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References from Astrocytic NOX2 contributes to ROS-associated mitochondrial dysfunction in cerebral ischemia–reperfusion injury: modulation by electroacupuncture. Local targets link to admitted publications; unresolved targets remain external evidence.
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology
10.1152/physrev.00044.2005 · 2007 · External reference
NADPH oxidase family proteins: signaling dynamics to disease management
10.1038/s41423-022-00858-1 · 2022 · External reference
Mitochondrial dynamics and its involvement in disease
10.1146/annurev-pathmechdis-012419-032711 · 2020 · External reference
ROS-Drp1-mediated mitochondria fission contributes to hippocampal HT22cell apoptosis induced by silver nanoparticles
10.1016/j.redox.2023.102739 · 2023 · External reference
Cellular and temporal expression of NADPH oxidase (NOX) isotypes after brain injury
10.1186/1742-2094-10-155 · 2013 · External reference
Molecular machineries and pathways of mitochondrial protein transport
10.1038/s41580-025-00865-w · 2025 · External reference
World stroke organization: global stroke fact sheet 2025
10.1177/17474930241308142 · 2025 · External reference
Mitofusin 2: from functions to disease
10.1038/s41419-017-0023-6 · 2018 · External reference
NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury
10.1093/brain/aws012 · 2012 · External reference
Oxidative insults disrupt OPA1-mediated mitochondrial dynamics in cultured mammalian cells
10.1080/13510002.2018.1492766 · 2018 · External reference
Global, regional, and national burden of epilepsy, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021
10.1016/s2468-2667(24)00302-5 · 2025 · External reference
Experimental evidence-based construction of electroacupuncture for ischemic stroke: a meta-analysis and systematic review
10.3389/fneur.2025.1491132 · 2025 · External reference
Global, regional, and national epidemiology of ischemic stroke from 1990 to 2021
10.1111/ene.16481 · 2024 · External reference
The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury
10.1016/j.biopha.2023.114671 · 2023 · External reference
New insights into targeting mitochondria in ischemic injury
10.1007/s10495-021-01661-5 · 2021 · External reference
Inhibition of NAPDH oxidase 2 (NOX2) prevents oxidative stress and mitochondrial abnormalities caused by saturated fat in cardiomyocytes
10.1371/journal.pone.0145750 · 2016 · External reference
Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis
10.1083/jcb.200309082 · 2004 · External reference
Mitochondrial function, oxidative stress, inflammation and thrombolytic treatment in ischemic stroke
10.3390/ijms262110289 · 2025 · External reference
Isoliquiritigenin alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the Nrf2 pathway
10.1016/j.redox.2024.103406 · 2024 · External reference
Electroacupuncture protects against cerebral ischemia-reperfusion injury through mitochondrial dynamics
2024 · External reference
Electroacupuncture improves motor function after ischemic stroke via regulating mitochondrial dynamics
10.1016/j.brainresbull.2025.111599 · 2025 · External reference
Reactive astrocytes: production, function, and therapeutic potential
10.1016/j.immuni.2017.06.006 · 2017 · External reference
Epidemiology and future trend predictions of ischemic stroke based on the global burden of disease study 1990–2021
10.1038/s43856-025-00939-y · 2025 · External reference
tPA and proteolysis in the neurovascular unit
10.1161/01.str.0000115164.80010.8a · 2004 · External reference
Reversible middle cerebral artery occlusion without craniectomy in rats
10.1161/01.str.20.1.84 · 1989 · External reference
Increased NOX2 expression in astrocytes leads to eNOS uncoupling through dihydrofolate reductase in endothelial cells after subarachnoid hemorrhage
10.3389/fnmol.2023.1121944 · 2023 · External reference
Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury
10.1161/circulationaha.109.906610 · 2010 · External reference
PRDX6-iPLA2 aggravates neuroinflammation after ischemic stroke via regulating astrocytes-induced M1 microglia
10.1186/s12964-024-01476-2 · 2024 · External reference
Pleiotropic mitochondria: the influence of mitochondria on neuronal development and disease
10.1523/jneurosci.1157-19.2019 · 2019 · External reference
Astrocyte-neuron metabolic crosstalk in ischaemic stroke
10.1016/j.neuint.2025.105954 · 2025 · External reference
Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission
10.1096/fj.12-226225 · 2014 · External reference
Mitochondrial dysfunctions induce PANoptosis and ferroptosis in cerebral ischemia/reperfusion injury: from pathology to therapeutic potential
10.3389/fncel.2023.1191629 · 2023 · External reference
Activation and role of astrocytes in ischemic stroke
10.3389/fncel.2021.755955 · 2021 · External reference
Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells
10.1091/mbc.12.8.2245 · 2001 · External reference
NOX enzymes in the central nervous system: from signaling to disease
10.1089/ars.2009.2578 · 2009 · External reference
The Nox family of NADPH oxidases: friend or foe of the vascular system?
