Research graph
References from Samm50 downregulation-driven mitochondrial dysfunction triggers ferroptosis and contributes to ketamine-induced neurotoxicity and cognitive impairment. Local targets link to admitted publications; unresolved targets remain external evidence.
Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury
10.1002/hep.32471 · 2022 · External reference
Similar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia
10.1016/j.schres.2018.02.049 · 2018 · External reference
Metabolism and metabolomics of ketamine: a toxicological approach
10.1080/20961790.2017.1285219 · 2017 · External reference
Reviewing the ketamine model for schizophrenia
10.1177/0269881113512909 · 2014 · External reference
Molecular mechanisms of programmed cell death in methamphetamine-induced neuronal damage
2022 · External reference
The interplay of cannabinoid and NMDA glutamate receptor systems in humans: preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects
10.1016/j.pnpbp.2010.11.002 · 2011 · External reference
Insufficient autophagy enables the nuclear factor erythroid 2-related factor 2 (NRF2) to promote ferroptosis in morphine-treated SH-SY5Y cells
10.1007/s00213-023-06485-6 · 2024 · External reference
Ketamine causes mitochondrial dysfunction in human induced pluripotent stem cell-derived neurons
10.1371/journal.pone.0128445 · 2015 · External reference
The epidemiology and patterns of acute and chronic toxicity associated with recreational ketamine use
10.3402/ehtj.v4i0.7107 · 2011 · External reference
Impaired hippocampal-dependent memory and reduced parvalbumin-positive interneurons in a ketamine mouse model of schizophrenia
10.1016/j.schres.2016.01.023 · 2016 · External reference
First injection of ketamine among young injection drug users (IDUs) in three U.S. cities
10.1016/j.drugalcdep.2006.08.015 · 2007 · External reference
Long-term neurocognitive dysfunction in offspring via NGF/ERK/CREB signaling pathway caused by ketamine exposure during the second trimester of pregnancy in rats
10.18632/oncotarget.16042 · 2017 · External reference
Reduced dorsal prefrontal gray matter after chronic ketamine use
10.1016/j.biopsych.2010.08.030 · 2011 · External reference
Ketamine use, cognition and psychological wellbeing: a comparison of frequent, infrequent and ex-users with polydrug and non-using controls
10.1111/j.1360-0443.2008.02394.x · 2009 · External reference
Rave drug tested against depression
10.1038/517130a · 2015 · External reference
Ketamine as a fast acting antidepressant: current knowledge and open questions
10.1111/cns.12103 · 2013 · External reference
Acute ketamine impairs mitochondrial function and promotes superoxide dismutase activity in the rat brain
10.1213/ane.0000000000000539 · 2015 · External reference
The amino acid metabolism pathway of peripheral T lymphocytes and ketamine-induced schizophrenia-like phenotype
10.1503/jpn-240038 · 2024 · External reference
Molecular mechanism of programmed cell death in drug-induced neuronal damage: a special focus on ketamine-induced neurotoxicity
10.1016/j.tox.2025.154102 · 2025 · External reference
Astrocyte activation, but not microglia, is associated with the experimental mouse model of schizophrenia induced by chronic ketamine
10.1007/s12031-022-02046-2 · 2022 · External reference
The multifaceted regulation of Mitochondria in ferroptosis
2021 · External reference
Proteomic characteristics of the prefrontal cortex and Hippocampus in mice with chronic ketamine-induced anxiety and cognitive impairment
10.1016/j.neuroscience.2023.10.008 · 2024 · External reference
Ketamine induces hippocampal apoptosis through a mechanism associated with the caspase-1 dependent pyroptosis
10.1016/j.neuropharm.2017.09.035 · 2018 · External reference
Retraction note: ketamine exerts neurotoxic effects on the offspring of pregnant rats via the Wnt/β-catenin pathway
10.1007/s11356-024-32774-4 · 2024 · External reference
