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References from Mechanistic link of obesity to depression and cognitive decline in Alzheimer’s disease. Local targets link to admitted publications; unresolved targets remain external evidence.
A high-fat diet exacerbates depressive-like behavior in the Flinders Sensitive Line (FSL) rat, a genetic model of depression
10.1016/j.psyneuen.2010.09.004 · 2011 · External reference
10.7326/annals-24-03016
10.7326/annals-24-03016 · External reference
Health effects of dietary risks in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
10.1016/s0140-6736(19)30041-8 · 2019 · External reference
Interplay between the gut-brain axis, obesity and cognitive function
2018 · External reference
The relationship between diet, depression, and alzheimer’s disease: a narrative review
10.1002/mnfr.202300419 · 2024 · External reference
Behavioral changes in male mice fed a high-fat diet are associated with IL-1β expression in specific brain regions
10.1016/j.physbeh.2016.11.016 · 2017 · External reference
The gut microbiota as a link between Alzheimer’s disease and obesity
10.1152/ajpgi.00174.2024 · 2024 · External reference
The effect of dietary fat consumption on Alzheimer’s disease pathogenesis in mouse models
10.1038/s41398-022-02067-w · 2022 · External reference
The effect of a low-calorie diet on depressive symptoms in individuals with overweight or obesity: a systematic review and meta-analysis of interventional studies
10.1017/s0033291723003586 · 2024 · External reference
Impact of High-Fat Diet and Early Stress on Depressive-Like Behavior and Hippocampal Plasticity in Adult Male Rats
10.1007/s12035-017-0538-y · 2017 · External reference
High Fat Diet Mediates Amyloid-β Cleaving Enzyme 1 Phosphorylation and SUMOylation, Enhancing Cognitive Impairment in APP/PS1 Mice
2022 · External reference
Plant-Based Diets and Cognitive Outcomes: A Systematic Review and Meta-analysis
10.1016/j.advnut.2025.100537 · 2025 · External reference
Dissecting the molecular mechanisms of gene x environment interactions: implications for diagnosis and treatment of stress-related psychiatric disorders
10.1080/20008198.2017.1412745 · 2017 · External reference
Metabolically Healthy Obesity
10.1210/endrev/bnaa004 · 2020 · External reference
Developmental programming of brain and behavior by perinatal diet: focus on inflammatory mechanisms
10.31887/dcns.2014.16.3/jbolton · 2014 · External reference
Can treatment of obesity reduce depression or vice versa?
10.1503/jpn.210036 · 2021 · External reference
Effect of Multinutrient Supplementation and Food-Related Behavioral Activation Therapy on Prevention of major depressive disorder among overweight or obese adults with subsyndromal depressive symptoms: the MooDFOOD randomized clinical trial
10.1001/jama.2019.0556 · 2019 · External reference
High fat diet worsens Alzheimer’s disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow
10.1038/s41598-020-65908-y · 2020 · External reference
Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
10.1016/s0140-6736(24)00933-4 · 2024 · External reference
Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system
10.1016/j.bbi.2013.06.007 · 2014 · External reference
Role of adiposity-driven inflammation in depressive morbidity
10.1038/npp.2016.123 · 2017 · External reference
A new experimental design to study inflammation-related versus non-inflammation-related depression in mice
10.1186/s12974-021-02330-9 · 2021 · External reference
High fructose corn syrup-moderate fat diet potentiates anxio-depressive behavior and alters ventral striatal neuronal signaling
10.3389/fnins.2021.669410 · 2021 · External reference
Protein kinase C-regulated aβ production and clearance
2011 · External reference
PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice
10.1073/pnas.0509725103 · 2006 · External reference
A one month high fat diet disrupts the gut microbiome and integrity of the colon inducing adiposity and behavioral despair in male Sprague Dawley rats
10.1016/j.heliyon.2022.e11194 · 2022 · External reference
A β3-Adrenergic-Leptin-Melanocortin circuit regulates behavioral and metabolic changes induced by chronic stress
10.1016/j.biopsych.2009.12.003 · 2010 · External reference
Low 24-hour adiponectin and high nocturnal leptin concentrations in a case-control study of community-dwelling premenopausal women with major depressive disorder: the Premenopausal, Osteopenia/Osteoporosis, Women, Alendronate, Depression (POWER) study
10.4088/jcp.09m05314blu · 2010 · External reference
What is the functional significance of chronic stress-induced CA3 dendritic retraction within the hippocampus?
