References

Behavioral and neurochemical vulnerability during adolescence in mice: studies with nicotine

10.1038/sj.npp.1300366 · 2004 · External reference

Assessing nicotine dependence using an oral nicotine free-choice paradigm in mice

10.1016/j.neuropharm.2019.107669 · 2019 · External reference

Characterization of functional subgroups among genetically identified cholinergic neurons in the pedunculopontine nucleus

10.1007/s00018-019-03025-4 · 2019 · External reference

Alteration of Mesopontine Cholinergic Function by the Lack of KCNQ4 Subunit

10.3389/fncel.2021.707789 · 2021 · External reference

Muscarinic Receptor Activation Preferentially Inhibits Rebound in Vulnerable Dopaminergic Neurons

10.1523/jneurosci.1443-24.2025 · 2025 · External reference

Action potential broadening in a presynaptic channelopathy

10.1038/ncomms12102 · 2016 · External reference

Daily intake of nicotine during cigarette smoking

10.1038/clpt.1984.67 · 1984 · External reference

Role of pedunculopontine cholinergic neurons in the vulnerability of nigral dopaminergic neurons in Parkinson’s disease

10.1016/j.expneurol.2015.11.004 · 2016 · External reference

History of falls in Parkinson disease is associated with reduced cholinergic activity

10.1212/wnl.0b013e3181c1ded6 · 2009 · External reference

The M-current contributes to high threshold membrane potential oscillations in a cell type-specific way in the pedunculopontine nucleus of mice

10.3389/fncel.2015.00121 · 2015 · External reference

Partial recovery of striatal nicotinic receptors in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned monkeys with chronic oral nicotine

10.1124/jpet.106.106997 · 2006 · External reference

Association between Parkinson’s Disease and Cigarette Smoking, Rural Living, Well-Water Consumption, Farming and Pesticide Use: Systematic Review and Meta-Analysis

10.1371/journal.pone.0151841 · 2016 · External reference

Nicotine Disrupts Top-Down Habenular Control Over Cholinergic Inputs to the Ventral Tegmental Area to Increase Motivational Valence of Food Rewards

2025 · External reference

Pedunculopontine Nucleus Degeneration Contributes to Both Motor and Non-Motor Symptoms of Parkinson’s Disease

10.3389/fphar.2019.01494 · 2019 · External reference

“Rejuvenation” protects neurons in mouse models of Parkinson’s disease

10.1038/nature05865 · 2007 · External reference

Comparing tonic and phasic dendritic calcium in cholinergic pedunculopontine neurons and dopaminergic substantia nigra neurons

10.1111/ejn.16281 · 2024 · External reference

Pedunculopontine Nucleus Microstructure Predicts Postural and Gait Symptoms in Parkinson’s Disease

10.1002/mds.28051 · 2020 · External reference

A major external source of cholinergic innervation of the striatum and nucleus accumbens originates in the brainstem

10.1523/jneurosci.5071-13.2014 · 2014 · External reference

Segregated cholinergic transmission modulates dopamine neurons integrated in distinct functional circuits

10.1038/nn.4335 · 2016 · External reference

Effects of scopolamine on dopamine neurons in the substantia nigra: role of the pedunculopontine tegmental nucleus

10.1002/syn.20650 · 2009 · External reference

Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons

10.1523/jneurosci.5311-12.2013 · 2013 · External reference

Adolescent nicotine-induced dendrite remodeling in the nucleus accumbens is rapid, persistent, and D1-dopamine receptor dependent

10.1007/s00429-014-0897-3 · 2016 · External reference

Nicotine-induced and D1-receptor-dependent dendritic remodeling in a subset of dorsolateral striatum medium spiny neurons

10.1016/j.neuroscience.2017.05.036 · 2017 · External reference

Differential Control of Dopaminergic Excitability and Locomotion by Cholinergic Inputs in Mouse Substantia Nigra

10.1016/j.cub.2017.05.084 · 2017 · External reference

The Effects of NMDA Subunit Composition on Calcium Influx and Spike Timing-Dependent Plasticity in Striatal Medium Spiny Neurons

10.1371/journal.pcbi.1002493 · 2012 · External reference

Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons

10.1016/j.celrep.2020.108156 · 2020 · External reference

Dopamine Inhibition Differentially Controls Excitability of Substantia Nigra Dopamine Neuron Subpopulations through T-Type Calcium Channels

10.1523/jneurosci.0117-17.2017 · 2017 · External reference

Inhibitory basal ganglia nuclei differentially innervate pedunculopontine nucleus subpopulations and evoke differential motor and valence behaviors

