Research graph
References from Muscle oxygen saturation (SmO2): An Upstream Metabolic Link Connecting Peripheral Muscle Metabolism to Central Neurobiological Adaptations. Local targets link to admitted publications; unresolved targets remain external evidence.
Exercise training and depression and anxiety in musculoskeletal pain patients: A meta-analysis of randomized control trials
2023 · External reference
Understanding near infrared spectroscopy and its application to skeletal muscle research
10.1152/japplphysiol.00166.2018 · 2019 · External reference
The relationship between brain-derived neurotrophic factor, irisin and cognitive skills of endurance athletes
10.1080/00913847.2016.1196125 · 2016 · External reference
Lactate transport and signaling in the brain: Potential therapeutic targets and roles in body-brain interaction
10.1038/jcbfm.2014.206 · 2015 · External reference
The expression of lactate transporters (MCT1 and MCT4) in heart and muscle
10.1007/s004210100516 · 2001 · External reference
Lactate and the injured brain: Friend or foe?
10.1097/mcc.0000000000000072 · 2014 · External reference
The Science and Translation of Lactate Shuttle Theory
10.1016/j.cmet.2018.03.008 · 2018 · External reference
The tortuous path of lactate shuttle discovery: From cinders and boards to the lab and ICU
10.1016/j.jshs.2020.02.006 · 2020 · External reference
Dexamethasone for prevention of AMS, HACE, and HAPE and for limiting impairment of performance after rapid ascent to high altitude: A narrative review
10.1186/s40779-025-00634-y · 2025 · External reference
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
10.1097/mol.0b013e328328d0a4 · 2009 · External reference
Exercise for the treatment of depression and anxiety
10.2190/pm.41.1.c · 2011 · External reference
Peripheral administration of lactate produces antidepressant-like effects
10.1038/mp.2016.179 · 2018 · External reference
Physical activity for cognitive health promotion: An overview of the underlying neurobiological mechanisms
10.1016/j.arr.2023.101868 · 2023 · External reference
AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy
10.1111/cns.70657 · 2025 · External reference
Endocrine Crosstalk Between Skeletal Muscle and the Brain
10.3389/fneur.2018.00698 · 2018 · External reference
Exercise and mental health: Many reasons to move
10.1159/000223730 · 2009 · External reference
Applications of near-infrared spectroscopy in “anaerobic” diagnostics – SmO2 kinetics reflect PCr dephosphorylation and correlate with maximal lactate accumulation and maximal pedalling rate
10.5114/biolsport.2023.122481 · 2023 · External reference
Lactate Mediates the Effects of Exercise on Learning and Memory through SIRT1-Dependent Activation of Hippocampal Brain-Derived Neurotrophic Factor (BDNF)
10.1523/jneurosci.1661-18.2019 · 2019 · External reference
Lactate Mediates the Effects of Exercise on Learning and Memory through SIRT1-Dependent Activation of Hippocampal Brain-Derived Neurotrophic Factor (BDNF)
10.1523/jneurosci.1661-18.2019 · 2019 · External reference
Hypoxia and inflammation
10.1056/nejmra0910283 · 2011 · External reference
Physical exercise for people with Parkinson’s disease: A systematic review and network meta-analysis
2023 · External reference
Near-infrared spectroscopy-derived muscle oxygen saturation on a 0% to 100% scale: Reliability and validity of the Moxy Monitor
10.1117/1.jbo.24.11.115001 · 2019 · External reference
The use of near-infrared spectroscopy in understanding skeletal muscle physiology: Recent developments
2011 · External reference
Extracellular vesicles as mediators of neuron-glia communication
10.3389/fncel.2013.00182 · 2013 · External reference
Defining the Role of Anti- and Pro-inflammatory Outcomes of Interleukin-6 in Mental Health
10.1016/j.neuroscience.2022.03.020 · 2022 · External reference
Lactate metabolism: A new paradigm for the third millennium
10.1113/jphysiol.2003.058701 · 2004 · External reference
Mitochondrial reticulum for cellular energy distribution in muscle
