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References from Capsid-engineered AAV vector overcomes a key intracellular barrier and efficiently transduces spiral ganglion neurons in adult mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2021 · External reference
Hearing, Cognition, and Healthy Aging: Social and Public Health Implications of the Links between Age-Related Declines in Hearing and Cognition
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Correlation of Electrically Evoked Compound Action Potential Amplitude Growth Function Slope and Anamnestic Parameters in Cochlear Implant Patients—Identification of Predictors for the Neuronal Health Status
10.3390/life11030203 · 2021 · External reference
Age at Intervention for Permanent Hearing Loss and 5-Year Language Outcomes
10.1542/peds.2016-4274 · 2017 · External reference
A Retrospective Multicenter Study Comparing Speech Perception Outcomes for Bilateral Implantation and Bimodal Rehabilitation
10.1097/aud.0000000000000150 · 2015 · External reference
A Prospective Longitudinal Study of U.S. Children Unable to Achieve Open-Set Speech Recognition 5 Years After Cochlear Implantation
10.1097/mao.0000000000000723 · 2015 · External reference
Factors affecting open-set word recognition in adults with cochlear implants
10.1097/aud.0b013e3182741aa7 · 2013 · External reference
Role of BDNF and neurotrophic receptors in human inner ear development
10.1007/s00441-017-2686-9 · 2017 · External reference
Relationship Between Serum Brain-Derived Neurotrophic Factor and Neurotrophin-3 Levels and Hearing Thresholds in Patients With Age-Related Hearing Loss
10.1044/2024_jslhr-23-00440 · 2024 · External reference
Detection of BDNF-Related Proteins in Human Perilymph in Patients With Hearing Loss
10.3389/fnins.2019.00214 · 2019 · External reference
The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration
10.3390/jpm13040652 · 2023 · External reference
AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial
10.1016/s0140-6736(23)02874-x · 2024 · External reference
Neurotrophin gene therapy to promote survival of spiral ganglion neurons after deafness
10.1016/j.heares.2020.107955 · 2020 · External reference
Gene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate
10.1016/j.omtm.2018.11.003 · 2018 · External reference
Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP
10.1016/j.heares.2020.107882 · 2020 · External reference
Transduction of adeno-associated virus vectors targeting hair cells and supporting cells in the neonatal mouse cochlea
10.3389/fncel.2019.00008 · 2019 · External reference
Preclinical testing of AAV9-PHP.B for transgene expression in the non-human primate cochlea
10.1016/j.heares.2020.107930 · 2020 · External reference
AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear
10.1016/j.omtm.2021.03.019 · 2021 · External reference
Delivering AAV to the central nervous and sensory systems
10.1016/j.tips.2021.03.004 · 2021 · External reference
AAV2.7m8 is a powerful viral vector for inner ear gene therapy
10.1038/s41467-018-08243-1 · 2019 · External reference
Hair Cell Transduction Efficiency of Single- and Dual-AAV Serotypes in Adult Murine Cochleae
10.1016/j.omtm.2020.05.007 · 2020 · External reference
Screened AAV variants permit efficient transduction access to supporting cells and hair cells
10.1038/s41421-019-0115-9 · 2019 · External reference
AAV-ie enables safe and efficient gene transfer to inner ear cells
10.1038/s41467-019-11687-8 · 2019 · External reference
Delivery of Adeno-Associated Virus Vectors in Adult Mammalian Inner-Ear Cell Subtypes Without Auditory Dysfunction
10.1089/hum.2017.120 · 2018 · External reference
AAV-ie-K558R mediated cochlear gene therapy and hair cell regeneration
10.1038/s41392-022-00938-8 · 2022 · External reference
Adeno-associated virus-mediated gene delivery into the scala media of the normal and deafened adult mouse ear
10.1038/gt.2010.175 · 2011 · External reference
Towards the Clinical Application of Gene Therapy for Genetic Inner Ear Diseases
10.3390/jcm12031046 · 2023 · External reference
Engineering adeno-associated virus vectors for gene therapy
10.1038/s41576-019-0205-4 · 2020 · External reference
