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References from RAAVioli: A comprehensive approach to characterizing AAV vector integrations and rearrangements. Local targets link to admitted publications; unresolved targets remain external evidence.
Adeno-associated virus vector as a platform for gene therapy delivery
10.1038/s41573-019-0012-9 · 2019 · External reference
Emerging Issues in AAV-Mediated In Vivo Gene Therapy
10.1016/j.omtm.2017.11.007 · 2018 · External reference
Phase I open label liver-directed gene therapy clinical trial for acute intermittent porphyria
10.1016/j.jhep.2016.05.012 · 2016 · External reference
A largely random AAV integration profile after LPLD gene therapy
10.1038/nm.3230 · 2013 · External reference
In Utero Transfer of Adeno-Associated Viral Vectors Produces Long-Term Factor IX Levels in a Cynomolgus Macaque Model
10.1016/j.ymthe.2017.04.003 · 2017 · External reference
Safety and liver transduction efficacy of rAAV5-cohPBGD in nonhuman primates: a potential therapy for acute intermittent porphyria
10.1089/hum.2013.166 · 2013 · External reference
Recombinant AAV Integration Is Not Associated With Hepatic Genotoxicity in Nonhuman Primates and Patients
10.1038/mt.2016.52 · 2016 · External reference
Intrathymic AAV delivery results in therapeutic site-specific integration at TCR loci
2023 · External reference
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells
10.1016/j.stem.2022.09.001 · 2022 · External reference
Evaluating the state of the science for adeno-associated virus integration: An integrated perspective
10.1016/j.ymthe.2022.06.004 · 2022 · External reference
Adeno-associated virus vector integration
2009 · External reference
Adeno-associated virus vectors integrate at chromosome breakage sites
10.1038/ng1380 · 2004 · External reference
Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo
10.1128/jvi.75.15.6969-6976.2001 · 2001 · External reference
AAV integration in human hepatocytes
10.1016/j.ymthe.2021.08.031 · 2021 · External reference
Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy
10.1172/jci79213 · 2015 · External reference
Isolation of recombinant adeno-associated virus vector-cellular DNA junctions from mouse liver
10.1128/jvi.73.7.5438-5447.1999 · 1999 · External reference
AAV serotype 2 vectors preferentially integrate into active genes in mice
10.1038/ng1179 · 2003 · External reference
Integration frequency and intermolecular recombination of rAAV vectors in non-human primate skeletal muscle and liver
10.1038/mt.2012.47 · 2012 · External reference
Genotoxicity in Mice Following AAV Gene Delivery: A Safety Concern for Human Gene Therapy?
10.1038/mt.2016.17 · 2016 · External reference
Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas
10.1038/ng.3389 · 2015 · External reference
Molecular evaluation and vector integration analysis of HCC complicating AAV gene therapy for hemophilia B
10.1182/bloodadvances.2023009876 · 2023 · External reference
Adeno-associated virus in the liver: natural history and consequences in tumour development
10.1136/gutjnl-2019-318281 · 2020 · External reference
High levels of AAV vector integration into CRISPR-induced DNA breaks
10.1038/s41467-019-12449-2 · 2019 · External reference
Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy
10.1038/s41591-019-0344-3 · 2019 · External reference
Integrated vector genomes may contribute to long-term expression in primate liver after AAV administration
10.1038/s41587-023-01974-7 · 2024 · External reference
VIRUSBreakend: Viral Integration Recognition Using Single Breakends
10.1093/bioinformatics/btab343 · 2021 · External reference
ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer
10.1093/nar/gky180 · 2018 · External reference
VERSE: a novel approach to detect virus integration in host genomes through reference genome customization
10.1186/s13073-015-0126-6 · 2015 · External reference
Isling: A Tool for Detecting Integration of Wild-Type Viruses and Clinical Vectors
10.1016/j.jmb.2021.167408 · 2022 · External reference
INSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes
10.1016/j.omtm.2016.11.002 · 2017 · External reference
ITR-Seq, a next-generation sequencing assay, identifies genome-wide DNA editing sites in vivo following adeno-associated viral vector-mediated genome editing
10.1186/s12864-020-6655-4 · 2020 · External reference
VSeq-Toolkit: Comprehensive Computational Analysis of Viral Vectors in Gene Therapy
10.1016/j.omtm.2020.03.024 · 2020 · External reference
INSERT-seq enables high-resolution mapping of genomically integrated DNA using Nanopore sequencing
10.1186/s13059-022-02778-9 · 2022 · External reference
A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells
10.1038/s41587-020-0741-7 · 2021 · External reference
Retrieval of vector integration sites from cell-free DNA
10.1038/s41591-021-01389-4 · 2021 · External reference
Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies
10.1038/s41591-024-03478-6 · 2025 · External reference
Sleeping Beauty-engineered CAR T cells achieve antileukemic activity without severe toxicities
10.1172/jci138473 · 2020 · External reference
GREAT improves functional interpretation of cis-regulatory regions
10.1038/nbt.1630 · 2010 · External reference
Estimating abundances of retroviral insertion sites from DNA fragment length data
10.1093/bioinformatics/bts004 · 2012 · External reference
Long-term lineage commitment in haematopoietic stem cell gene therapy
10.1038/s41586-024-08250-x · 2024 · External reference
Hematopoietic Stem- and Progenitor-Cell Gene Therapy for Hurler Syndrome
10.1056/nejmoa2106596 · 2021 · External reference
A case of T-cell acute lymphoblastic leukemia in retroviral gene therapy for ADA-SCID
10.1038/s41467-024-47866-5 · 2024 · External reference
Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver
10.1128/jvi.79.6.3606-3614.2005 · 2005 · External reference
Non-homologous DNA end joining and alternative pathways to double-strand break repair
10.1038/nrm.2017.48 · 2017 · External reference
Adeno-Associated Virus Type 2 Wild-Type and Vector-Mediated Genomic Integration Profiles of Human Diploid Fibroblasts Analyzed by Third-Generation PacBio DNA Sequencing
10.1128/jvi.01356-14 · 2014 · External reference
Accuracy of Next Generation Sequencing Platforms
2014 · External reference
Benchmarking of long-read correction methods
10.1093/nargab/lqaa037 · 2020 · External reference
Efficient prime editing in mouse brain, liver and heart with dual AAVs
10.1038/s41587-023-01758-z · 2024 · External reference
Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci
10.1038/s41587-024-02137-y · 2025 · External reference
Nanopore sequencing technology, bioinformatics and applications
10.1038/s41587-021-01108-x · 2021 · External reference
