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References from Humanized mice enable in vivo evaluation of engineered plasma cell biology and therapeutic function. Local targets link to admitted publications; unresolved targets remain external evidence.
Management of toxicities associated with novel immunotherapy agents in acute lymphoblastic leukemia
10.1177/2040620719899897 · 2020 · External reference
Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems
10.1038/s41573-023-00670-0 · 2023 · External reference
Improving treatment adherence in patients with rheumatoid arthritis: what are the options?
10.2217/ijr.15.39 · 2015 · External reference
Antibody-based protection against HIV infection by vectored immunoprophylaxis
10.1038/nature10660 · 2011 · External reference
In Vivo Production of Monoclonal Antibodies by Gene Transfer via Electroporation Protects against Lethal Influenza and Ebola Infections
10.1016/j.omtm.2017.09.003 · 2017 · External reference
Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys
10.1038/nm.1967 · 2009 · External reference
Lentiviral gene therapy with CD34+ hematopoietic cells for hemophilia A
10.1056/nejmoa2410597 · 2025 · External reference
Reprogramming the antigen specificity of B cells using genome-editing technologies
10.7554/elife.42995 · 2019 · External reference
Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion
10.1038/s41467-020-19649-1 · 2020 · External reference
HIV-specific humoral immune responses by CRISPR/Cas9-edited B cells
10.1084/jem.20190287 · 2019 · External reference
Vaccine Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B cells
10.1038/s41467-020-19650-8 · 2020 · External reference
B cells engineered to express pathogen-specific antibodies protect against infection
10.1126/sciimmunol.aax0644 · 2019 · External reference
Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration
10.1038/s41419-020-03187-1 · 2020 · External reference
Lifetime of plasma cells in the bone marrow
10.1038/40540 · 1997 · External reference
Duration of humoral immunity to common viral and vaccine antigens
10.1056/nejmoa066092 · 2007 · External reference
Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring
10.1038/nbt.3964 · 2017 · External reference
Competence and competition: the challenge of becoming a long-lived plasma cell
10.1038/nri1886 · 2006 · External reference
Limiting dilution analysis of the B cell compartment in human bone marrow
10.1002/eji.1830160206 · 1986 · External reference
Ex vivo engineered human plasma cells exhibit robust protein secretion and long-term engraftment in vivo
10.1038/s41467-022-33787-8 · 2022 · External reference
Human plasma cells engineered to secrete bispecifics drive effective in vivo leukemia killing
10.1016/j.ymthe.2024.06.004 · 2024 · External reference
B cells as drug factories
10.1038/s41587-024-02283-3 · 2024 · External reference
Engineering Protein-Secreting Plasma Cells by Homology-Directed Repair in Primary Human B Cells
10.1016/j.ymthe.2017.11.012 · 2018 · External reference
Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/gammac-/-Balb/c-Rag1-/-gammac-/-and C.B-17-scid/bg immunodeficient mice
10.1016/j.humimm.2009.06.005 · 2009 · External reference
The Bone Marrow as Sanctuary for Plasma Cells and Memory T-Cells: Implications for Adaptive Immunity and Vaccinology
10.3390/cells10061508 · 2021 · External reference
Macrophages induce differentiation of plasma cells through CXCL10/IP-10
10.1084/jem.20112142 · 2012 · External reference
Humoral immunity in humanized mice: a work in progress
10.1093/infdis/jit448 · 2013 · External reference
BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
10.1172/jci18025 · 2003 · External reference
BAFF bestows longevity on splenic plasma cells
10.1182/blood-2018-02-832089 · 2018 · External reference
BCMA is essential for the survival of long-lived bone marrow plasma cells
10.1084/jem.20031330 · 2004 · External reference
IL-6 supports the generation of human long-lived plasma cells in combination with either APRIL or stromal cell-soluble factors
10.1038/leu.2014.61 · 2014 · External reference
IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
10.4049/jimmunol.175.12.7867 · 2005 · External reference
Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage
10.3389/fimmu.2014.00065 · 2014 · External reference
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells
10.4049/jimmunol.174.10.6477 · 2005 · External reference
Improved multilineage human hematopoietic reconstitution and function in NSGS mice
10.1371/journal.pone.0209034 · 2018 · External reference
An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus
