Research graph
References from Post-weaning social environment shapes reward learning, social hierarchy, and pCREB signaling in adult male rats exposed to early-life adversity. Local targets link to admitted publications; unresolved targets remain external evidence.
Psychological aspects of child maltreatment
10.3340/jkns.2021.0300 · 2022 · External reference
Early social experience is critical for the development of cognitive control and dopamine modulation of prefrontal cortex function
10.1038/npp.2013.47 · 2013 · External reference
Impact of early vs. late childhood early life stress on brain morphometrics
10.1007/s11682-012-9215-y · 2013 · External reference
CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli
10.1073/pnas.172091899 · 2002 · External reference
The physiology, signaling, and pharmacology of dopamine receptors
10.1124/pr.110.002642 · 2011 · External reference
Regulation of dopamine system responsivity and its adaptive and pathological response to stress
2015 · External reference
Early childhood stress exposure, reward pathways, and adult decision making
10.1073/pnas.1708791114 · 2017 · External reference
Development and function of the midbrain dopamine system: what we know and what we need to
10.1111/gbb.12257 · 2016 · External reference
Social defeat as a stressor in humans
10.1016/s0031-9384(01)00490-5 · 2001 · External reference
Effects of early-life stress on social and anxiety-like behaviors in adult mice: sex-specific effects
10.1155/2018/1538931 · 2018 · External reference
The effects of different types of social interactions on the electrophysiology of neurons in the nucleus accumbens in rodents
10.1016/j.neubiorev.2024.105809 · 2024 · External reference
Maternal care and mental health
1951 · External reference
Genes and environments, development and time
10.1073/pnas.2016710117 · 2020 · External reference
Individual differences in anticipatory activity to food rewards predict cue-induced appetitive 50-kHz calls in rats
10.1016/j.physbeh.2015.05.012 · 2015 · External reference
An experimental analysis of social factors affecting the performance of white rats. III. Dominance and cooperation motivated by water and food deprivation
10.1037/h0056901 · 1941 · External reference
The role of genetics in stress effects on health and addiction
10.1016/j.copsyc.2018.09.005 · 2019 · External reference
Acute stress‐induced reductions in neural response to reward are related to acute stress‐related increases in cortisol
10.1111/psyp.14683 · 2024 · External reference
Social behavior and social stress in adolescence: a focus on animal models
10.1016/j.neubiorev.2010.10.004 · 2011 · External reference
Regulation of cocaine reward by CREB
10.1126/science.282.5397.2272 · 1998 · External reference
Food scarcity, neuroadaptations, and the pathogenic potential of dieting in an unnatural ecology: binge eating and drug abuse
10.1016/j.physbeh.2011.04.023 · 2011 · External reference
Distinct prefrontal projections conversely orchestrate social competition and hierarchy
2023 · External reference
Novel competition test for food rewards reveals stable dominance status in adult male rats
10.1038/s41598-021-93818-0 · 2021 · External reference
Effects of positive and negative childhood experiences on adult family health
10.1186/s12889-021-10732-w · 2021 · External reference
The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome
10.1016/j.psyneuen.2013.06.008 · 2013 · External reference
Social defeat disrupts reward learning and potentiates striatal nociceptin/orphanin FQ mRNA in rats
10.1007/s00213-017-4584-y · 2017 · External reference
An early experience of mild adversity involving temporary denial of maternal contact affects the serotonergic system of adult male rats and leads to a depressive-like phenotype and inability to adapt to a chronic social stress
10.1016/j.physbeh.2017.11.004 · 2018 · External reference
Denial of reward in the neonate shapes sociability and serotonergic activity in the adult rat
10.1371/journal.pone.0033793 · 2012 · External reference
Effects of denial of reward through maternal contact in the neonatal period on adult hypothalamic-pituitary-adrenal axis function in the rat
10.1016/j.psyneuen.2012.09.007 · 2013 · External reference
Alterations in HPA-axis and autonomic nervous system functioning in childhood anxiety disorders point to a chronic stress hypothesis
10.1016/j.psyneuen.2014.09.002 · 2015 · External reference
Food deprivation, body weight loss and anxiety-related behavior in rats
10.3390/ani6010004 · 2016 · External reference
Sustained corticosterone rise in the prefrontal cortex is a key factor for chronic stress-induced working memory deficits in mice
