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References from Role of viral protein ratio in the structure and separation of empty and full adeno-associated virus capsids: A molecular dynamics study. Local targets link to admitted publications; unresolved targets remain external evidence.
My Life with Adeno-Associated Virus: A Long Time Spent Studying a Short Genome
10.1089/dna.2013.2120 · 2013 · External reference
Entering the Modern Era of Gene Therapy
10.1146/annurev-med-012017-043332 · 2019 · External reference
Clinical applications of gene therapy for rare diseases: A review
10.1111/iep.12478 · 2023 · External reference
Adeno-Associated Virus (AAV) as a Vector for Gene Therapy
10.1007/s40259-017-0234-5 · 2017 · External reference
The clinical landscape for AAV gene therapies
10.1038/d41573-021-00017-7 · 2021 · External reference
OneBac: Platform for Scalable and High-Titer Production of Adeno-Associated Virus Serotype 1–12 Vectors for Gene Therapy
10.1089/hum.2013.184 · 2014 · External reference
Universal Method for the Purification of Recombinant AAV Vectors of Differing Serotypes
10.1016/j.omtm.2017.12.004 · 2018 · External reference
Emerging Issues in AAV-Mediated In Vivo Gene Therapy
10.1016/j.omtm.2017.11.007 · 2018 · External reference
Subgenomic particles in rAAV vectors result from DNA lesion/break and non-homologous end joining of vector genomes
10.1016/j.omtn.2022.08.027 · 2022 · External reference
Empty virions in AAV8 vector preparations reduce transduction efficiency and may cause total viral particle dose-limiting side effects
10.1038/mtm.2013.9 · 2014 · External reference
Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys
10.1126/scitranslmed.3005795 · 2013 · External reference
AAV Empty Capsids: For Better or for Worse?
10.1038/mt.2013.268 · 2014 · External reference
AAV Vectors: Are They Safe? Hum
10.1089/hum.2020.187 · 2020 · External reference
Separation of full and empty adeno-associated virus capsids by anion-exchange chromatography using choline-type salts
10.1016/j.ab.2023.115421 · 2024 · External reference
Adeno-associated viral capsid stability on anion exchange chromatography column and its impact on empty and full capsid separation
10.1016/j.omtm.2023.101112 · 2023 · External reference
Structural Changes Likely Cause Chemical Differences between Empty and Full AAV Capsids
10.3390/biomedicines12092128 · 2024 · External reference
Removal of empty capsids from adeno-associated virus preparations by multimodal metal affinity chromatography
10.1016/j.chroma.2021.462210 · 2021 · External reference
Empty and Full AAV Capsid Charge and Hydrophobicity Differences Measured with Single-Particle AFM
10.1021/acs.langmuir.2c02643 · 2023 · External reference
Mapping the AAV Capsid Host Antibody Response toward the Development of Second Generation Gene Delivery Vectors
10.3389/fimmu.2014.00009 · 2014 · External reference
Mutational Analysis of Narrow Pores at the Fivefold Symmetry Axes of Adeno-Associated Virus Type 2 Capsids Reveals a Dual Role in Genome Packaging and Activation of Phospholipase A2 Activity
10.1128/jvi.79.4.2528-2540.2005 · 2005 · External reference
AAV capsid structure and cell interactions
2011 · External reference
Adeno-associated virus capsid assembly is divergent and stochastic
10.1038/s41467-021-21935-5 · 2021 · External reference
Mutagenesis of Adeno-Associated Virus Type 2 Capsid Protein VP1 Uncovers New Roles for Basic Amino Acids in Trafficking and Cell-Specific Transduction
10.1128/jvi.00687-10 · 2010 · External reference
Biophysical and structural insights into AAV genome ejection
10.1128/jvi.00899-24 · 2025 · External reference
Adeno-associated virus 9 (AAV9) viral proteins VP1, VP2, and membrane-associated accessory protein (MAAP) differentially influence in vivo transgene expression
10.1128/jvi.01681-24 · 2024 · External reference
Structural basis for nuclear import of adeno-associated virus serotype 6 capsid protein
10.1128/jvi.01345-24 · 2025 · External reference
Comparative Analysis of the Capsid Structures of AAVrh.10, AAVrh.39, and AAV8
10.1128/jvi.01769-19 · 2020 · External reference
Structure and Dynamics of Adeno-Associated Virus Serotype 1 VP1-Unique N-Terminal Domain and Its Role in Capsid Trafficking
10.1128/jvi.02524-12 · 2013 · External reference
A Conformational Change in the Adeno-Associated Virus Type 2 Capsid Leads to the Exposure of Hidden VP1 N Termini
10.1128/jvi.79.9.5296-5303.2005 · 2005 · External reference
Adeno-Associated Virus Type 2 Capsids with Externalized VP1/VP2 Trafficking Domains Are Generated prior to Passage through the Cytoplasm and Are Maintained until Uncoating Occurs in the Nucleus
