Research graph
References from Post-mortem human brain evidence for presynaptic dopaminergic dysregulation in cocaine use disorder: A systematic review. Local targets link to admitted publications; unresolved targets remain external evidence.
Molecular adaptations of apoptotic pathways and signaling partners in the cerebral cortex of human cocaine addicts and cocaine-treated rats
10.1016/j.neuroscience.2011.08.074 · 2011 · External reference
Association of Stimulant Use with Dopaminergic Alterations in Users of Cocaine, Amphetamine, Or Methamphetamine
10.1001/jamapsychiatry.2017.0135 · 2017 · External reference
A molecular profile of cocaine abuse includes the differential expression of genes that regulate transcription, chromatin, and dopamine cell phenotype
10.1038/npp.2014.70 · 2014 · External reference
Transcription factors specifying dopamine phenotype are decreased in cocaine users
10.1097/00001756-200403010-00003 · 2004 · External reference
Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers
10.1073/pnas.092654299 · 2002 · External reference
Investigating the Potential Influence of Cause of Death and Cocaine Levels on the Differential Expression of Genes Associated with Cocaine Abuse
10.1371/journal.pone.0117580 · 2015 · External reference
The vesicular monoamine transporter 2: an underexplored pharmacological target
10.1016/j.neuint.2013.12.003 · 2014 · External reference
Methylphenidate for the treatment of cocaine use disorder: a systematic review and meta-analysis
2025 · External reference
Acute and chronic cocaine-induced potentiation of synaptic strength in the ventral tegmental area: electrophysiological and behavioral correlates in individual rats
10.1523/jneurosci.1312-04.2004 · 2004 · External reference
Genome-wide association meta-analysis of cocaine dependence: shared genetics with comorbid conditions
10.1016/j.pnpbp.2019.109667 · 2019 · External reference
Speed kills: cellular and molecular bases of methamphetamine-induced nerve terminal degeneration and neuronal apoptosis
10.1096/fj.03-0073rev · 2003 · External reference
From neuroadaptation to neuroprogression: rethinking chronic cocaine exposure through a model of cocaine-related cerebropathy
10.3390/jcm15062222 · 2026 · External reference
Dopamine transporter mRNA in autopsy studies of chronic cocaine users
10.1016/s0169-328x(99)00233-8 · 1999 · External reference
Effects of lowered serotonin transmission on cocaine-induced striatal dopamine response: PET [ 11 C]raclopride study in humans
10.1192/bjp.bp.110.084178 · 2011 · External reference
Unresolved reference
External reference
Dopamine transporter levels in cocaine dependent subjects
10.1016/j.drugalcdep.2008.04.014 · 2008 · External reference
Synergism Between a Serotonin 5-HT 2A Receptor (5-HT 2A R) Antagonist and 5-HT 2C R Agonist Suggests New Pharmacotherapeutics for Cocaine Addiction
10.1021/cn300072u · 2013 · External reference
Meta-Analysis of Structural and Functional Brain Abnormalities in Cocaine Addiction
10.3389/fpsyt.2022.927075 · 2022 · External reference
Tyrosine hydroxylase and regulation of dopamine synthesis
10.1016/j.abb.2010.12.017 · 2011 · External reference
PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)-[ 11C]O-methylreboxetine and HRRT
10.1002/syn.20696 · 2010 · External reference
Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance
10.3389/fncel.2014.00275 · 2014 · External reference
The role of D2-autoreceptors in regulating dopamine neuron activity and transmission
10.1016/j.neuroscience.2014.01.025 · 2014 · External reference
Cocaine-induced dopamine overflow within the nucleus accumbens measured by in vivo microdialysis: a meta-analysis
10.1002/syn.20489 · 2008 · External reference
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene
10.1038/mp.2013.99 · 2014 · External reference
Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex
10.1176/appi.ajp.159.10.1642 · 2002 · External reference
Differential effects of cocaine and MDMA self-administration on cortical serotonin transporter availability in monkeys
10.1016/j.neuropharm.2011.04.007 · 2011 · External reference
Cell-based radiotracer binding and uptake inhibition assays: a comparison of in vitro methods to assess the potency of drugs that target monoamine transporters
10.3389/fphar.2020.00673 · 2020 · External reference
Elevated central serotonin transporter binding availability in acutely abstinent cocaine-dependent patients
10.1176/appi.ajp.157.7.1134 · 2000 · External reference
Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons
10.1523/jneurosci.3910-09.2009 · 2009 · External reference
A double-blind, placebo-controlled trial of topiramate for the treatment of comorbid cocaine and alcohol dependence
10.1016/j.drugalcdep.2013.05.026 · 2013 · External reference
The dopamine hypothesis of the reinforcing properties of cocaine
10.1016/0166-2236(91)90141-g · 1991 · External reference
Genome-wide meta-analyses of cross substance use disorders in diverse populations
2025 · External reference
Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys
10.1523/jneurosci.21-08-02799.2001 · 2001 · External reference