10.1007/s11906-011-0238-3 · 2012 · External reference
Electroacupuncture ameliorates neuronal injury by NLRP3/ASC/caspase-1 mediated pyroptosis in cerebral ischemia-reperfusion
10.1007/s12035-023-03712-1 · 2024 · External reference
Electroacupuncture pretreatment ameliorates cerebral ischemia/reperfusion injury by inhibiting the miR-124/NF-κB/Fas signaling pathway
10.1097/wnr.0000000000002211 · 2025 · External reference
The role of astrocytes in ischemic stroke - mechanisms, functions and treatment
10.3389/fcell.2025.1700564 · 2025 · External reference
Mitochondrial quality control in cerebral ischemia-reperfusion injury
10.1007/s12035-021-02494-8 · 2021 · External reference
miR-124-5p/NOX2 axis modulates the ROS production and the inflammatory microenvironment to protect against the cerebral I/R injury
10.1007/s11064-019-02931-0 · 2020 · External reference
Advances in the mechanisms of electroacupuncture in the treatment of cerebral ischemia-reperfusion injury
10.3389/fnins.2026.1806298 · 2026 · External reference
Electroacupuncture attenuates ferroptosis by promoting Nrf2 nuclear translocation and activating Nrf2/SLC7A11/GPX4 pathway in ischemic stroke
10.1186/s13020-024-01047-0 · 2025 · External reference
NOX2-mediated reactive oxygen species are double-edged swords in focal cerebral ischemia in mice
10.1186/s12974-022-02551-6 · 2022 · External reference
The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1
10.1128/mcb.23.15.5409-5420.2003 · 2003 · External reference
Mitochondrial fission, fusion, and stress
10.1126/science.1219855 · 2012 · External reference
The balance of MFN2 and OPA1 in mitochondrial dynamics, cellular homeostasis, and disease
10.3390/biom15030433 · 2025 · External reference
Sirt3 inhibits cerebral ischemia-reperfusion injury through normalizing Wnt/β-catenin pathway and blocking mitochondrial fission
10.1007/s12192-018-0917-y · 2018 · External reference
Nur77 promotes cerebral ischemia-reperfusion injury via activating INF2-mediated mitochondrial fragmentation
10.1007/s10735-018-9798-8 · 2018 · External reference
Electroacupuncture alleviates cerebral ischemia-reperfusion injury by downregulating IL-17A and inhibiting neurotoxic astrocyte activation
10.1007/s11064-025-04603-8 · 2025 · External reference
Crosstalk between the oxidative stress and glia cells after stroke: from mechanism to therapies
2022 · External reference
Neuroprotective effects of electroacupuncture in ischemic stroke: from mechanisms to clinical implications
10.3389/fnagi.2025.1562925 · 2025 · External reference
Xuesaitong injection (lyophilized) combined with aspirin and clopidogrel protect against focal cerebral ischemic/reperfusion injury in rats by suppressing oxidative stress and inflammation and regulating the NOX2/IL-6/STAT3 pathway
10.21037/apm-20-1681 · 2021 · External reference