Adeno-associated virus structural biology as a tool in vector development
10.2217/fvl.13.112 · 2013 · External reference
Heparin binding induces conformational changes in Adeno-associated virus serotype 2
10.1016/j.jsb.2008.12.002 · 2009 · External reference
Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors
10.1128/jvi.74.6.2777-2785.2000 · 2000 · External reference
Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors
10.1128/jvi.78.6.3110-3122.2004 · 2004 · External reference
Vector uncoating limits adeno-associated viral vector-mediated transduction of human dendritic cells and vector immunogenicity
10.1038/s41598-019-40071-1 · 2019 · External reference
Engineering adeno-associated virus serotype 2-based targeting vectors using a new insertion site-position 453-and single point mutations
10.1002/jgm.1392 · 2009 · External reference
Modifying immune responses to adeno-associated virus vectors by capsid engineering
10.1016/j.omtm.2023.08.015 · 2023 · External reference
Establishment and characterization of conditionally immortalized organ of corti cell lines
10.1006/cbir.1998.0339 · 1999 · External reference
Cell lines in inner ear research
10.1002/neu.10111 · 2002 · External reference
Working with Auditory HEI-OC1 Cells
2016 · External reference
Molecular characterization of the heparin-dependent transduction domain on the capsid of a novel adeno-associated virus isolate, AAV(VR-942)
10.1128/jvi.00672-08 · 2008 · External reference
Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding
10.1128/jvi.77.12.6995-7006.2003 · 2003 · External reference
Successful target cell transduction of capsid-engineered rAAV vectors requires clathrin-dependent endocytosis
10.1038/gt.2011.78 · 2011 · External reference
A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear
10.1038/nbt.3781 · 2017 · External reference
Distributional comparison of different AAV vectors after unilateral cochlear administration
10.1038/s41434-023-00431-z · 2023 · External reference
Hearing of Otof-deficient mice restored by trans-splicing of N- and C-terminal otoferlin
10.1007/s00439-022-02504-2 · 2023 · External reference
Capsid Engineering Overcomes Barriers Toward Adeno-Associated Virus Vector-Mediated Transduction of Endothelial Cells
10.1089/hum.2019.027 · 2019 · External reference
Adeno-associated virus type 2 (AAV2) uncoating is a stepwise process and is linked to structural reorganization of the nucleolus
10.1371/journal.ppat.1010187 · 2022 · External reference
Host determinants of adeno-associated viral vector entry
10.1016/j.coviro.2017.06.003 · 2017 · External reference
AAVR: A multi-serotype receptor for AAV
10.1038/mt.2016.49 · 2016 · External reference
Adeno-associated virus 2 bound to its cellular receptor AAVR
10.1038/s41564-018-0356-7 · 2019 · External reference
Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR
10.7554/elife.44707 · 2019 · External reference
Spiral ganglion neuron survival and function in the deafened cochlea following chronic neurotrophic treatment
10.1016/j.heares.2011.06.007 · 2011 · External reference
NT-3 and/or BDNF therapy prevents loss of auditory neurons following loss of hair cells
10.1097/00001756-199603220-00011 · 1996 · External reference
DB-OTO gene therapy for inherited deafness
2025 · External reference
Unresolved reference
External reference
Advances in gene therapy hold promise for treating hereditary hearing loss
10.1016/j.ymthe.2023.02.001 · 2023 · External reference
High-Throughput Method for Ranking the Affinity of Peptide Ligands Selected from Phage Display Libraries
10.1021/bc700279y · 2008 · External reference
Potential of phage-displayed peptide library technology to identify functional targeting peptides
10.1517/17460441.2.4.525 · 2007 · External reference
Phage Display of Random Peptide Libraries: Applications, Limits, and Potential
10.1081/rrs-120026973 · 2003 · External reference
Development of fetal hearing
10.1136/fn.71.2.f81 · 1994 · External reference
Scanning Thin-Sheet Laser Imaging Microscopy Elucidates Details on Mouse Ear Development
10.1002/dvdy.23736 · 2012 · External reference
Ontogeny of the acoustic startle response in C57BL/6J mouse pups
