Research graph
References from Extracellular vesicles: Multi-source regulatory mechanisms in hippocampal homeostasis. Local targets link to admitted publications; unresolved targets remain external evidence.
The concept of trophic units in the central nervous system
10.1016/0301-0082(95)00017-p · 1995 · External reference
Dual ligand cooperation at the plasma membrane drives transport of engineered small extracellular vesicles across brain endothelial cells
10.1016/j.jconrel.2026.114974 · 2026 · External reference
Angiotensin II-Mediated Neuroinflammation in the Hippocampus Contributes to Neuronal Deficits and Cognitive Impairment in Heart Failure Rats
10.1161/hypertensionaha.123.21070 · 2023 · External reference
Functional coupling between neurons and glia
10.1523/jneurosci.20-11-04091.2000 · 2000 · External reference
Extracellular vesicles from L. paracasei improve neuroinflammation, GABA neurotransmission and motor incoordination in hyperammonemic rats
10.1016/j.bbi.2024.10.002 · 2025 · External reference
Comparative Profiling of Mouse and Human Microglial Small Extracellular Vesicles Reveals Conserved Core Functions with Distinct miRNA Signatures
10.3390/cells15020184 · 2026 · External reference
cRGD-Functionalized macrophage extracellular vesicles loaded with GSK2033 enhance T cell antitumor immunity in GBM by disrupting the LXR/ABCA1-Mediated Myelin lipid transfer axis
10.1186/s12951-026-04116-8 · 2026 · External reference
Revealing the Heterogeneity of Extracellular Vesicles: From Population to Single Particle Level
10.1002/pmic.70024 · 2026 · External reference
Effect of peripheral cellular senescence on brain aging and cognitive decline
10.1111/acel.13817 · 2023 · External reference
Extracellular vesicles round off communication in the nervous system
10.1038/nrn.2015.29 · 2016 · External reference
Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression
2025 · External reference
Regulatory T cells administration reduces anxiety-like behavior in mice submitted to chronic restraint stress
10.3389/fncel.2024.1406832 · 2024 · External reference
Neuropathogenic role of astrocyte-derived extracellular vesicles in HIV-associated neurocognitive disorders
10.1002/jev2.12439 · 2024 · External reference
Exosomes Derived from M2 Microglial Cells Modulated by 1070-nm Light Improve Cognition in an Alzheimer's Disease Mouse Model
2023 · External reference
Combined Catalpol and Tetramethylpyrazine Promote Axonal Plasticity in Alzheimer's Disease by Inducing Astrocytes to Secrete Exosomes Carrying CDK5 mRNA and Regulating STAT3 Phosphorylation
10.1007/s12035-024-04251-z · 2024 · External reference
Human-Derived Induced GABAergic Progenitor Cells Improve Cognitive Function in Mice and Inhibit Astrocyte Activation with Anti-Inflammatory Exosomes
10.1002/ana.27001 · 2024 · External reference
Migrasomes from adipose derived stem cells enrich CXCL12 to recruit stem cells via CXCR4/RhoA for a positive feedback loop mediating soft tissue regeneration
10.1186/s12951-024-02482-9 · 2024 · External reference
10.1080/19490976.2025.2611546
10.1080/19490976.2025.2611546 · External reference
Exercise-induced adipokine Nrg4 alleviates MASLD by disrupting hepatic cGAS-STING signaling
10.1016/j.celrep.2025.115251 · 2025 · External reference
Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation
10.1136/gutjnl-2021-326269 · 2022 · External reference
Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer's disease
10.1016/j.neuron.2021.05.012 · 2021 · External reference
BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis
10.1016/j.molimm.2017.11.008 · 2018 · External reference
Brain neuron-derived WDFY1 induces bone loss
10.1038/s43587-025-01032-8 · 2026 · External reference
GATA1 repression-mediated ADRB2/cAMP/PKA signaling activation underlies the antidepressant effects of targeted geniposide delivery
10.1038/s41420-026-03190-z · 2026 · External reference
Local infusion of ghrelin enhanced hippocampal synaptic plasticity and spatial memory through activation of phosphoinositide 3-kinase in the dentate gyrus of adult rats
