390/ijms22126467 · 2021 · External reference
HGF/c-MET pathway in cancer: from molecular characterization to clinical evidence
10.1038/s41388-021-01863-w · 2021 · External reference
Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux
10.1080/15548627.2015.1085742 · 2015 · External reference
Restoring the epigenetically silenced PCK2 suppresses renal cell carcinoma progression and increases sensitivity to sunitinib by promoting endoplasmic reticulum stress
10.7150/thno.48469 · 2020 · External reference
Exosome-transmitted lncARSR promotes sunitinib resistance in renal cancer by acting as a competing endogenous RNA
10.1016/j.ccell.2016.03.004 · 2016 · External reference
Sp5 negatively regulates the proliferation of HCT116 cells by upregulating the transcription of p27
2018 · External reference
Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers
10.1016/j.bbrc.2005.12.068 · 2006 · External reference
Identification of SP5 as a downstream gene of the beta-catenin/tcf pathway and its enhanced expression in human colon cancer
2005 · External reference
CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells
2024 · External reference
Circular RNA circSP5 promotes liver metastasis of colorectal cancer via SP5-mediated BAMBI transcription
10.1007/s10142-023-01142-9 · 2023 · External reference
WNT inhibitor SP5-mediated SERPING1 suppresses lung adenocarcinoma progression via TSC2/mTOR pathway
10.1038/s41419-025-07440-3 · 2025 · External reference
VEGFA and tumour angiogenesis
10.1111/joim.12019 · 2013 · External reference
VEGFR1 signaling in retinal angiogenesis and microinflammation
10.1016/j.preteyeres.2021.100954 · 2021 · External reference
VEGF-A splicing: the key to anti-angiogenic therapeutics?
10.1038/nrc2505 · 2008 · External reference
Molecular mapping and functional characterization of the VEGF164 heparin-binding domain
10.1074/jbc.m700319200 · 2007 · External reference
Epithelial Vegfa specifies a distinct endothelial population in the mouse lung
10.1016/j.devcel.2020.01.009 · 2020 · External reference
Biology and therapeutic targeting of vascular endothelial growth factor A
10.1038/s41580-023-00631-w · 2023 · External reference
Immune microenvironment and the effect of vascular endothelial growth factor inhibition in hepatocellular carcinoma
10.3390/ijms252413590 · 2024 · External reference
Targeting the HIF2-VEGF axis in renal cell carcinoma
10.1038/s41591-020-1093-z · 2020 · External reference
A clear picture of renal cell carcinoma
2013 · External reference
The genetic basis of kidney cancer: a metabolic disease
10.1038/nrurol.2010.47 · 2010 · External reference
A systematic review of sequencing and combinations of systemic therapy in metastatic renal cancer
10.1016/j.eururo.2014.04.006 · 2015 · External reference
Epigenetic activation of VEGFA by SMARCD1 mediates tumor progression and bevacizumab resistance in clear cell renal cell carcinoma
2026 · External reference
Downregulation of UBB potentiates SP1/VEGFA-dependent angiogenesis in clear cell renal cell carcinoma
10.1038/s41388-024-03003-6 · 2024 · External reference
Helicobacter pylori stimulates host vascular endothelial growth factor-A (vegf-A) gene expression via MEK/ERK-dependent activation of Sp1 and Sp3
10.1096/fj.03-0055fje · 2004 · External reference
Role of sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells
10.1158/0008-5472.can-04-0713 · 2004 · External reference