10.1016/j.ynstr.2019.100161 · 2019 · External reference
CREB modulates excitability of nucleus accumbens neurons
10.1038/nn1661 · 2006 · External reference
Life stress impairs self-control in early adolescence
10.3389/fpsyg.2012.00608 · 2013 · External reference
Relationship between multiple forms of childhood maltreatment and adult mental health in community respondents: results from the adverse childhood experiences study
10.1176/appi.ajp.160.8.1453 · 2003 · External reference
Design and statistical methods in studies using animal models of development
10.1093/ilar.47.1.5 · 2006 · External reference
Areal and synaptic interconnectivity of prelimbic (area 32), infralimbic (area 25) and insular cortices in the rat
10.1016/j.brainres.2003.08.056 · 2003 · External reference
Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation
10.1073/pnas.1307893110 · 2013 · External reference
Reduced nucleus accumbens reactivity and adolescent depression following early-life stress
10.1016/j.neuroscience.2012.12.010 · 2013 · External reference
A standardized protocol for repeated social defeat stress in mice
10.1038/nprot.2011.361 · 2011 · External reference
Prefrontal cortex dysfunction increases susceptibility to schizophrenia-like changes induced by adolescent stress exposure
2016 · External reference
Maternal separation impairs cocaine-induced behavioural sensitization in adolescent mice
10.1371/journal.pone.0167483 · 2016 · External reference
Behavioral alterations in reward system function: the role of childhood maltreatment and psychopathology
10.1097/01.chi.0000227882.50404.11 · 2006 · External reference
Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training
10.1073/pnas.94.6.2693 · 1997 · External reference
Blunted ventral striatum development in adolescence reflects emotional neglect and predicts depressive symptoms
10.1016/j.biopsych.2015.05.010 · 2015 · External reference
Impact of early life stress on reward circuit function and regulation
10.3389/fpsyt.2021.744690 · 2021 · External reference
The effect of total social deprivation on the development of monkey behavior
1964 · External reference
Early life stress and brain function: activity and connectivity associated with processing emotion and reward
10.1016/j.neuroimage.2019.116493 · 2020 · External reference
Sex-specific disruptions in spatial memory and anhedonia in a “two hit” rat model correspond with alterations in hippocampal brain-derived neurotrophic factor expression and signaling
10.1002/hipo.22302 · 2014 · External reference
The multifaceted role of the ventromedial prefrontal cortex in emotion, decision making, social cognition, and psychopathology
10.1016/j.biopsych.2017.10.030 · 2018 · External reference
Managing threat: do social‐cognitive processes mediate the link between peer victimization and adjustment problems in early adolescence?
10.1111/j.1532-7795.2007.00533.x · 2007 · External reference
Social defeat as an animal model for depression
10.1093/ilar/ilu002 · 2014 · External reference
Aberrant extracellular dopamine clearance in the prefrontal cortex exhibits ADHD ‐like behavior in NCX 3 heterozygous mice
10.1111/febs.17339 · 2025 · External reference
Social defeat stress induces a depression-like phenotype in adolescent male c57BL/6 mice
10.3109/10253890.2014.910650 · 2014 · External reference
The development of the mesoprefrontal dopaminergic system in health and disease
10.3389/fncir.2021.746582 · 2021 · External reference
Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders
10.1186/s13148-015-0156-3 · 2015 · External reference
High-content single-cell förster resonance energy transfer imaging of cultured striatal neurons reveals novel cross-talk in the regulation of nuclear signaling by protein kinase a and extracellular signal-regulated kinase 1/2
10.1124/molpharm.121.000290 · 2021 · External reference
Long-term memory is facilitated by cAMP response element-binding protein overexpression in the amygdala
10.1523/jneurosci.21-07-02404.2001 · 2001 · External reference
Effects of maternal deprivation and complex housing on rat social behavior in adolescence and adulthood
10.3389/fnbeh.2018.00193 · 2018 · External reference
Cognitive abilities of alzheimers disease transgenic mice are modulated by social context and circadian rhythm
10.2174/156720511798192745 · 2011 · External reference
Chronic cannabinoid treatment during young adulthood induces sex-specific behavioural deficits in maternally separated rats
10.1016/j.bbr.2012.05.019 · 2012 · External reference
Early life manipulations alter learning and memory in rats
