Research graph
References from Enhanced transcriptional insulation of lentiviral vectors using “sequence-upgraded polyA long terminal repeats” or “supA-LTRs”. Local targets link to admitted publications; unresolved targets remain external evidence.
Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy
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Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases
10.3390/v13081526 · 2021 · External reference
Tat is a multifunctional viral protein that modulates cellular gene expression and functions
10.18632/oncotarget.15174 · 2017 · External reference
Development of a Self-Inactivating Lentivirus Vector
10.1128/jvi.72.10.8150-8157.1998 · 1998 · External reference
Replication-competent Lentivirus Analysis of Clinical Grade Vector Products
10.1038/mt.2010.278 · 2011 · External reference
Development of a replication-competent lentivirus assay for dendritic cell-targeting lentiviral vectors
10.1038/mtm.2015.17 · 2015 · External reference
Involvement of long terminal repeat U3 sequences overlapping the transcription control region in human immunodeficiency virus type 1 mRNA 3′ end formation
1991 · External reference
Overlapping enhancer/promoter and transcriptional termination signals in the lentiviral long terminal repeat
10.1186/1742-4690-4-4 · 2007 · External reference
The ability of the HIV-1 AAUAAA signal to bind polyadenylation factors is controlled by local RNA structure
10.1093/nar/27.2.446 · 1999 · External reference
A Hairpin Structure in the R Region of the Human Immunodeficiency Virus Type 1 RNA Genome Is Instrumental in Polyadenylation Site Selection
10.1128/jvi.73.1.81-91.1999 · 1999 · External reference
Transcription termination factor Pcf11 limits the processivity of Pol II on an HIV provirus to repress gene expression
10.1101/gad.1542707 · 2007 · External reference
Poly(A) site selection in the HIV-1 provirus: inhibition of promoter-proximal polyadenylation by the downstream major splice donor site
10.1101/gad.9.23.3008 · 1995 · External reference
The HIV-1 5′ LTR poly(A) site is inactivated by U1 snRNP interaction with the downstream major splice donor site
10.1093/emboj/16.18.5752 · 1997 · External reference
Stem-loop 1 of the U1 snRNP plays a critical role in the suppression of HIV-1 polyadenylation
10.1017/s1355838200991957 · 2000 · External reference
Mutation of the major 5′ splice site renders a CMV-driven HIV-1 proviral clone Tat-dependent: connections between transcription and splicing
10.1016/s0014-5793(04)00277-7 · 2004 · External reference
RNA 3′ Readthrough of Oncoretrovirus and Lentivirus: Implications for Vector Safety and Efficacy
10.1128/jvi.76.14.7209-7219.2002 · 2002 · External reference
Genotoxicity of Retroviral Integration In Hematopoietic Cells
10.1016/j.ymthe.2006.03.001 · 2006 · External reference
Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations
10.1172/jci62189 · 2012 · External reference
Risk assessment in skin gene therapy: viral–cellular fusion transcripts generated by proviral transcriptional read-through in keratinocytes transduced with self-inactivating lentiviral vectors
10.1038/gt.2011.12 · 2011 · External reference
Lentiviral Vector Promoter is Decisive for Aberrant Transcript Formation
10.1089/hum.2017.162 · 2017 · External reference
Self-Inactivating Lentiviral Vectors with U3 and U5 Modifications
10.1006/viro.1999.9850 · 1999 · External reference
Refinement of lentiviral vector for improved RNA processing and reduced rates of self inactivation repair
10.1186/1472-6750-9-86 · 2009 · External reference
Transcriptional start site heterogeneity modulates the structure and function of the HIV-1 genome
10.1073/pnas.1616627113 · 2016 · External reference
Structural basis for transcriptional start site control of HIV-1 RNA fate
10.1126/science.aaz7959 · 2020 · External reference
Selective packaging of HIV-1 RNA genome is guided by the stability of 5′ untranslated region polyA stem