10.1177/1534582306289043 · 2006 · External reference
Dietary Fats and Depressive Symptoms in Italian Adults
10.3390/nu15030675 · 2023 · External reference
Bariatric surgery and gut-brain-axis driven alterations in cognition and inflammation
10.2147/jir.s437156 · 2023 · External reference
Hippocampal function is impaired by a short-term high-fat diet in mice: increased blood–brain barrier permeability and neuroinflammation as triggering events
10.3389/fnins.2021.734158 · 2021 · External reference
Prolonged saturated, but not monounsaturated, high-fat feeding provokes anxiodepressive-like behaviors in female mice despite similar metabolic consequences
2021 · External reference
Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat
10.1016/j.molmet.2018.01.018 · 2018 · External reference
A high-fat diet induced depression-like phenotype via hypocretin-HCRTR1 mediated inflammation activation
10.1039/d4fo00210e · 2024 · External reference
High-fat diet induced anxiety and Anhedonia: impact on brain homeostasis and inflammation
10.1038/npp.2015.357 · 2016 · External reference
High-fat diet–induced activation of SGK1 promotes Alzheimer’s disease–associated tau pathology
10.1093/hmg/ddab115 · 2021 · External reference
Impact of alcohol use disorder on cognition in correlation with aging: a community-based retrospective cohort study
10.1093/alcalc/agae080 · 2024 · External reference
Implication of adult hippocampal neurogenesis in Alzheimer’s disease and potential therapeutic approaches
10.3390/cells11020286 · 2022 · External reference
Intentional weight loss and changes in symptoms of depression: a systematic review and meta-analysis
10.1038/ijo.2011.2 · 2011 · External reference
High-fat diet alleviates neuroinflammation and metabolic disorders of APP/PS1 mice and the intervention with Chinese medicine
10.3389/fnagi.2021.658376 · 2021 · External reference
Reversal of a treatment-resistant, depression-related brain state with the Kv7 channel opener retigabine
10.1016/j.neuroscience.2019.03.003 · 2019 · External reference
High-fat diet selectively protects against the effects of chronic social stress in the mouse
10.1016/j.neuroscience.2011.06.072 · 2011 · External reference
P2-113: high-fat diet affects inflammation and increases TREM2 level in app mice
10.1016/j.jalz.2016.06.1483 · 2016 · External reference
A maternal high-fat diet during pregnancy and lactation induced depression-like behavior in offspring and myelin-related changes in the rat prefrontal cortex
2023 · External reference
New landscape of the diagnosis of Alzheimer’s disease
10.1016/s0140-6736(25)01294-2 · 2025 · External reference
PPARγ dysfunction in the medial prefrontal cortex mediates high-fat diet-induced depression
10.1007/s12035-022-02806-6 · 2022 · External reference
Evaluating the efficacy and mechanisms of a ketogenic diet as adjunctive treatment for people with treatment-resistant depression: a protocol for a randomised controlled trial
10.1016/j.jpsychires.2024.04.023 · 2024 · External reference
The epigenetic overlap between obesity and mood disorders: a systematic review
10.3390/ijms21186758 · 2020 · External reference
Dissecting PANoptosis in the nervous system: a unified cell-death mechanism driving neuroimmune activation and chronic neuroinflammation
10.1007/s12035-026-06031-3 · 2026 · External reference
High fat diet aggravates AD-related pathogenic processes in APP/PS1 mice
10.2174/1567205018666210628100812 · 2021 · External reference
Endogenous Omega (n)-3 Fatty Acids in Fat-1 Mice Attenuated Depression-Like Behavior, Imbalance between Microglial M1 and M2 Phenotypes, and Dysfunction of Neurotrophins Induced by Lipopolysaccharide Administration
10.3390/nu10101351 · 2018 · External reference
S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice
10.1038/srep42946 · 2017 · External reference
Stress-associated molecular and cellular hippocampal mechanisms common for epilepsy and comorbid depressive disorders
10.1134/s0006297921060031 · 2021 · External reference
Obesity: appetite hormone weighs in
10.1038/493480d · 2013 · External reference
