Research graph
References from PDE5 inhibition restores mitochondrial function and improves neurobehavioral outcomes after repeated mild blast TBI. Local targets link to admitted publications; unresolved targets remain external evidence.
Serotonin 5-HT2A receptor expression is chronically decreased in the anterior cerebral cortex of Male rats following repetitive low-level blast exposure
10.3389/fneur.2025.1594335 · 2025 · External reference
Repetitive low-level blast exposure alters circulating myeloperoxidase, matrix metalloproteinases, and neurovascular endothelial molecules in experienced military breachers
10.3390/ijms26051808 · 2025 · External reference
Occupational risk of low-level blast exposure and TBI-related medical diagnoses: a population-based epidemiological investigation (2005-2015)
10.3390/ijerph182412925 · 2021 · External reference
Cumulative blast exposure during a military career negatively impacts recovery from traumatic brain injury
10.1089/neu.2022.0192 · 2024 · External reference
Effects of low-level blast on neurovascular health and cerebral blood flow: current findings and future opportunities in neuroimaging
10.3390/ijms25010642 · 2024 · External reference
High lifetime blast exposure using the blast exposure threshold survey is associated with worse warfighter brain health following mild traumatic brain injury
10.1089/neu.2023.0133 · 2024 · External reference
Low-level blast exposure disrupts gliovascular and neurovascular connections and induces a chronic vascular pathology in rat brain
10.1186/s40478-018-0647-5 · 2019 · External reference
The neurovascular unit as a locus of injury in low-level blast-induced neurotrauma
10.3390/ijms25021150 · 2024 · External reference
Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury
10.1073/pnas.2417224122 · 2025 · External reference
P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition
10.1073/pnas.2010430117 · 2020 · External reference
Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war veterans with persistent post-concussive symptoms
10.1016/j.neuroimage.2010.04.008 · 2011 · External reference
Combat-related blast exposure and traumatic brain injury influence brain glucose metabolism during REM sleep in military veterans
10.1016/j.neuroimage.2014.05.067 · 2014 · External reference
Acute mitochondrial dysfunction after blast exposure: potential role of mitochondrial glutamate oxaloacetate transaminase
10.1089/neu.2012.2834 · 2013 · External reference
Proteomic analysis and biochemical correlates of mitochondrial dysfunction after low-intensity primary blast exposure
10.1089/neu.2018.6114 · 2019 · External reference
Mitochondrial dysfunction after repeated mild blast traumatic brain injury is attenuated by a mild mitochondrial uncoupling prodrug
10.1089/neu.2023.0102 · 2023 · External reference
Subacute oxidative stress and glial reactivity in the amygdala are associated with increased anxiety following blast neurotrauma
10.1097/shk.0000000000000311 · 2015 · External reference
Restoring mitochondrial health after blast-induced traumatic brain injury: modifiable factors and therapeutic opportunities
10.1038/s44324-026-00111-7 · 2026 · External reference
Repeated blast exposures cause brain DNA fragmentation in mice
10.1089/neu.2013.3074 · 2014 · External reference
Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury
2024 · External reference
Oxidative stress alters mitochondrial homeostasis in isolated brain capillaries
10.1186/s12987-024-00579-9 · 2024 · External reference
LRP1 deficiency promotes mitostasis in response to oxidative stress: implications for mitochondrial targeting after traumatic brain injury
10.3390/cells12101445 · 2023 · External reference
Synergistic role of oxidative stress and blood-brain barrier permeability as injury mechanisms in the acute pathophysiology of blast-induced neurotrauma
10.1038/s41598-019-44147-w · 2019 · External reference
Primary blast causes mild, moderate, severe and lethal TBI with increasing blast overpressures: experimental rat injury model
10.1038/srep26992 · 2016 · External reference
Induction of oxidative and nitrosative damage leads to cerebrovascular inflammation in an animal model of mild traumatic brain injury induced by primary blast
10.1016/j.freeradbiomed.2013.02.029 · 2013 · External reference
Mitochondrial dysfunction and apoptosis in brain microvascular endothelial cells following blast traumatic brain injury
10.1007/s10571-023-01372-2 · 2023 · External reference
Phosphodiesterase-5 (PDE-5) inhibitors as therapy for cerebrovascular dysfunction in chronic traumatic brain injury
10.1007/s13311-023-01430-z · 2023 · External reference
Phosphodiesterase-5 inhibition potentiates cerebrovascular reactivity in chronic traumatic brain injury
10.1002/acn3.541 · 2018 · External reference
PDE5 inhibition rescues mitochondrial dysfunction and angiogenic responses induced by Akt 3 inhibition by promotion of PRC expression
10.1074/jbc.ra120.013716 · 2020 · External reference
Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy
10.1016/j.cell.2026.02.008 · 2026 · External reference
Resilience of females to acute blood-brain barrier damage and anxiety behavior following mild blast traumatic brain injury