10.1111/j.1460-9568.2010.07491.x · 2011 · External reference
Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice
10.1038/s41467-023-44242-7 · 2023 · External reference
The role of hippocampal niche exosomes in rat hippocampal neurogenesis after fimbria-fornix transection
10.1074/jbc.ra120.015561 · 2021 · External reference
Exerkine fibronectin type-III domain-containing protein 5/irisin-enriched extracellular vesicles delay vascular ageing by increasing SIRT6 stability
10.1093/eurheartj/ehac431 · 2022 · External reference
Strategies for Targeted Delivery of Exosomes to the Brain: Advantages and Challenges
10.3390/pharmaceutics14030672 · 2022 · External reference
Large extracellular vesicles: Size matters in tumor progression
10.1016/j.cytogfr.2019.12.007 · 2020 · External reference
Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model
2021 · External reference
Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model
10.7150/thno.62069 · 2021 · External reference
A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice
10.1080/19490976.2026.2614030 · 2026 · External reference
Microglial Extracellular Vesicles Mediate C1q Deposition at the Pre-Synapse and Promote Synaptic Pruning
10.1002/jev2.70173 · 2025 · External reference
Ebselen prevents cigarette smoke-induced cognitive dysfunction in mice by preserving hippocampal synaptophysin expression
10.1186/s12974-022-02432-y · 2022 · External reference
Neuronal and Astrocytic Extracellular Vesicle Biomarkers in Blood Reflect Brain Pathology in Mouse Models of Alzheimer's Disease
10.3390/cells10050993 · 2021 · External reference
Ghrelin controls hippocampal spine synapse density and memory performance
10.1038/nn1656 · 2006 · External reference
MRI Metrics of Cerebral Endothelial Cell-Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
10.2337/db21-0754 · 2022 · External reference
Cigarette Smoke Exposure Induces Neurocognitive Impairments and Neuropathological Changes in the Hippocampus
10.3389/fnmol.2022.893083 · 2022 · External reference
Sex-dependent changes in AMPAR expression and Na, K-ATPase activity in the cerebellum and hippocampus of α-Klotho-Hypomorphic mice
2024 · External reference
Umbilical Cord-Mesenchymal Stromal Cell-Derived Extracellular Vesicles Target the Liver to Improve Neurovascular Health in Type 2 Diabetes With Non-Alcoholic Fatty Liver Disease
10.1002/jev2.70125 · 2025 · External reference
Bifidobacterium animalis subspecies lactic derived-vesicles alleviate cognitive impairment in mice via modulating gut microbiota metabolism and 5-HT/BDNF pathway
2026 · External reference
Overexpression of miR-1 in the heart attenuates hippocampal synaptic vesicle exocytosis by the posttranscriptional regulation of SNAP-25 through the transportation of exosomes
10.1186/s12964-018-0303-5 · 2018 · External reference
Extracellular vesicle secretion is tissue-dependent ex vivo and skeletal muscle myofiber extracellular vesicles reach the circulation in vivo
10.1152/ajpcell.00580.2020 · 2022 · External reference
Impact of high-fat diet on cognitive behavior and central and systemic inflammation with aging and sex differences in mice
10.1016/j.bbi.2024.02.025 · 2024 · External reference
Exosome therapy protects the hippocampus in mice exposed to chronic methamphetamine: Insights into angiogenic and inflammatory signaling pathways
10.1016/j.neuropharm.2025.110790 · 2026 · External reference
Temporal changes in total and hippocampal brain volume and cognitive function in patients with chronic heart failure-the COGNITION.MATTERS-HF cohort study
10.1093/eurheartj/ehab003 · 2021 · External reference
Oligodendrocytes support axonal transport and maintenance via exosome secretion
10.1371/journal.pbio.3000621 · 2020 · External reference
Brain-derived extracellular vesicles circUsp32 polarized macrophages causing acute kidney injury after traumatic brain injury
10.1126/sciadv.adz1243 · 2025 · External reference
Do Exercise-Induced Extracellular Vesicles Carry Cognitive Benefits to the Brain?