10.1037/h0077648 · 1980 · External reference
Gene Therapy in the Inner Ear Using Adenovirus Vectors
2009 · External reference
Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear In Vivo
10.1155/2016/9409846 · 2016 · External reference
Helper-dependent adenovirus-mediated gene transfer into the adult mouse cochlea
10.1097/mao.0b013e318158973f · 2007 · External reference
Gene transfer using bovine adeno-associated virus in the guinea pig cochlea
10.1038/gt.2009.57 · 2009 · External reference
HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage
10.1006/mthe.2001.0334 · 2001 · External reference
Axonal transport of adeno-associated viral vectors is serotype-dependent
10.1038/gt.2012.27 · 2013 · External reference
Retrograde capabilities of adeno-associated virus vectors in the central nervous system
10.5114/bta.2021.111111 · 2021 · External reference
Heparan Sulfate Binding Promotes Accumulation of Intravitreally Delivered Adeno-associated Viral Vectors at the Retina for Enhanced Transduction but Weakly Influences Tropism
10.1128/jvi.01568-16 · 2016 · External reference
Intravitreal injection of a rationally designed AAV capsid library in non-human primate identifies variants with enhanced retinal transduction and neutralizing antibody evasion
10.1016/j.ymthe.2023.10.001 · 2023 · External reference
Adeno-associated virus serotype 2 capsid variants for improved liver-directed gene therapy
10.1002/hep.32733 · 2023 · External reference
Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders
10.15252/emmm.202013392 · 2021 · External reference
Targeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness
10.2147/ijn.s77480 · 2015 · External reference
Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment
10.1523/jneurosci.08-08-02986.1988 · 1988 · External reference
BDNF-induced survival of auditory neurons in vivo: Cessation of treatment leads to accelerated loss of survival effects
10.1002/jnr.10542 · 2003 · External reference
Neurotrophins and their role in the cochlea
10.1016/j.heares.2012.03.002 · 2012 · External reference
Local magnetic delivery of adeno-associated virus AAV2(quad Y-F)-mediated BDNF gene therapy restores hearing after noise injury
10.1016/j.ymthe.2021.07.013 · 2022 · External reference
Improving Control of Gene Therapy-Based Neurotrophin Delivery for Inner Ear Applications
10.3389/fbioe.2022.892969 · 2022 · External reference
AAV-Mediated Neurotrophin Gene Therapy Promotes Improved Survival of Cochlear Spiral Ganglion Neurons in Neonatally Deafened Cats: Comparison of AAV2-hBDNF and AAV5-hGDNF
10.1007/s10162-019-00723-5 · 2019 · External reference
Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure
10.1038/srep24907 · 2016 · External reference
Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2
10.1038/12491 · 1999 · External reference
Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cells
10.1006/mthe.2001.0424 · 2001 · External reference
Adeno-associated virus serotypes 1 to 5 mediated tumor cell directed gene transfer and improvement of transduction efficiency
10.1002/jgm.782 · 2005 · External reference
Production of High-Titer Recombinant Adeno-Associated Virus Vectors in the Absence of Helper Adenovirus
10.1128/jvi.72.3.2224-2232.1998 · 1998 · External reference
A cochlear cell line as an in vitro system for drug ototoxicity screening
10.1159/000071059 · 2003 · External reference
Rosetta3: An Object-Oriented Software Suite for the Simulation and Design of Macromolecules
10.1016/b978-0-12-381270-4.00019-6 · 2011 · External reference
RosettaScripts: A Scripting Language Interface to the Rosetta Macromolecular Modeling Suite
10.1371/journal.pone.0020161 · 2011 · External reference
Alternate states of proteins revealed by detailed energy landscape mapping
10.1016/j.jmb.2010.11.008 · 2011 · External reference
Development and evaluation of GlycanDock: A protein–glycoligand docking refinement algorithm in Rosetta
10.1021/acs.jpcb.1c00910 · 2021 · External reference
UCSF ChimeraX: Structure visualization for researchers, educators, and developers
10.1002/pro.3943 · 2021 · External reference
Hearing Preservation Following Repeated Adenovector Delivery
10.1002/ar.24347 · 2020 · External reference
