Research graph
References from Genetic and pharmacological evidence linking CB1R signaling to hippocampal GABAergic dysfunction in ASD mouse model. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2013 · External reference
Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure
10.1038/s41398-023-02317-5 · 2023 · External reference
Motor cortex excitability and inhibitory imbalance in autism spectrum disorder assessed with transcranial magnetic stimulation: a systematic review
10.1038/s41398-019-0444-3 · 2019 · External reference
Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring
10.1126/science.1247190 · 2014 · External reference
The neuropathology of autism: a systematic review of post-mortem studies of autism and related disorders
10.1016/j.neubiorev.2021.07.014 · 2021 · External reference
Prenatal exposure to valproic acid induces increased autism-like behaviors and impairment of learning and memory functions in rat offspring by upregulating ADAM10 expression
10.1007/s11064-025-04398-8 · 2025 · External reference
GABA and glutamate measurements in temporal cortex of autistic children
10.1002/aur.3253 · 2024 · External reference
16p11.2 deletion mice exhibit compromised fronto-temporal connectivity, GABAergic dysfunction, and enhanced attentional ability
10.1038/s42003-023-04891-2 · 2023 · External reference
PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking
10.1038/ncomms10861 · 2016 · External reference
Astragaloside IV ameliorates autism-like behaviors in BTBR mice by modulating Camk2n2-dependent OXPHOS and neurotransmission in the mPFC
10.1016/j.jare.2025.01.030 · 2025 · External reference
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
10.1038/nature09582 · 2010 · External reference
Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits
10.1016/j.cell.2011.08.040 · 2011 · External reference
Postweaning positive modulation of alpha5GABAA receptors improves autism-like features in prenatal valproate rat model in a sex-specific manner
10.1002/aur.2699 · 2022 · External reference
How do stupendous cannabinoids modulate memory processing via affecting neurotransmitter systems?
10.1016/j.neubiorev.2020.10.018 · 2021 · External reference
Basal forebrain-lateral habenula inputs and control of impulsive behavior
10.1038/s41386-024-01963-7 · 2024 · External reference
Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CB(1)R signaling and anxiety-like behavior
10.1111/jnc.13267 · 2015 · External reference
The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period
10.1016/j.neuron.2010.03.021 · 2010 · External reference
CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex
10.1038/mp.2014.14 · 2014 · External reference
Activation of CB1R alleviates autism spectrum disorder-like behavior and synaptic impairments
10.1016/j.lfs.2025.123797 · 2025 · External reference
The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: lessons from behavioral studies on mouse models
10.1016/j.neubiorev.2021.11.031 · 2022 · External reference
CB1 receptor antagonism in capuchin monkeys alters social interaction and aversive memory extinction
10.1007/s00213-019-05305-0 · 2019 · External reference
Alterations of the endocannabinoid system and its therapeutic potential in autism spectrum disorder
10.1098/rsob.200306 · 2021 · External reference
Augmentation of endogenous 2-Arachidonoylglycerol mitigates autistic behaviors of BTBR mice
10.1007/s12035-024-04606-6 · 2025 · External reference
Communication and social interaction in the cannabinoid-type 1 receptor null mouse: implications for autism spectrum disorder
10.1002/aur.2562 · 2021 · External reference
AUTISTIC-LIKE behaviors mediated BY the DYSREGULATION OF ENDOCRINE SYSTEMS via OXYTOCIN and CORTICOSTERONE IN CANNABINOID CB1 receptor knockout mice
10.1093/ijnp/pyae059.452 · 2025 · External reference
Physiological impact of CB1 receptor expression by hippocampal GABAergic interneurons
10.1007/s00424-015-1782-5 · 2016 · External reference
Hippocampal CB1 receptors control incidental associations
10.1016/j.neuron.2018.08.014 · 2018 · External reference
Dichotomic hippocampal transcriptome after glutamatergic vs. GABAergic deletion of the cannabinoid CB1 receptor
