Research graph
References from Effects of metabotropic 2/3-glutamate receptor agonism and antagonism on activity-based anorexia model in mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Targeting metabotropic glutamate receptors for symptomatic and disease-modifying treatment in Parkinson’s disease
10.1038/s41531-025-01138-1 · 2025 · External reference
Timing matters: The contribution of running during different periods of the light/dark cycle to susceptibility to activity-based anorexia in rats
10.1016/j.physbeh.2023.114349 · 2023 · External reference
Atypical antipsychotic use does not impact weight gain for individuals with extreme anorexia nervosa: a retrospective case-control study
10.1186/s40337-023-00941-6 · 2023 · External reference
Vulnerable and Resilient Phenotypes in a Mouse Model of Anorexia Nervosa
2021 · External reference
Metabotropic Glutamate2 Receptors Play a Key Role in Modulating Head Twitches Induced by a Serotonergic Hallucinogen in Mice
10.3389/fphar.2018.00208 · 2018 · External reference
Habituation deficits induced by metabotropic glutamate receptors 2/3 receptor blockade in mice: reversal by antipsychotic drugs
10.1124/jpet.106.110684 · 2007 · External reference
Evidence for Thalamocortical Circuit Abnormalities and Associated Cognitive Dysfunctions in Underweight Individuals with Anorexia Nervosa
10.1038/npp.2015.314 · 2016 · External reference
Prevalence, heritability, and prospective risk factors for anorexia nervosa
10.1001/archpsyc.63.3.305 · 2006 · External reference
Gender differences in eating disorders
10.3389/fnut.2025.1583672 · 2025 · External reference
Adolescent anorexia nervosa: cross-sectional and follow-up frontal gray matter disturbances detected with proton magnetic resonance spectroscopy
10.1016/j.jpsychires.2006.09.013 · 2007 · External reference
mGlu2/3 receptor as a novel target for rapid acting antidepressants
10.1016/bs.apha.2020.04.001 · 2020 · External reference
mGlu2/3 and mGlu5 receptors: Potential targets for novel antidepressants
10.1016/j.neuropharm.2012.05.022 · 2013 · External reference
Time-dependent reversal of long-term potentiation by low-frequency stimulation at the hippocampal mossy fiber-CA3 synapses
10.1523/jneurosci.21-11-03705.2001 · 2001 · External reference
NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise
10.1007/s00429-016-1341-7 · 2017 · External reference
Metabotropic Glutamate Receptors As Emerging Targets for the Treatment of Schizophrenia
10.1124/molpharm.121.000460 · 2022 · External reference
Targeting metabotropic glutamate receptors for the treatment of depression and other stress-related disorders
10.1016/j.neuropharm.2021.108687 · 2021 · External reference
Targeting metabotropic glutamate receptors for the treatment of depression and other stress-related disorders
10.1016/j.neuropharm.2021.108687 · 2021 · External reference
Activating mGlu3 metabotropic glutamate receptors rescues schizophrenia-like cognitive deficits through metaplastic adaptations within the hippocampus
10.1016/j.biopsych.2021.02.970 · 2021 · External reference
Subanesthetic Ketamine Ameliorates Activity-Based Anorexia of Adult Mice
10.1002/syn.70005 · 2025 · External reference
Subanesthetic Ketamine Ameliorates Activity-Based Anorexia of Adult Mice
10.1002/syn.70005 · 2025 · External reference
Mechanisms underlying sustained resilience against anorexia nervosa from sub-anesthetic ketamine: A review and new research based on electron microscopic analyses of synapses using a mouse model
10.1016/j.physbeh.2025.114956 · 2025 · External reference
Ketamine Sustains and Enhances the Protective Effects of a Ketogenic Diet Against Relapses in an Anorexia Mouse Model
10.1002/hipo.70039 · 2025 · External reference
Metabotropic glutamate receptors as targets for novel anxiolytics
10.1016/j.coph.2018.02.004 · 2018 · External reference
Taking better advantage of the activity-based anorexia model