The impact of various methods of obesity treatment on the quality of life and mental health—a narrative review
10.3390/ijerph20032122 · 2023 · External reference
Metabolic stress alters antioxidant systems, suppresses the adiponectin receptor 1 and induces Alzheimer’s like pathology in mice brain
10.3390/cells9010249 · 2020 · External reference
High-fat diet induces depression-like behaviour in mice associated with changes in microbiome, neuropeptide Y, and brain metabolome
10.1080/1028415x.2018.1465713 · 2019 · External reference
Anhedonia induced by high-fat diet in mice depends on gut microbiota and leptin
10.1080/1028415x.2020.1751508 · 2022 · External reference
The Effects of Chronic Unpredictable Mild Stress and Semi-Pure Diets on the Brain, Gut and Adrenal Medulla in C57BL6 Mice
10.3390/ijms241914618 · 2023 · External reference
High-fat diet induces neuroinflammation and reduces the serotonergic response to escitalopram in the hippocampus of obese rats
10.1016/j.bbi.2021.05.010 · 2021 · External reference
Mechanisms, pathophysiology, and management of obesity
10.1056/nejmra1514009 · 2017 · External reference
Obesity weighs down memory through a mechanism involving the neuroepigenetic dysregulation of Sirt1
10.1523/jneurosci.1934-15.2016 · 2016 · External reference
Chronic intermittent ethanol exposure alters behavioral flexibility in aged rats compared to adult rats and modifies protein and protein pathways related to Alzheimer’s disease
10.1021/acsomega.2c04528 · 2022 · External reference
Changes in behavior and in brain glucose metabolism in rats after nine weeks on a high fat diet: a randomized controlled trial
2014 · External reference
The protective effects of Ghrelin/GHSR on hippocampal neurogenesis in CUMS mice
10.1016/j.neuropharm.2019.05.013 · 2019 · External reference
Hippocampal Glycerol-3-Phosphate Acyltransferases 4 and BDNF in the progress of obesity-induced depression
10.3389/fendo.2021.667773 · 2021 · External reference
The effects of brain serotonin deficiency on responses to high fat diet in female mice
10.3389/fnins.2021.683103 · 2021 · External reference
Association between repeated unpredictable chronic mild stress (UCMS) procedures with a high fat diet: a model of fluoxetine resistance in mice
10.1371/journal.pone.0010404 · 2010 · External reference
Altered serum adiponectin and interleukin-8 levels are associated in the pathophysiology of major depressive disorder: a case-control study
10.1371/journal.pone.0276619 · 2022 · External reference
The effect of a high-fat diet on brain plasticity, inflammation and cognition in female ApoE4-Knockin and ApoE-knockout mice
10.1371/journal.pone.0155307 · 2016 · External reference
Dietary intervention with Omega-3 fatty acids mitigates maternal high-fat diet-induced behavioral and myelin-related alterations in adult offspring
10.2174/1570159x23666241014164940 · 2024 · External reference
Targeting autophagy, ferroptosis, and neuroinflammation: polyphenol-mediated modulation of emerging signaling pathways in neurodegeneration
10.1007/s12035-026-05760-9 · 2026 · External reference
A possible link between food and mood: dietary impact on gut microbiota and behavior in BALB/c mice
2014 · External reference
Low to moderate ethanol exposure reduces astrocyte-induced neuroinflammatory signaling and cognitive decline in presymptomatic APP/PS1 mice
2024 · External reference
Dissecting the association between inflammation, metabolic dysregulation, and specific depressive symptoms: a genetic correlation and 2-Sample Mendelian Randomization Study
10.1001/jamapsychiatry.2020.3436 · 2021 · External reference
Brain 5-HT Deficiency Prevents Antidepressant-Like Effects of High-Fat-Diet and Blocks High-Fat-Diet-Induced GSK3β Phosphorylation in the Hippocampus
10.3389/fnmol.2019.00298 · 2019 · External reference
Nanomedicine targeting neuroinflammatory pathways in Alzheimer’s disease: a new frontier in inflammopharmacology
2026 · External reference
Targeting the GLP-1 receptor pathways for dual management of obesity and depression