10.1038/nature14614 · 2015 · External reference
Lactate: Brain fuel in human traumatic brain injury: a comparison with normal healthy control subjects
10.1089/neu.2014.3483 · 2015 · External reference
Molecular mechanisms of skeletal muscle atrophy: Clinical challenges and future therapeutic strategies
10.1016/j.bcp.2026.117913 · 2026 · External reference
Slow VO₂ kinetics during moderate-intensity exercise as markers of lower metabolic stability and lower exercise tolerance
10.1007/s00421-010-1609-1 · 2011 · External reference
The monocarboxylate transporter family—Structure and functional characterization
10.1002/iub.573 · 2012 · External reference
Review of early development of near-infrared spectroscopy and recent advancement of studies on muscle oxygenation and oxidative metabolism
10.1007/s12576-019-00697-2 · 2019 · External reference
Near-infrared spectroscopy/imaging for monitoring muscle oxygenation and oxidative metabolism in healthy and diseased humans
10.1117/1.2805437 · 2007 · External reference
AMPK: Guardian of metabolism and mitochondrial homeostasis
10.1038/nrm.2017.95 · 2018 · External reference
Molecular basis of cardioprotection: Signal transduction in ischemic pre-, post-, and remote conditioning
10.1161/circresaha.116.305348 · 2015 · External reference
Myostatin Decreases with Aerobic Exercise and Associates with Insulin Resistance
10.1249/mss.0b013e3181e0b9a8 · 2010 · External reference
Cellular metabolic homeostasis during large-scale change in ATP turnover rates in muscles
10.1242/jeb.200.2.381 · 1997 · External reference
The effect of severe and moderate hypoxia on exercise at a fixed level of perceived exertion
10.1007/s00421-019-04111-y · 2019 · External reference
Neuroplasticity - exercise-induced response of peripheral brain-derived neurotrophic factor: A systematic review of experimental studies in human subjects
10.2165/11534530-000000000-00000 · 2010 · External reference
Muscle-brain crosstalk mediated by exercise-induced myokines—Insights from experimental studies
10.3389/fphys.2024.1488375 · 2024 · External reference
BDNF and Hippocampal Synaptic Plasticity
10.1016/bs.vh.2016.10.004 · 2017 · External reference
Role of Myokines in Regulating Skeletal Muscle Mass and Function
10.3389/fphys.2019.00042 · 2019 · External reference
The neuroendocrine network imbalance in post-traumatic stress disorder: From core mechanisms to clinical translation
2026 · External reference
Myokines and the Brain: A Novel Neuromuscular Endocrine Loop
10.1176/appi.neuropsych.20240173 · 2025 · External reference
Exercise interventions in Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials
10.1016/j.arr.2021.101479 · 2021 · External reference
High-intensity interval exercise and cerebrovascular health: Curiosity, cause, and consequence
10.1038/jcbfm.2015.49 · 2015 · External reference
Lactate in the brain: From metabolic end-product to signalling molecule
10.1038/nrn.2018.19 · 2018 · External reference
Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase
10.1007/s00125-009-1364-1 · 2009 · External reference
Skeletal Muscle Oxidative Metabolism during Exercise Measured with Near Infrared Spectroscopy
10.3390/ndt2040025 · 2024 · External reference
Skeletal Muscle Oxidative Metabolism during Exercise Measured with Near Infrared Spectroscopy
10.3390/ndt2040025 · 2024 · External reference
Performance comparison of the MOXY and PortaMon near-infrared spectroscopy muscle oximeters at rest and during exercise
10.1117/1.jbo.23.1.015007 · 2018 · External reference
Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member
10.1038/387083a0 · 1997 · External reference
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1
10.1038/ncomms15557 · 2017 · External reference
Cerebral and muscle tissue oxygenation during exercise in healthy adults: A systematic review
10.1016/j.jshs.2024.03.003 · 2024 · External reference
Transport of brain-derived neurotrophic factor across the blood-brain barrier
10.1016/s0028-3908(98)00141-5 · 1998 · External reference