10.1186/s40478-022-01395-8 · 2022 · External reference
Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner
10.1016/j.nbd.2013.12.016 · 2014 · External reference
Sex-dependent blood-brain barrier alterations following repeated mild blast traumatic brain injury at varying inter-injury intervals
10.1016/j.expneurol.2025.115325 · 2025 · External reference
Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis
10.1128/mcb.25.14.6225-6234.2005 · 2005 · External reference
The role for myc in coordinating glycolysis, oxidative phosphorylation, glutaminolysis, and fatty acid metabolism in normal and neoplastic tissues
10.3389/fendo.2018.00129 · 2018 · External reference
Ultrastructural brain abnormalities and associated behavioral changes in mice after low-intensity blast exposure
10.1016/j.bbr.2018.03.007 · 2018 · External reference
Formoterol, a β(2)-adrenoreceptor agonist, induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury
10.1016/j.nbd.2020.104866 · 2020 · External reference
Inflammatory signaling induces mitochondrial dysfunction and neuronal death in traumatic brain injury via downregulation of OXPHOS genes
10.1007/s10528-024-10980-6 · 2025 · External reference
Unresolved reference
2026 · External reference
NAD(+) metabolism: pathophysiologic mechanisms and therapeutic potential
10.1038/s41392-020-00311-7 · 2020 · External reference
Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice
10.1186/s40478-023-01636-4 · 2023 · External reference
Blast-induced temporal alterations in blood-brain barrier properties in a rodent model
10.1038/s41598-021-84730-8 · 2021 · External reference
Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation
10.1186/s40478-021-01269-5 · 2021 · External reference
Sildenafil-mediated neuroprotection from adult to neonatal brain injury: evidence, mechanisms, and future translation
10.3390/cells10102766 · 2021 · External reference
Sildenafil as a candidate drug for Alzheimer's disease: real-world patient data observation and mechanistic observations from patient-induced pluripotent stem cell-derived neurons
10.3233/jad-231391 · 2024 · External reference
The role of sildenafil in treating brain injuries in adults and neonates
10.3389/fncel.2022.879649 · 2022 · External reference
Phosphodiesterase 5 inhibitors prevent 3,4-methylenedioxymethamphetamine-induced 5-HT deficits in the rat
10.1111/j.1471-4159.2008.05825.x · 2009 · External reference
Sildenafil protects neuronal cells from mitochondrial toxicity induced by β-amyloid peptide via ATP-Sensitive K(+) channels
10.1016/j.bbrc.2018.04.128 · 2018 · External reference
Phosphodiesterase-5 inhibition potentiates cerebrovascular reactivity in chronic traumatic brain injury
10.1002/acn3.541 · ExternalCitation · doi-reference
Inflammatory signaling induces mitochondrial dysfunction and neuronal death in traumatic brain injury via downregulation of OXPHOS genes
10.1007/s10528-024-10980-6 · ExternalCitation · doi-reference
Mitochondrial dysfunction and apoptosis in brain microvascular endothelial cells following blast traumatic brain injury
10.1007/s10571-023-01372-2 · ExternalCitation · doi-reference
Phosphodiesterase-5 (PDE-5) inhibitors as therapy for cerebrovascular dysfunction in chronic traumatic brain injury
10.1007/s13311-023-01430-z · ExternalCitation · doi-reference
Ultrastructural brain abnormalities and associated behavioral changes in mice after low-intensity blast exposure
10.1016/j.bbr.2018.03.007 · ExternalCitation · doi-reference
Sildenafil protects neuronal cells from mitochondrial toxicity induced by β-amyloid peptide via ATP-Sensitive K(+) channels
10.1016/j.bbrc.2018.04.128 · ExternalCitation · doi-reference
Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy
10.1016/j.cell.2026.02.008 · ExternalCitation · doi-reference
Sex-dependent blood-brain barrier alterations following repeated mild blast traumatic brain injury at varying inter-injury intervals
10.1016/j.expneurol.2025.115325 · ExternalCitation · doi-reference
Induction of oxidative and nitrosative damage leads to cerebrovascular inflammation in an animal model of mild traumatic brain injury induced by primary blast
10.1016/j.freeradbiomed.2013.02.029 · ExternalCitation · doi-reference
Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner
10.1016/j.nbd.2013.12.016 · ExternalCitation · doi-reference
Formoterol, a β(2)-adrenoreceptor agonist, induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury
10.1016/j.nbd.2020.104866 · ExternalCitation · doi-reference
Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war veterans with persistent post-concussive symptoms
10.1016/j.neuroimage.2010.04.008 · ExternalCitation · doi-reference
Combat-related blast exposure and traumatic brain injury influence brain glucose metabolism during REM sleep in military veterans
10.1016/j.neuroimage.2014.05.067 · ExternalCitation · doi-reference
NAD(+) metabolism: pathophysiologic mechanisms and therapeutic potential
10.1038/s41392-020-00311-7 · ExternalCitation · doi-reference
Synergistic role of oxidative stress and blood-brain barrier permeability as injury mechanisms in the acute pathophysiology of blast-induced neurotrauma