10.1128/jvi.01056-06 · 2006 · External reference
The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity
10.1099/0022-1317-83-5-973 · 2002 · External reference
Surface-Exposed Adeno-Associated Virus Vp1-NLS Capsid Fusion Protein Rescues Infectivity of Noninfectious Wild-Type Vp2/Vp3 and Vp3-Only Capsids but Not That of Fivefold Pore Mutant Virions
10.1128/jvi.00580-07 · 2007 · External reference
Probe capsid structure stability and dynamics of adeno-associated virus as an important viral vector for gene therapy by hydrogen-deuterium exchange-mass spectrometry
10.1002/pro.5074 · 2024 · External reference
Surface charge distribution: a key parameter for understanding protein behavior in chromatographic processes
10.1016/j.chroma.2021.462151 · 2021 · External reference
Molecular Dynamics Simulations of the Complete Satellite Tobacco Mosaic Virus
10.1016/j.str.2005.11.014 · 2006 · External reference
Physical properties of the HIV-1 capsid from all-atom molecular dynamics simulations
10.1038/ncomms15959 · 2017 · External reference
Non-equilibrium virus particle dynamics: Microsecond MD simulations of the complete Flock House virus capsid under different conditions
10.1016/j.jsb.2023.107964 · 2023 · External reference
All-atom molecular dynamics calculation study of entire poliovirus empty capsids in solution
10.1063/1.4897557 · 2014 · External reference
All-Atom Multiscale Simulation of Cowpea Chlorotic Mottle Virus Capsid Swelling
10.1021/jp102314e · 2010 · External reference
Screening for the Location of RNA using the Chloride Ion Distribution in Simulations of Virus Capsids
10.1021/ct3002128 · 2012 · External reference
Virus Capsid Dissolution Studied by Microsecond Molecular Dynamics Simulations
10.1371/journal.pcbi.1002502 · 2012 · External reference
Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis
10.1371/journal.pbio.3001015 · 2020 · External reference
Details of charge distribution in stable viral capsid
10.1016/j.molliq.2018.06.019 · 2018 · External reference
Rational design and experimental evaluation of peptide ligands for the purification of adeno-associated viruses via affinity chromatography
10.1002/biot.202300230 · 2024 · External reference
Studying the ssDNA loaded adeno-associated virus aggregation using coarse-grained molecular dynamics simulations
10.1016/j.ijpharm.2024.123985 · 2024 · External reference
Impact of salt on AAV8 capsid aggregation with single-stranded DNA: insights from coarse-grained molecular dynamics simulations
10.1016/j.ijpharm.2025.125867 · 2025 · External reference
Divergent engagements between adeno-associated viruses with their cellular receptor AAVR
10.1038/s41467-019-11668-x · 2019 · External reference
Production and characterization of an AAV1-VP3-only capsid: An analytical benchmark standard
10.1016/j.omtm.2023.05.002 · 2023 · External reference
The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy
10.1073/pnas.162250899 · 2002 · External reference
Adeno-associated virus 2 bound to its cellular receptor AAVR
10.1038/s41564-018-0356-7 · 2019 · External reference
Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging
10.1128/jvi.00575-16 · 2016 · External reference
Atomic structure of a rationally engineered gene delivery vector, AAV2.5
10.1016/j.jsb.2018.05.004 · 2018 · External reference
Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant
10.1038/s41467-018-06076-6 · 2018 · External reference
Structural and functional insights of the catalytic GH5 and Calx-β domains from the metagenome-derived endoglucanase CelE2
10.1016/j.enzmictec.2023.110206 · 2023 · External reference
The structure of adeno-associated virus serotype 3B (AAV-3B): Insights into receptor binding and immune evasion
10.1016/j.virol.2010.03.027 · 2010 · External reference
Cellular and structural characterisation of VP1 and VP2 knockout mutants of AAV3B serotype and implications for AAV manufacturing
10.1089/hum.2022.119 · 2022 · External reference
Cryo-EM structure of adeno-associated virus 4 at 2.2 Å resolution
10.1107/s2059798322012190 · 2023 · External reference
Structurally Mapping the Diverse Phenotype of Adeno-Associated Virus Serotype 4
10.1128/jvi.01536-06 · 2006 · External reference
The Structure of an AAV5-AAVR Complex at 2.5 Å Resolution: Implications for Cellular Entry and Immune Neutralization of AAV Gene Therapy Vectors
10.3390/v12111326 · 2020 · External reference
Structure–function analysis of receptor-binding in adeno-associated virus serotype 6 (AAV-6)
10.1016/j.virol.2011.08.011 · 2011 · External reference
Structural Characterization of the Dual Glycan Binding Adeno-Associated Virus Serotype 6