10.7554/elife.102308.3 · 2025 · External reference

Asymmetric pedunculopontine network connectivity in parkinsonian patients with freezing of gait

10.1093/brain/awt172 · 2013 · External reference

Pedunculopontine tegmental stimulation evokes striatal dopamine efflux by activation of acetylcholine and glutamate receptors in the midbrain and pons of the rat

10.1046/j.1460-9568.2003.02511.x · 2003 · External reference

Mechanisms involved in systemic nicotine-induced glutamatergic synaptic plasticity on dopamine neurons in the ventral tegmental area

10.1523/jneurosci.1943-10.2010 · 2010 · External reference

In vivo structural connectome of arousal and motor brainstem nuclei by 7 Tesla and 3 Tesla MRI

10.1002/hbm.25962 · 2022 · External reference

Smoking during pregnancy: postnatal effects on arousal and attentional brain systems

10.1016/j.neuro.2007.01.007 · 2007 · External reference

Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse

10.1016/s0896-6273(00)80339-6 · 1997 · External reference

Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS

10.1016/0896-6273(95)90076-4 · 1995 · External reference

On Cell Loss and Selective Vulnerability of Neuronal Populations in Parkinson’s Disease

10.3389/fneur.2018.00455 · 2018 · External reference

Voltage-Gated Potassium Channels Ensure Action Potential Shape Fidelity in Distal Axons

10.1523/jneurosci.2765-20.2021 · 2021 · External reference

Selective neuronal vulnerability in Parkinson’s disease

10.1016/bs.pbr.2020.02.005 · 2020 · External reference

Muscarinic and nicotinic responses in the developing pedunculopontine nucleus (PPN)

10.1016/j.brainres.2006.10.046 · 2007 · External reference

Cholinergic projections to the substantia nigra from the pedunculopontine and laterodorsal tegmental nuclei

10.1016/0306-4522(89)90008-0 · 1989 · External reference

Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro

10.1523/jneurosci.09-10-03463.1989 · 1989 · External reference

Chronic continuous nicotine treatment causes decreased burst firing of nigral dopamine neurons in rats partially hemitransected at the meso-diencephalic junction

10.1016/0006-8993(91)90646-d · 1991 · External reference

Kv7/KCNQ/M and HCN/h, but not KCa2/SK channels, contribute to the somatic medium after-hyperpolarization and excitability control in CA1 hippocampal pyramidal cells

10.1113/jphysiol.2005.086835 · 2005 · External reference

Population adaptation in efficient balanced networks

10.7554/elife.46926 · 2019 · External reference

Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress

10.1172/jci95898 · 2018 · External reference

Robust pacemaking in substantia nigra dopaminergic neurons

10.1523/jneurosci.2519-09.2009 · 2009 · External reference

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

10.1038/nature09536 · 2010 · External reference

Tonic firing rate controls dendritic Ca2+ signaling and synaptic gain in substantia nigra dopamine neurons

10.1523/jneurosci.3904-14.2015 · 2015 · External reference

A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson’s disease

10.1002/ana.10277 · 2002 · External reference

Pedunculopontine tegmental nucleus neurons provide reward, sensorimotor, and alerting signals to midbrain dopamine neurons

10.1016/j.neuroscience.2014.07.002 · 2014 · External reference

Pedunculopontine tegmental nucleus neurons provide reward, sensorimotor, and alerting signals to midbrain dopamine neurons

10.1016/j.neuroscience.2014.07.002 · 2014 · External reference

Control and plasticity of the presynaptic action potential waveform at small CNS nerve terminals

10.1016/j.neuron.2014.09.038 · 2014 · External reference

Differential Control of Axonal and Somatic Resting Potential by Voltage-Dependent Conductances in Cortical Layer 5 Pyramidal Neurons

10.1016/j.neuron.2018.02.016 · 2018 · External reference

Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeys

10.1111/j.1471-4159.2009.06011.x · 2009 · External reference

Whole-brain mapping of monosynaptic inputs to midbrain cholinergic neurons

10.1038/s41598-021-88374-6 · 2021 · External reference

Distribution of Midbrain Cholinergic Axons in the Thalamus

10.1523/eneuro.0454-19.2019 · 2020 · External reference

The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity

10.1016/j.neuron.2007.06.001 · 2007 · External reference

The pedunculopontine nucleus in Parkinson’s disease, progressive supranuclear palsy and Alzheimer’s disease