10.1111/tra.70046 · 2026 · External reference
Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease
10.1093/brain/awac083 · 2022 · External reference
Extracellular vesicle-mediated transfer of miR-21-5p from mesenchymal stromal cells to neurons alleviates early brain injury to improve cognitive function via the PTEN/Akt pathway after subarachnoid hemorrhage
10.1038/s41419-020-2530-0 · 2020 · External reference
Protocol for isolating leukemia-derived extracellular vesicles from the spleen of preclinical models of leukemia using ultracentrifugation
10.1016/j.xpro.2024.103244 · 2024 · External reference
Urinary Extracellular Vesicles Carrying Klotho Improve the Recovery of Renal Function in an Acute Tubular Injury Model
10.1016/j.ymthe.2019.11.013 · 2020 · External reference
Single-cell and Spatial Transcriptomics Reveals Ferroptosis as The Most Enriched Programmed Cell Death Process in Hemorrhage Stroke-induced Oligodendrocyte-mediated White Matter Injury
10.7150/ijbs.96262 · 2024 · External reference
Regulation of Neuronal Stem Cell Proliferation in the Hippocampus by Endothelial Ceramide
10.1159/000447789 · 2016 · External reference
cGAS-STING drives ageing-related inflammation and neurodegeneration
10.1038/s41586-023-06373-1 · 2023 · External reference
Cdo1 promotes PPARγ-mediated adipose tissue lipolysis in male mice
10.1038/s42255-022-00644-3 · 2022 · External reference
Ghrelin exhibited antidepressant and anxiolytic effect via the p38-MAPK signaling pathway in hippocampus
10.1016/j.pnpbp.2019.02.013 · 2019 · External reference
Nano pom-poms prepared exosomes enable highly specific cancer biomarker detection
10.1038/s42003-022-03598-0 · 2022 · External reference
Extracellular vesicles set the stage for brain plasticity and recovery by multimodal signalling
10.1093/brain/awad332 · 2024 · External reference
Annexin A5 derived from lung alleviates brain damage after ischemic stroke
10.1016/j.brainres.2024.149303 · 2025 · External reference
Senescent-like border-associated macrophages regulate cognitive aging via migrasome-mediated induction of paracrine senescence in microglia
10.1038/s43587-025-00956-5 · 2025 · External reference
Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model
10.1038/s41467-023-39693-x · 2023 · External reference
Bone marrow mesenchymal stem cells protect against cerebral amyloid angiopathy by enhancing neutrophil mitocytosis
10.4103/nrr.nrr-d-24-01273 · 2026 · External reference
Preconditioning Exercise Inhibits Neuron Ferroptosis and Ameliorates Brain Ischemia Damage by Skeletal Muscle-Derived Exosomes via Regulating miR-484/ACSL4 Axis
10.1089/ars.2023.0492 · 2024 · External reference
Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender
2025 · External reference
Mesenchymal stromal cells alleviate depressive and anxiety-like behaviors via a lung vagal-to-brain axis in male mice
10.1038/s41467-023-43150-0 · 2023 · External reference
Divergence in the metabolome between natural aging and Alzheimer’s disease
2020 · External reference
Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17
10.1038/s41586-022-04722-0 · 2022 · External reference
Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease
10.1038/s41392-023-01657-4 · 2023 · External reference
Neutrophil-derived migrasomes are an essential part of the coagulation system
10.1038/s41556-024-01440-9 · 2024 · External reference
The Protective Effects of Osteocyte-Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging
10.1002/advs.202105316 · 2022 · External reference
Mitocytosis, a migrasome-mediated mitochondrial quality-control process
10.1016/j.cell.2021.04.027 · 2021 · External reference
Apolipoprotein E-mediated regulation of selenoprotein P transportation via exosomes
10.1007/s00018-019-03287-y · 2020 · External reference
10.1158/1541-7786.mcr-24-0052
10.1158/1541-7786.mcr-24-0052 · External reference
Neutrophil-macrophage communication via extracellular vesicle transfer promotes itaconate accumulation and ameliorates cytokine storm syndrome
10.1038/s41423-024-01174-6 · 2024 · External reference