10.1128/jvi.01235-10 · 2010 · External reference
Completion of the AAV Structural Atlas: Serotype Capsid Structures Reveals Clade-Specific Features
10.3390/v13010101 · 2021 · External reference
Structure of Adeno-Associated Virus Serotype 8, a Gene Therapy Vector
10.1128/jvi.01304-07 · 2007 · External reference
Structural Studies of Adeno-Associated Virus Serotype 8 Capsid Transitions Associated with Endosomal Trafficking
10.1128/jvi.05305-11 · 2011 · External reference
Methods Matter: Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct Vectors
10.1016/j.omtm.2020.05.018 · 2020 · External reference
An adeno-associated virus variant enabling efficient ocular-directed gene delivery across species
10.1038/s41467-024-48221-4 · 2024 · External reference
Structural Insight into the Unique Properties of Adeno-Associated Virus Serotype 9
10.1128/jvi.07232-11 · 2012 · External reference
Adeno-associated Virus 9 Structural Rearrangements Induced by Endosomal Trafficking pH and Glycan Attachment
10.1128/jvi.00843-21 · 2021 · External reference
Selection and evaluation of clinically relevant AAV variants in a xenograft liver model
10.1038/nature12875 · 2014 · External reference
Age-Related Seroprevalence of Antibodies Against AAV-LK03 in a UK Population Cohort
10.1089/hum.2018.098 · 2019 · External reference
lDDT: a local superposition-free score for comparing protein structures and models using distance difference tests
10.1093/bioinformatics/btt473 · 2013 · External reference
AlphaFold2 models indicate that protein sequence determines both structure and dynamics
2022 · External reference
Unresolved reference
2016 · External reference
Preferential exclusion chromatography as a capture step for extracellular AAV harvest from adherent and suspension productions
10.1002/elps.202300038 · 2023 · External reference
High-Density Recombinant Adeno-Associated Viral Particles are Competent Vectors for In Vivo Transduction
10.1089/hum.2016.055 · 2016 · External reference
Enhancement of recombinant adeno-associated virus activity by improved stoichiometry and homogeneity of capsid protein assembly
10.1016/j.omtm.2023.101142 · 2023 · External reference
Unresolved reference
2022 · External reference
Unresolved reference
2025 · External reference
A Molecular View of the Dynamics of dsDNA Packing Inside Viral Capsids in the Presence of Ions
10.1016/j.bpj.2017.02.015 · 2017 · External reference
Osmotic Shock and the Strength of Viral Capsids
10.1016/s0006-3495(03)74455-5 · 2003 · External reference
Influence of Structural Details in Modeling Electrostatically Driven Protein Adsorption
10.1021/la970608u · 1997 · External reference
Unified superresolution experiments and stochastic theory provide mechanistic insight into protein ion-exchange adsorptive separations
10.1073/pnas.1318405111 · 2014 · External reference
Electrostatic Contributions to Protein Retention in Ion-Exchange Chromatography. 2. Proteins with Various Degrees of Structural Differences
10.1021/ac048733f · 2005 · External reference
Characterization of Adeno-Associated Virus Capsid Proteins Using Hydrophilic Interaction Chromatography Coupled with Mass Spectrometry
10.1016/j.jpba.2020.113481 · 2020 · External reference
Characterizing Glycosylation of Adeno-Associated Virus Serotype 9 Capsid Proteins Generated from HEK293 Cells through Glycopeptide Mapping and Released Glycan Analysis
10.3390/microorganisms12050946 · 2024 · External reference
Recombinant AAV genome size effect on viral vector production, purification, and thermostability
10.1016/j.omtm.2024.101188 · 2024 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
CHARMM36m: an improved force field for folded and intrinsically disordered proteins
10.1038/nmeth.4067 · 2017 · External reference
Improved Treatment of the Protein Backbone in Empirical Force Fields
10.1021/ja036959e · 2004 · External reference
A modified TIP3P water potential for simulation with Ewald summation
10.1063/1.1808117 · 2004 · External reference
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Scalable molecular dynamics on CPU and GPU architectures with NAMD
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Exploring Multidimensional Free Energy Landscapes Using Time-Dependent Biases on Collective Variables
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MDAnalysis: A Python Package for the Rapid Analysis of Molecular Dynamics Simulations
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Improvements to the APBS biomolecular solvation software suite
10.1002/pro.3280 · 2018 · External reference
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