Research graph
References from Nanotechnology-driven strategies for phytochemical-based cancer therapy: Mechanistic and translational perspectives. Local targets link to admitted publications; unresolved targets remain external evidence.
A comprehensive review of capsaicin: biosynthesis, industrial productions, processing to applications, and clinical uses
10.1016/j.heliyon.2024.e39721 · 2024 · External reference
Antimicrobial properties of capsaicin: available data and future research perspectives
10.3390/nu15194097 · 2023 · External reference
Capsaicin: emerging pharmacological and therapeutic insights
10.3390/cimb46080468 · 2024 · External reference
Anticancer properties of capsaicin against human cancer
2016 · External reference
Capsaicin: from plants to a cancer-suppressing agent
10.3390/molecules21080931 · 2016 · External reference
Application of capsaicin as a potential new therapeutic drug in human cancers
10.1111/jcpt.13039 · 2020 · External reference
Potential of capsaicin as a combinatorial agent to overcome chemoresistance and to improve outcomes of cancer therapy
10.1016/j.bcp.2025.116828 · 2025 · External reference
Calcium Entry through TRPV1: A Potential Target for the Regulation of Proliferation and Apoptosis in Cancerous and Healthy Cells
10.3390/ijms21114177 · 2020 · External reference
Mechanism of capsaicin receptor TRPV1-mediated toxicity in pain-sensing neurons focusing on the effects of Na(+)/Ca(2+) fluxes and the Ca(2+)-binding protein calretinin
10.1016/j.bbamcr.2012.08.018 · 2013 · External reference
The Impact of TRPV1 on Cancer Pathogenesis and Therapy: A Systematic Review
10.7150/ijbs.59918 · 2021 · External reference
Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
10.3389/fonc.2022.908487 · 2022 · External reference
Recent Advances in the Applications and Studies of Polysaccharide-, Protein-, and Lipid-Based Delivery Systems in Enhancing the Bioavailability of Capsaicin-A Review
10.3390/polym17091196 · 2025 · External reference
Capsaicin-the major bioactive ingredient of chili peppers: bio-efficacy and delivery systems
10.1039/d0fo00351d · 2020 · External reference
Biocompatible Chitosan/Starch/Graphene Quantum Dots/Titanium Dioxide Nanocomposite: A Stimuli-Responsive, Porous Nanocarrier for Prolonged Quercetin Delivery in Lung Cancer Treatment
10.1007/s12668-024-01461-6 · 2024 · External reference
Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity
10.1016/j.jcis.2023.01.139 · 2023 · External reference
PEG-modified Fe(2)O(3) coated agarose hydrogel: A synthesized nanocomposite for regulated 5-fluorouracil delivery
10.1016/j.ijbiomac.2024.133900 · 2024 · External reference
a journal of neurology
10.1093/brain/awaf044 · 2025 · External reference
Function and mechanism of action of the TRPV1 channel in the development of triple-negative breast cancer
10.3724/abbs.2024068 · 2024 · External reference
ROS-Mediated Cancer Cell Killing through Dietary Phytochemicals
10.1155/2019/9051542 · 2019 · External reference
Capsaicinoids and Their Effects on Cancer: The "Double-Edged Sword" Postulate from the Molecular Scale
10.3390/cells12212573 · 2023 · External reference
Capsaicin exerts synergistic pro-apoptotic effects with cisplatin in TSCC through the calpain pathway via TRPV1
10.7150/jca.98075 · 2024 · External reference
Capsaicin inhibits the migration and invasion via the AMPK/NF-κB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression
10.1042/bsr20190819 · 2019 · External reference
Unraveling TRPV1’s Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin
10.3390/molecules29194729 · 2024 · External reference
Transient receptor potential vanilloid 1 (TRPV1)-independent actions of capsaicin on cellular excitability and ion transport
10.1002/med.21945 · 2023 · External reference
Capsaicinoids: Multiple effects on angiogenesis, invasion and metastasis in human cancers
2019 · External reference
Capsaicin inhibits HIF-1α accumulation through suppression of mitochondrial respiration in lung cancer cells
2022 · External reference
Composition, preparation methods, and applications of nanoniosomes as codelivery systems: a review of emerging therapies with emphasis on cancer