10.3389/fnsyn.2021.660718 · 2021 · External reference
CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolation stress-induced social impairments in male mice
10.1016/j.neuron.2023.10.027 · 2024 · External reference
Maternal immune activation alters glutamic acid decarboxylase-67 expression in the brains of adult rat offspring
10.1016/j.schres.2016.01.041 · 2016 · External reference
Endocannabinoids and cortical plasticity: CB1R as a possible regulator of the excitation/inhibition balance in health and disease
10.1111/ejn.15110 · 2022 · External reference
Activation of type-1 cannabinoid receptor shifts the balance between excitation and inhibition towards excitation in layer II/III pyramidal neurons of the rat prelimbic cortex
10.1007/s00424-014-1586-z · 2015 · External reference
Specific hippocampal interneurons shape consolidation of recognition memory
10.1016/j.celrep.2020.108046 · 2020 · External reference
Hardwiring the brain: endocannabinoids shape neuronal connectivity
10.1126/science.1137406 · 2007 · External reference
Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons
10.1523/jneurosci.19-11-04544.1999 · 1999 · External reference
Role of endogenous cannabinoids in synaptic signaling
10.1152/physrev.00004.2003 · 2003 · External reference
Endocannabinoid-mediated control of synaptic transmission
10.1152/physrev.00019.2008 · 2009 · External reference
Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens
10.1146/annurev.neuro.23.1.185 · 2000 · External reference
The corticostriatal projection: from synaptic plasticity to dysfunctions of the basal ganglia
10.1016/0166-2236(96)81862-5 · 1996 · External reference
It could be habit forming: drugs of abuse and striatal synaptic plasticity
10.1016/s0166-2236(03)00065-1 · 2003 · External reference
Direct and indirect pathways of basal ganglia: a critical reappraisal
10.1038/nn.3743 · 2014 · External reference
Prenatal exposure to the CB1 and CB2 cannabinoid receptor agonist WIN 55,212-2 alters migration of early-born glutamatergic neurons and GABAergic interneurons in the rat cerebral cortex
10.1111/jnc.12636 · 2014 · External reference
Restoration of CB1 receptor function in hippocampal GABAergic neurons rescues memory deficits in Huntington’s disease models
10.1186/s40035-025-00500-w · 2025 · External reference
Cannabinoid receptors CB1 and CB2 activation restores hippocampal lipid profiles and alleviates autism-like behaviors in valproic acid-induced ASD rats
10.1111/cns.70591 · 2025 · External reference
Cell-autonomous GABAARs are essential for NMDAR-mediated synaptic transmission, LTP, and spatial memory
10.1038/s44319-025-00538-x · 2025 · External reference
GABA dysfunction in schizophrenia: the GABAA receptor as a potential therapeutic target
10.1016/j.bionps.2025.100130 · 2025 · External reference
A single main-chain hydrogen bond required to keep GABA(A) receptors closed
10.1038/s41467-025-61447-0 · 2025 · External reference
Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling
10.1186/s13229-023-00557-2 · 2023 · External reference
5-HT(3)(A) receptors maintain hippocampal LTP in a CB(1) and GABA(A) receptor- dependent manner for spatial memory
10.1111/bph.15793 · 2022 · External reference
Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish—implications for neurodevelopmental disorders
10.1038/s41398-021-01651-w · 2021 · External reference
Dysregulation of neural tube vascular development as an aetiological factor in autism spectrum disorder: insights from valproic acid exposure
2025 · External reference
Transcriptome meta-analysis of valproic acid exposure in human embryonic stem cells
10.1016/j.euroneuro.2022.04.008 · 2022 · External reference
Pax6-dependent cortical glutamatergic neuronal differentiation regulates autism-like behavior in prenatally valproic acid-exposed rat offspring
10.1007/s12035-013-8535-2 · 2014 · External reference
The state of the dopaminergic and glutamatergic systems in the valproic acid mouse model of autism spectrum disorder
10.3390/biom12111691 · 2022 · External reference
Prenatal valproic acid exposure impairs offspring cognition through disturbing Interneuron development
10.1111/cns.70303 · 2025 · External reference