10.1016/j.neubiorev.2012.07.003 · 2012 · External reference
Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: implications for interventions based on social enrichment
10.3389/fnbeh.2014.00257 · 2014 · External reference
Adolescence as a neurobiological critical period for the development of higher-order cognition
10.1016/j.neubiorev.2018.09.005 · 2018 · External reference
Social interaction reward in rats has anti‐stress effects
10.1111/adb.12878 · 2021 · External reference
A further study of infantile handling and adult avoidance learning
10.1111/j.1467-6494.1956.tb01289.x · 1956 · External reference
Developmental determinants of sensitivity and resistance to stress
10.1016/j.psyneuen.2005.03.013 · 2005 · External reference
Co-learning facilitates memory in mice: a new avenue in social neuroscience
10.1016/j.neuropharm.2012.06.054 · 2013 · External reference
Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress
10.1126/science.277.5332.1659 · 1997 · External reference
Reward network immediate early gene expression in mood disorders
10.3389/fnbeh.2017.00077 · 2017 · External reference
Improving measurement of child abuse and neglect: a systematic review and analysis of national prevalence studies
10.1371/journal.pone.0227884 · 2020 · External reference
Periodic maternal separation of neonatal rats produces region- and gender-specific effects on biogenic amine content in postmortem adult brain
10.1002/1098-2396(200104)40:1<1::aid-syn1020>3.0.co;2-e · 2001 · External reference
Repeated maternal separation of preweanling rats attenuates behavioral responses to primary and conditioned incentives in adulthood
10.1016/0031-9384(95)02069-1 · 1996 · External reference
Short- and long-periods of neonatal maternal separation differentially affect anxiety and feeding in adult rats: gender-dependent effects
10.1016/s0165-3806(99)00005-x · 1999 · External reference
Hyporesponsive reward anticipation in the basal ganglia following severe institutional deprivation early in life
10.1162/jocn.2009.21394 · 2010 · External reference
Neural mechanisms of social risk for psychiatric disorders
10.1038/nn.3083 · 2012 · External reference
Activation of CREB in the nucleus accumbens shell produces anhedonia and resistance to extinction of fear in rats
10.1523/jneurosci.5973-10.2011 · 2011 · External reference
Effects of pair-housing after social defeat experience on elevated plus-maze behavior in rats
10.1016/j.beproc.2008.02.007 · 2008 · External reference
Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disorders
10.1017/s1461145710001239 · 2011 · External reference
Acute and lifetime stress and psychotic illness: the roles of reward and salience networks
2022 · External reference
Adolescent environmental enrichment induces social resilience and alters neural gene expression in a selectively bred rodent model with anxious phenotype
2024 · External reference
HPA axis interactions with behavioral systems
2016 · External reference
Social competence in internationally adopted and institutionalized children
10.1016/j.ecresq.2012.08.003 · 2013 · External reference
Learning of a T-maze by rat pups when contact with the mother is either permitted or denied
10.1016/j.nlm.2008.09.007 · 2009 · External reference
Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse
10.1038/s41380-023-02258-x · 2023 · External reference
Circadian mechanisms of food anticipatory rhythms in rats fed once or twice daily: clock gene and endocrine correlates
10.1371/journal.pone.0112451 · 2014 · External reference
Attention biases to threat link behavioral inhibition to social withdrawal over time in very young children
10.1007/s10802-011-9495-5 · 2011 · External reference
Multilevel developmental approaches to understanding the effects of child maltreatment: recent advances and future challenges
10.1017/s0954579415000826 · 2015 · External reference
Long-term effects of early-life environmental manipulations in rodents and primates: potential animal models in depression research
10.1016/j.neubiorev.2005.03.011 · 2005 · External reference
Prefrontal involvement in the regulation of emotion: convergence of rat and human studies
10.1016/j.conb.2006.07.004 · 2006 · External reference
Effects of an early experience of reward through maternal contact or its denial on the dopaminergic system of the rat brain
10.1016/j.neuroscience.2014.03.035 · 2014 · External reference
Salience network response to changes in emotional expressions of others is heightened during early adolescence: relevance for social functioning
10.1111/desc.12571 · 2018 · External reference
Early deprivation under specific conditions leads to reduced interest in reward in adulthood in Wistar rats