Increment of CSF fractalkine-positive microvesicles preceded the spatial memory impairment in amyloid beta neurotoxicity
10.1016/j.cyto.2022.156050 · 2022 · External reference
Inorganic Phosphate Activates the AKT/mTORC1 Pathway and Shortens the Life Span of an α‑Klotho-Deficient Model
10.1681/asn.2015040446 · 2016 · External reference
Emerging Links between Nonalcoholic Fatty Liver Disease and Neurodegeneration
10.1055/s-0043-1762585 · 2023 · External reference
The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
10.1016/j.psyneuen.2014.10.015 · 2015 · External reference
Ghrelin is required for dietary restriction-induced enhancement of hippocampal neurogenesis: lessons from ghrelin knockout mice
10.1507/endocrj.ej14-0436 · 2015 · External reference
Strain- and species-specific immune responses to human adipose stem cell-derived extracellular vesicles: A comparative pharmacological evaluation in mice and human PBMCs
10.1016/j.ejpb.2026.115008 · 2026 · External reference
The hippocampus
10.1016/j.cub.2015.10.049 · 2015 · External reference
Ghrelin: structure and function
10.1152/physrev.00012.2004 · 2005 · External reference
Hippocampal Neural Stem Cell Exosomes Promote Brain Resilience against the Impact of Tau Oligomers
10.1523/jneurosci.1664-24.2025 · 2025 · External reference
Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response
10.1038/s42255-022-00723-5 · 2023 · External reference
Activation of the Gut-Brain Interaction by Urolithin A and Its Molecular Basis
10.3390/nu16193369 · 2024 · External reference
Neuropeptide SP protects against colitis and linked anxiety-like behavior through the putative roles of gut microbiota and metabolite inositol
10.1038/s41467-025-67904-0 · 2026 · External reference
Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity
10.1016/j.neuron.2025.08.016 · 2025 · External reference
Small Neuron-Derived Extracellular Vesicles from Individuals with Down Syndrome Propagate Tau Pathology in the Wildtype Mouse Brain
10.3390/jcm10173931 · 2021 · External reference
Migrasomal autophagosomes relieve endoplasmic reticulum stress in glioblastoma cells
10.1186/s12915-024-01829-w · 2024 · External reference
The extracellular vesicle of gut microbial Paenalcaligenes hominis is a risk factor for vagus nerve-mediated cognitive impairment
10.1186/s40168-020-00881-2 · 2020 · External reference
Maternal exercise prevents metabolic disorders in offspring mice through SERPINA3C
10.1038/s42255-024-01213-6 · 2025 · External reference
Hepatic Sirt2-PARP1-HMGB1 axis promotes exercise-mediated amelioration of MASH in mice
2026 · External reference
HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway
10.1016/j.celrep.2023.112731 · 2023 · External reference
Expression and function of Ndel1 during the differentiation of neural stem cells induced by hippocampal exosomesticle
10.1186/s13287-020-02119-2 · 2021 · External reference
Cellular insights into hydrocephalus: The diverse roles and intricate crosstalk of multiple cell types
10.1016/j.expneurol.2025.115596 · 2026 · External reference
Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors
10.1038/s41467-025-59377-y · 2025 · External reference
Exercise alleviates cognitive dysfunction in Alzheimer's disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia
10.1038/s43587-026-01075-5 · 2026 · External reference
Muscle-Derived Small Extracellular Vesicles Mediate Exercise-Induced Cognitive Protection in Chronic Cerebral Hypoperfusion
10.1002/advs.202410209 · 2025 · External reference
Interleukin-1β-Treated Mesenchymal Stem Cells Inhibit Inflammation in Hippocampal Astrocytes Through Exosome-Activated Nrf-2 Signaling
10.2147/ijn.s289914 · 2021 · External reference
Advanced glycation end products promote the release of endothelial cell-derived mitocytosis
10.1002/2211-5463.70035 · 2025 · External reference
Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus
10.1073/pnas.1703920114 · 2017 · External reference
Astrocyte-Derived Small Extracellular Vesicles Regulate Dendritic Complexity through miR-26a-5p Activity
10.3390/cells9040930 · 2020 · External reference