10.1136/jnnp.51.4.540 · 1988 · External reference

Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns

10.1016/j.celrep.2024.114187 · 2024 · External reference

Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease

10.1172/jci42642 · 2010 · External reference

Nicotine partially protects against paraquat-induced nigrostriatal damage in mice; link to alpha6beta2* nAChRs

10.1111/j.1471-4159.2006.04177.x · 2007 · External reference

Characterization of M-current in ventral tegmental area dopamine neurons

10.1152/jn.00574.2005 · 2006 · External reference

Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release

10.7554/elife.55729 · 2020 · External reference

Nicotine use in schizophrenia: the self medication hypotheses

10.1016/j.neubiorev.2005.02.006 · 2005 · External reference

Lesions of the tegmental pedunculopontine nucleus block the rewarding effects and reveal the aversive effects of nicotine in the ventral tegmental area

10.1523/jneurosci.22-19-08653.2002 · 2002 · External reference

Pedunculopontine nucleus in the squirrel monkey: cholinergic and glutamatergic projections to the substantia nigra

10.1002/cne.903440205 · 1994 · External reference

Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders

10.1111/j.1755-5949.2010.00142.x · 2010 · External reference

Oscillations in pedunculopontine nucleus in Parkinson’s disease and its relationship with deep brain stimulation

10.3389/fncir.2015.00047 · 2015 · External reference

Association between cigarette smoking and Parkinson’s disease: A meta-analysis

10.1016/j.archger.2015.08.004 · 2015 · External reference

An inhibitory brainstem input to dopamine neurons encodes nicotine aversion

10.1016/j.neuron.2022.07.003 · 2022 · External reference

The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons

10.1073/pnas.0510715103 · 2006 · External reference

Nicotinic modulation of glutamate receptor function at nerve terminal level: a fine-tuning of synaptic signals

10.3389/fphar.2015.00089 · 2015 · External reference

Topographical organization of the pedunculopontine nucleus

10.3389/fnana.2011.00022 · 2011 · External reference

Differential contribution of Ih to the integration of excitatory synaptic inputs in substantia nigra pars compacta and ventral tegmental area dopaminergic neurons

10.1111/ejn.13066 · 2015 · External reference

Advanced CUBIC tissue clearing for whole-organ cell profiling

10.1038/s41596-019-0240-9 · 2019 · External reference

Dual-component miniature excitatory synaptic currents in rat hippocampal CA3 pyramidal neurons

10.1152/jn.1992.68.1.16 · 1992 · External reference

Periadolescent nicotine administration produces enduring changes in dendritic morphology of medium spiny neurons from nucleus accumbens

10.1016/j.neulet.2005.05.041 · 2005 · External reference

Substantia nigra cell death from kainic acid or folic acid injections into the pontine tegmentum

10.1016/0006-8993(84)91433-1 · 1984 · External reference

Rethinking the Pedunculopontine Nucleus: From Cellular Organization to Function

10.1016/j.neuron.2017.02.027 · 2017 · External reference

TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating

10.1016/j.neuron.2007.08.022 · 2007 · External reference

Sex Differences in the Nicotinic Acetylcholine Receptor System of Rodents: Impacts on Nicotine and Alcohol Reward Behaviors

10.3389/fnins.2021.745783 · 2021 · External reference

Subregion and sex differences in ethanol activation of cholinergic and glutamatergic cells in the mesopontine tegmentum

10.1038/s41598-023-50526-1 · 2024 · External reference

Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path

10.1523/jneurosci.2199-07.2007 · 2007 · External reference

Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area

10.1523/jneurosci.15-09-05859.1995 · 1995 · External reference

Transdermal Nicotine Treatment and Progression of Early Parkinson’s Disease

10.1056/evidoa2200311 · 2023 · External reference

Sex Differences in Midbrain Dopamine D2-Type Receptor Availability and Association with Nicotine Dependence

10.1038/npp.2016.105 · 2016 · External reference

The pedunculopontine nucleus and Parkinson’s disease

10.1093/brain/123.9.1767 · 2000 · External reference

Pedunculopontine tegmental nucleus controls conditioned responses of midbrain dopamine neurons in behaving rats

10.1523/jneurosci.0277-05.2005 · 2005 · External reference

Unresolved reference

External reference

Plasma nicotine and cotinine concentrations in mice after chronic oral nicotine administration and challenge doses

10.1016/0928-0987(93)90013-z · 1993 · External reference

Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson’s disease

10.1038/npjparkd.2016.1 · 2016 · External reference

Decoding brain state transitions in the pedunculopontine nucleus: cooperative phasic and tonic mechanisms