10.1016/j.drudis.2026.104727 · 2026 · External reference
Exercise attenuates high-fat diet-induced disease progression in 3xTg-AD mice
10.1249/mss.0000000000001166 · 2017 · External reference
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
10.1038/nn.3275 · 2012 · External reference
High-fat diet-induced memory impairment in triple-transgenic Alzheimer’s disease (3xTgAD) mice is independent of changes in amyloid and tau pathology
10.1016/j.neurobiolaging.2014.02.010 · 2014 · External reference
10.1152/jn.00359.2015
10.1152/jn.00359.2015 · External reference
Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion
10.1038/tp.2014.77 · 2014 · External reference
Degree of lipid saturation affects depressive-like behaviour and gut microbiota in mice
10.1080/09637486.2019.1681380 · 2020 · External reference
Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer’s Disease
10.3389/fnbeh.2021.778456 · 2022 · External reference
Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression
10.1016/j.neubiorev.2011.12.005 · 2012 · External reference
Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons
10.1038/s41380-020-0649-0 · 2020 · External reference
PANoptosis: Cross-Talk Among Apoptosis, Necroptosis, and Pyroptosis in Neurological Disorders
10.2147/jir.s526158 · 2025 · External reference
Inflammation-activated C/EBPβ mediates high-fat diet-induced depression-like behaviors in mice
10.3389/fnmol.2022.1068164 · 2022 · External reference
High fat diet-induced obesity leads to depressive and anxiety-like behaviors in mice via AMPK/mTOR-mediated autophagy
10.1016/j.expneurol.2021.113949 · 2022 · External reference
Ketogenic diet attenuates neuroinflammation and restores hippocampal neurogenesis to improve CUMS induced depression-like behavior in mice
10.1039/d5fo00226e · 2025 · External reference
High-fat-diet intake enhances cerebral amyloid angiopathy and cognitive impairment in a mouse model of alzheimer’s disease, independently of metabolic disorders
10.1161/jaha.115.003154 · 2016 · External reference
Obesity in adults
10.1016/s0140-6736(24)01210-8 · 2024 · External reference
Meranzin Hydrate Improves Depression-Like Behaviors and Hypomotility via Ghrelin and Neurocircuitry
10.1007/s11655-022-3308-2 · 2022 · External reference
High-fat diet-induced diabetes couples to Alzheimer’s disease through inflammation-activated C/EBPβ/AEP pathway
10.1038/s41380-022-01600-z · 2022 · External reference
Combined Effects of Early Life Stress and Prolonged Exposure to Western Diet on Emotional Responses and Gut Microbiota
10.7334/psicothema2023.287 · 2024 · External reference
Pilot trial of a group cognitive behavioural therapy program for comorbid depression and obesity
10.1186/s40359-020-00400-w · 2020 · External reference
Is metabolic-healthy obesity associated with risk of dementia? An age-stratified analysis of the Whitehall II cohort study
10.1186/s12916-023-03155-4 · 2023 · External reference
Neuroinflammatory mechanisms linking high-fat diets to Alzheimer’s disease vulnerability: beyond the amyloid hypothesis
10.1002/alz.70911 · 2025 · External reference
Stress, depression, diet, and the gut microbiota: human–bacteria interactions at the core of psychoneuroimmunology and nutrition
10.1016/j.cobeha.2019.01.011 · 2019 · External reference
High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review
10.3390/cells10113164 · 2021 · External reference
A high fat/cholesterol diet recapitulates some alzheimer’s disease-like features in mice: Focus on hippocampal mitochondrial dysfunction
10.3233/jad-210122 · 2021 · External reference
Mitochondrial abnormalities and synaptic loss underlie memory deficits seen in mouse models of obesity and Alzheimer’s disease
10.3233/jad-160640 · 2017 · External reference
Nutritional psychiatry: the present state of the evidence
10.1017/s0029665117002026 · 2017 · External reference
Associations between nutrition and the incidence of depression in middle-aged and older adults: a systematic review and meta-analysis of prospective observational population-based studies
