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References from Acidic cannabinoids in brain disorders: Neurobiological mechanisms, preclinical evidence, and translational challenges. Local targets link to admitted publications; unresolved targets remain external evidence.
PGC-1alpha Is a Master Regulator of Mitochondrial Lifecycle and ROS Stress Response
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Behavioural and molecular effects of cannabidiolic acid in mice
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Mitochondrial dysfunction and oxidative stress in Alzheimer's disease, and Parkinson's disease, Huntington's disease and Amyotrophic Lateral Sclerosis -An updated review
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Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions
10.1111/epi.16355 · 2019 · External reference
Cannabichromene, Related Phytocannabinoids, and 5-Fluoro-cannabichromene Have Anticonvulsant Properties in a Mouse Model of Dravet Syndrome
10.1021/acschemneuro.0c00677 · 2021 · External reference
Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a+/- mouse model of Dravet syndrome
10.1371/journal.pone.0280842 · 2023 · External reference
Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy
10.1111/bph.15661 · 2021 · External reference
Pharmacokinetics of Phytocannabinoid Acids and Anticonvulsant Effect of Cannabidiolic Acid in a Mouse Model of Dravet Syndrome
10.1021/acs.jnatprod.9b00600 · 2019 · External reference
Olivetolic acid, a cannabinoid precursor in Cannabis sativa, but not CBGA methyl ester exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome
10.1186/s42238-021-00113-w · 2022 · External reference
Cannabidiol Enhances the Passage of Lipid Nanocapsules across the Blood-Brain Barrier Both in Vitro and in Vivo
10.1021/acs.molpharmaceut.8b01344 · 2019 · External reference
Antibacterial cannabinoids from Cannabis sativa: a structure-activity study
10.1021/np8002673 · 2008 · External reference
Cannabidiol disrupts conditioned fear expression and cannabidiolic acid reduces trauma-induced anxiety-related behaviour in mice
10.1097/fbp.0000000000000565 · 2020 · External reference
Metabolomics and lipidomics strategies in modern drug discovery and development
10.1016/j.drudis.2023.103751 · 2023 · External reference
The direct actions of cannabidiol and 2-arachidonoyl glycerol at GABA(A) receptors
10.1016/j.phrs.2017.02.022 · 2017 · External reference
The role of cannabinoid ligands in neurodegenerative diseases: Emerging anti-inflammatory, immunomodulation and disease-modifying perspectives
2026 · External reference
Evaluation of the Possible Anticonvulsant Effect of Delta(9)-Tetrahydrocannabinolic Acid in Murine Seizure Models
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Epigenetic Regulation in Neurodegenerative Diseases
10.1016/j.tins.2018.05.005 · 2018 · External reference
Antidepressant drug use in Europe: past consumption, prescribing patterns and forecast until 2030
10.1007/s11096-025-02078-9 · 2026 · External reference
Cannabidiol as a Potential Treatment for Anxiety Disorders
10.1007/s13311-015-0387-1 · 2015 · External reference
Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation
10.1111/bph.12043 · 2013 · External reference
Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels
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CBD in the Treatment of Epilepsy
10.3390/molecules29091981 · 2024 · External reference
Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease
10.1016/j.bcp.2013.01.017 · 2013 · External reference
Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid
10.1093/carcin/bgu205 · 2014 · External reference
Neuromotor tolerability and behavioural characterisation of cannabidiolic acid, a phytocannabinoid with therapeutic potential for anticipatory nausea
10.1007/s00213-015-4100-1 · 2016 · External reference
Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid
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The association between 5-HT1A binding and temporal lobe epilepsy: A meta-analysis of molecular imaging studies
10.1016/j.yebeh.2023.109354 · 2023 · External reference
Cannabinoids, Blood-Brain Barrier, and Brain Disposition
10.3390/pharmaceutics12030265 · 2020 · External reference
Therapeutic potential of minor cannabinoids in psychiatric disorders: A systematic review
10.1016/j.euroneuro.2024.10.006 · 2025 · External reference
Memantine inhibits calcium-permeable AMPA receptors
10.1038/s41467-025-60543-5 · 2025 · External reference
Delta(9)-tetrahydrocannabinol (Delta(9)-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease
10.1111/j.1365-2990.2011.01248.x · 2012 · External reference
Prognostic serum miRNA biomarkers associated with Alzheimer's disease shows concordance with neuropsychological and neuroimaging assessment
10.1038/mp.2014.127 · 2015 · External reference
Whole proteome mapping of compound-protein interactions
10.1016/j.crchbi.2022.100035 · 2022 · External reference
Analysis of cannabinoids in commercial hemp seed oil and decarboxylation kinetics studies of cannabidiolic acid (CBDA)
10.1016/j.jpba.2017.11.044 · 2018 · External reference
dCas9-Based Scn1a gene activation restores inhibitory interneuron excitability and attenuates seizures in dravet syndrome mice
10.1016/j.ymthe.2019.08.018 · 2020 · External reference
Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
10.1016/s1474-4422(18)30499-x · 2019 · External reference
The Rodent Forced Swim Test Measures Stress-Coping Strategy, Not Depression-like Behavior
10.1021/acschemneuro.7b00042 · 2017 · External reference
Cannabinoids and the expanded endocannabinoid system in neurological disorders
10.1038/s41582-019-0284-z · 2020 · External reference
Major depressive disorder: hypothesis, mechanism, prevention and treatment
10.1038/s41392-024-01738-y · 2024 · External reference
Identification and characterization of phytocannabinoids as novel dual PPARalpha/gamma agonists by a computational and in vitro experimental approach
10.1016/j.bbagen.2019.01.002 · 2019 · External reference
CBG, CBD, Delta9-THC, CBN, CBGA, CBDA and Delta9-THCA as antioxidant agents and their intervention abilities in antioxidant action
10.1016/j.fitote.2021.104915 · 2021 · External reference
Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels
10.1007/s11481-009-9177-z · 2010 · External reference
Chapter 2 - The Biosynthesis of Cannabinoids
2017 · External reference
Effect of Cannabidiolic Acid, N-Trans-Caffeoyltyramine and Cannabisin B from Hemp Seeds on microRNA Expression in Human Neural Cells
10.3390/cimb44100347 · 2022 · External reference
Omics in neurodegenerative disease: hope or hype?
10.1016/j.tig.2019.12.002 · 2020 · External reference
The chemistry of cannabis and cannabinoids
10.1071/ch21006 · 2021 · External reference
A Comparative In Vitro Study of the Neuroprotective Effect Induced by Cannabidiol, Cannabigerol, and Their Respective Acid Forms: Relevance of the 5-HT(1A) Receptors
10.1007/s12640-020-00277-y · 2021 · External reference
Comorbid Major Depressive Disorder in Schizophrenia: A Systematic Review and Meta-Analysis
10.1093/schbul/sbaa153 · 2021 · External reference
Potential common pathogenesis of several neurodegenerative diseases
10.4103/nrr.nrr-d-24-01054 · 2026 · External reference
Global burden of mental disorders in 204 countries and territories, 1990-2021: results from the global burden of disease study 2021
10.1186/s12888-025-06932-y · 2025 · External reference
Acidic cannabinoids suppress proinflammatory cytokine release by blocking store-operated calcium entry
2022 · External reference
Biosynthesis of cannabinoids. Incorporation experiments with (13)C-labeled glucoses
10.1046/j.1432-1327.2001.02030.x · 2001 · External reference
Preprint
2025 · External reference
10.3390/molecules25112638
10.3390/molecules25112638 · External reference
Safety and efficacy of cannabidiol-cannabidiolic acid rich hemp extract in the treatment of refractory epileptic seizures in dogs
10.3389/fvets.2022.939966 · 2022 · External reference
Preclinical evaluation of cannabidiolic acid as a neuroprotective agent in TDP-43 transgenic mice, an experimental model of amyotrophic lateral sclerosis
10.1016/j.biopha.2025.118288 · 2025 · External reference
Role of Calcium Homeostasis in Alzheimer's Disease
10.2147/ndt.s350939 · 2022 · External reference
Rodent tests of depression and anxiety: Construct validity and translational relevance
10.3758/s13415-024-01171-2 · 2024 · External reference
Safety and pharmacokinetics of medical cannabis preparation in a monocentric series of young patients with drug resistant epilepsy
10.1016/j.ctim.2020.102402 · 2020 · External reference
Cannabidiolic Acid Rescues Deficits in Hippocampal Long-Term Potentiation in Models of Alzheimer's Disease: An Electrophysiological and Proteomic Analysis
10.3390/ijms26104944 · 2025 · External reference
Serotonergic therapy in epilepsy
10.1097/wco.0000000000000901 · 2021 · External reference
Cannabidiolic acid exhibits entourage-like improvements of anticonvulsant activity in an acute rat model of seizures
10.1016/j.eplepsyres.2020.106525 · 2021 · External reference
