Research graph
References from Chronic manganese exposure disrupts dopamine biosynthesis and amphetamine response in a mouse model of altered dopamine transport. Local targets link to admitted publications; unresolved targets remain external evidence.
Testing genetic modifiers of behavior and response to atomoxetine in autism spectrum disorder with ADHD
10.1007/s10882-018-9590-4 · 2018 · External reference
Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study
10.1002/ajmg.b.30874 · 2008 · External reference
Dopamine Transporter and CYP2D6 gene relationships with attention-deficit/hyperactivity disorder treatment response in the methylphenidate and atomoxetine crossover study
10.1089/cap.2024.0069 · 2024 · External reference
Altered expression of ZnT10 in Alzheimer’s disease brain
10.1371/journal.pone.0065475 · 2013 · External reference
Hair manganese and hyperactive behaviors: pilot study of school-age children exposed through tap water
10.1289/ehp.9504 · 2007 · External reference
Intellectual impairment in school-age children exposed to manganese from drinking water
10.1289/ehp.1002321 · 2011 · External reference
Role of manganese in neurodegenerative diseases
10.1016/j.jtemb.2011.08.144 · 2011 · External reference
Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: implications for drug development
10.1074/jbc.m111.262790 · 2011 · External reference
Acute manganese administration alters dopamine transporter levels in the non-human primate striatum
10.1016/j.neuro.2005.10.008 · 2006 · External reference
Sex and ovarian hormone cycles alter effects of stimulant drugs on mouse dopaminergic signaling
10.1172/jci178630 · 2026 · External reference
Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors
10.1172/jci127411 · 2019 · External reference
Manganese induced brain lesions in Macaca fascicularis as revealed by positron emission tomography and magnetic resonance imaging
10.1007/bf02035130 · 1992 · External reference
Association between COMT methylation and response to treatment in children with ADHD
10.1016/j.jpsychires.2021.01.008 · 2021 · External reference
Manganese in children with attention-deficit/hyperactivity disorder: relationship with methylphenidate exposure
10.1089/cap.2009.0073 · 2010 · External reference
Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder
10.1016/j.ridd.2014.04.007 · 2014 · External reference
Effect of CYP2D6 genetic variation on patient-reported symptom improvement and side effects among children and adolescents treated with amphetamines
10.1097/fpc.0000000000000529 · 2024 · External reference
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
10.1038/379606a0 · 1996 · External reference
Candidate gene studies of ADHD: a meta-analytic review
10.1007/s00439-009-0694-x · 2009 · External reference
Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): Implications to manganese-induced parkinsonism
10.1111/j.1471-4159.2008.05695.x · 2008 · External reference
De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder
10.1038/mp.2013.102 · 2013 · External reference
Sex-Specific, intermediate behavioral phenotypes in heterozygous dopamine transporter mutant DAT T356M Mice
10.1111/gbb.70041 · 2025 · External reference
Associations of early childhood manganese and lead coexposure with neurodevelopment
10.1289/ehp.1003300 · 2012 · External reference
Blood manganese levels in relation to comorbid behavioral and emotional problems in children with attention-deficit/hyperactivity disorder
10.1016/j.psychres.2014.05.049 · 2014 · External reference
Manganese is essential for neuronal health
10.1146/annurev-nutr-071714-034419 · 2015 · External reference
The interaction between dopamine transporter function, gender differences, and possible laterality in depression
10.1016/j.pscychresns.2012.06.004 · 2013 · External reference
Dopamine transporter binding in chronic manganese intoxication
10.1007/s00415-003-0214-1 · 2003 · External reference
Sex differences in striatal dopaminergic function within heterozygous mutant dopamine transporter knock-out mice
10.1007/s00702-007-0017-0 · 2008 · External reference
Developmental exposure to methylmercury and ADHD, a literature review of epigenetic studies
10.1093/eep/dvab014 · 2021 · External reference