Cocaine occupancy of sigma 1 receptors and dopamine transporters in mice
10.1002/syn.21877 · 2016 · External reference
Loss of striatal vesicular monoamine transporter protein (VMAT2) in Human Cocaine Users
10.1176/appi.ajp.160.1.47 · 2003 · External reference
Brain dopamine transporter messenger rna and binding sites in cocaine users
10.1001/archpsyc.55.9.793 · 1998 · External reference
Decreased brain dopamine cell numbers in human cocaine users
10.1016/j.psychres.2008.10.034 · 2009 · External reference
Mechanisms and regulation of dopamine release
10.1016/j.conb.2019.01.001 · 2019 · External reference
Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [ 123 I]β-CIT SPECT
10.1176/ajp.155.6.832 · 1998 · External reference
Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
10.1176/ajp.2007.164.4.622 · 2007 · External reference
Brain biomarkers for identifying excited delirium as a cause of sudden death
10.1016/j.forsciint.2009.05.012 · 2009 · External reference
Cocaine Abusers Have an Overexpression of α-Synuclein in Dopamine Neurons
10.1523/jneurosci.23-07-02564.2003 · 2003 · External reference
Anticonvulsants for cocaine dependence
2015 · External reference
Intronic polymorphisms affecting alternative splicing of human dopamine d2 receptor are associated with cocaine abuse
10.1038/npp.2010.208 · 2011 · External reference
Decreased vesicular monoamine transporter type 2 availability in the striatum following chronic cocaine self-administration in nonhuman primates
10.1016/j.biopsych.2014.06.012 · 2015 · External reference
Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias
10.1111/j.1365-2125.2010.03629.x · 2010 · External reference
Cocaine-induced changes in NMDA Receptor Signaling
10.1007/s12035-014-8636-6 · 2014 · External reference
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews
10.1136/bmj.n71 · 2021 · External reference
A role for α-synuclein in the regulation of dopamine biosynthesis
10.1523/jneurosci.22-08-03090.2002 · 2002 · External reference
Effects of stimulant drug use on the dopaminergic system: a systematic review and meta-analysis of in vivo neuroimaging studies
10.1016/j.eurpsy.2019.03.003 · 2019 · External reference
Cocaine abuse elevates alpha-synuclein and dopamine transporter levels in the human striatum
10.1097/01.wnr.0000175617.39054.ba · 2005 · External reference
Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: a structure-activity study
10.1016/0024-3205(90)90132-b · 1990 · External reference
Cocaine receptors on dopamine transporters are related to self-administration of cocaine
10.1126/science.2820058 · 1987 · External reference
Serotonin transport in the 21st century
10.1085/jgp.201812066 · 2019 · External reference
α-Synuclein in synaptic function and dysfunction
10.1016/j.tins.2022.11.007 · 2023 · External reference
Topiramate for cocaine dependence: a systematic review and meta-analysis of randomized controlled trials
10.1111/add.13328 · 2016 · External reference
Cocaine-induced changes in the expression of NMDA Receptor Subunits
10.2174/1570159x17666190617101726 · 2019 · External reference
Radioligand binding and immunoautoradiographic evidence for a lack of toxicity to dopaminergic nerve terminals in human cocaine overdose victims
10.1016/s0006-8993(96)01196-1 · 1997 · External reference
ACMT position statement: end the use of the Term "Excited Delirium”
2023 · External reference
Mechanisms of neurotransmitter release by amphetamines: a review
10.1016/j.pneurobio.2005.04.003 · 2005 · External reference
A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interaction
10.1503/jpn.180098 · 2020 · External reference
Molecular profiling of midbrain dopamine regions in cocaine overdose victims
10.1046/j.1471-4159.2003.01740.x · 2003 · External reference
Serotonin transporter protein in autopsied brain of chronic users of cocaine
10.1007/s00213-020-05562-4 · 2020 · External reference
Disulfiram for the treatment of cocaine dependence
2024 · External reference
Mechanisms of dopamine transporter regulation in normal and disease states
10.1016/j.tips.2013.07.005 · 2013 · External reference
Decreased dopamine D 2 receptor availability is associated with reduced frontal metabolism in cocaine abusers
10.1002/syn.890140210 · 1993 · External reference
Dopamine in Drug Abuse and Addiction
10.1001/archneur.64.11.1575 · 2007 · External reference
Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers
10.1038/mp.2014.58 · 2014 · External reference
Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
10.1038/386830a0 · 1997 · External reference
Unresolved reference
External reference
Striatal dopamine, dopamine transporter, and vesicular monoamine transporter in chronic cocaine users
10.1002/ana.410400312 · 1996 · External reference
Unresolved reference
External reference
Morphological assessment of GABA and glutamate inputs to GnRH neurons in intact female mice using expansion microscopy
10.1111/jne.13021 · 2021 · External reference
Ventral midbrain correlation between genetic variation and expression of the dopamine transporter gene in cocaine-abusing versus non-abusing subjects
10.1111/j.1369-1600.2011.00391.x · 2014 · External reference