Hepatic Klf10-Fh1 axis promotes exercise-mediated amelioration of NASH in mice
10.1016/j.metabol.2024.155916 · 2024 · External reference
The extracellular vesicle of depressive patient-derived Escherichia fergusonii induces vagus nerve-mediated neuroinflammation in mice
10.1186/s12974-024-03211-7 · 2024 · External reference
MSC-derived exosomal miR-140-3p improves cognitive dysfunction in sepsis-associated encephalopathy by HMGB1 and S-lactoylglutathione metabolism
10.1038/s42003-024-06236-z · 2024 · External reference
Exosomal miR-132-3p from mesenchymal stromal cells improves synaptic dysfunction and cognitive decline in vascular dementia
10.1186/s13287-022-02995-w · 2022 · External reference
Effects of spleen nerve denervation on depression-like phenotype, systemic inflammation, and abnormal composition of gut microbiota in mice after administration of lipopolysaccharide: A role of brain-spleen axis
10.1016/j.jad.2022.08.087 · 2022 · External reference
Ghrelin-attenuated cognitive dysfunction in streptozotocin-induced diabetic rats
10.1097/wad.0b013e31820ce536 · 2011 · External reference
The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting
10.1016/j.molmet.2017.06.011 · 2017 · External reference
Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson's disease?
10.1186/s40478-017-0470-4 · 2017 · External reference
Gingerol-Enriched Ginger Extract Effects on Anxiety-like Behavior in a Neuropathic Pain Model via Colonic Microbiome-Neuroimmune Modulation
10.3390/molecules31010166 · 2026 · External reference
Helicobacter pylori outer membrane vesicles directly promote Aβ aggregation and enhance Aβ toxicity in APP/PS1 mice
10.1038/s42003-024-07125-1 · 2024 · External reference
The liver-brain axis in metabolic dysfunction-associated steatotic liver disease
10.1016/s2468-1253(24)00320-0 · 2025 · External reference
Microglial NLRP3 Inflammasome Induces Excitatory Synaptic Loss Through IL-1β-Enriched Microvesicle Release: Implications for Sepsis-Associated Encephalopathy
10.1007/s12035-022-03067-z · 2023 · External reference
Chronic nSMase inhibition suppresses neuronal exosome spreading and sex-specifically attenuates amyloid pathology in APP knock-in Alzheimer's disease mice
10.1016/j.nbd.2023.106213 · 2023 · External reference
L-Theanine/α-ketoglutarate/Nrf2 axis promotes exercise-mediated amelioration of nonalcoholic steatohepatitis in mice
10.26599/fshw.2024.9250242 · 2025 · External reference
Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus
10.1111/jnc.14244 · 2018 · External reference
Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein
10.1073/pnas.1200448109 · 2012 · External reference
Multi-omics reveals associations between the microbiota-gut-brain axis and antidepressant effects of vagus nerve stimulation
10.1016/j.ynstr.2025.100777 · 2026 · External reference
Association of hippocampal atrophy with tau pathology of temporal regions in preclinical Alzheimer's disease
10.1177/13872877251314785 · 2025 · External reference
Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes
10.1083/jcb.101.3.942 · 1985 · External reference
NSC-derived extracellular vesicles-mediates neuronal plasticity enhancement in vascular dementia via transferring miR-210
10.1186/s40478-025-02073-1 · 2025 · External reference
Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice
10.1038/s43587-023-00468-0 · 2023 · External reference
Probiotics alleviate chronic ethanol exposure-induced anxiety-like behavior and hippocampal neuroinflammation in male mice through gut microbiota-derived extracellular vesicles
10.1186/s12951-024-03017-y · 2024 · External reference
Intranasal delivery of engineered extracellular vesicles loaded with miR-206-3p antagomir ameliorates Alzheimer's disease phenotypes
10.7150/thno.103596 · 2024 · External reference
Muscle Cathepsin B Treatment Improves Behavioral and Neurogenic Deficits in a Mouse Model of Alzheimer's Disease
10.1111/acel.70242 · 2025 · External reference
Extracellular Vesicle Release Within Energetic and Quantitative Constraints: Implications for Function
