Research graph
References from A TMEM119-tankyrase axis restrains microglial phagocytosis to maintain memory and enables pharmacological forgetting. Local targets link to admitted publications; unresolved targets remain external evidence.
Finding the engram
10.1038/nrn4000 · 2015 · External reference
Stably maintained dendritic spines are associated with lifelong memories
10.1038/nature08577 · 2009 · External reference
Experience leaves a lasting structural trace in cortical circuits
10.1038/nature07487 · 2009 · External reference
Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits
10.1038/s41582-022-00635-8 · 2022 · External reference
Alzheimer's disease
10.1016/s0140-6736(20)32205-4 · 2021 · External reference
Microglia Function in the Central Nervous System During Health and Neurodegeneration
10.1146/annurev-immunol-051116-052358 · 2017 · External reference
Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling
10.1038/s41593-019-0511-3 · 2019 · External reference
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
10.1126/science.1110647 · 2005 · External reference
Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals
10.1523/jneurosci.4363-08.2009 · 2009 · External reference
Microglial interactions with synapses are modulated by visual experience
10.1371/journal.pbio.1000527 · 2010 · External reference
Synaptic pruning by microglia is necessary for normal brain development
10.1126/science.1202529 · 2011 · External reference
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
10.1016/j.neuron.2012.03.026 · 2012 · External reference
Microglia mediate forgetting via complement-dependent synaptic elimination
10.1126/science.aaz2288 · 2020 · External reference
Complement and microglia mediate early synapse loss in Alzheimer mouse models
10.1126/science.aad8373 · 2016 · External reference
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease
10.1016/j.cell.2017.05.018 · 2017 · External reference
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
10.1016/j.immuni.2017.08.008 · 2017 · External reference
The classical complement cascade mediates CNS synapse elimination
10.1016/j.cell.2007.10.036 · 2007 · External reference
The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity
10.1016/j.immuni.2018.04.016 · 2018 · External reference
TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model
10.1016/j.cell.2015.01.049 · 2015 · External reference
TAM receptors regulate multiple features of microglial physiology
10.1038/nature17630 · 2016 · External reference
New tools for studying microglia in the mouse and human CNS
10.1073/pnas.1525528113 · 2016 · External reference
Protein Expression of the Microglial Marker Tmem119 Decreases in Association With Morphological Changes and Location in a Mouse Model of Traumatic Brain Injury
10.3389/fncel.2022.820127 · 2022 · External reference
Co-expression patterns of microglia markers Iba1, TMEM119 and P2RY12 in Alzheimer's disease
10.1016/j.nbd.2022.105684 · 2022 · External reference
OBIF, an osteoblast induction factor, plays an essential role in bone formation in association with osteoblastogenesis
10.1111/j.1440-169x.2012.01333.x · 2012 · External reference
Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration
10.1016/j.immuni.2022.07.004 · 2022 · External reference
Tankyrase-targeted therapeutics: expanding opportunities in the PARP family
10.1038/nrd3868 · 2012 · External reference
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
10.1038/ncb2222 · 2011 · External reference
Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling
10.1371/journal.pone.0022595 · 2011 · External reference
Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs
10.1002/pro.3413 · 2018 · External reference
Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal
10.1038/nature13826 · 2015 · External reference
Wnt signaling and cancer
10.1101/gad.14.15.1837 · 2000 · External reference
Adenomatous polyposis coli nucleates actin assembly to drive cell migration and microtubule-induced focal adhesion turnover
10.1083/jcb.201702007 · 2017 · External reference
The cytoskeleton in phagocytosis and macropinocytosis
10.1016/j.cub.2021.01.036 · 2021 · External reference
Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization
10.1083/jcb.145.4.741 · 1999 · External reference
Neuronal circuits for fear and anxiety
10.1038/nrn3945 · 2015 · External reference
TAT-based drug delivery system--new directions in protein delivery for new hopes?
10.1517/17425240902887029 · 2009 · External reference
Mechanistic insights into Wnt-beta-catenin pathway activation and signal transduction
10.1038/s41580-024-00823-y · 2025 · External reference
WNT signaling in activated microglia is proinflammatory
10.1002/glia.21081 · 2011 · External reference
Postnatal maturation of microglia is associated with alternative activation and activated TGFbeta signaling
10.1002/glia.23332 · 2018 · External reference
Microglia states and nomenclature: A field at its crossroads
10.1016/j.neuron.2022.10.020 · 2022 · External reference
Microglial TMEM119 binds to amyloid-beta to promote its clearance in an Abeta-depositing mouse model of Alzheimer's disease
10.1016/j.immuni.2025.04.018 · 2025 · External reference
Isolation and Culture of Rodent Microglia to Promote a Dynamic Ramified Morphology in Serum-free Medium
2018 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
Isolation of myelin
2007 · External reference
Quantifying Microglia Morphology from Photomicrographs of Immunohistochemistry Prepared Tissue Using ImageJ
2018 · External reference
Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina
10.1016/j.immuni.2022.10.018 · 2022 · External reference
Neuronal morphometry directly from bitmap images
10.1038/nmeth.3125 · 2014 · External reference
Impaired D2 receptor-dependent dopaminergic transmission in prefrontal cortex of awake mouse model of Parkinson's disease
10.1093/brain/awz243 · 2019 · External reference
ATP mediates rapid microglial response to local brain injury in vivo
10.1038/nn1472 · 2005 · External reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · 2024 · External reference