Therapeutic potential of cannabidiol (CBD) in anxiety disorders: A systematic review and meta-analysis
10.1016/j.psychres.2024.116049 · 2024 · External reference
Single-cell transcriptomics analysis of cellular heterogeneity and immune mechanisms in neurodegenerative diseases
10.1111/ejn.16242 · 2024 · External reference
Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression
10.1016/j.bbr.2018.05.027 · 2018 · External reference
Unraveling the molecular basis of cannabidiolic acid methyl Ester's anti-depressive effects in a rat model of treatment-resistant depression
10.1016/j.jpsychires.2024.04.033 · 2024 · External reference
Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats
10.3390/ijms24043828 · 2023 · External reference
Digital Medical Cannabis as Market Differentiator: Second-Generation Artificial Intelligence Systems to Improve Response
2021 · External reference
Drug research: a plan for mental illness
10.1038/483269a · 2012 · External reference
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
10.1016/j.tips.2009.07.006 · 2009 · External reference
Evaluating Potential Anxiolytic Effects of Minor Cannabinoids and Terpenes After Acute and Chronic Oral Administration in Rats
10.1089/can.2023.0083 · 2023 · External reference
PGC-1alpha, mitochondrial dysfunction, and Huntington's disease
10.1016/j.freeradbiomed.2013.04.016 · 2013 · External reference
Detection of Delta9-tetrahydrocannabinolic acid A in human urine and blood serum by LC-MS/MS
10.1002/jms.1167 · 2007 · External reference
Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases
10.1038/s41583-024-00806-0 · 2024 · External reference
Cannabidiol/cannabidiolic acid-rich hemp (Cannabis sativa L.) extract attenuates cognitive impairments and glial activations in rats exposed to chronic stress
10.1016/j.jep.2024.119113 · 2025 · External reference
Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome
10.1073/pnas.1711351114 · 2017 · External reference
Central activation of PPAR-gamma ameliorates diabetes induced cognitive dysfunction and improves BDNF expression
10.1016/j.neurobiolaging.2014.09.028 · 2015 · External reference
The Cannabinoids, CBDA and THCA, Rescue Memory Deficits and Reduce Amyloid-Beta and Tau Pathology in an Alzheimer's Disease-like Mouse Model
2023 · External reference
Detectability of cannabinoids in the serum samples of cannabis users: Indicators of recent cannabis use? A follow-up study
10.1002/dta.3110 · 2021 · External reference
The Effects of Cannabis sativa L. Extract on Oxidative Stress Markers In Vivo
2021 · External reference
Highly Purified Cannabidiol for Epilepsy Treatment: A Systematic Review of Epileptic Conditions Beyond Dravet Syndrome and Lennox-Gastaut Syndrome
10.1007/s40263-021-00807-y · 2021 · External reference
Meconium drug testing reveals maternal misuse of medicinal opioids among addicted mothers
10.1002/dta.1459 · 2013 · External reference
Post traumatic stress disorder associated hypothalamic-pituitary-adrenal axis dysregulation and physical illness
2024 · External reference
Chronic Stress-Associated Depressive Disorders: The Impact of HPA Axis Dysregulation and Neuroinflammation on the Hippocampus-A Mini Review
10.3390/ijms26072940 · 2025 · External reference
Multi-omics and artificial intelligence for precision drug discovery and potential clinical applications
2026 · External reference
Green method for recovery of cannabinoids from Cannabis sativa flowers: pH-controlled aqueous leaching
10.1016/j.seppur.2023.124754 · 2023 · External reference
Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases
10.1016/j.chembiol.2020.10.010 · 2020 · External reference
Therapeutic potential of cannabidiol polypharmacology in neuropsychiatric disorders
10.1016/j.tips.2024.12.005 · 2025 · External reference
Molecular targets of cannabinoids and their derivatives in epilepsy - a review with focus on CBD
10.3389/abp.2025.15251 · 2025 · External reference
The endocannabinoid system and the brain
10.1146/annurev-psych-113011-143739 · 2013 · External reference
Cannabidiol as a Potential Treatment for Anxiety and Mood Disorders: Molecular Targets and Epigenetic Insights from Preclinical Research
10.3390/ijms22041863 · 2021 · External reference
Lipid nano-carriers loaded with Cannabis sativa extract for epilepsy treatment - in vitro characterization and in vivo efficacy studies
10.1016/j.xphs.2022.09.012 · 2022 · External reference
Inhibition of human recombinant T-type calcium channels by phytocannabinoids in vitro
10.1111/bph.15842 · 2022 · External reference