10.1002/jev2.70340 · 2026 · External reference
M1-Type Microglia-Derived Extracellular Vesicles Overexpressing IL-1R1 Promote Postoperative Cognitive Dysfunction by Regulating Neuronal Inflammation
10.1007/s10753-023-01875-6 · 2023 · External reference
Neuropathological and functional impact of astrocyte-derived extracellular vesicles in an aged model of Alzheimer's disease
10.1016/j.expneurol.2026.115893 · 2026 · External reference
Characterization and distribution of receptors for the atrial natriuretic peptides in mammalian brain
10.1073/pnas.83.1.174 · 1986 · External reference
Extracellular vesicles through the blood-brain barrier: a review
10.1186/s12987-022-00359-3 · 2022 · External reference
Extracellular Vesicles in Reproductive Physiology and Pathology
10.1152/physrev.00037.2025 · 2026 · External reference
Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
10.1002/alz.12999 · 2023 · External reference
Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons
10.1093/brain/awaa376 · 2021 · External reference
Brain cholinergic terminal density utilizing [(18)F]-fluoroethoxybenzovesamicol PET in adults with Down's syndrome: Relationship to amyloid PET and cognitive performance
10.1002/alz.70134 · 2025 · External reference
Relationship of cholinergic basal forebrain atrophy with the time course of Alzheimer's disease pathology and cognitive decline in adults with Down syndrome: a longitudinal cohort study
10.1002/alz.71028 · 2026 · External reference
Hippocampal neural stem cell-derived extracellular vesicles modulate microglia to promote resilience against tau oligomers
2025 · External reference
Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus
2019 · External reference
Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons
10.1073/pnas.1212137110 · 2013 · External reference
Extracellular Membrane Vesicles as Vehicles for Brain Cell-to-Cell Interactions in Physiological as well as Pathological Conditions
10.1155/2015/152926 · 2015 · External reference
Neurobiological effects of exercise on major depressive disorder: A systematic review
10.1016/j.neubiorev.2015.11.012 · 2016 · External reference
Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement
10.1038/339620a0 · 1989 · External reference
Transduction of inflammation from peripheral immune cells to the hippocampus induces neuronal hyperexcitability mediated by Caspase-1 activation
10.1016/j.nbd.2021.105535 · 2021 · External reference
Neuroprotective effects of coenzyme Q10-loaded exosomes obtained from adipose-derived stem cells in a rat model of Alzheimer's disease
10.1016/j.biopha.2022.113224 · 2022 · External reference
αKlotho Mitigates Progression of AKI to CKD through Activation of Autophagy
10.1681/asn.2015060613 · 2016 · External reference
Gene-modified Exosomes Protect the Brain Against Prolonged Deep Hypothermic Circulatory Arrest
10.1016/j.athoracsur.2020.05.075 · 2021 · External reference
T cell responses in depressed mice induced by chronic unpredictable mild stress
10.1016/j.jad.2021.09.064 · 2022 · External reference
Muscle-Derived miR-200a-3p Through Light-Intensity Exercise May Contribute to Improve Memory Dysfunction in Type 2 Diabetic Mice. FASEB. J
2025 · External reference
Vital Role of Visceral Adipose Tissue in Maintaining Cognitive Functions
10.3390/ijms26146597 · 2025 · External reference
Extracellular Vesicle ASC: A Novel Mediator for Lung-Brain Axis in Preterm Brain Injury
10.1165/rcmb.2023-0402oc · 2024 · External reference
Visceral adiposity, inflammation, and hippocampal function in obesity
10.1016/j.neuropharm.2021.108920 · 2022 · External reference
MSC-Derived Extracellular Vesicles Activate Mitophagy to Alleviate Renal Ischemia/Reperfusion Injury via the miR-223-3p/NLRP3 Axis
10.1155/2022/6852661 · 2022 · External reference
Exosome-Based Therapeutics: A Natural Solution to Overcoming the Blood-Brain Barrier in Neurodegenerative Diseases
10.1002/mco2.70386 · 2025 · External reference
Intranasal administration of exosomes derived from adipose mesenchymal stem cells ameliorates depressive-like behaviors and inhibits inflammation via AMPK/mTOR-mediated autophagy