10.1038/s41598-019-44147-w · ExternalCitation · doi-reference
Blast-induced temporal alterations in blood-brain barrier properties in a rodent model
10.1038/s41598-021-84730-8 · ExternalCitation · doi-reference
Restoring mitochondrial health after blast-induced traumatic brain injury: modifiable factors and therapeutic opportunities
10.1038/s44324-026-00111-7 · ExternalCitation · doi-reference
Primary blast causes mild, moderate, severe and lethal TBI with increasing blast overpressures: experimental rat injury model
10.1038/srep26992 · ExternalCitation · doi-reference
P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition
10.1073/pnas.2010430117 · ExternalCitation · doi-reference
Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury
10.1073/pnas.2417224122 · ExternalCitation · doi-reference
PDE5 inhibition rescues mitochondrial dysfunction and angiogenic responses induced by Akt 3 inhibition by promotion of PRC expression
10.1074/jbc.ra120.013716 · ExternalCitation · doi-reference
Acute mitochondrial dysfunction after blast exposure: potential role of mitochondrial glutamate oxaloacetate transaminase
10.1089/neu.2012.2834 · ExternalCitation · doi-reference
Repeated blast exposures cause brain DNA fragmentation in mice
10.1089/neu.2013.3074 · ExternalCitation · doi-reference
Proteomic analysis and biochemical correlates of mitochondrial dysfunction after low-intensity primary blast exposure
10.1089/neu.2018.6114 · ExternalCitation · doi-reference
Cumulative blast exposure during a military career negatively impacts recovery from traumatic brain injury
10.1089/neu.2022.0192 · ExternalCitation · doi-reference
Mitochondrial dysfunction after repeated mild blast traumatic brain injury is attenuated by a mild mitochondrial uncoupling prodrug
10.1089/neu.2023.0102 · ExternalCitation · doi-reference
High lifetime blast exposure using the blast exposure threshold survey is associated with worse warfighter brain health following mild traumatic brain injury
10.1089/neu.2023.0133 · ExternalCitation · doi-reference
Subacute oxidative stress and glial reactivity in the amygdala are associated with increased anxiety following blast neurotrauma
10.1097/shk.0000000000000311 · ExternalCitation · doi-reference
Phosphodiesterase 5 inhibitors prevent 3,4-methylenedioxymethamphetamine-induced 5-HT deficits in the rat
10.1111/j.1471-4159.2008.05825.x · ExternalCitation · doi-reference
Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis
10.1128/mcb.25.14.6225-6234.2005 · ExternalCitation · doi-reference
Oxidative stress alters mitochondrial homeostasis in isolated brain capillaries
10.1186/s12987-024-00579-9 · ExternalCitation · doi-reference
Low-level blast exposure disrupts gliovascular and neurovascular connections and induces a chronic vascular pathology in rat brain
10.1186/s40478-018-0647-5 · ExternalCitation · doi-reference
Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation
10.1186/s40478-021-01269-5 · ExternalCitation · doi-reference
Resilience of females to acute blood-brain barrier damage and anxiety behavior following mild blast traumatic brain injury
10.1186/s40478-022-01395-8 · ExternalCitation · doi-reference
Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice
10.1186/s40478-023-01636-4 · ExternalCitation · doi-reference
Sildenafil as a candidate drug for Alzheimer's disease: real-world patient data observation and mechanistic observations from patient-induced pluripotent stem cell-derived neurons
10.3233/jad-231391 · ExternalCitation · doi-reference
The role for myc in coordinating glycolysis, oxidative phosphorylation, glutaminolysis, and fatty acid metabolism in normal and neoplastic tissues
10.3389/fendo.2018.00129 · ExternalCitation · doi-reference
The role of sildenafil in treating brain injuries in adults and neonates
10.3389/fncel.2022.879649 · ExternalCitation · doi-reference
Serotonin 5-HT2A receptor expression is chronically decreased in the anterior cerebral cortex of Male rats following repetitive low-level blast exposure
10.3389/fneur.2025.1594335 · ExternalCitation · doi-reference
Sildenafil-mediated neuroprotection from adult to neonatal brain injury: evidence, mechanisms, and future translation
10.3390/cells10102766 · ExternalCitation · doi-reference
LRP1 deficiency promotes mitostasis in response to oxidative stress: implications for mitochondrial targeting after traumatic brain injury
10.3390/cells12101445 · ExternalCitation · doi-reference
Occupational risk of low-level blast exposure and TBI-related medical diagnoses: a population-based epidemiological investigation (2005-2015)
10.3390/ijerph182412925 · ExternalCitation · doi-reference
Effects of low-level blast on neurovascular health and cerebral blood flow: current findings and future opportunities in neuroimaging
10.3390/ijms25010642 · ExternalCitation · doi-reference
The neurovascular unit as a locus of injury in low-level blast-induced neurotrauma
10.3390/ijms25021150 · ExternalCitation · doi-reference
Repetitive low-level blast exposure alters circulating myeloperoxidase, matrix metalloproteinases, and neurovascular endothelial molecules in experienced military breachers
10.3390/ijms26051808 · ExternalCitation · doi-reference
