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References from Suppression of ER Stress Underlies Montelukast’s Neuroprotective Actions in D-Gal/AlCl3-Induced Alzheimer’s Disease in Rats. Local targets link to admitted publications; unresolved targets remain external evidence.
The Tragedy of Alzheimer’s Disease: Towards Better Management via Resveratrol-Loaded Oral Bilosomes
10.3390/pharmaceutics13101635 · 2021 · External reference
ER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments
10.1038/s41419-022-05153-5 · 2022 · External reference
Montelukast and Acute Coronary Syndrome: The Endowed Drug
10.3390/ph15091147 · 2022 · External reference
Trimetazidine Modulates Mitochondrial Redox Status and Disrupted Glutamate Homeostasis in a Rat Model of Epilepsy
10.3389/fphar.2021.735165 · 2021 · External reference
Evaluation of regression of diabetes-induced nephropathy and vascular dysfunction in rats by Montelukast via antioxidative and anti-inflammatory actions
10.7324/japs.2023.115441 · 2023 · External reference
Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
10.1016/j.tcb.2012.02.006 · 2012 · External reference
Brain Structural and Functional Changes in Cognitive Impairment Due to Alzheimer’s Disease
10.3389/fpsyg.2022.886619 · 2022 · External reference
Ameliorative effect of montelukast against STZ induced diabetic nephropathy: targeting HMGB1, TLR4, NF-κB, NLRP3 inflammasome, and autophagy pathways
2023 · External reference
Neuromodulatory effect of vardenafil on aluminium chloride/d-galactose induced Alzheimer’s disease in rats: emphasis on amyloid-beta, p-tau, PI3K/Akt/p53 pathway, endoplasmic reticulum stress, and cellular senescence
10.1007/s10787-023-01287-w · 2023 · External reference
Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer’s disease
10.3389/fnagi.2023.1281338 · 2023 · External reference
Improved method for the determination of blood glutathione
1963 · External reference
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
10.1016/0003-2697(76)90527-3 · 1976 · External reference
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-β, and Tau: Effects on cognitive impairments
10.1074/jbc.m110.100420 · 2010 · External reference
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer’s disease
10.1016/j.bbi.2020.03.022 · 2020 · External reference
Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment
10.3892/br.2017.850 · 2017 · External reference
Amyloid beta: structure, biology and structure-based therapeutic development
10.1038/aps.2017.28 · 2017 · External reference
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets
10.1038/s41392-023-01570-w · 2023 · External reference
d-galactose and aluminium chloride induced rat model with cognitive impairments
10.1016/j.biopha.2018.04.152 · 2018 · External reference
Unresolved reference
External reference
Drug repurposing for Alzheimer’s disease and other neurodegenerative disorders
10.1038/s41467-025-56690-4 · 2025 · External reference
Rheb-mTOR activation rescues Aβ-induced cognitive impairment and memory function by restoring miR-146 activity in glial cells
10.1016/j.omtn.2021.04.008 · 2021 · External reference
Microglia and Astrocytes in Alzheimer’s Disease: Significance and Summary of Recent Advances
2024 · External reference
Ameliorative effect of montelukast against carbon tetrachloride-induced hepatotoxicity: Targeting NLRP3 inflammasome pathway
10.1016/j.lfs.2022.120707 · 2022 · External reference
Combined β-sitosterol and trimetazidine mitigate potassium dichromate-induced cardiotoxicity in rats through the interplay between NF-κB/AMPK/mTOR/TLR4 and HO-1/NADPH signaling pathways
10.1007/s11356-023-27021-1 · 2023 · External reference
Impact of different processing methods on the phenolics and neuroprotective activity of Fragaria ananassa Duch. extracts in a D-galactose and aluminum chloride-induced rat model of aging
10.1039/d2fo00645f · 2022 · External reference
Hippocampal CysLT1R overexpression or activation accelerates memory deficits, synaptic dysfunction, and amyloidogenesis in young APP/PS1 transgenic mice
10.21037/atm-21-4518 · 2021 · External reference
Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti-asthmatic drug
10.1016/j.phrs.2019.02.025 · 2019 · External reference
Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway
10.1080/17425247.2023.2153831 · 2023 · External reference
Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer’s disease
10.1111/febs.14332 · 2018 · External reference
Involvement of endoplasmic reticulum stress in amyloid β (1-42)-induced Alzheimer’s like neuropathological process in rat brain
10.1016/j.brainresbull.2020.09.022 · 2020 · External reference
ER stress and the unfolded protein response in neurodegeneration
10.1038/nrneurol.2017.99 · 2017 · External reference
CysLTR1 Blockage Ameliorates Liver Injury Caused by Aluminum-Overload via PI3K/AKT/mTOR-Mediated Autophagy Activation in Vivo and in Vitro
10.1021/acs.molpharmaceut.8b00121 · 2018 · External reference
Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1-Mediated NF-B Activation and Down-Regulation of TRAF2 Expression
10.1128/mcb.26.8.3071-3084.2006 · 2006 · External reference
MitoQ alleviates hippocampal damage after cerebral ischemia: The potential role of SIRT6 in regulating mitochondrial dysfunction and neuroinflammation
10.1016/j.lfs.2023.121895 · 2023 · External reference
Leukotriene Receptor Antagonist Use and Dementia Risk in Patients With Asthma: A Retrospective Cohort Study
10.21873/invivo.12625 · 2021 · External reference
Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: Possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats
10.1016/j.neuroscience.2010.08.039 · 2010 · External reference
Anti-asthmatic effects of type-A procyanidine polyphenols from cinnamon bark in ovalbumin-induced airway hyperresponsiveness in laboratory animals
10.1016/j.biomag.2013.01.003 · 2013 · External reference
MTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway
10.1038/cdd.2011.98 · 2012 · External reference
Formoterol attenuated mitochondrial dysfunction in rotenone-induced Parkinson’s disease in a rat model: Role of PINK-1/PARKIN and PI3K/Akt/CREB/BDNF/TrKB axis
10.1016/j.intimp.2023.111207 · 2023 · External reference
A quantitative analysis of spontaneous alternation behaviors on a Y-maze reveals adverse effects of acute social isolation on spatial working memory
2023 · External reference
Montelukast targeting the cysteinyl leukotriene receptor 1 ameliorates Aβ1-42-induced memory impairment and neuroinflammatory and apoptotic responses in mice
10.1016/j.neuropharm.2014.01.011 · 2014 · External reference
Montelukast rescues primary neurons against Aβ1-42-induced toxicity through inhibiting CysLT1R-mediated NF-κB signaling
10.1016/j.neuint.2014.05.006 · 2014 · External reference
mTOR signaling at a glance
10.1242/jcs.051011 · 2009 · External reference
Zanthoxylum alkylamides activate the Shh/Ptch1/Smo signaling pathway to ameliorate cognitive impairment in Alzheimer’s disease mice
10.1016/j.jff.2024.106376 · 2024 · External reference
IRE1-mTOR-PERK Axis Coordinates Autophagy and ER Stress-Apoptosis Induced by P2X7-Mediated Ca2+ Influx in Osteoarthritis
2021 · External reference
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
10.1006/meth.2001.1262 · 2001 · External reference
Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes
10.1038/emm.2016.157 · 2017 · External reference
Montelukast attenuates rotenone-induced microglial activation/p38 MAPK expression in rats: Possible role of its antioxidant, anti-inflammatory and antiapoptotic effects
10.1016/j.taap.2018.09.012 · 2018 · External reference
Leukotrienes vs. Montelukast—Activity, Metabolism, and Toxicity Hints for Repurposing
10.3390/ph15091039 · 2022 · External reference
Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug
10.1038/ncomms9466 · 2015 · External reference
Novel object recognition in the rat: A facile assay for cognitive function
10.1002/0471141755.ph0559s49 · 2010 · External reference
The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice
10.3390/ijms22052782 · 2021 · External reference
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10.1016/0165-0270(84)90007-4 · 1984 · External reference
Tau and mTOR: The Hotspots for Multifarious Diseases in Alzheimer’s Development
10.3389/fnins.2018.01017 · 2019 · External reference
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Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease
10.1038/s41392-023-01608-z · 2023 · External reference
Searching for cognitive enhancement in the Morris water maze: better and worse performance in D-amino acid oxidase knockout (Dao−/−) mice