Regulation of LRRK2 activity by metabolic stress and heavy metal exposure
10.1016/j.brainres.2025.149785 · 2025 · External reference
Preweaning manganese exposure causes hyperactivity, disinhibition, and spatial learning and memory deficits associated with altered dopamine receptor and transporter levels
10.1002/syn.20736 · 2010 · External reference
Role of dopaminergic RE1-silencing transcription factor (REST) in manganese-induced behavioral deficits and dysregulating dopaminergic and serotonergic neurotransmission in mice
10.1016/j.neuro.2025.03.001 · 2025 · External reference
Evaluation of SLC6A2 and CYP2D6 polymorphisms’ effects on atomoxetine treatment in attention deficit and hyperactivity disorder
10.1007/s00228-024-03744-z · 2024 · External reference
Dopaminergic dysregulation in syndromic autism spectrum disorders: insights from genetic mouse models
10.3389/fncir.2021.700968 · 2021 · External reference
A benchmark concentration analysis for manganese in drinking water and IQ deficits in children
10.1016/j.envint.2019.05.083 · 2019 · External reference
Early postnatal manganese exposure reduces rat cortical and striatal biogenic amine activity in adulthood
10.1093/toxsci/kfz208 · 2020 · External reference
Early Postnatal Manganese Exposure Reduces Rat Cortical and Striatal Biogenic Amine Activity in Adulthood
10.1093/toxsci/kfz208 · 2020 · External reference
Effect of high-fat feeding on expression of genes controlling availability of dopamine in mouse hypothalamus
10.1016/j.nut.2009.05.007 · 2010 · External reference
Association between 10 urinary heavy metal exposure and attention deficit hyperactivity disorder for children
10.1007/s11356-020-09421-9 · 2020 · External reference
Mechanism of manganese dysregulation of dopamine neuronal activity
10.1523/jneurosci.2830-19.2020 · 2020 · External reference
Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease
10.1111/ejn.13357 · 2017 · External reference
Tremor, olfactory and motor changes in Italian adolescents exposed to historical ferro-manganese emission
10.1016/j.neuro.2012.01.005 · 2012 · External reference
Sex differences in social adaptive function in autism spectrum disorder and attention-deficit hyperactivity disorder
10.3389/fpsyt.2019.00607 · 2019 · External reference
Sex differences in methylphenidate-induced dopamine increases in ventral striatum
10.1038/s41380-021-01294-9 · 2022 · External reference
DRD1 and DRD2 receptor polymorphisms: genetic neuromodulation of the dopaminergic system as a risk factor for ASD, ADHD and ASD/ADHD Overlap
10.3389/fnins.2021.705890 · 2021 · External reference
Leaky lessons learned: efflux prone dopamine transporter variant reveals sex and circuit specific contributions of D2 receptor signalling to neuropsychiatric disease
10.1111/bcpt.13964 · 2024 · External reference
Gender differences in the behavioral and subjective effects of methamphetamine in healthy humans
10.1007/s00213-019-05276-2 · 2019 · External reference
Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes
10.1016/j.neuroscience.2008.03.070 · 2008 · External reference
The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants
10.1073/pnas.1417294111 · 2014 · External reference
Sex differences in (+)-amphetamine- and (+)-methamphetamine-induced behavioral response in male and female Sprague-Dawley rats
10.1016/j.pbb.2006.12.018 · 2007 · External reference
Age-dependent susceptibility to manganese-induced neurological dysfunction
10.1093/toxsci/kfp220 · 2009 · External reference
Sex differences in the response to treatment of attention deficit hyperactivity disorder
10.1007/s00210-025-04716-5 · 2026 · External reference
Pharmacogenetics predictors of methylphenidate efficacy in childhood ADHD
10.1038/mp.2017.234 · 2018 · External reference
Neurobehavioral function in school-age children exposed to manganese in drinking water
10.1289/ehp.1307918 · 2014 · External reference
Association between ANKK1 (rs1800497) polymorphism of DRD2 gene and attention deficit hyperactivity disorder: a meta-analysis
10.1016/j.neulet.2015.01.076 · 2015 · External reference
SLC39A8 deficiency: biochemical correction and major clinical improvement by manganese therapy