Effects of cannabinoids Delta(9)-tetrahydrocannabinol, Delta(9)-tetrahydrocannabinolic acid and cannabidiol in MPP+ affected murine mesencephalic cultures
10.1016/j.phymed.2012.04.002 · 2012 · External reference
Molecular targets of the phytocannabinoids: a complex picture
2017 · External reference
Cannabidiol inhibits the hyperlocomotion induced by psychotomimetic drugs in mice
10.1016/j.ejphar.2005.02.040 · 2005 · External reference
Efficacy of Acetylcholinesterase Inhibitors on Cognitive Function in Alzheimer's Disease. Review of Reviews
10.3390/biomedicines9111689 · 2021 · External reference
Delta-9-tetrahydrocannabinolic acid A (THC-A) in urine of a 15-month-old child: A case report
10.1016/j.forsciint.2018.03.020 · 2018 · External reference
Molecular pathways linking the serotonin transporters (SERT) to depressive disorder: from mechanisms to treatments
10.1016/j.neuroscience.2025.08.009 · 2025 · External reference
Tetrahydrocannabinolic acid is a potent PPARgamma agonist with neuroprotective activity
10.1111/bph.14019 · 2017 · External reference
Multi-omics approaches to major psychiatric disorders
10.1007/s40211-025-00564-0 · 2026 · External reference
Tetrahydrocannabinolic acid A (THCA-A) reduces adiposity and prevents metabolic disease caused by diet-induced obesity
10.1016/j.bcp.2019.113693 · 2020 · External reference
Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis
10.3389/fneur.2018.00759 · 2018 · External reference
Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)
10.1016/0028-3908(93)90029-3 · 1993 · External reference
Quality Traits of "Cannabidiol Oils": Cannabinoids Content, Terpene Fingerprint and Oxidation Stability of European Commercially Available Preparations
10.3390/molecules23051230 · 2018 · External reference
Fever-Associated Seizures or Epilepsy: An Overview of Old and Recent Literature Acquisitions
10.3389/fped.2022.858945 · 2022 · External reference
Pharmacokinetics and tolerability of oral cannabis preparations in patients with medication overuse headache (MOH)-a pilot study
10.1007/s00228-018-2516-3 · 2018 · External reference
Epigenetic regulation of brain development, plasticity, and response to early-life stress
10.1038/s41386-025-02179-z · 2026 · External reference
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin
10.1038/sj.bjp.0707442 · 2008 · External reference
Unresolved reference
2014 · External reference
Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT(1A) receptor-mediated suppression of nausea and anxiety in rats
10.1111/bph.14073 · 2018 · External reference
Marijuana correlates with use of other illicit drugs in a pain patient population
2010 · External reference
The effects of antidepressants on cardiometabolic and other physiological parameters: a systematic review and network meta-analysis
10.1016/s0140-6736(25)01293-0 · 2025 · External reference
Uncovering the molecular targets of phytocannabinoids: mechanistic insights from inverse molecular docking fingerprint approaches
10.3389/fphar.2025.1611461 · 2025 · External reference
Therapeutic-like activity of cannabidiolic acid methyl ester in the MK-801 mouse model of schizophrenia: Role for cannabinoid CB1 and serotonin-1A receptors
10.1111/ejn.16278 · 2024 · External reference
Effect of cannabidiolic acid and ∆(9)-tetrahydrocannabinol on carrageenan-induced hyperalgesia and edema in a rodent model of inflammatory pain
10.1007/s00213-018-5034-1 · 2018 · External reference
Therapeutic Potential of Cannabidiol, Cannabidiolic Acid, and Cannabidiolic Acid Methyl Ester as Treatments for Nausea and Vomiting
10.1089/can.2021.0041 · 2021 · External reference
Effect of prior foot shock stress and Delta(9)-tetrahydrocannabinol, cannabidiolic acid, and cannabidiol on anxiety-like responding in the light-dark emergence test in rats
10.1007/s00213-017-4626-5 · 2017 · External reference
Constituents of Cannabis sativa
10.1007/978-3-030-57369-0_1 · 2021 · External reference
Investigation in the CB1 and CB2 receptor binding profile and intrinsic activity of (−) and (+)-enantiomers of some naturally occurring phytocannabinoids or synthetic derivatives
2025 · External reference
Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects
10.1111/j.1476-5381.2011.01238.x · 2011 · External reference
Cannabis and epilepsy: An ancient treatment returns to the fore
10.1016/j.yebeh.2016.09.040 · 2017 · External reference
The Heat Sensing Trpv1 Receptor Is Not a Viable Anticonvulsant Drug Target in the Scn1a (+/-) Mouse Model of Dravet Syndrome
10.3389/fphar.2021.675128 · 2021 · External reference
Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer's Disease
