Research graph
References from Mdivi-1 regulates mitochondrial fission and function via the CaMK2/Drp1 pathway in amyotrophic lateral sclerosis. Local targets link to admitted publications; unresolved targets remain external evidence.
ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues
10.1016/j.nbd.2016.11.001 · 2017 · External reference
Mitochondrial dyshomeostasis as an early hallmark and a therapeutic target in amyotrophic lateral sclerosis
10.3390/ijms242316833 · 2023 · External reference
Mitochondria: a promising convergent target for the treatment of amyotrophic lateral sclerosis
2024 · External reference
Structural basis for the rescue of hyperexcitable cells by the amyotrophic lateral sclerosis drug riluzole
10.1038/s41467-024-52539-4 · 2024 · External reference
Current concepts on genetic aspects of mitochondrial dysfunction in amyotrophic lateral sclerosis
10.3390/ijms22189832 · 2021 · External reference
Neural activity and CaMKII protect mitochondria from fragmentation in aging caenorhabditis elegans neurons
10.1073/pnas.1501831112 · 2015 · External reference
Mdivi-1: a promising drug and its underlying mechanisms in the treatment of neurodegenerative diseases
2022 · External reference
Defective mitochondrial dynamics is an early event in skeletal muscle of an amyotrophic lateral sclerosis mouse model
10.1371/journal.pone.0082112 · 2013 · External reference
Detailed analysis of Mdivi-1 effects on complex I and respiratory supercomplex assembly
10.1038/s41598-024-69748-y · 2024 · External reference
The link between oxidative stress, redox status, bioenergetics and mitochondria in the pathophysiology of ALS
10.3390/ijms22126352 · 2021 · External reference
Dynamics of dynamin-related protein 1 in alzheimer’s disease and other neurodegenerative diseases
10.3390/cells8090961 · 2019 · External reference
Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts
10.1186/s40478-016-0316-5 · 2016 · External reference
Trial of sodium phenylbutyrate–taurursodiol for amyotrophic lateral sclerosis
10.1056/nejmoa1916945 · 2020 · External reference
Mitochondrial dynamics, a key executioner in neurodegenerative diseases
10.1016/j.mito.2018.11.002 · 2019 · External reference
Dynamin-related protein 1: a critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases
10.1002/jcp.27866 · 2019 · External reference
Mitochondrial division inhibitor 1 (mdivi-1) protects neurons against excitotoxicity through the modulation of mitochondrial function and intracellular Ca(2+) signaling
10.3389/fnmol.2018.00003 · 2018 · External reference
Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1α
10.1016/j.nbd.2012.07.004 · 2013 · External reference
Mitochondrial dynamics in brain cells during normal and pathological aging
2024 · External reference
Drp1: focus on diseases triggered by the mitochondrial pathway
10.1007/s12013-024-01245-5 · 2024 · External reference
CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation
10.1038/ncomms13189 · 2016 · External reference
Update on antioxidant therapy with edaravone: expanding applications in neurodegenerative diseases
2024 · External reference
CaMK II -induced Drp1 phosphorylation contributes to blue light-induced AIF-mediated necroptosis in retinal R28 cells
10.1016/j.bbrc.2021.04.082 · 2021 · External reference