10.1039/d3nr03495j · 2024 · External reference
Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain
10.1016/j.pharmthera.2020.107743 · 2021 · External reference
Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
2016 · External reference
Effect of Capsaicin on 3-NP-Induced Neurotoxicity: A Pre-Clinical Study
10.1007/s11064-024-04158-0 · 2024 · External reference
Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells
10.1021/tx025599q · 2003 · External reference
official journal of the European Federation for Pharmaceutical Sciences
2022 · External reference
Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging
2022 · External reference
Enhanced permeability and retention (EPR) effect: Advances in nanomedicine for improved tumor targeting
10.1016/j.bioadv.2025.214636 · 2026 · External reference
Recent advancements in Irinotecan-loaded nanomaterials as a smart drug delivery system for cancer therapy: A state-of-art-review
10.1016/j.inoche.2024.112028 · 2024 · External reference
An Overview of Nanostructured Lipid Carriers and its Application in Drug Delivery through Different Routes
10.34172/apb.2023.056 · 2023 · External reference
vitro and in silico protein corona formation evaluation of curcumin and capsaicin loaded-solid lipid nanoparticles
2019 · External reference
Chitosan/poly(lactic-co-glycolic)acid Nanoparticle Formulations with Finely-Tuned Size Distributions for Enhanced Mucoadhesion
10.3390/pharmaceutics14010095 · 2022 · External reference
PLGA nanoparticles for capsaicin delivery: enhanced encapsulation efficiency and pro-apoptotic activity in HEPG2 cells
10.3389/fbioe.2025.1617022 · 2025 · External reference
Lipid polymer hybrid nanoparticles as potent vehicles for drug delivery in cancer therapeutics
10.1016/j.medidd.2023.100165 · 2023 · External reference
Lipid-Polymer Hybrid Nanosystems: A Rational Fusion for Advanced Therapeutic Delivery
10.3390/jfb14090437 · 2023 · External reference
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
2017 · External reference
pH-responsive vesicular carriers as promising tools for tumor targeting
2025 · External reference
PLGA nanoparticles for capsaicin delivery: enhanced encapsulation efficiency and pro-apoptotic activity in HEPG2 cells
10.3389/fbioe.2025.1617022 · 2025 · External reference
Oral delivery of capsaicin using MPEG-PCL nanoparticles
10.1038/aps.2014.113 · 2015 · External reference
Capsaicin-loaded folic acid-conjugated lipid nanoparticles for enhanced therapeutic efficacy in ovarian cancers
10.1016/j.biopha.2017.04.097 · 2017 · External reference
Unresolved reference
2024 · External reference
Design of Polymeric Nanoparticles for Theranostic Delivery of Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped Graphene Quantum Dots
10.1002/mabi.202400149 · 2024 · External reference
Co-Delivery of Doxorubicin and Capsaicin Loaded-PEGylated PLGA Nanoparticles to Improve Therapeutic Efficacy against Breast Cancer Cells
10.1007/s12247-025-10269-0 · 2026 · External reference
Preparation, Characterization, and Anticancer Effects of Capsaicin-Loaded Nanoliposomes
10.3390/nu13113995 · 2021 · External reference
Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
10.3389/fonc.2022.908487 · 2022 · External reference
Oxygenation: Nanotechnological Strategies for Conquering Tumor Hypoxia in Photodynamic Therapy
10.2147/ijn.s569340 · 2026 · External reference
Pharmacokinetic analysis of capsaicin after topical administration of a high-concentration capsaicin patch to patients with peripheral neuropathic pain
10.1097/ftd.0b013e3181a8b200 · 2009 · External reference
Capsaicin-loaded folic acid-conjugated lipid nanoparticles for enhanced therapeutic efficacy in ovarian cancers
10.1016/j.biopha.2017.04.097 · 2017 · External reference
Preparation, characterization, and anticancer effect of Capsaicin-functionalized selenium nanoparticles
10.3389/fnut.2024.1515657 · 2024 · External reference
Capsaicin enhanced the efficacy of photodynamic therapy against osteosarcoma via a pro-death strategy by inducing ferroptosis and alleviating hypoxia
10.1002/smll.202306916 · 2024 · External reference