10.1038/gim.2017.106 · 2018 · External reference
SLC39A8 deficiency: a disorder of manganese transport and glycosylation
10.1016/j.ajhg.2015.11.003 · 2015 · External reference
Leveraging the genetics of psychiatric disorders to prioritize potential drug targets and compounds
10.1038/s41386-026-02380-8 · 2026 · External reference
Chronic exposure to manganese decreases striatal dopamine turnover in human alpha-synuclein transgenic mice
10.1016/j.neuroscience.2011.02.017 · 2011 · External reference
A review of sex and gender factors in stimulant treatment for ADHD: knowledge gaps and future directions
10.1177/10870547251315601 · 2025 · External reference
Review of rodent models of attention deficit hyperactivity disorder
10.1016/j.neubiorev.2021.11.041 · 2022 · External reference
Associations between hair manganese levels and cognitive, language, and motor development in preschool children from Montevideo, Uruguay
10.1080/19338244.2012.725229 · 2014 · External reference
Characterization of zinc uptake by mouse primary cultured astrocytes and microglia
2015 · External reference
Effects of dietary manganese contents on 54Mn metabolism in mice
10.1269/jrr.37.125 · 1996 · External reference
Catechol-O-methyltransferase (COMT) protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain
10.1371/journal.pone.0061392 · 2013 · External reference
Exposure to manganese in drinking water during childhood and association with attention-deficit hyperactivity disorder: a nationwide cohort study
10.1289/ehp6391 · 2020 · External reference
Exposure to manganese in drinking water during childhood and association with attention-deficit hyperactivity disorder: a nationwide cohort study
10.1289/ehp6391 · 2020 · External reference
Polymorphism of DRD2 gene and ADHD
2006 · External reference
Association of hair manganese level with symptoms in attention-deficit/hyperactivity disorder
10.4306/pi.2015.12.1.66 · 2015 · External reference
Sex-dependent changes in striatal dopamine transport in preadolescent rats exposed prenatally and/or postnatally to methamphetamine
10.1007/s11064-016-1902-4 · 2016 · External reference
Sex differences in the response of children with ADHD to once-daily formulations of methylphenidate
10.1097/chi.0b013e31804659f1 · 2007 · External reference
The ins and outs of dopamine transporter gene manipulation: in vivo models of DAT Dysfunction
10.1007/978-3-031-96364-3_10 · 2025 · External reference
The role of CYP2D in rat brain in methamphetamine-induced striatal dopamine and serotonin release and behavioral sensitization
10.1007/s00213-021-05808-9 · 2021 · External reference
Manganese action in brain function
10.1016/s0165-0173(02)00234-5 · 2003 · External reference
Exposure to air pollution in early childhood and the association with Attention-Deficit Hyperactivity Disorder
10.1016/j.envres.2019.108930 · 2020 · External reference
DRD4 rare variants in Attention-Deficit/Hyperactivity Disorder (ADHD): further evidence from a birth cohort study
10.1371/journal.pone.0085164 · 2013 · External reference
Sex differences in novelty- and psychostimulant-induced behaviors of C57BL/6 mice
10.1007/s00213-012-2860-4 · 2013 · External reference
Human sex differences in d-amphetamine self-administration
10.1111/j.1360-0443.2009.02858.x · 2010 · External reference
Mechanisms of dopamine transporter regulation in normal and disease states
10.1016/j.tips.2013.07.005 · 2013 · External reference
Manganese-induced hyperactivity and dopaminergic dysfunction depend on age, sex and YAC128 genotype
10.1016/j.pbb.2022.173337 · 2022 · External reference
Chronic exposure to manganese alters brain responses to amphetamine: a pharmacological magnetic resonance imaging study
10.1093/toxsci/kfq002 · 2010 · External reference
Unresolved reference
2012 · External reference
Sex differences in dopamine receptors and relevance to neuropsychiatric disorders
10.3390/brainsci11091199 · 2021 · External reference
Age-related changes of brain iron load changes in the frontal cortex in APPswe/PS1ΔE9 transgenic mouse model of Alzheimer’s disease
10.1016/j.jtemb.2014.11.009 · 2015 · External reference
Sex differences in dopamine release regulation in the striatum
10.1038/s41386-020-00915-1 · 2021 · External reference