10.1016/j.arr.2021.101403 · 2021 · External reference
A high-fat diet exacerbates the Alzheimer’s disease pathology in the hippocampus of the AppNL−F/NL−F knock-in mouse model
10.1111/acel.13429 · 2021 · External reference
The brain and body on stress: allostatic load and mechanisms for depression and dementia
2018 · External reference
Ketogenic diet is less effective in ameliorating depression and anxiety in obesity than Mediterranean diet: A pilot study for exploring the GUT-brain axis
10.1016/j.bbi.2025.106167 · 2026 · External reference
Immune and Neuroendocrine Mechanisms of Stress Vulnerability and Resilience
10.1038/npp.2016.90 · 2017 · External reference
Depression Heterogeneity and Its Biological Underpinnings: Toward Immunometabolic Depression
10.1016/j.biopsych.2020.01.014 · 2020 · External reference
Leptin dysregulation is specifically associated with major depression with atypical features: evidence for a mechanism connecting obesity and depression
10.1016/j.biopsych.2015.10.023 · 2017 · External reference
Modulation of gut microbiota by antibiotics did not affect anhedonia in a high-fat diet-induced model of depression in male mice
10.55976/fnds.12023117220-32 · 2023 · External reference
Obesity and depression: a pathophysiotoxic relationship
10.3390/ijms262311590 · 2025 · External reference
Obesity and depression: a pathophysiotoxic relationship
10.3390/ijms262311590 · 2025 · External reference
The effect of MEditerranean DIet and MINdfulness eating on Depression severity in people with major depressive disorder and obesity (MEDIMIND): a study protocol of a randomised controlled clinical trial with multifactorial design
2025 · External reference
Effect of Metabolic Syndrome on Depression in Mice
10.5530/ijper.51.4s.94 · 2017 · External reference
Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice
10.1038/s41598-017-04412-2 · 2017 · External reference
Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression
10.1038/s41398-018-0210-y · 2018 · External reference
Obesity affects brain structure and function- rescue by bariatric surgery?
10.1016/j.neubiorev.2019.11.025 · 2020 · External reference
Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice
10.1016/j.nbd.2006.04.013 · 2006 · External reference
Adenosine A2A receptor blockade prevents cisplatin-induced impairments in neurogenesis and cognitive function
10.1073/pnas.2206415119 · 2022 · External reference
Clinical management of major depressive disorder with comorbid obesity
10.1016/s2215-0366(25)00193-2 · 2025 · External reference
Mental health outcomes in obesity interventions with GLP-1 receptor agonists: is it similar to other obesity interventions? A narrative review with systematic evidence synthesis
10.1038/s41366-025-02002-1 · 2025 · External reference
Prebiotics modulate the microbiota–gut–brain axis and ameliorate anxiety and depression-like behavior in HFD-fed mice
10.1016/j.foodres.2024.114153 · 2024 · External reference
Hippocampal GSK3β as a Molecular Link Between Obesity and Depression
10.1007/s12035-014-8863-x · 2014 · External reference
Diet overall and hypocaloric diets are associated with improvements in depression but not anxiety in people with metabolic conditions: a systematic review and meta-analysis
10.1016/j.advnut.2024.100169 · 2024 · External reference
A multidomain intervention for modifying lifestyle habits reduces the dementia risk in community-dwelling older adults: a single-blinded randomized controlled pilot study
10.3233/jad-190016 · 2019 · External reference
Cognitive performance and brain-boosting foods
10.1201/9781032687162-3 · 2026 · External reference
Ghrelin alleviates depression-like behaviour in rats subjected to high-fat diet and diurnal rhythm disturbance
2022 · External reference
A Review of miRNAs as Biomarkers and Effect of Dietary Modulation in Obesity Associated Cognitive Decline and Neurodegenerative Disorders
10.3389/fnmol.2021.756499 · 2021 · External reference
High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents
10.1016/j.bbadis.2015.05.004 · 2015 · External reference