10.1016/j.jad.2025.04.059 · 2025 · External reference
Adipose chemokine ligand CX3CL1 contributes to maintaining the hippocampal BDNF level, and the effect is attenuated in advanced age
10.1007/s11357-025-01546-4 · 2025 · External reference
Alteration in peritoneal cells with the chemokine CX3CL1 reverses age-associated impairment of recognition memory
10.1007/s11357-022-00579-3 · 2022 · External reference
Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer's disease mouse model
10.1186/s40035-023-00383-9 · 2023 · External reference
Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4
10.1016/j.neuron.2018.12.036 · 2019 · External reference
Inter-organ communication is a critical machinery to regulate metabolism and aging
10.1016/j.tem.2024.11.013 · 2025 · External reference
Young fibroblast-derived migrasomes alleviate keratinocyte senescence and enhance wound healing in aged skin
10.1186/s12951-025-03293-2 · 2025 · External reference
Shedding light on the cell biology of extracellular vesicles
10.1038/nrm.2017.125 · 2018 · External reference
The release and trans-synaptic transmission of Tau via exosomes
10.1186/s13024-016-0143-y · 2017 · External reference
Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis
10.1016/j.stem.2019.09.009 · 2019 · External reference
Exosomes activate hippocampal microglia in atrial fibrillation through long-distance heart-brain communication
10.1186/s12872-024-04274-3 · 2024 · External reference
Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance
10.1016/j.cmet.2022.08.004 · 2022 · External reference
Microglia-derived extracellular vesicles mediate fine particulate matter-induced Alzheimer's disease-like behaviors through the miR-34a-5p/DUSP10/p-p38 MAPK pathway
2025 · External reference
MiR-106a-5p in extracellular vesicles derived from alveolar epithelial cells mediates cognitive dysfunction induced by chronic intermittent hypoxia in mice through MAPK signaling pathway
10.1186/s12974-025-03628-8 · 2025 · External reference
GHSR suppression in neurons protects against aging-associated metabolic and cognitive impairments
10.1007/s11357-025-01922-0 · 2025 · External reference
Influence of lung function on macro- and micro-structural brain changes in mid- and late-life
10.1097/js9.0000000000002228 · 2025 · External reference
Visceral adipose tissue-derived extracellular vesicles promote stress susceptibility in obese mice via miR-140-5p
10.1038/s41401-025-01484-z · 2025 · External reference
Targeting the muscle-brain axis to improve post-stroke cognition via the FNDC5/irisin/BDNF pathway
2025 · External reference
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
10.1002/jev2.12404 · 2024 · External reference
Complement and the Regulation of T Cell Responses
10.1146/annurev-immunol-042617-053245 · 2018 · External reference
Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration
10.1016/j.arr.2021.101397 · 2021 · External reference
Chaihu-Shugan-San alleviates post-stroke depression in mice: Mechanistic insights into exosome-mediated neuroprotection
10.1016/j.jep.2025.119700 · 2025 · External reference
RhANP attenuates endotoxin-derived cognitive dysfunction through subdiaphragmatic vagus nerve-mediated gut microbiota-brain axis
10.1186/s12974-021-02356-z · 2021 · External reference
Intestinal Epithelial Cell Exosome Launches IL-1β-Mediated Neuron Injury in Sepsis-Associated Encephalopathy
2021 · External reference
Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors
10.1038/s41467-021-26302-y · 2021 · External reference
Helicobacter pylori-derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3-C3aR signalling
10.1002/jev2.12306 · 2023 · External reference
Escherichia coli Nissle 1917 alleviates Alzheimer's disease in mice through OmpA-containing outer membrane vesicles
2026 · External reference
Quercetin Improves Hippocampal Neurogenesis in Depression by Regulating the Level of Let-7e-5p in Microglia Exosomes
10.2147/dddt.s493779 · 2025 · External reference