Baicalin Attenuates ketamine-induced neurotoxicity in the developing rats: involvement of PI3K/Akt and CREB/BDNF/Bcl-2 pathways
10.1007/s12640-016-9611-y · 2016 · External reference
Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury
10.1002/hep.32471 · ExternalCitation · doi-reference
Insufficient autophagy enables the nuclear factor erythroid 2-related factor 2 (NRF2) to promote ferroptosis in morphine-treated SH-SY5Y cells
10.1007/s00213-023-06485-6 · ExternalCitation · doi-reference
Retraction note: ketamine exerts neurotoxic effects on the offspring of pregnant rats via the Wnt/β-catenin pathway
10.1007/s11356-024-32774-4 · ExternalCitation · doi-reference
Astrocyte activation, but not microglia, is associated with the experimental mouse model of schizophrenia induced by chronic ketamine
10.1007/s12031-022-02046-2 · ExternalCitation · doi-reference
Baicalin Attenuates ketamine-induced neurotoxicity in the developing rats: involvement of PI3K/Akt and CREB/BDNF/Bcl-2 pathways
10.1007/s12640-016-9611-y · ExternalCitation · doi-reference
Reduced dorsal prefrontal gray matter after chronic ketamine use
10.1016/j.biopsych.2010.08.030 · ExternalCitation · doi-reference
First injection of ketamine among young injection drug users (IDUs) in three U.S. cities
10.1016/j.drugalcdep.2006.08.015 · ExternalCitation · doi-reference
Ketamine induces hippocampal apoptosis through a mechanism associated with the caspase-1 dependent pyroptosis
10.1016/j.neuropharm.2017.09.035 · ExternalCitation · doi-reference
Proteomic characteristics of the prefrontal cortex and Hippocampus in mice with chronic ketamine-induced anxiety and cognitive impairment
10.1016/j.neuroscience.2023.10.008 · ExternalCitation · doi-reference
The interplay of cannabinoid and NMDA glutamate receptor systems in humans: preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects
10.1016/j.pnpbp.2010.11.002 · ExternalCitation · doi-reference
Impaired hippocampal-dependent memory and reduced parvalbumin-positive interneurons in a ketamine mouse model of schizophrenia
10.1016/j.schres.2016.01.023 · ExternalCitation · doi-reference
Similar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia
10.1016/j.schres.2018.02.049 · ExternalCitation · doi-reference
Molecular mechanism of programmed cell death in drug-induced neuronal damage: a special focus on ketamine-induced neurotoxicity
10.1016/j.tox.2025.154102 · ExternalCitation · doi-reference
Rave drug tested against depression
10.1038/517130a · ExternalCitation · doi-reference
Metabolism and metabolomics of ketamine: a toxicological approach
10.1080/20961790.2017.1285219 · ExternalCitation · doi-reference
Ketamine as a fast acting antidepressant: current knowledge and open questions
10.1111/cns.12103 · ExternalCitation · doi-reference
Ketamine use, cognition and psychological wellbeing: a comparison of frequent, infrequent and ex-users with polydrug and non-using controls
10.1111/j.1360-0443.2008.02394.x · ExternalCitation · doi-reference
Reviewing the ketamine model for schizophrenia
10.1177/0269881113512909 · ExternalCitation · doi-reference
Acute ketamine impairs mitochondrial function and promotes superoxide dismutase activity in the rat brain
10.1213/ane.0000000000000539 · ExternalCitation · doi-reference
Ketamine causes mitochondrial dysfunction in human induced pluripotent stem cell-derived neurons
10.1371/journal.pone.0128445 · ExternalCitation · doi-reference
The amino acid metabolism pathway of peripheral T lymphocytes and ketamine-induced schizophrenia-like phenotype
10.1503/jpn-240038 · ExternalCitation · doi-reference
Long-term neurocognitive dysfunction in offspring via NGF/ERK/CREB signaling pathway caused by ketamine exposure during the second trimester of pregnancy in rats
10.18632/oncotarget.16042 · ExternalCitation · doi-reference
The epidemiology and patterns of acute and chronic toxicity associated with recreational ketamine use
10.3402/ehtj.v4i0.7107 · ExternalCitation · doi-reference