10.3389/fncir.2015.00068 · 2015 · External reference

Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior

10.1016/j.neuron.2012.08.036 · 2012 · External reference

Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine

10.1038/34413 · 1998 · External reference

Parkinson disease

10.1038/nrdp.2017.13 · 2017 · External reference

Nicotine and Parkinson’s disease: implications for therapy

10.1002/mds.21900 · 2008 · External reference

Chronic oral nicotine treatment protects against striatal degeneration in MPTP-treated primates

10.1111/j.1471-4159.2006.04078.x · 2006 · External reference

Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration

2025 · External reference

Loss of cholinergic neurons in the pedunculopontine nucleus in Parkinson’s disease is related to disability of the patients

10.1016/j.parkreldis.2008.01.006 · 2008 · External reference

Pooled analysis of tobacco use and risk of Parkinson disease

10.1001/archneur.64.7.990 · 2007 · External reference

Pedunculopontine tegmental nucleus of the rat: cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum

10.1002/cne.902590403 · 1987 · External reference

Remodeling of synaptic AMPA receptor subtype alters the probability and pattern of action potential firing

10.1523/jneurosci.2608-10.2011 · 2011 · External reference

Normal and pathological neuronal distribution of the human mesencephalic locomotor region

10.1002/mds.27578 · 2019 · External reference

Stereological analysis of cholinergic neurons within bilateral pedunculopontine nuclei in health and when affected by Parkinson’s disease

10.1111/bpa.70011 · 2025 · External reference

DREADD Activation of Pedunculopontine Cholinergic Neurons Reverses Motor Deficits and Restores Striatal Dopamine Signaling in Parkinsonian Rats

10.1007/s13311-019-00830-4 · 2020 · External reference

Neuroprotection by nicotine in mouse primary cortical cultures involves activation of calcineurin and L-type calcium channel inactivation

10.1523/jneurosci.23-31-10093.2003 · 2003 · External reference

Inhibition of L-Type Ca2+ Channels by TRPC1-STIM1 Complex Is Essential for the Protection of Dopaminergic Neurons

10.1523/jneurosci.3010-16.2017 · 2017 · External reference

Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis

10.1016/j.cell.2014.03.042 · 2014 · External reference

Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex

10.1038/srep14099 · 2015 · External reference

Alpha oscillations in the pedunculopontine nucleus correlate with gait performance in parkinsonism

10.1093/brain/awr315 · 2012 · External reference

Can nicotine be used medicinally in Parkinson’s disease?

10.1586/ecp.11.27 · 2011 · External reference

Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+

10.1096/fj.11-182824 · 2011 · External reference

Long-Term Inactivation of Sodium Channels as a Mechanism of Adaptation in CA1 Pyramidal Neurons

10.1523/jneurosci.1914-21.2022 · 2022 · External reference

Ca(V)1.3-driven SK channel activation regulates pacemaking and spike frequency adaptation in mouse chromaffin cells

10.1523/jneurosci.3715-12.2012 · 2012 · External reference

Spike frequency adaptation is developmentally regulated in substantia nigra pars compacta dopaminergic neurons

10.1016/j.neuroscience.2011.07.017 · 2011 · External reference

Sex differences in the nicotinic acetylcholine and dopamine receptor systems underlying tobacco smoking addiction

10.1016/j.cobeha.2018.04.004 · 2018 · External reference

Voluntary oral nicotine intake in mice down-regulates GluR2 but does not modulate depression-like behaviors

10.1016/j.neulet.2008.01.021 · 2008 · External reference

Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum

10.1038/s41467-018-04654-2 · 2018 · External reference

Cholinergic Mesopontine Signals Govern Locomotion and Reward through Dissociable Midbrain Pathways

10.1016/j.neuron.2016.03.028 · 2016 · External reference

Chronic nicotine selectively enhances alpha4beta2* nicotinic acetylcholine receptors in the nigrostriatal dopamine pathway

10.1523/jneurosci.2939-09.2009 · 2009 · External reference

Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence

10.1038/s41401-019-0299-4 · 2020 · External reference

Relative sparing in Parkinson’s disease of substantia nigra dopamine neurons containing calbindin-D28K

10.1016/0006-8993(90)91236-a · 1990 · External reference

CHRNA5 gene variation affects the response of VTA dopaminergic neurons during chronic nicotine exposure and withdrawal

10.1016/j.neuropharm.2023.109547 · 2023 · External reference