The gut-brain axis in Alzheimer's disease is shaped by commensal gut microbiota derived extracellular vesicles
10.1080/19490976.2025.2501193 · 2025 · External reference
Extracellular vesicle-derived LINC00482 induces microglial M2 polarization to facilitate brain metastasis of NSCLC
10.1016/j.canlet.2023.216146 · 2023 · External reference
Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway
10.7150/thno.42259 · 2020 · External reference
Chronic ozone exposure induces hippocampal microglia activation by microbial dysbiosis in rat lungs
10.1016/j.ecoenv.2025.118393 · 2025 · External reference
ATP Synthase Abundance in Neuronal Extracellular Vesicles Reflects Changes in the Mitochondria of Parent Neurons
10.1002/jev2.70140 · 2025 · External reference
BM-MSC-derived migrasomes reverse stroke-induced thymic atrophy and immunosuppression via Pin1 delivery to thymic epithelial cells
10.1186/s12974-025-03604-2 · 2025 · External reference
Uptake and tumor-suppressive pathways of exosome-associated GKN1 protein in gastric epithelial cells
10.1007/s10120-020-01068-2 · 2020 · External reference
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1
10.1038/s41591-019-0440-4 · 2019 · External reference
Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials
10.1186/s12951-023-01969-1 · 2023 · External reference
Pituitary crosstalk with bone, adipose tissue and brain
10.1038/s41574-023-00894-5 · 2023 · External reference
ADSC-derived exosomes provide neuroprotection in sepsis-associated encephalopathy by regulating hippocampal pyroptosis
10.1016/j.expneurol.2024.114900 · 2024 · External reference
Abnormal expression of colony stimulating factor 1 receptor (CSF1R) and transcription factor PU.1 (SPI1) in the spleen from patients with major psychiatric disorders: A role of brain-spleen axis
10.1016/j.jad.2020.03.128 · 2020 · External reference
Ageing related thyroid deficiency increases brain-targeted transport of liver-derived ApoE4-laden exosomes leading to cognitive impairment
10.1038/s41419-022-04858-x · 2022 · External reference
Brain-Derived Exosomal miR-9-5p Induces Ferroptosis in Traumatic Brain Injury-Induced Acute Lung Injury by Targeting Scd1
10.1111/cns.70189 · 2024 · External reference
Oligodendrocyte-derived exosomes-containing SIRT2 ameliorates depressive-like behaviors and restores hippocampal neurogenesis and synaptic plasticity via the AKT/GSK-3β pathway in depressed mice
10.1111/cns.14661 · 2024 · External reference
Sbno1 mediates cell-cell communication between neural stem cells and microglia through small extracellular vesicles
10.1186/s13578-024-01296-4 · 2024 · External reference
Engineering RVG-modified exosomes for targeting TGF-β1 signaling in stroke recovery
10.1186/s12967-026-08271-2 · 2026 · External reference
An anti-CD19-exosome delivery system navigates the blood-brain barrier for targeting of central nervous system lymphoma
10.1186/s12951-025-03238-9 · 2025 · External reference
Migrasomes: a journey from biogenesis to multifaceted roles in health and disease
10.1186/s40364-026-00904-4 · 2026 · External reference
Obesity-Related Cognitive Impairment: An Update Overview of Mechanisms and Treatments
10.1017/erm.2026.10049 · 2026 · External reference
Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact
2025 · External reference
Microglial exosomal miR-466i-5p induces brain injury via promoting hippocampal neuron apoptosis in heatstroke
10.3389/fimmu.2022.968520 · 2022 · External reference
Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice
10.1016/j.metabol.2022.155241 · 2022 · External reference
Exercise-induced anti-obesity effects in male mice generated by a FOXO1-KLF10 reinforcing loop promoting adipose lipolysis
10.1038/s41467-025-58467-1 · 2025 · External reference
Exercise-regulated lipolysis: Its role and mechanism in health and diseases
10.1016/j.jare.2024.11.031 · 2024 · External reference
Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
10.1186/s13024-022-00562-8 · 2022 · External reference
Klotho controls the brain-immune system interface in the choroid plexus
10.1073/pnas.1808609115 · 2018 · External reference