A synergistic approach for management of lung carcinoma through folic acid functionalized co-therapy of capsaicin and gefitinib nanoparticles: Enhanced apoptosis and metalloproteinase-9 down-regulation
10.1016/j.phymed.2018.09.013 · 2019 · External reference
Nanoparticle biodistribution coefficients: a quantitative approach for understanding the tissue distribution of nanoparticles
10.1016/j.addr.2023.114708 · 2023 · External reference
Charting new frontiers in nanoparticle immunotoxicity: A perspective on current, emerging, and future approaches
10.1016/j.bbrc.2025.152280 · 2025 · External reference
Unresolved reference
2025 · External reference
10.4028/b-xdtcg5
10.4028/b-xdtcg5 · 2025 · External reference
Design of Polymeric Nanoparticles for Theranostic Delivery of Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped Graphene Quantum Dots
10.1002/mabi.202400149 · ExternalCitation · doi-reference
Transient receptor potential vanilloid 1 (TRPV1)-independent actions of capsaicin on cellular excitability and ion transport
10.1002/med.21945 · ExternalCitation · doi-reference
Capsaicin enhanced the efficacy of photodynamic therapy against osteosarcoma via a pro-death strategy by inducing ferroptosis and alleviating hypoxia
10.1002/smll.202306916 · ExternalCitation · doi-reference
Effect of Capsaicin on 3-NP-Induced Neurotoxicity: A Pre-Clinical Study
10.1007/s11064-024-04158-0 · ExternalCitation · doi-reference
Co-Delivery of Doxorubicin and Capsaicin Loaded-PEGylated PLGA Nanoparticles to Improve Therapeutic Efficacy against Breast Cancer Cells
10.1007/s12247-025-10269-0 · ExternalCitation · doi-reference
Biocompatible Chitosan/Starch/Graphene Quantum Dots/Titanium Dioxide Nanocomposite: A Stimuli-Responsive, Porous Nanocarrier for Prolonged Quercetin Delivery in Lung Cancer Treatment
10.1007/s12668-024-01461-6 · ExternalCitation · doi-reference
Nanoparticle biodistribution coefficients: a quantitative approach for understanding the tissue distribution of nanoparticles
10.1016/j.addr.2023.114708 · ExternalCitation · doi-reference
Mechanism of capsaicin receptor TRPV1-mediated toxicity in pain-sensing neurons focusing on the effects of Na(+)/Ca(2+) fluxes and the Ca(2+)-binding protein calretinin
10.1016/j.bbamcr.2012.08.018 · ExternalCitation · doi-reference
Charting new frontiers in nanoparticle immunotoxicity: A perspective on current, emerging, and future approaches
10.1016/j.bbrc.2025.152280 · ExternalCitation · doi-reference
Potential of capsaicin as a combinatorial agent to overcome chemoresistance and to improve outcomes of cancer therapy
10.1016/j.bcp.2025.116828 · ExternalCitation · doi-reference
Enhanced permeability and retention (EPR) effect: Advances in nanomedicine for improved tumor targeting
10.1016/j.bioadv.2025.214636 · ExternalCitation · doi-reference
Capsaicin-loaded folic acid-conjugated lipid nanoparticles for enhanced therapeutic efficacy in ovarian cancers
10.1016/j.biopha.2017.04.097 · ExternalCitation · doi-reference
A comprehensive review of capsaicin: biosynthesis, industrial productions, processing to applications, and clinical uses
10.1016/j.heliyon.2024.e39721 · ExternalCitation · doi-reference
PEG-modified Fe(2)O(3) coated agarose hydrogel: A synthesized nanocomposite for regulated 5-fluorouracil delivery
10.1016/j.ijbiomac.2024.133900 · ExternalCitation · doi-reference
Recent advancements in Irinotecan-loaded nanomaterials as a smart drug delivery system for cancer therapy: A state-of-art-review
10.1016/j.inoche.2024.112028 · ExternalCitation · doi-reference
Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity
10.1016/j.jcis.2023.01.139 · ExternalCitation · doi-reference
Lipid polymer hybrid nanoparticles as potent vehicles for drug delivery in cancer therapeutics
10.1016/j.medidd.2023.100165 · ExternalCitation · doi-reference
Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain
10.1016/j.pharmthera.2020.107743 · ExternalCitation · doi-reference
A synergistic approach for management of lung carcinoma through folic acid functionalized co-therapy of capsaicin and gefitinib nanoparticles: Enhanced apoptosis and metalloproteinase-9 down-regulation
10.1016/j.phymed.2018.09.013 · ExternalCitation · doi-reference
Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells
10.1021/tx025599q · ExternalCitation · doi-reference
Oral delivery of capsaicin using MPEG-PCL nanoparticles
10.1038/aps.2014.113 · ExternalCitation · doi-reference
Capsaicin-the major bioactive ingredient of chili peppers: bio-efficacy and delivery systems
10.1039/d0fo00351d · ExternalCitation · doi-reference
Composition, preparation methods, and applications of nanoniosomes as codelivery systems: a review of emerging therapies with emphasis on cancer
10.1039/d3nr03495j · ExternalCitation · doi-reference
Capsaicin inhibits the migration and invasion via the AMPK/NF-κB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression
10.1042/bsr20190819 · ExternalCitation · doi-reference
a journal of neurology
10.1093/brain/awaf044 · ExternalCitation · doi-reference
Pharmacokinetic analysis of capsaicin after topical administration of a high-concentration capsaicin patch to patients with peripheral neuropathic pain
10.1097/ftd.0b013e3181a8b200 · ExternalCitation · doi-reference
Application of capsaicin as a potential new therapeutic drug in human cancers
10.1111/jcpt.13039 · ExternalCitation · doi-reference
ROS-Mediated Cancer Cell Killing through Dietary Phytochemicals
10.1155/2019/9051542 · ExternalCitation · doi-reference
Oxygenation: Nanotechnological Strategies for Conquering Tumor Hypoxia in Photodynamic Therapy
10.2147/ijn.s569340 · ExternalCitation · doi-reference
PLGA nanoparticles for capsaicin delivery: enhanced encapsulation efficiency and pro-apoptotic activity in HEPG2 cells
10.3389/fbioe.2025.1617022 · ExternalCitation · doi-reference
Preparation, characterization, and anticancer effect of Capsaicin-functionalized selenium nanoparticles
10.3389/fnut.2024.1515657 · ExternalCitation · doi-reference
Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
10.3389/fonc.2022.908487 · ExternalCitation · doi-reference
Capsaicinoids and Their Effects on Cancer: The "Double-Edged Sword" Postulate from the Molecular Scale
10.3390/cells12212573 · ExternalCitation · doi-reference
Capsaicin: emerging pharmacological and therapeutic insights
10.3390/cimb46080468 · ExternalCitation · doi-reference
Calcium Entry through TRPV1: A Potential Target for the Regulation of Proliferation and Apoptosis in Cancerous and Healthy Cells
10.3390/ijms21114177 · ExternalCitation · doi-reference
Lipid-Polymer Hybrid Nanosystems: A Rational Fusion for Advanced Therapeutic Delivery
10.3390/jfb14090437 · ExternalCitation · doi-reference
Capsaicin: from plants to a cancer-suppressing agent
10.3390/molecules21080931 · ExternalCitation · doi-reference
Unraveling TRPV1’s Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin
10.3390/molecules29194729 · ExternalCitation · doi-reference
Preparation, Characterization, and Anticancer Effects of Capsaicin-Loaded Nanoliposomes
10.3390/nu13113995 · ExternalCitation · doi-reference
Antimicrobial properties of capsaicin: available data and future research perspectives
10.3390/nu15194097 · ExternalCitation · doi-reference
Chitosan/poly(lactic-co-glycolic)acid Nanoparticle Formulations with Finely-Tuned Size Distributions for Enhanced Mucoadhesion
10.3390/pharmaceutics14010095 · ExternalCitation · doi-reference
Recent Advances in the Applications and Studies of Polysaccharide-, Protein-, and Lipid-Based Delivery Systems in Enhancing the Bioavailability of Capsaicin-A Review
10.3390/polym17091196 · ExternalCitation · doi-reference
An Overview of Nanostructured Lipid Carriers and its Application in Drug Delivery through Different Routes
10.34172/apb.2023.056 · ExternalCitation · doi-reference
Function and mechanism of action of the TRPV1 channel in the development of triple-negative breast cancer
10.3724/abbs.2024068 · ExternalCitation · doi-reference
10.4028/b-xdtcg5
10.4028/b-xdtcg5 · ExternalCitation · doi-reference
The Impact of TRPV1 on Cancer Pathogenesis and Therapy: A Systematic Review
10.7150/ijbs.59918 · ExternalCitation · doi-reference
Capsaicin exerts synergistic pro-apoptotic effects with cisplatin in TSCC through the calpain pathway via TRPV1
10.7150/jca.98075 · ExternalCitation · doi-reference
