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References from Glabridin and glabrene from Glycyrrhiza glabra L. as natural Co-operative modulators of the human serotonin transporter: Evidence from docking, molecular simulations and machine-learning QSAR models. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2013 · External reference
Autism: an early-onset neurodevelopmental disorder
2016 · External reference
A review of central 5-HT receptors and their function
10.1016/s0028-3908(99)00010-6 · 1999 · External reference
The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation
10.1016/s0021-9150(97)00251-7 · 1998 · External reference
The expanded biology of serotonin
10.1146/annurev.med.60.042307.110802 · 2009 · External reference
Quantifying the chemical beauty of drugs
10.1038/nchem.1243 · 2012 · External reference
The solute carrier 6 family of transporters correspondence keywords monoamine transporters; antidepressants; transport mechanism; transporter pharmacology
2012 · External reference
Fluvoxamine is a potent inhibitor of cytochrome P4501A2
10.1016/0006-2952(93)90272-x · 1993 · External reference
Unresolved reference
2020 · External reference
Pharmacokinetics of selective serotonin reuptake inhibitors: clinical relevance
10.1111/j.1600-0773.1996.tb00206.x · 1996 · External reference
Serotonin modulation of cortical neurons and networks
10.3389/fnint.2013.00025 · 2013 · External reference
Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption
1999 · External reference
Structural basis for recognition of diverse antidepressants by the human serotonin transporter
10.1038/s41594-018-0026-8 · 2018 · External reference
X-ray structures and mechanism of the human serotonin transporter
10.1038/nature17629 · 2016 · External reference
Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder
10.1016/0024-3205(93)90685-v · 1993 · External reference
Unresolved reference
2022 · External reference
Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests
2006 · External reference
AutoDock vina 1.2.0: new docking methods, expanded force field, and python bindings
10.1021/acs.jcim.1c00203 · 2021 · External reference
Selective serotonin reuptake inhibitors and adverse effects: a narrative review
10.3390/neurolint13030038 · 2021 · External reference
ChEMBL
2017 · External reference
Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms
10.1371/journal.pone.0067947 · 2013 · External reference
Glabridin as a major active isoflavan from Glycyrrhiza glabra (licorice) reverses learning and memory deficits in diabetic rats
10.1556/aphysiol.98.2011.2.14 · 2011 · External reference
A structural model of the human serotonin transporter in an outward-occluded state
10.1371/journal.pone.0217377 · 2018 · External reference
Deciphering serotonin's role in neurodevelopment
2014 · External reference
The HADDOCK2.4 web server for integrative modeling of biomolecular complexes
10.1038/s41596-024-01011-0 · 2024 · External reference
In vitro interactions between fluoxetine or fluvoxamine and methadone or buprenorphine
10.1111/j.1472-8206.1998.tb00941.x · 1998 · External reference
A hierarchical approach to all‐atom protein loop prediction
10.1002/prot.10613 · 2004 · External reference
SLC6A4 markers modulate platelet 5-HT level and specific behaviors of autism: a study from an Indian population
2015 · External reference
Serotonin mediated immunoregulation and neural functions: complicity in the aetiology of autism spectrum disorders
10.1016/j.neubiorev.2015.05.013 · 2015 · External reference
Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis
10.3390/nu8010056 · 2016 · External reference
Scalable algorithms for molecular dynamics simulations on commodity clusters
2006 · External reference
Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion
10.1016/j.nbd.2011.12.056 · 2012 · External reference
SLC6 neurotransmitter transporters: structure, function, and regulation
10.1124/pr.108.000869 · 2011 · External reference
A critical appraisal on phytochemical constituents and therapeutic effect of yashtimadhu (Glycyrrhiza glabra)
2018 · External reference
Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter
10.1111/bph.13411 · 2016 · External reference
Unresolved reference
2019 · External reference
Flavonoid constituents from Glycyrrhiza glabra hairy root cultures
10.1016/s0031-9422(00)00337-x · 2000 · External reference
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
2012 · External reference
Protein–ligand blind docking using CB-Dock2
2024 · External reference
Accurate prediction of the relative potencies of members of a series of kinase inhibitors using molecular docking and MM-GBSA scoring
10.1021/jm060522a · 2006 · External reference
Special issues in the management of depression in women
2004 · External reference
ChEMBL: towards direct deposition of bioassay data
10.1093/nar/gky1075 · 2019 · External reference
Conformational dynamics of the human serotonin transporter during substrate and drug binding
10.1038/s41467-019-09675-z · 2019 · External reference
Review of pharmacological effects of glycyrrhiza sp. and its bioactive compounds
2008 · External reference
Role of medhya rasayanas (nootropic drugs) in developmental disabilities of children
2019 · External reference
Pharmacological and therapeutic properties of licorice preparations (A review)
10.1007/bf02510095 · 1999 · External reference
Inhibition of serotonin re-uptake by licorice constituents
10.1385/jmn:20:2:135 · 2003 · External reference
UCSF Chimera - a visualization system for exploratory research and analysis
10.1002/jcc.20084 · 2004 · External reference
pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures
10.1021/acs.jmedchem.5b00104 · 2015 · External reference
The dynamics of autism spectrum disorders: how neurotoxic compounds and neurotransmitters interact
10.3390/ijerph10083384 · 2013 · External reference
Commentary on ‘Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD).’
2011 · External reference
Serotonin transporters - structure and function
10.1007/s00232-006-0878-4 · 2006 · External reference
Inhibition of CYP2C9 by selective serotonin reuptake inhibitors in vitro: studies of phenytoin p-hydroxylation
10.1046/j.1365-2125.1997.00601.x · 1997 · External reference
Unresolved reference
2019 · External reference
Unresolved reference
2024 · External reference
Two decades under the influence of the rule of five and the changing properties of approved oral drugs
10.1021/acs.jmedchem.8b00686 · 2019 · External reference
Phytoestrogens and cognitive function: a review
10.1016/j.maturitas.2013.12.010 · 2014 · External reference
Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells
2000 · External reference
Pharmacological perspective of glycyrrhiza glabraLinn.: a mini-review
10.15406/japlr.2017.05.00156 · 2017 · External reference
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
10.1002/jcc.21334 · 2010 · External reference
Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation
10.1016/s0891-5849(97)00089-0 · 1997 · External reference
Glycyrrhiza glabra (Licorice): a comprehensive review on its phytochemistry, biological activities, clinical evidence and toxicology
10.3390/plants10122751 · 2021 · External reference
Effects of yokukansan, a Japanese kampo medicine for symptoms associated autism spectrum disorder
10.2174/1871527315666160413120541 · 2016 · External reference
Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD)
2013 · External reference
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties
10.1093/nar/gkab255 · 2021 · External reference
PRODIGY: a web server for predicting the binding affinity of protein-protein complexes
10.1093/bioinformatics/btw514 · 2016 · External reference
Molecular mechanism for the allosteric inhibition of the human serotonin transporter by antidepressant escitalopram
10.1021/acschemneuro.1c00694 · 2022 · External reference
Neuroprotective effects of liquiritigenin isolated from licorice roots on glutamate-induced apoptosis in hippocampal neuronal cells
10.1016/j.neuro.2013.08.012 · 2013 · External reference
In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice)
2008 · External reference
Molecular dynamics simulations and steered molecular dynamics simulations of glabridin bound to wild type and V30A mutant transthyretin: ligand-Linked perturbation of tertiary conformation
10.1007/s40242-018-8085-2 · 2018 · External reference
The serotonergic system: its role in pathogenesis and early developmental treatment of autism
10.2174/157015909788848848 · 2009 · External reference
