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References from Pdcd4–Rictor interaction suppresses mTORC2-PFKFB3 axis and tumorigenesis in NSCLC. Local targets link to admitted publications; unresolved targets remain external evidence.
mTOR signaling in growth, metabolism, and disease
10.1016/j.cell.2017.02.004 · 2017 · External reference
The mTORC2 signaling network: targets and cross-talks
10.1042/bcj20220325 · 2024 · External reference
The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2
10.1074/jbc.m111.282590 · 2011 · External reference
Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer
10.1158/1078-0432.ccr-09-1249 · 2009 · External reference
mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin
10.1038/s41598-023-33872-y · 2023 · External reference
mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor
10.1158/0008-5472.can-07-2223 · 2007 · External reference
mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways
10.1158/0008-5472.can-10-4058 · 2011 · External reference
Rictor-A mediator of progression and metastasis in lung cancer
10.3390/cancers16030543 · 2024 · External reference
A comprehensive pan-cancer analysis of the potential biological functions and prognosis values of RICTOR
10.3390/genes14061280 · 2023 · External reference
Role of the integrin-linked kinase (ILK)/rictor complex in TGFbeta-1-induced epithelial-mesenchymal transition (EMT)
10.1038/onc.2012.30 · 2013 · External reference
Regulation and metabolic functions of mTORC1 and mTORC2
10.1152/physrev.00026.2020 · 2021 · External reference
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
10.1101/gad.889901 · 2001 · External reference
mTORC2 mediates CXCL12-induced angiogenesis
10.1007/s10456-016-9509-6 · 2016 · External reference
Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase
10.1042/bj1920897 · 1980 · External reference
Expression of PFKFB3 and Ki67 in lung adenocarcinomas and targeting PFKFB3 as a therapeutic strategy
10.1007/s11010-017-3258-8 · 2018 · External reference
Increased 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity in response to EGFR signaling contributes to non-small cell lung cancer cell survival
10.1074/jbc.ra119.007784 · 2019 · External reference
The role of Pdcd4 in tumour suppression and protein translation
10.1111/boc.201800014 · 2018 · External reference
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene
10.1038/onc.2008.72 · 2008 · External reference
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth
10.1126/science.1130276 · 2006 · External reference
Control mechanisms of the tumor suppressor PDCD4: expression and functions
10.3390/ijms20092304 · 2019 · External reference
Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma
10.1038/onc.2017.228 · 2017 · External reference
AKT activation by Pdcd4 knockdown up-regulates cyclin D1 expression and promotes cell proliferation
10.1177/1947601911431082 · 2011 · External reference
RSK-mediated down-regulation of PDCD4 is required for proliferation, survival, and migration in a model of triple-negative breast cancer
10.18632/oncotarget.8375 · 2016 · External reference
Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion
10.1128/mcb.26.4.1297-1306.2006 · 2006 · External reference
The kinase PLK1 promotes Hedgehog signaling-dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer
10.1126/scisignal.adi5174 · 2025 · External reference
The impact of Pdcd4, a translation inhibitor, on drug resistance
10.3390/ph17101396 · 2024 · External reference
IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas
10.1038/s41392-020-0204-0 · 2020 · External reference
Translational inhibition of slug by Pdcd4 contributes to invasion inhibition in colorectal cancer cells
10.1002/cam4.71145 · 2025 · External reference
Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2
10.1128/mcb.06317-11 · 2012 · External reference
An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4
10.1093/nar/gku800 · 2014 · External reference
microRNA-21-induced dissociation of PDCD4 from rictor contributes to akt-IKKbeta-mTORC1 axis to regulate renal cancer cell invasion
10.1016/j.yexcr.2014.06.022 · 2014 · External reference
Protein arginine methyltransferase 5 accelerates tumor growth by arginine methylation of the tumor suppressor programmed cell death 4
10.1158/0008-5472.can-11-0458 · 2011 · External reference
mTORC2-AKT signaling to PFKFB2 activates glycolysis that enhances stemness and tumorigenicity of intestinal epithelial cells
2024 · External reference
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
10.1158/0008-5472.can-05-2925 · 2006 · External reference
Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP, sequentially regulate glycolysis during the cell cycle
10.1073/pnas.1102247108 · 2011 · External reference
Enhanced arginine methylation of programmed cell death 4 protein during nutrient deprivation promotes tumor cell viability
10.1074/jbc.m113.541300 · 2014 · External reference
mTOR-dependent cell survival mechanisms
10.1101/cshperspect.a008771 · 2012 · External reference
Concomitant targeting of the mTOR/MAPK pathways: novel therapeutic strategy in subsets of RICTOR/KRAS-altered non-small cell lung cancer
10.18632/oncotarget.26129 · 2018 · External reference
RICTOR amplification defines a novel subset of patients with lung cancer who may benefit from treatment with mTORC1/2 inhibitors
10.1158/2159-8290.cd-14-0971 · 2015 · External reference
Suppression of feedback loops mediated by PI3K/mTOR induces multiple overactivation of compensatory pathways: an unintended consequence leading to drug resistance
10.1158/1535-7163.mct-14-0330 · 2014 · External reference
Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated protein kinase kinase pathways
10.1074/jbc.m113.492702 · 2013 · External reference
Control of glycolysis through regulation of PFK1: old friends and recent additions
10.1101/sqb.2011.76.010868 · 2011 · External reference
PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth
10.1016/j.celrep.2025.116071 · 2025 · External reference
Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes
10.1073/pnas.1012362107 · 2010 · External reference
Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both beta-catenin/tcf and AP-1-dependent transcription in colon carcinoma cells
10.1038/sj.onc.1210793 · 2008 · External reference
De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues
10.1074/jbc.ra119.008743 · 2019 · External reference
Inhibition of p70S6K1 activation by Pdcd4 overcomes the resistance to an IGF-1R/IR inhibitor in colon carcinoma cells
10.1158/1535-7163.mct-14-0648 · 2015 · External reference
Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer
10.1016/j.cell.2018.03.022 · 2018 · External reference
Genomic landscape of lung adenocarcinoma in east asians
10.1038/s41588-019-0569-6 · 2020 · External reference