Research graph
References from SV2A attenuates interictal anxiety in pharmacoresistant epilepsy via the SYT3–GluA2 axis. Local targets link to admitted publications; unresolved targets remain external evidence.
Evaluation of potential anticonvulsant fluorinated N-benzamide enaminones as T-type Ca(2+) channel blockers
10.1016/j.bmc.2022.116766 · 2022 · External reference
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting
10.1126/science.aav1483 · 2019 · External reference
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting
10.1126/science.aav1483 · 2019 · External reference
The C2 domains of synaptotagmin--partners in exocytosis
10.1016/j.tibs.2004.01.008 · 2004 · External reference
The synaptotagmin C2B domain calcium-binding loops modulate the rate of fusion pore expansion
10.1091/mbc.e17-11-0623 · 2018 · External reference
Prevalence of anxiety disorders in patients with refractory focal epilepsy--a prospective clinic based survey
10.1016/j.yebeh.2009.12.009 · 2010 · External reference
The functions of repressor element 1-silencing transcription factor in models of epileptogenesis and post-ischemia
10.1007/s11011-021-00719-2 · 2021 · External reference
Molecular mechanisms of AMPA receptor trafficking in the nervous system
10.3390/ijms25010111 · 2023 · External reference
Comparative effectiveness of brivaracetam, cenobamate, lacosamide, and perampanel in focal epilepsy
10.1001/jamaneurol.2025.5625 · 2026 · External reference
Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)
10.1073/pnas.96.26.15268 · 1999 · External reference
Psychiatric comorbidity in refractory focal epilepsy: a study of 490 patients
10.1016/j.yebeh.2012.09.026 · 2012 · External reference
Comparative analysis between open field and elevated plus Maze tests as a method for evaluating anxiety-like behavior in mice
10.1016/j.heliyon.2023.e14522 · 2023 · External reference
Calcium Permeable-AMPA receptors and excitotoxicity in neurological disorders
2021 · External reference
Synaptic AMPA receptor composition in development, plasticity and disease
10.1038/nrn.2016.37 · 2016 · External reference
Economic burden of epilepsy in a developing country: a retrospective cost analysis in China
10.1111/j.1528-1167.2009.02185.x · 2009 · External reference
The calcium sensor synaptotagmin 1 is expressed and regulated in hippocampal postsynaptic spines
10.1002/hipo.22761 · 2017 · External reference
Effects of Delta(9)-THC and Type-1 cannabinoid receptor agonists in the elevated plus maze test of anxiety: a systematic review and meta-analysis
10.1089/can.2022.0078 · 2023 · External reference
Elevated anxiety and depressive-like behavior in a rat model of genetic generalized epilepsy suggesting common causation
10.1016/j.expneurol.2007.09.026 · 2008 · External reference
Accounting for comorbidity in assessing the burden of epilepsy among US adults: results from the National Comorbidity Survey Replication (NCS-R)
10.1038/mp.2011.56 · 2012 · External reference
Definition of drug resistant epilepsy: consensus proposal by the ad hoc task force of the ILAE commission on therapeutic strategies
10.1111/j.1528-1167.2009.02397.x · 2010 · External reference
Emotion induction after direct intracerebral stimulations of human amygdala
10.1093/cercor/bhl041 · 2007 · External reference
Synaptic vesicle protein 2A mitigates parthanatos via apoptosis-inducing factor in a rat model of pharmacoresistant epilepsy
10.1111/cns.14778 · 2024 · External reference
Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke
10.1016/j.celrep.2023.112233 · 2023 · External reference
Interactions between N-ethylmaleimide-sensitive factor and GluR2 in the nucleus accumbens contribute to the expression of locomotor sensitization to cocaine
10.1523/jneurosci.2594-13.2014 · 2014 · External reference
Effects of electroacupuncture on Syt3 and GluA2 in rats with limb spasms after intracerebral hemorrhage
10.1002/brb3.70366 · 2025 · External reference
Changes in depression, anxiety, anger, and personality after resective surgery for drug-resistant temporal lobe epilepsy: a 2-year follow-up study
10.1016/j.eplepsyres.2007.08.005 · 2007 · External reference
Evidence-based guideline update: vagus nerve stimulation for the treatment of epilepsy: report of the guideline development subcommittee of the American academy of neurology
10.1212/wnl.0b013e3182a393d1 · 2013 · External reference
Extracellular calcium influx through L-type calcium channels, intracellular calcium currents and extracellular signal-regulated kinase signaling are involved in the abscisic acid-induced precognitive and anti-anxiety effects
10.1016/j.biopha.2018.10.141 · 2019 · External reference
Anxiety and Alzheimer's disease: behavioral analysis and neural basis in rodent models of alzheimer's-related neuropathology
10.1016/j.neubiorev.2021.05.005 · 2021 · External reference
Morphological and functional alterations in the CA1 pyramidal neurons of the Rat Hippocampus in the chronic phase of the lithium-pilocarpine model of epilepsy
10.3390/ijms25147568 · 2024 · External reference
Epilepsy and psychiatric comorbidity: a nationally representative population-based study
10.1111/j.1528-1167.2012.03500.x · 2012 · External reference
Reliability of common mouse behavioural tests of anxiety: a systematic review and meta-analysis on the effects of anxiolytics
10.1016/j.neubiorev.2022.104928 · 2022 · External reference
Nucleus accumbens AMPA receptors are necessary for morphine-withdrawal-induced negative-affective states in rats
10.1523/jneurosci.2875-12.2016 · 2016 · External reference
Differential effects of levetiracetam on hippocampal CA1 synaptic plasticity and molecular changes in the dentate gyrus in epileptic rats
10.1016/j.neuint.2022.105378 · 2022 · External reference
Synaptic vesicle protein 2A regulates mossy fiber sprouting in a drug-resistant epilepsy rat model via laminin alpha5/integrin beta1
10.1016/j.brainresbull.2025.111536 · 2025 · External reference
Entorhinal cortex layer III input to the hippocampus is crucial for temporal association memory
10.1126/science.1210125 · 2011 · External reference
A missense mutation of the gene encoding synaptic vesicle glycoprotein 2A (SV2A) confers seizure susceptibility by disrupting amygdalar synaptic GABA release
10.3389/fphar.2016.00210 · 2016 · External reference
Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission
10.1038/srep27420 · 2016 · External reference
The C2B domain of synaptotagmin I is a Ca2+-binding module
10.1021/bi010340c · 2001 · External reference
Evaluating the efficacy of vagus nerve stimulation across 'Minor' and 'Major' seizure types: a retrospective analysis of clinical outcomes in pharmacoresistant epilepsy
10.3390/jcm13144114 · 2024 · External reference
Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice
10.1002/jnr.23111 · 2012 · External reference
Cost-effectiveness analysis of vagus nerve stimulation in drug-resistant epilepsy
10.1186/s42494-025-00219-1 · 2025 · External reference
Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A
10.1038/s41467-024-47322-4 · 2024 · External reference
Effect of intranasal and oral administration of levetiracetam on the temporal and spatial distributions of SV2A in the KA-induced rat model of SE
10.1111/jcmm.17986 · 2023 · External reference
Adenosine A1 receptors play an important protective role against cognitive impairment and long-term potentiation inhibition in a pentylenetetrazol mouse model of epilepsy
10.1007/s12035-017-0571-x · 2018 · External reference