10.1007/s12035-019-1637-8 · 2019 · External reference
Proteomics and Lipidomics in the Elucidation of Endocannabinoid Signaling in Healthy and Schizophrenia Brains
10.1002/pmic.201700270 · 2018 · External reference
Men and women respond differently to antipsychotic drugs
10.1016/j.neuropharm.2019.05.008 · 2020 · External reference
Epidiolex as adjunct therapy for treatment of refractory epilepsy: a comprehensive review with a focus on adverse effects
10.12688/f1000research.16515.1 · 2019 · External reference
Artificial Intelligence (AI) Applications in Drug Discovery and Drug Delivery: Revolutionizing Personalized Medicine
10.3390/pharmaceutics16101328 · 2024 · External reference
Alzheimer's disease
10.1016/s0140-6736(26)00198-4 · 2026 · External reference
Effects of cannabidiol in males and females in two different rat models of depression
10.1016/j.physbeh.2018.12.019 · 2019 · External reference
Characterization of age-dependent changes in the striatum: Response to the mitochondrial toxin 3-nitropropionic acid
10.1016/j.mad.2016.04.008 · 2017 · External reference
Therapeutic potential of acidic cannabinoids: an update
10.1186/s42238-026-00387-y · 2026 · External reference
Rodent models of Alzheimer's disease: Critical analysis of current hypotheses and pathways for future research
10.1016/j.pneurobio.2025.102821 · 2025 · External reference
Mapping human brain cell type origin and diseases through single-cell transcriptomics
10.1038/s41398-025-03562-6 · 2025 · External reference
Entrapment of drugs in dental calculus - Detection validation based on test results from post-mortem investigations
10.1016/j.forsciint.2020.110647 · 2021 · External reference
The Role of Bioenergetics in Neurodegeneration
10.3390/ijms23169212 · 2022 · External reference
The current status of artisanal cannabis for the treatment of epilepsy in the United States
10.1016/j.yebeh.2016.12.032 · 2017 · External reference
miR-143-3p inhibition promotes neuronal survival in an Alzheimer's disease cell model by targeting neuregulin-1
10.5114/fn.2020.94002 · 2020 · External reference
Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism
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Determination of the relative percentage distribution of THCA and Delta(9)-THC in herbal cannabis seized in Austria - Impact of different storage temperatures on stability
10.1016/j.forsciint.2015.07.019 · 2015 · External reference
Depressive and anxiety disorders in concert-A synthesis of findings on comorbidity in the NESDA study
10.1016/j.jad.2021.02.004 · 2021 · External reference
From Synaptic Plasticity to Neurodegeneration: BDNF as a Transformative Target in Medicine
10.3390/ijms26094271 · 2025 · External reference
Cannabidiol but not cannabidiolic acid reduces behavioural sensitisation to methamphetamine in rats, at pharmacologically effective doses
10.1007/s00213-022-06119-3 · 2022 · External reference
Endocannabinoid Modulation in Neurodegenerative Diseases: In Pursuit of Certainty
2022 · External reference
Clinical Pharmacokinetics of Cannabinoids and Potential Drug-Drug Interactions
10.1007/978-3-030-61663-2_3 · 2021 · External reference
Safety and tolerability of natural and synthetic cannabinoids in adults aged over 50 years: A systematic review and meta-analysis
10.1371/journal.pmed.1003524 · 2021 · External reference
Identification of Cannabidiolic and Cannabigerolic Acids as MTDL AChE, BuChE, and BACE-1 Inhibitors Against Alzheimer's Disease by In Silico, In Vitro, and In Vivo Studies
10.1002/ptr.8369 · 2025 · External reference
The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need
2024 · External reference
Oxidative stress and mitochondrial impairment: Key drivers in neurodegenerative disorders
10.1016/j.arr.2025.102667 · 2025 · External reference
Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010
10.1016/s0140-6736(13)61611-6 · 2013 · External reference
The efficacy and safety of cannabinoids for the treatment of mental disorders and substance use disorders: a systematic review and meta-analysis
10.1016/s2215-0366(26)00015-5 · 2026 · External reference
Unresolved reference
External reference
vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa
10.1038/s41598-020-77175-y · 2020 · External reference
An overview of major depression disorder: The endocannabinoid system as a potential target for therapy
10.1111/bcpt.14089 · 2024 · External reference
An evaluation of the anti-hyperalgesic effects of cannabidiolic acid-methyl ester in a preclinical model of peripheral neuropathic pain
10.1111/bph.14997 · 2020 · External reference
