Research graph
References from Normothermic perfusion of human livers for profiling lentiviral vector pharmacokinetics and transduction. Local targets link to admitted publications; unresolved targets remain external evidence.
Viral vector platforms within the gene therapy landscape
10.1038/s41392-021-00487-6 · 2021 · External reference
Unresolved reference
2025 · External reference
Adeno-associated virus antibody profiles in newborns, children, and adolescents
10.1128/cvi.05107-11 · 2011 · External reference
Worldwide epidemiology of neutralizing antibodies to adeno-associated viruses
10.1086/595830 · 2009 · External reference
Global Seroprevalence of Pre-existing Immunity Against AAV5 and Other AAV Serotypes in People with Hemophilia A
10.1089/hum.2021.287 · 2022 · External reference
VSV-G pseudotyped lentiviral vector particles produced in human cells are inactivated by human serum
10.1006/mthe.2000.0116 · 2000 · External reference
Genome editing for scalable production of alloantigen-free lentiviral vectors for in vivo gene therapy
10.15252/emmm.201708148 · 2017 · External reference
Vesiculovirus neutralization by natural IgM and complement
10.1128/jvi.00074-14 · 2014 · External reference
Unresolved reference
2025 · External reference
In vivo CAR T cells move into clinical trials
10.1038/d41573-024-00150-z · 2024 · External reference
Developmental and Inherited Liver Disease
2018 · External reference
Rapid and efficient clearance of blood-borne virus by liver sinusoidal endothelium
10.1371/journal.ppat.1002281 · 2011 · External reference
Development of alternative gene transfer techniques for ex vivo and in vivo gene therapy in a canine model
10.1016/j.reth.2021.08.009 · 2021 · External reference
In vivo lentiviral vector gene therapy to cure hereditary tyrosinemia type 1 and prevent development of precancerous and cancerous lesions
10.1038/s41467-022-32576-7 · 2022 · External reference
Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates
10.1038/s41467-022-30102-3 · 2022 · External reference
Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects
10.1007/s10545-017-0053-3 · 2017 · External reference
Parsing clinical success rates
2016 · External reference
Phase II and phase III failures: 2013-2015
10.1038/nrd.2016.184 · 2016 · External reference
A randomized trial of normothermic preservation in liver transplantation
10.1038/s41586-018-0047-9 · 2018 · External reference
Harnessing whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation
10.1038/s41467-024-46194-y · 2024 · External reference
AAV capsid prioritization in normal and steatotic human livers maintained by machine perfusion
10.1038/s41587-024-02523-6 · 2025 · External reference
Development of Clinical Criteria for Functional Assessment to Predict Primary Nonfunction of High-Risk Livers Using Normothermic Machine Perfusion
10.1002/lt.25291 · 2018 · External reference
Structure, Function, and Responses to Injury
2018 · External reference
Assessment of Deceased Brain Dead Donor Liver Grafts via Normothermic Machine Perfusion: Lactate Clearance Time Threshold Can Be Safely Extended to 6 Hours
10.1002/lt.26317 · 2022 · External reference
Unresolved reference
2023 · External reference
Normothermic Machine Perfusion of Donor Livers for Transplantation in the United States: A Randomized Controlled Trial
10.1097/sla.0000000000005934 · 2023 · External reference
Unresolved reference
2025 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
An integrated perfusion machine preserves injured human livers for 1 week
10.1038/s41587-019-0374-x · 2020 · External reference
Normothermic Perfusion in the Assessment and Preservation of Declined Livers Before Transplantation: Hyperoxia and Vasoplegia-Important Lessons From the First 12 Cases
10.1097/tp.0000000000001661 · 2017 · External reference
Observations on the ex situ perfusion of livers for transplantation
10.1111/ajt.14687 · 2018 · External reference
24-hour normothermic machine perfusion of discarded human liver grafts: Case series single-center study
2023 · External reference
Blood alanine aminotransferase levels >1,000 IU/l - causes and outcomes
10.7861/clinmedicine.15-3-244 · 2015 · External reference
Enhancing titers of therapeutic lentiviral vectors using PKC agonists
10.1016/j.omtm.2025.101484 · 2025 · External reference
Quantitation of Integrated HIV Provirus by Pulsed-Field Gel Electrophoresis and Droplet Digital PCR
10.1128/jcm.01158-18 · 2018 · External reference
The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases
10.1186/s40164-024-00527-1 · 2024 · External reference