Communication and social interaction in the cannabinoid-type 1 receptor null mouse: implications for autism spectrum disorder
10.1002/aur.2562 · ExternalCitation · doi-reference
Postweaning positive modulation of alpha5GABAA receptors improves autism-like features in prenatal valproate rat model in a sex-specific manner
10.1002/aur.2699 · ExternalCitation · doi-reference
GABA and glutamate measurements in temporal cortex of autistic children
10.1002/aur.3253 · ExternalCitation · doi-reference
CB1 receptor antagonism in capuchin monkeys alters social interaction and aversive memory extinction
10.1007/s00213-019-05305-0 · ExternalCitation · doi-reference
Activation of type-1 cannabinoid receptor shifts the balance between excitation and inhibition towards excitation in layer II/III pyramidal neurons of the rat prelimbic cortex
10.1007/s00424-014-1586-z · ExternalCitation · doi-reference
Physiological impact of CB1 receptor expression by hippocampal GABAergic interneurons
10.1007/s00424-015-1782-5 · ExternalCitation · doi-reference
Prenatal exposure to valproic acid induces increased autism-like behaviors and impairment of learning and memory functions in rat offspring by upregulating ADAM10 expression
10.1007/s11064-025-04398-8 · ExternalCitation · doi-reference
Pax6-dependent cortical glutamatergic neuronal differentiation regulates autism-like behavior in prenatally valproic acid-exposed rat offspring
10.1007/s12035-013-8535-2 · ExternalCitation · doi-reference
Augmentation of endogenous 2-Arachidonoylglycerol mitigates autistic behaviors of BTBR mice
10.1007/s12035-024-04606-6 · ExternalCitation · doi-reference
The corticostriatal projection: from synaptic plasticity to dysfunctions of the basal ganglia
10.1016/0166-2236(96)81862-5 · ExternalCitation · doi-reference
GABA dysfunction in schizophrenia: the GABAA receptor as a potential therapeutic target
10.1016/j.bionps.2025.100130 · ExternalCitation · doi-reference
Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits
10.1016/j.cell.2011.08.040 · ExternalCitation · doi-reference
Specific hippocampal interneurons shape consolidation of recognition memory
10.1016/j.celrep.2020.108046 · ExternalCitation · doi-reference
Transcriptome meta-analysis of valproic acid exposure in human embryonic stem cells
10.1016/j.euroneuro.2022.04.008 · ExternalCitation · doi-reference
Astragaloside IV ameliorates autism-like behaviors in BTBR mice by modulating Camk2n2-dependent OXPHOS and neurotransmission in the mPFC
10.1016/j.jare.2025.01.030 · ExternalCitation · doi-reference
Activation of CB1R alleviates autism spectrum disorder-like behavior and synaptic impairments
10.1016/j.lfs.2025.123797 · ExternalCitation · doi-reference
How do stupendous cannabinoids modulate memory processing via affecting neurotransmitter systems?
10.1016/j.neubiorev.2020.10.018 · ExternalCitation · doi-reference
The neuropathology of autism: a systematic review of post-mortem studies of autism and related disorders
10.1016/j.neubiorev.2021.07.014 · ExternalCitation · doi-reference
The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: lessons from behavioral studies on mouse models
10.1016/j.neubiorev.2021.11.031 · ExternalCitation · doi-reference
The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period
10.1016/j.neuron.2010.03.021 · ExternalCitation · doi-reference
Hippocampal CB1 receptors control incidental associations
10.1016/j.neuron.2018.08.014 · ExternalCitation · doi-reference
CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolation stress-induced social impairments in male mice
10.1016/j.neuron.2023.10.027 · ExternalCitation · doi-reference
Maternal immune activation alters glutamic acid decarboxylase-67 expression in the brains of adult rat offspring
10.1016/j.schres.2016.01.041 · ExternalCitation · doi-reference
It could be habit forming: drugs of abuse and striatal synaptic plasticity
10.1016/s0166-2236(03)00065-1 · ExternalCitation · doi-reference
CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex
10.1038/mp.2014.14 · ExternalCitation · doi-reference
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
10.1038/nature09582 · ExternalCitation · doi-reference
PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking
10.1038/ncomms10861 · ExternalCitation · doi-reference
Direct and indirect pathways of basal ganglia: a critical reappraisal
10.1038/nn.3743 · ExternalCitation · doi-reference
Basal forebrain-lateral habenula inputs and control of impulsive behavior
10.1038/s41386-024-01963-7 · ExternalCitation · doi-reference
Motor cortex excitability and inhibitory imbalance in autism spectrum disorder assessed with transcranial magnetic stimulation: a systematic review
10.1038/s41398-019-0444-3 · ExternalCitation · doi-reference
Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish—implications for neurodevelopmental disorders
10.1038/s41398-021-01651-w · ExternalCitation · doi-reference
Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure
10.1038/s41398-023-02317-5 · ExternalCitation · doi-reference
A single main-chain hydrogen bond required to keep GABA(A) receptors closed
10.1038/s41467-025-61447-0 · ExternalCitation · doi-reference
16p11.2 deletion mice exhibit compromised fronto-temporal connectivity, GABAergic dysfunction, and enhanced attentional ability
10.1038/s42003-023-04891-2 · ExternalCitation · doi-reference
Cell-autonomous GABAARs are essential for NMDAR-mediated synaptic transmission, LTP, and spatial memory
10.1038/s44319-025-00538-x · ExternalCitation · doi-reference
AUTISTIC-LIKE behaviors mediated BY the DYSREGULATION OF ENDOCRINE SYSTEMS via OXYTOCIN and CORTICOSTERONE IN CANNABINOID CB1 receptor knockout mice
10.1093/ijnp/pyae059.452 · ExternalCitation · doi-reference
Alterations of the endocannabinoid system and its therapeutic potential in autism spectrum disorder
10.1098/rsob.200306 · ExternalCitation · doi-reference
5-HT(3)(A) receptors maintain hippocampal LTP in a CB(1) and GABA(A) receptor- dependent manner for spatial memory
10.1111/bph.15793 · ExternalCitation · doi-reference
Prenatal valproic acid exposure impairs offspring cognition through disturbing Interneuron development
10.1111/cns.70303 · ExternalCitation · doi-reference
Cannabinoid receptors CB1 and CB2 activation restores hippocampal lipid profiles and alleviates autism-like behaviors in valproic acid-induced ASD rats
10.1111/cns.70591 · ExternalCitation · doi-reference
Endocannabinoids and cortical plasticity: CB1R as a possible regulator of the excitation/inhibition balance in health and disease
10.1111/ejn.15110 · ExternalCitation · doi-reference
Prenatal exposure to the CB1 and CB2 cannabinoid receptor agonist WIN 55,212-2 alters migration of early-born glutamatergic neurons and GABAergic interneurons in the rat cerebral cortex
10.1111/jnc.12636 · ExternalCitation · doi-reference
Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CB(1)R signaling and anxiety-like behavior
10.1111/jnc.13267 · ExternalCitation · doi-reference
Hardwiring the brain: endocannabinoids shape neuronal connectivity
10.1126/science.1137406 · ExternalCitation · doi-reference
Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring
10.1126/science.1247190 · ExternalCitation · doi-reference
Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens
10.1146/annurev.neuro.23.1.185 · ExternalCitation · doi-reference
Role of endogenous cannabinoids in synaptic signaling
10.1152/physrev.00004.2003 · ExternalCitation · doi-reference
Endocannabinoid-mediated control of synaptic transmission
10.1152/physrev.00019.2008 · ExternalCitation · doi-reference
Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling
10.1186/s13229-023-00557-2 · ExternalCitation · doi-reference
Restoration of CB1 receptor function in hippocampal GABAergic neurons rescues memory deficits in Huntington’s disease models
10.1186/s40035-025-00500-w · ExternalCitation · doi-reference
Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons
10.1523/jneurosci.19-11-04544.1999 · ExternalCitation · doi-reference
Dichotomic hippocampal transcriptome after glutamatergic vs. GABAergic deletion of the cannabinoid CB1 receptor
10.3389/fnsyn.2021.660718 · ExternalCitation · doi-reference
The state of the dopaminergic and glutamatergic systems in the valproic acid mouse model of autism spectrum disorder
10.3390/biom12111691 · ExternalCitation · doi-reference
