Research graph
References from CCR5 protects against permanent brain ischemia by suppressing neuronal ferroptosis through AMPK/ACC signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021
10.1016/s1474-4422(24)00369-7 · 2024 · External reference
Stroke
10.1016/s0140-6736(20)31179-x · 2020 · External reference
Pathobiology of ischaemic stroke: an integrated view
10.1016/s0166-2236(99)01401-0 · 1999 · External reference
Targeting ferroptosis for cerebral neuroprotection in ischemic stroke: pathophysiological insights
10.2147/ijgm.s605531 · 2026 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Nrf2/SLC7A11/GPX4 pathway, a potential target of oridonin in inhibiting ferroptosis during cerebral ischemia-reperfusion injury progression
2026 · External reference
Inhibition of neuronal ferroptosis protects hemorrhagic brain
10.1172/jci.insight.90777 · 2017 · External reference
Single-cell RNA-seq reveals the transcriptional landscape in ischemic stroke
10.1177/0271678x211026770 · 2022 · External reference
The neurovascular unit coming of Age: a journey through neurovascular coupling in health and disease
10.1016/j.neuron.2017.07.030 · 2017 · External reference
Neuroinflammation: friend and foe for ischemic stroke
10.1186/s12974-019-1516-2 · 2019 · External reference
CCR5 is a therapeutic target for recovery after stroke and traumatic brain injury
10.1016/j.cell.2019.01.044 · 2019 · External reference
C-C chemokine receptor type 5 (CCR5)-Mediated docking of transferred tregs protects against early blood-brain barrier disruption after stroke
10.1161/jaha.117.006387 · 2017 · External reference
Brain-derived CCR5 contributes to neuroprotection and brain repair after experimental stroke
10.14336/ad.2020.0406 · 2021 · External reference
A novel small-molecular CCR5 antagonist promotes neural repair after stroke
10.1038/s41401-023-01100-y · 2023 · External reference
Increased brain damage after ischaemic stroke in mice lacking the chemokine receptor CCR5
10.1111/j.1476-5381.2010.00697.x · 2010 · External reference
Hypoxia-inducible factors in physiology and medicine
10.1016/j.cell.2012.01.021 · 2012 · External reference
HIF1 and oxygen sensing in the brain
10.1038/nrn1408 · 2004 · External reference
AMPK: restoring metabolic homeostasis over space and time
10.1016/j.molcel.2021.08.015 · 2021 · External reference
Energy-stress-mediated AMPK activation inhibits ferroptosis
10.1038/s41556-020-0461-8 · 2020 · External reference
Activated AMPK protects against chronic cerebral ischemia in bilateral carotid artery stenosis mice
10.1007/s10571-022-01312-6 · 2023 · External reference
The use of cobalt chloride as a chemical hypoxia model
10.1002/jat.3749 · 2019 · External reference
A differentiated SH-SY5Y model of hypoxic-ischaemic injury reveals dynamic transcriptomic responses during reoxygenation
10.3390/pathophysiology33030043 · 2026 · External reference
Insight into the roles of CCR5 in learning and memory in normal and disordered states
10.1016/j.bbi.2020.11.037 · 2021 · External reference
Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents
10.7554/elife.103245.3 · 2025 · External reference
Silencing CCL5 suppresses ferroptosis to alleviate calcific aortic valve disease through chemokine pathway inhibition
10.1016/j.atherosclerosis.2026.120640 · 2026 · External reference
CXCL6 reshapes lipid metabolism and induces neutrophil extracellular trap formation in cholangiocarcinoma progression and immunotherapy resistance
2025 · External reference
CCR2 antagonist attenuates calcium oxalate-induced kidney oxidative stress and inflammation by regulating macrophage activation
10.1538/expanim.23-0113 · 2024 · External reference
Chemokine CXCL13-CXCR5 signaling in neuroinflammation and pathogenesis of chronic pain and neurological diseases
10.1186/s11658-024-00653-y · 2024 · External reference
Dual effect of C-C motif chemokine receptor 5 on ischemic stroke: more harm than benefit?
10.1016/j.ejphar.2023.175857 · 2023 · External reference
Dl-3-n-butylphthalein inhibits neuronal apoptosis and ferroptosis after cerebral ischemia-reperfusion injury in rats by regulating CXCR4
10.1016/j.ntt.2025.107434 · 2025 · External reference
Ferroptosis in ischemic stroke: mechanisms, pathological implications, and therapeutic strategies
10.3389/fnins.2025.1623485 · 2025 · External reference
AMPK: potential therapeutic target for ischemic stroke
10.7150/thno.25674 · 2018 · External reference
Energy stress inhibits ferroptosis via AMPK
2020 · External reference
Ferroptosis inhibition and AMPK activation: key mechanisms of soy isoflavones against cerebral injury
2026 · External reference
The role of AMP-activated protein kinase in oxytosis/ferroptosis: protector or potentiator?
10.1089/ars.2022.0013 · 2024 · External reference
Metformin inhibits chemokine expression through the AMPK/NF-κB signaling pathway
10.1089/jir.2018.0061 · 2018 · External reference
AMPK: guardian of metabolism and mitochondrial homeostasis
10.1038/nrm.2017.95 · 2018 · External reference