Graphene Oxide Causes Disordered Zonation Due to Differential Intralobular Localization in the Liver
10.1021/acsnano.9b08127 · 2020 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
The Molecular Signatures Database (MSigDB) hallmark gene set collection
10.1016/j.cels.2015.12.004 · 2015 · External reference
Molecular signatures database (MSigDB) 3.0
10.1093/bioinformatics/btr260 · 2011 · External reference
Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial
10.1097/sla.0000000000003540 · 2019 · External reference
Transplantation of discarded livers following viability testing with normothermic machine perfusion
10.1038/s41467-020-16251-3 · 2020 · External reference
Long-term normothermic perfusion of human livers for longer than 12 days
10.1111/aor.14372 · 2022 · External reference
LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus
10.1073/pnas.1214441110 · 2013 · External reference
Kupffer cells and not liver sinusoidal endothelial cells prevent lentiviral transduction of hepatocytes
10.1016/j.ymthe.2004.09.012 · 2005 · External reference
Enhancing the potency of in vivo lentiviral vector mediated gene therapy to hepatocytes
10.1038/s41467-025-60073-0 · 2025 · External reference
Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates
10.1126/scitranslmed.aav7325 · 2019 · External reference
Effects of vector backbone and pseudotype on lentiviral vector-mediated gene transfer: studies in infant ADA-deficient mice and rhesus monkeys
10.1038/mt.2014.88 · 2014 · External reference
Micromorphological characteristics of hepatic sinusoidal endothelial cells and their basal laminae in five different animal species
10.2535/ofaj.79.135 · 2002 · External reference
Kinetics of lentiviral vector transduction in human CD34(+) cells
10.1016/j.exphem.2015.10.003 · 2016 · External reference
Enhanced gene expression conferred by stepwise modification of a nonprimate lentiviral vector
10.1089/hum.2006.127 · 2007 · External reference
Assembly of hepatitis B virus envelope proteins onto a lentivirus pseudotype that infects primary human hepatocytes
10.1128/jvi.00959-07 · 2007 · External reference
Prolonged liver-specific transgene expression by a non-primate lentiviral vector
10.1016/j.bbrc.2004.06.044 · 2004 · External reference
Deciphering the Ets-1/2-mediated transcriptional regulation of F8 gene identifies a minimal F8 promoter for hemophilia A gene therapy
10.3324/haematol.2019.239202 · 2021 · External reference
Elements of lentiviral vector design toward gene therapy for treating mucopolysaccharidosis I
2016 · External reference
The Effect of Normothermic Machine Perfusion on the Immune Profile of Donor Liver
2022 · External reference
In-vivo B-cell maturation antigen CAR T-cell therapy for relapsed or refractory multiple myeloma
10.1016/s0140-6736(25)01030-x · 2025 · External reference
Interleukin-6 and the acute phase response
10.1042/bj2650621 · 1990 · External reference
The role of IL-6 in host defence against infections: immunobiology and clinical implications
10.1038/nrrheum.2017.83 · 2017 · External reference
AST 17600 U/l after liver transplantation, what are you up to? - A case report
10.12659/aot.883910 · 2013 · External reference
Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease
10.1002/hep.22109 · 2008 · External reference
Perfusion settings and additives in liver normothermic machine perfusion with red blood cells as oxygen carrier. A systematic review of human and porcine perfusion protocols
10.1111/tri.13306 · 2018 · External reference
Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration
10.1002/hep.30475 · 2019 · External reference
The spleen in local and systemic regulation of immunity
10.1016/j.immuni.2013.10.010 · 2013 · External reference
Long-term ex situ normothermic perfusion of human split livers for more than 1 week
10.1038/s41467-023-40154-8 · 2023 · External reference
Prolonged Ex Vivo Normothermic Perfusion of a Split Liver: An Innovative Approach to Increase the Number of Available Grafts
10.1097/txd.0000000000001216 · 2021 · External reference
Unresolved reference
2024 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
NIH Image to ImageJ: 25 years of image analysis
10.1038/nmeth.2089 · 2012 · External reference
Near-optimal probabilistic RNA-seq quantification
10.1038/nbt.3519 · 2016 · External reference
Ensembl 2025
10.1093/nar/gkae1071 · 2025 · External reference
Hsapiens.v86: Bioconductor annotation package
2025 · External reference
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
10.1038/ng1180 · 2003 · External reference