10.1073/pnas.2114494118 · 2021 · External reference
HIV-1 usurps transcription start site heterogeneity of host RNA polymerase II to maximize replication fitness
10.1073/pnas.2305103120 · 2023 · External reference
The TAR Hairpin of Human Immunodeficiency Virus Type 1 Can Be Deleted When Not Required for Tat-Mediated Activation of Transcription
10.1128/jvi.00392-07 · 2007 · External reference
R Region Sequences in the Long Terminal Repeat of a Murine Retrovirus Specifically Increase Expression of Unspliced RNAs
10.1128/jvi.73.4.3477-3483.1999 · 1999 · External reference
The HIV-1 Tat Protein Has a Versatile Role in Activating Viral Transcription
10.1128/jvi.00650-11 · 2011 · External reference
Definition of an efficient synthetic poly(A) site
10.1101/gad.3.7.1019 · 1989 · External reference
Improving Transcriptional Termination of Self-inactivating Gamma-retroviral and Lentiviral Vectors
10.1038/sj.mt.6300152 · 2007 · External reference
Improved production and quality of lentiviral vectors by major-splice-donor mutation and co-expression of a novel U1 snRNA-based enhancer
10.1016/j.heliyon.2025.e43732 · 2025 · External reference
Enhancing titers of therapeutic lentiviral vectors using PKC agonists
10.1016/j.omtm.2025.101484 · 2025 · External reference
HIV-based lentiviral vectors: Origin and sequence differences
10.1016/j.omtm.2021.03.018 · 2021 · External reference
Assessment of Integration-defective HIV-1 and EIAV Vectors In Vitro and In Vivo
10.1038/mtna.2012.53 · 2012 · External reference
Comparative efficacy of dermal fibroblast-mediated and direct adenoviral bone morphogenetic protein-2 gene therapy for bone regeneration in an equine rib model
10.1038/gt.2010.13 · 2010 · External reference
The Old and the New: Prospects for Non-Integrating Lentiviral Vector Technology
10.3390/v12101103 · 2020 · External reference
Specific and Independent Recognition of U3 and U5 att Sites by Human Immunodeficiency Virus Type 1 Integrase In Vivo
10.1128/jvi.72.10.8396-8402.1998 · 1998 · External reference
Genome-wide integration site detection using Cas9 enriched amplification-free long-range sequencing
10.1093/nar/gkaa1152 · 2021 · External reference
Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells
10.1073/pnas.83.10.3194 · 1986 · External reference
Handicapped retroviral vectors efficiently transduce foreign genes into hematopoietic stem cells
10.1073/pnas.84.8.2406 · 1987 · External reference
Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity
10.1007/s11684-011-0159-1 · 2011 · External reference
Safety and Efficacy of Retroviral and Lentiviral Vectors for Gene Therapy
2017 · External reference
Physiological Promoters Reduce the Genotoxic Risk of Integrating Gene Vectors
10.1038/mt.2008.5 · 2008 · External reference
Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral Vectors
10.1038/mt.2009.179 · 2009 · External reference
Uncovering and Dissecting the Genotoxicity of Self-inactivating Lentiviral Vectors In Vivo
10.1038/mt.2014.3 · 2014 · External reference
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
10.1172/jci37630 · 2009 · External reference
Viral Vectors: The Road to Reducing Genotoxicity
10.1093/toxsci/kfw220 · 2017 · External reference
Investigating the Barrier Activity of Novel, Human Enhancer-Blocking Chromatin Insulators for Hematopoietic Stem Cell Gene Therapy
10.1089/hum.2021.142 · 2021 · External reference
Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts
10.1172/jci61852 · 2012 · External reference
Integrated Self-Inactivating Lentiviral Vectors Produce Full-Length Genomic Transcripts Competent for Encapsidation and Integration
10.1128/jvi.78.16.8421-8436.2004 · 2004 · External reference
Mobilization and Mechanism of Transcription of Integrated Self-Inactivating Lentiviral Vectors
10.1128/jvi.79.13.8410-8421.2005 · 2005 · External reference
Risks of replication-competent retro/lentivirus from associated vector systems: Is it time for a roadmap toward reduced testing?