Neurotrophin regulation of neural circuit development and function
10.1038/nrn3379 · 2013 · External reference
Muscles, exercise and obesity: Skeletal muscle as a secretory organ
10.1038/nrendo.2012.49 · 2012 · External reference
Continuous Monitoring of Muscle Oxygenation in Endurance Athletes During Incremental Cycling: Experimental Validation of a Wearable Continuous-Wave NIRS Sensor Using Frequency-Domain Near-Infrared Spectroscopy
10.3390/bioengineering12111153 · 2025 · External reference
Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization
10.1073/pnas.91.22.10625 · 1994 · External reference
Muscle Oxygenation Unlocks the Secrets of Physiological Responses to Exercise: Time to Exploit it in the Training Monitoring
10.3389/fspor.2022.864825 · 2022 · External reference
Muscle Oximetry in Sports Science: A Systematic Review
10.1007/s40279-017-0820-1 · 2018 · External reference
Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production
10.1152/physrev.00031.2007 · 2008 · External reference
Lactate as a Metabolite and a Regulator in the Central Nervous System
10.3390/ijms17091450 · 2016 · External reference
The role of exercise-induced myokines in promoting angiogenesis
10.3389/fphys.2022.981577 · 2022 · External reference
Regulation of cerebral blood flow during exercise
10.2165/00007256-200737090-00002 · 2007 · External reference
Evidence for a release of brain-derived neurotrophic factor from the brain during exercise
10.1113/expphysiol.2009.048512 · 2009 · External reference
Neurotrophin-regulated signalling pathways
10.1098/rstb.2006.1894 · 2006 · External reference
Myoglobin O2 desaturation during exercise. Evidence of limited O2 transport
10.1172/jci118237 · 1995 · External reference
Health Benefits of Exercise
10.1101/cshperspect.a029694 · 2018 · External reference
Exercise Increases Mitochondrial PGC-1α Content and Promotes Nuclear-Mitochondrial Cross-talk to Coordinate Mitochondrial Biogenesis
10.1074/jbc.m110.211466 · 2011 · External reference
Hypoxia-inducible factors in physiology and medicine
10.1016/j.cell.2012.01.021 · 2012 · External reference
Muscle-Organ Crosstalk: The Emerging Roles of Myokines
10.1210/endrev/bnaa016 · 2020 · External reference
Near-Infrared Spectroscopy Used to Assess Physiological Muscle Adaptations in Exercise Clinical Trials: A Systematic Review
10.3390/biology11071073 · 2022 · External reference
Blood lactate is an important energy source for the human brain
10.1038/jcbfm.2009.35 · 2009 · External reference
Calculating Load and Intensity Using Muscle Oxygen Saturation Data
10.3390/sports12040113 · 2024 · External reference
Determinants of maximal oxygen transport and utilization
10.1146/annurev.ph.58.030196.000321 · 1996 · External reference
BDNF Signaling in Context: From Synaptic Regulation to Psychiatric Disorders
10.1016/j.cell.2021.12.003 · 2022 · External reference
The Dual Role of Interleukin-6 in the Pathophysiology of Skeletal Muscle: Mechanisms, Challenges, and Therapeutic Prospects
10.3390/ph19060868 · 2026 · External reference
Therapeutic Challenges and Future Breakthroughs in Amyotrophic Lateral Sclerosis: From Precision Medicine to Innovative Trial Design
10.2147/dddt.s626069 · 2026 · External reference
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
10.1016/j.cmet.2013.09.008 · 2013 · External reference
The optimal exercise intervention for sleep quality in adults: A systematic review and network meta-analysis
10.1016/j.ypmed.2024.107955 · 2024 · External reference
Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons
2014 · External reference
Myokine-mediated muscle-organ interactions: Molecular mechanisms and clinical significance
2025 · External reference
Comparing the reliability of muscle oxygen saturation with common performance and physiological markers across cycling exercise intensity
10.3389/fspor.2023.1143393 · 2023 · External reference
Dysregulation of energy metabolism in Alzheimer’s disease
10.1007/s00415-024-12800-8 · 2025 · External reference