10.1016/j.molmed.2023.11.011 · 2024 · External reference
Brain glutamate in anorexia nervosa: a magnetic resonance spectroscopy case control study at 7 Tesla
10.1007/s00213-016-4477-5 · 2017 · External reference
Effectiveness of olanzapine in the treatment of anorexia nervosa: A systematic review and meta‐analysis
10.1002/brb3.2498 · 2022 · External reference
Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders
10.1038/npp.2016.199 · 2017 · External reference
Anorexia nervosa--diagnosis, aetiology, and treatment
10.1136/pgmj.71.842.712 · 1995 · External reference
Anorexia nervosa, zinc deficiency and the glutamate system: The ketamine option
10.1016/j.pnpbp.2020.109921 · 2020 · External reference
10.1016/j.eurpsy.2016.01.1553
10.1016/j.eurpsy.2016.01.1553 · External reference
Individual contribution of metabotropic glutamate receptor (mGlu) 2 and 3 to c-Fos expression pattern evoked by mGlu2/3 antagonism
10.1007/s00213-008-1236-2 · 2008 · External reference
Extinction of cued fear memory involves a distinct form of depotentiation at cortical input synapses onto the lateral amygdala
10.1111/j.1460-9568.2009.07004.x · 2009 · External reference
Therapeutic Potential of Metabotropic Glutamate Receptor Modulators
10.2174/157015912799362805 · 2012 · External reference
Adolescent female rats recovered from the activity‐based anorexia display blunted hedonic responding
10.1002/eat.23752 · 2022 · External reference
The Preclinical Properties of a Novel Group II Metabotropic Glutamate Receptor Agonist LY379268
10.1111/j.1527-3458.2007.00024.x · 2007 · External reference
mGlu2 and mGlu3 negative allosteric modulators divergently potentiate thalamocortical transmission and exert rapid antidepressant-like effects
10.1016/j.neuron.2019.09.044 · 2020 · External reference
Novel treatments for anorexia nervosa: Insights from neuroplasticity research
10.1002/erv.3039 · 2024 · External reference
The activity-based anorexia mouse model
10.1007/978-1-61779-458-2_25 · 2012 · External reference
Ketamine ameliorates activity-based anorexia of adolescent female mice through changes in GluN2B-containing NMDA receptors at postsynaptic cytoplasmic locations of pyramidal neurons and interneurons of medial prefrontal cortex
10.1007/s00429-023-02740-w · 2024 · External reference
Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495
10.1016/j.neuropharm.2009.05.002 · 2009 · External reference
Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice
10.1007/s00213-004-2098-x · 2005 · External reference
Targeting metabotropic glutamate receptors for novel treatments of schizophrenia
10.1186/s13041-017-0293-z · 2017 · External reference
Metabotropic glutamate receptors: Targets for neuroprotective therapies in Parkinson disease
10.1016/j.coph.2018.03.004 · 2018 · External reference
Developmental expression of mGlu2 and mGlu3 in the mouse brain
10.1016/j.gep.2016.10.001 · 2016 · External reference
The incidence of eating disorders in the UK in 2000–2009: findings from the General Practice Research Database
10.1136/bmjopen-2013-002646 · 2013 · External reference
Excitatory and inhibitory neurometabolites in anorexia nervosa: A systematic review of proton magnetic resonance spectroscopy studies
10.1016/j.neubiorev.2023.105279 · 2023 · External reference
Ketamine and Zinc: Treatment of Anorexia Nervosa Via Dual NMDA Receptor Modulation
10.1007/s40263-022-00984-4 · 2023 · External reference
Activity-Based Anorexia Dynamically Dysregulates the Glutamatergic Synapse in the Nucleus Accumbens of Female Adolescent Rats
10.3390/nu12123661 · 2020 · External reference
Long-lasting BDNF signaling alterations in the amygdala of adolescent female rats exposed to the activity-based anorexia model
10.3389/fnbeh.2022.1087075 · 2022 · External reference
Cortical reorganization of the glutamate synapse in the activity-based anorexia rat model: Impact on cognition