10.1016/j.immuni.2018.03.026 · 2018 · External reference
The presence of clonogenic cells in high-grade malignant lymphoma: a prognostic factor
10.1182/blood.v69.5.1307.1307 · 1987 · External reference
BCR signaling is required for posttransplant lymphoproliferative disease in immunodeficient mice receiving human B cells
10.1126/scitranslmed.adh8846 · 2024 · External reference
IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2
2022 · External reference
Functional engraftment of human peripheral T and B cells and sustained production of autoantibodies in NOD/LtSzscid/IL-2Rγ(-/-) mice
10.1002/eji.201444729 · 2014 · External reference
Production of therapeutic levels of human FIX-R338L by engineered B cells using GMP-compatible medium
10.1016/j.omtm.2023.101111 · 2023 · External reference
The establishment of the plasma cell survival niche in the bone marrow
10.1111/imr.12011 · 2013 · External reference
Humoral immunity due to long-lived plasma cells
10.1016/s1074-7613(00)80541-5 · 1998 · External reference
Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan
10.1016/j.immuni.2023.04.015 · 2023 · External reference
Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow
10.1084/jem.20221717 · 2023 · External reference
Monocytes derived from humanized neonatal NOD/SCID/IL2Rγ(null) mice are phenotypically immature and exhibit functional impairments
10.1016/j.humimm.2012.01.006 · 2012 · External reference
Human hemato-lymphoid system mice: current use and future potential for medicine
10.1146/annurev-immunol-032712-095921 · 2013 · External reference
In vivo tracking of ex-vivo-generated 89Zr-oxine-labeled plasma cells by PET in a non-human primate model
10.1016/j.ymthe.2024.12.042 · 2025 · External reference
Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding
10.1074/jbc.m109.081828 · 2010 · External reference
FcγRII (CD32) modulates antibody clearance in NOD SCID mice leading to impaired antibody-mediated tumor cell deletion
10.1136/jitc-2020-000619 · 2020 · External reference
Mouse strains influence clearance and efficacy of antibody and antibody-drug conjugate via Fc-FcγR interaction
10.1158/1535-7163.mct-18-0977 · 2019 · External reference
Crosstalk between human IgG isotypes and murine effector cells
10.4049/jimmunol.1200356 · 2012 · External reference
Antibody-dependent cellular phagocytosis by macrophages is a novel mechanism of action of elotuzumab
10.1158/1535-7163.mct-17-0998 · 2018 · External reference
Enhanced development of functional human NK cells in NOD-scid-IL2rgnull mice expressing human IL15
10.1096/fj.202200045r · 2022 · External reference
Human Hematopoietic Stem Cell Engrafted IL-15 Transgenic NSG Mice Support Robust NK Cell Responses and Sustained HIV-1 Infection
10.3390/v15020365 · 2023 · External reference
NK Cell-Fc Receptors Advance Tumor Immunotherapy
10.3390/jcm8101667 · 2019 · External reference
Complement lytic activity has no role in the pathogenesis of autoimmune diabetes in NOD mice
10.2337/diab.42.11.1574 · 1993 · External reference
A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo
10.1016/j.jim.2017.03.021 · 2017 · External reference
Kit regulates HSC engraftment across the human-mouse species barrier
10.1016/j.stem.2014.06.001 · 2014 · External reference
A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses
10.1038/s41590-024-01880-3 · 2024 · External reference
LysRS serves as a key signaling molecule in the immune response by regulating gene expression
10.1016/j.molcel.2009.05.019 · 2009 · External reference
Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein
10.1083/jcb.104.3.761 · 1987 · External reference
Engineering a therapeutic IgG molecule to address cysteinylation, aggregation and enhance thermal stability and expression
10.4161/mabs.23392 · 2013 · External reference
Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions
10.1093/protein/gzs042 · 2012 · External reference
Antibody production relies on the tRNA inosine wobble modification to meet biased codon demand
10.1126/science.adi1763 · 2024 · External reference
SEC-seq: association of molecular signatures with antibody secretion in thousands of single human plasma cells
10.1038/s41467-023-39367-8 · 2023 · External reference
A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection
10.4049/jimmunol.2000583 · 2020 · External reference
Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19
10.1016/j.cell.2020.11.029 · 2021 · External reference
2FAST2Q: a general-purpose sequence search and counting program for FASTQ files
10.7717/peerj.14041 · 2022 · External reference
Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays
10.3390/v12050513 · 2020 · External reference