10.1016/j.omtm.2025.101601 · 2025 · External reference
The woodchuck hepatitis virus post-transcriptional regulatory element reduces readthrough transcription from retroviral vectors
10.1038/sj.gt.3302979 · 2007 · External reference
Viral hijacking of the TENT4–ZCCHC14 complex protects viral RNAs via mixed tailing
10.1038/s41594-020-0427-3 · 2020 · External reference
Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution
10.1038/s41594-023-01187-1 · 2024 · External reference
The Post-Transcriptional Regulatory Element of Hepatitis B Virus: From Discovery to Therapy
10.3390/v16040528 · 2024 · External reference
Regulating the gene-therapy revolution
10.1038/d41586-018-07641-1 · 2018 · External reference
Enhancing titres of therapeutic viral vectors using the transgene repression in vector production (TRiP) system
10.1038/ncomms14834 · 2017 · External reference
Standardizing viral vector manufacture: maximizing production with the TRiP SystemTM
10.18609/cgti.2018.099 · 2018 · External reference
U1 snRNP telescripting: molecular mechanisms and beyond
10.1080/15476286.2021.1872963 · 2021 · External reference
A quantitative assay for HIV DNA integration in vivo
10.1038/87979 · 2001 · External reference
Analysis of 2-LTR Circle Junctions of Viral DNA in Infected Cells
10.1007/978-1-59745-170-3_6 · 2009 · External reference
A single-LTR HIV-1 vector optimized for functional genomics applications
10.1016/j.ymthe.2004.04.012 · 2004 · External reference
Superior lentiviral vectors designed for BSL-0 environment abolish vector mobilization
10.1038/s41434-018-0039-2 · 2018 · External reference
Ex vivo HIV DNA integration in STAT3 drives T cell persistence—A model of HIV-associated T cell
2025 · External reference
CRISPR/Cas9-Mediated Insertion of HIV Long Terminal Repeat within BACH2 Promotes Expansion of T Regulatory–like Cells
10.4049/jimmunol.2100491 · 2022 · External reference
Effects of Homology Length in the Repeat Region on Minus-Strand DNA Transfer and Retroviral Replication
10.1128/jvi.75.2.809-820.2001 · 2001 · External reference
Requirements for DNA Strand Transfer During Reverse Transcription in Mutant HIV-1 Virions
10.1006/jmbi.1994.0475 · 1995 · External reference
Cleavage and polyadenylation: Ending the message expands gene regulation
10.1080/15476286.2017.1306171 · 2017 · External reference
Unresolved reference
External reference
In cell mutational interference mapping experiment (in cell MIME) identifies the 5′ polyadenylation signal as a dual regulator of HIV-1 genomic RNA production and packaging
10.1093/nar/gky152 · 2018 · External reference
Off-on Polyadenylation Strategy as a Supplemental Mechanism for Silencing Toxic Transgene Expression During Lentiviral Vector Production
10.2144/000114178 · 2014 · External reference
Quantification of plasmid DNA copies in the nucleus after lipoplex and polyplex transfection
10.1016/j.jconrel.2008.12.016 · 2009 · External reference
Minimal Requirement for a Lentivirus Vector Based on Human Immunodeficiency Virus Type 1
10.1128/jvi.72.1.811-816.1998 · 1998 · External reference
A Rev-Independent Human Immunodeficiency Virus Type 1 (HIV-1)-Based Vector That Exploits a Codon-Optimized HIV-1 GagPol Gene
10.1128/jvi.74.10.4839-4852.2000 · 2000 · External reference
Factors that influence VSV-G pseudotyping and transduction efficiency of lentiviral vectors - in vitro and in vivo implications
10.1002/jgm.1022 · 2007 · External reference
The Sequence Alignment/Map format and SAMtools
10.1093/bioinformatics/btp352 · 2009 · External reference
Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer
10.1038/s41467-023-37266-6 · 2023 · External reference
Unresolved reference
2010 · External reference
Cutadapt removes adapter sequences from high-throughput sequencing reads
10.14806/ej.17.1.200 · 2011 · External reference
Fast and accurate long-read alignment with Burrows–Wheeler transform
10.1093/bioinformatics/btp698 · 2010 · External reference
BEDTools: a flexible suite of utilities for comparing genomic features
10.1093/bioinformatics/btq033 · 2010 · External reference
RIdeogram: drawing SVG graphics to visualize and map genome-wide data on the idiograms
10.7717/peerj-cs.251 · 2020 · External reference