10.1111/ejn.13192 · 2016 · External reference
Aluminum chloride-induced amyloid β accumulation and endoplasmic reticulum stress in rat brain are averted by melatonin
10.1016/j.fct.2020.111829 · 2020 · External reference
Neuroprotective potential of testosterone against aluminium chloride and d-galactose-induced Alzheimer-like pathology aggravated by overcrowding in mice: Role of Nrf2, HO-1, TNF-α, GSK-3β, PI3K and AKT pathway
2024 · External reference
Molecular Mechanism of Alzheimer’s Disease
10.3390/ijms242316837 · 2023 · External reference
Liraglutide mends cognitive impairment by averting Notch signaling pathway overexpression in a rat model of polycystic ovary syndrome
10.1016/j.lfs.2020.118731 · 2021 · External reference
ER stress in Alzheimer’s disease: A novel neuronal trigger for inflammation and Alzheimer’s pathology
10.1186/1742-2094-6-41 · 2009 · External reference
The role of endoplasmic reticulum stress in astrocytes
10.1002/glia.24082 · 2022 · External reference
Antagonism of cysteinyl leukotrienes and their receptors as a neuroinflammatory target in Alzheimer’s disease
10.1007/s10072-020-04369-7 · 2020 · External reference
The Discrimination Ratio derived from Novel Object Recognition tasks as a Measure of Recognition Memory Sensitivity, not Bias
10.1038/s41598-018-30030-7 · 2018 · External reference
Endoplasmic reticulum stress and inflammation in the central nervous system
10.1186/s13024-017-0183-y · 2017 · External reference
Personalizing the care and treatment of alzheimer’s disease: An overview
2021 · External reference
Trilateral association of autophagy, mTOR and Alzheimer’s disease: Potential pathway in the development for Alzheimer’s disease therapy
10.3389/fphar.2022.1094351 · 2022 · External reference
HMGB1 Box A gene therapy reverses cognitive and neuropathological features in AlCl3/D-galactose rat model of Alzheimer’s disease
10.1016/j.expneurol.2025.115583 · 2026 · External reference
Involvement of cysteinyl leukotriene receptor 1 in Aβ1-42-induced neurotoxicity invitro and invivo
10.1016/j.neurobiolaging.2013.09.036 · 2014 · External reference
The Possible Impact of Montelukast in Parkinson’s Disease: A Substantial Contribution
10.1177/08919887251409836 · 2026 · External reference
Montelukast sodium protects against focal cerebral ischemic injury by regulating inflammatory reaction via promoting microglia polarization
10.1016/j.brainres.2023.148498 · 2023 · External reference
The effects of festidinol treatment on the D-galactose and aluminum chloride–induced Alzheimer-like pathology in mouse brain
10.1016/j.phymed.2022.153925 · 2022 · External reference
The anti-inflammatory drug Montelukast ameliorates cognitive deficits by rescuing the inflammatory levels in young AD animal models
2025 · External reference
TOR signaling in growth and metabolism
10.1016/j.cell.2006.01.016 · 2006 · External reference
Bajijiasu Ameliorates β-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer’s Disease Model
10.1159/000488414 · 2018 · External reference
Protective effect of leukotriene receptor antagonist, montelukast, against cyclophosphamide-induced placental toxicity via modulation of NLRP3/IL-1β signaling pathway in rats
10.1016/j.intimp.2024.112700 · 2024 · External reference
Montelukast Ameliorates Scopolamine-induced Alzheimer’s Disease: Role on Cholinergic Neurotransmission, Antioxidant Defence System, Neuroinflammation and Expression of BDNF
10.2174/0118715273258337230925040049 · 2024 · External reference
Armillariella tabescens-derived polysaccharides alleviated Ɒ-Gal-induced neuroinflammation and cognitive injury through enterocerebral axis and activation of keap-1/Nrf2 pathway
10.1016/j.ijbiomac.2024.133035 · 2024 · External reference
Inhibition of ER stress-activated JNK pathway attenuates TNF-α-induced inflammatory response in bone marrow mesenchymal stem cells
10.1016/j.bbrc.2020.12.101 · 2021 · External reference
Montelukast attenuates neuropathic pain through inhibiting p38 mitogen-activated protein kinase and nuclear factor-kappa b in a rat model of chronic constriction injury
10.1213/ane.0000000000000174 · 2014 · External reference
Role of Montelukast in Asthma and Allergic rhinitis patients
10.12669/pjms.36.7.2657 · 2020 · External reference