Mitochondrial allostatic load puts the “gluc” back in glucocorticoids
10.1038/nrendo.2014.22 · 2014 · External reference
Stress, depression, and neuroplasticity: a convergence of mechanisms
10.1038/sj.npp.1301574 · 2008 · External reference
Association between military service and Alzheimer’s disease neuropathology at autopsy
10.1002/alz.13520 · 2024 · External reference
Meta-Analysis of Alzheimer’s Disease Risk with Obesity, Diabetes, and Related Disorders
10.1016/j.biopsych.2009.02.013 · 2010 · External reference
Insulin resistance in depressive disorders and Alzheimer’s disease: revisiting the missing link hypothesis
10.1016/j.neurobiolaging.2005.09.004 · 2005 · External reference
Chronic low-grade inflammation in obesity as a potential biomarker for Alzheimer’s disease
10.1002/alz70855_106637 · 2025 · External reference
Effect of high-fat diet on cognitive impairment in triple-transgenic mice model of Alzheimer’s disease
10.1016/j.bbrc.2017.08.122 · 2017 · External reference
Adiponectin: a potential target for obesity-associated Alzheimer’s disease
10.1007/s11011-021-00756-x · 2021 · External reference
Sex-dependent Effects of High-fat Diet and Stress on CNS Inflammation and Ceramides Production
10.1096/fasebj.2020.34.s1.05194 · 2020 · External reference
The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders
10.1038/s41583-021-00540-x · 2021 · External reference
Astroengrams: rethinking the cellular substrate for memory
2026 · External reference
High-fat diet impairs duodenal barrier function and elicits glia-dependent changes along the gut-brain axis that are required for anxiogenic and depressive-like behaviors
10.1186/s12974-021-02164-5 · 2021 · External reference
The role of obesity and diabetes in dementia
10.3390/ijms23169267 · 2022 · External reference
Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial
10.1038/s41398-024-03030-7 · 2024 · External reference
Sex differences in motivational responses to dietary fat in Syrian hamsters
10.1016/j.physbeh.2015.04.029 · 2015 · External reference
Adaptations in brain reward circuitry underlie palatable food cravings and anxiety induced by high-fat diet withdrawal
10.1038/ijo.2012.197 · 2013 · External reference
Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry
10.1038/ijo.2012.48 · 2013 · External reference
Exposure to Vicarious Social Defeat Stress and Western-Style Diets During Adolescence Leads to Physiological Dysregulation, Decreases in Reward Sensitivity, and Reduced Antidepressant Efficacy in Adulthood
10.3389/fnins.2021.701919 · 2021 · External reference
Appetite changes reveal depression subgroups with distinct endocrine, metabolic, and immune states
10.1038/s41380-018-0093-6 · 2020 · External reference
Early Life Obesity Increases Neuroinflammation, Amyloid Beta Deposition, and Cognitive Decline in a Mouse Model of Alzheimer’s Disease
10.3390/nu15112494 · 2023 · External reference
Glucocorticoids Mediate Short-Term High-Fat Diet Induction of Neuroinflammatory Priming, the NLRP3 Inflammasome, and the Danger Signal HMGB1
10.1523/eneuro.0113-16.2016 · 2016 · External reference
The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity
10.3390/ijms232113591 · 2022 · External reference
Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism
10.1038/s41380-018-0086-5 · 2018 · External reference
Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol diet
10.1016/j.bbi.2015.02.015 · 2015 · External reference
The role of the gut microbiota in depressive-like behavior induced by chlorpyrifos in mice
10.1016/j.ecoenv.2022.114470 · 2023 · External reference
Exploiting Common Aspects of Obesity and Alzheimer’s Disease
10.3389/fnhum.2020.602360 · 2020 · External reference
The links between stress and depression: psychoneuroendocrinological, genetic, and environmental interactions
10.1176/appi.neuropsych.15030053 · 2016 · External reference
High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status
10.1016/j.jnutbio.2014.02.003 · 2014 · External reference
Blood-brain barrier dysfunction precedes cognitive decline and neurodegeneration in diabetic insulin resistant mouse model: An implication for causal link