10.1111/jnc.15605 · 2022 · External reference
Developmental activity-based anorexia alters hippocampal non-genomic stress response and induces structural instability and spatial memory impairment in female rats
10.1016/j.pnpbp.2024.111065 · 2024 · External reference
Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex
10.1016/0896-6273(94)90459-6 · 1994 · External reference
Group II metabotropic glutamate receptor antagonists LY341495 and LY366457 increase locomotor activity in mice
10.1016/s0028-3908(03)00232-6 · 2003 · External reference
Role of group II metabotropic glutamate receptors in ketamine’s antidepressant actions
10.1016/j.pbb.2023.173531 · 2023 · External reference
Group II mGlu receptor antagonist LY341495 enhances the antidepressant-like effects of ketamine in the forced swim test in rats
10.1007/s00213-016-4325-7 · 2016 · External reference
Antidepressant Effects and Mechanisms of Group II mGlu Receptor-Specific Negative Allosteric Modulators
10.1016/j.neuron.2019.12.011 · 2020 · External reference
Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses
10.1002/glia.24579 · 2024 · External reference
Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors
10.1523/jneurosci.1519-16.2016 · 2016 · External reference
Activity Based Anorexia as an Animal Model for Anorexia Nervosa–A Systematic Review
10.3389/fnut.2019.00069 · 2019 · External reference
Neuronal activation in the paraventricular thalamus and lateral habenula during activity-based anorexia in mice
10.1016/j.nsa.2024.104055 · 2024 · External reference
mGlu2/3 receptor agonist (LY354740) in anxiety
10.1016/j.pbb.2024.173826 · 2024 · External reference
The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats’ performance in the 5-choice serial reaction time task
10.1016/j.neuropharm.2006.10.003 · 2007 · External reference
Relationship of ketamine’s antidepressant and psychotomimetic effects in unipolar depression
2013 · External reference
Examining anxious temperament in anorexia nervosa: Behavioural inhibition and intolerance of uncertainty and their contribution to trait anxiety in adolescents with anorexia nervosa
10.1016/j.jad.2023.12.035 · 2024 · External reference
Antipsychotic action of selective group II metabotropic glutamate receptor agonist MGS0008 and MGS0028 on conditioned avoidance responses in the rat
10.1016/s0024-3205(03)00509-5 · 2003 · External reference
Abnormal neuronal network in anorexia nervosa studied with I-123-IMP SPECT
10.1016/s0925-4927(01)00093-2 · 2001 · External reference
Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat
10.1523/jneurosci.14-05-03005.1994 · 1994 · External reference
Psychiatric and medical correlates of DSM-5 eating disorders in a nationally representative sample of adults in the United States
10.1002/eat.23004 · 2019 · External reference
Motor- and food-related metabolic cerebral changes in the activity-based rat model for anorexia nervosa: A voxel-based microPET study
10.1016/j.neuroimage.2006.12.009 · 2007 · External reference
Fluoxetine After Weight Restoration in Anorexia NervosaA Randomized Controlled Trial
10.1001/jama.295.22.2605 · 2006 · External reference
Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex
10.3389/fnana.2022.849937 · 2022 · External reference
The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity
10.1007/s00213-007-0974-x · 2008 · External reference
CNS distribution of metabotropic glutamate 2 and 3 receptors: Transgenic mice and [3H]LY459477 autoradiography
10.1016/j.neuropharm.2012.01.019 · 2013 · External reference
(2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions
10.1073/pnas.1819540116 · 2019 · External reference
Metabolic imaging of deep brain stimulation in anorexia nervosa: a 18F-FDG PET/CT study
10.1097/rlu.0000000000000261 · 2013 · External reference
The Utility of Animal Models for Studying the Metabo-Psychiatric Origins of Anorexia Nervosa
2021 · External reference