10.1016/j.bbr.2004.06.001 · 2005 · External reference
Maternal neglect alters reward-anticipatory behavior, social status stability, and reward circuit activation in adult male rats
10.3389/fnins.2023.1201345 · 2023 · External reference
Anhedonia and motivational deficits in rats: impact of chronic social stress
10.1016/j.bbr.2005.03.009 · 2005 · External reference
Low maternal licking/grooming stimulation increases pain sensitivity in male mouse offspring
10.1538/expanim.20-0030 · 2021 · External reference
Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine
10.1016/s0166-4328(02)00282-6 · 2002 · External reference
Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression
10.1523/jneurosci.3297-11.2011 · 2011 · External reference
Early life stress increases stress vulnerability through BDNF gene epigenetic changes in the rat hippocampus
10.1016/j.neuropharm.2016.02.009 · 2016 · External reference
Nucleus accumbens dichotomically controls social dominance in male mice
10.1038/s41386-021-01220-1 · 2022 · External reference
Early life stress- and drug-induced histone modifications within the ventral tegmental area
10.3389/fcell.2020.588476 · 2020 · External reference
Early deprivation disruption of associative learning is a developmental pathway to depression and social problems
10.1038/s41467-018-04381-8 · 2018 · External reference
Exposure to vicarious social defeat stress and western-style diets during adolescence leads to physiological dysregulation, decreases in reward sensitivity, and reduced antidepressant efficacy in adulthood
10.3389/fnins.2021.701919 · 2021 · External reference
Cognitive impact of social stress and coping strategy throughout development
10.1007/s00213-014-3654-7 · 2015 · External reference
The psychobiology of depression and resilience to stress: implications for prevention and treatment
10.1146/annurev.clinpsy.1.102803.143948 · 2005 · External reference
The adolescent brain and age-related behavioral manifestations
10.1016/s0149-7634(00)00014-2 · 2000 · External reference
Early life stress-induced alterations in the activity and morphology of ventral tegmental area neurons in female rats
10.1016/j.ynstr.2020.100250 · 2020 · External reference
Effects of an early experience involving training in a T-maze under either denial or receipt of expected reward through maternal contact
2013 · External reference
Effect of neonatal handling on adult rat spatial learning and memory following acute stress
10.1080/10253890701653039 · 2008 · External reference
Neonatal isolation augments social dominance by altering actin dynamics in the medial prefrontal cortex
10.1073/pnas.1606351113 · 2016 · External reference
Neonatal exposure to novel environment enhances hippocampal-dependent memory function during infancy and adulthood
10.1101/lm.43101 · 2001 · External reference
Learning under stress in the adult rat is differentially affected by ‘juvenile’ or ‘adolescent’ stress
10.1017/s1461145705006255 · 2006 · External reference
Effects of resocialization on post‐weaning social isolation‐induced abnormal aggression and social deficits in rats
10.1002/dev.21090 · 2014 · External reference
Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents
10.1523/jneurosci.1436-10.2010 · 2010 · External reference
Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of dopamine D1 receptors
10.1038/mp.2017.135 · 2018 · External reference
The Emanuel Miller memorial lecture 2006: adoption as intervention. Meta‐analytic evidence for massive catch‐up and plasticity in physical, socio‐emotional, and cognitive development
10.1111/j.1469-7610.2006.01675.x · 2006 · External reference
Asiaticoside produces an antidepressant–like effect in a chronic unpredictable mild stress model of depression in mice, involving reversion of inflammation and the PKA/pCREB/BDNF signaling pathway
10.3892/mmr.2020.11305 · 2020 · External reference
Difficulties with emotion regulation as a transdiagnostic mechanism linking child maltreatment with the emergence of psychopathology
10.1017/s0954579419000348 · 2019 · External reference
Gene-environment interactions across development: exploring DRD2 genotype and prenatal smoking effects on self-regulation
10.1037/a0014550 · 2009 · External reference
Social peers rescue autism‐relevant sociability deficits in adolescent mice
10.1002/aur.163 · 2011 · External reference
Switch-like PKA responses in the nucleus of striatal neurons
10.1242/jcs.216556 · 2018 · External reference
Know your place: neural processing of social hierarchy in humans
10.1016/j.neuron.2008.01.025 · 2008 · External reference