2017 · External reference
Obesity is associated with hypothalamic injury in rodents and humans
10.1172/jci59660 · 2012 · External reference
High fat diet exacerbates Alzheimer’s disease-related pathology in APPswe/PS1 mice
10.18632/oncotarget.12179 · 2016 · External reference
An anti-inflammatory diet as a potential intervention for depressive disorders: a systematic review and meta-analysis
10.1016/j.clnu.2018.11.007 · 2019 · External reference
Associations between plant-based dietary patterns and risks of cognitive impairment and dementia: a systematic review and dose-response meta-analysis
10.1016/j.tjpad.2026.100521 · 2026 · External reference
High-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens
10.1038/s41380-022-01787-1 · 2022 · External reference
High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice
10.1016/j.brainres.2018.07.017 · 2018 · External reference
Time-restricted feeding prevents depressive-like behaviors by suppressing changes in the gut microbiota
10.1016/j.bbrc.2025.152397 · 2025 · External reference
Interactive actions of Bdnf methylation and cell metabolism for building neural resilience under the influence of diet
10.1016/j.nbd.2014.09.014 · 2015 · External reference
The impact of maternal high-fat diet on offspring neurodevelopment
10.3389/fnins.2022.909762 · 2022 · External reference
Liraglutide improves memory in obese patients with prediabetes or early type 2 diabetes: a randomized, controlled study
10.1038/s41366-020-0535-5 · 2020 · External reference
A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling
10.1038/s41398-019-0470-1 · 2019 · External reference
Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration
2015 · External reference
P2-394: INSULIN REVERSES THE HIGH FAT DIET-INDUCED INCREASE IN BRAIN Aβ AND IMPROVES MEMORY IN AN ANIMAL MODEL OF ALZHEIMER’S DISEASE
10.1016/j.jalz.2014.05.1074 · 2014 · External reference
Prolonged diet-induced obesity modifies DNA methylation and gene expression in the Hippocampus
2022 · External reference
Weight loss is associated with improvements in cognitive function among overweight and obese people: a systematic review and meta-analysis
10.1016/j.neubiorev.2016.11.017 · 2017 · External reference
Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity
10.1016/j.psyneuen.2016.06.004 · 2016 · External reference
Chronic high-fat diet drives postnatal epigenetic regulation of μ-Opioid receptor in the brain
10.1038/npp.2011.4 · 2011 · External reference
Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes
10.1210/en.2010-0505 · 2010 · External reference
The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis
10.1038/mp.2014.34 · 2014 · External reference
High-fat diet consumption induces neurobehavioral abnormalities and neuronal morphological alterations accompanied by excessive microglial activation in the medial prefrontal cortex in adolescent mice
10.3390/ijms24119394 · 2023 · External reference
High-fat diet-induced atherosclerosis promotes neurodegeneration in the triple transgenic (3 × Tg) mouse model of Alzheimer’s disease associated with chronic platelet activation
10.1186/s13195-021-00890-9 · 2021 · External reference
Neuronal nitric oxide synthase regulates depression-like behaviors in shortening-induced obese mice
10.3390/nu14204302 · 2022 · External reference
Effects of High-fat Diet and Chronic Mild Stress on Depression-like Behaviors and Levels of Inflammatory Cytokines in the Hippocampus and Prefrontal Cortex of Rats
10.1016/j.neuroscience.2021.11.015 · 2022 · External reference
Dietary High-Fat Promotes Cognitive Impairment by Suppressing Mitophagy
2023 · External reference
Association between self-rating depression scores and total ghrelin and adipokine serum levels in a large population-based sample
10.3389/fpsyt.2022.891325 · 2022 · External reference
Glucocorticoid receptor activation impairs hippocampal plasticity by suppressing BDNF expression in obese mice
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