Research graph
References from The first oral relaxin receptor RXFP1 agonist for heart failure treatment: Translational studies from non-human primates to humans. Local targets link to admitted publications; unresolved targets remain external evidence.
2022 AHA/ACC/HFSA Guideline for the management of heart failure: executive summary: a report of the American College of Cardiology/American Heart Association Joint Committee on clinical practice guidelines
2022 · External reference
10.1002/ejhf.2333
10.1002/ejhf.2333 · 2022 · External reference
Trends in survival after a diagnosis of heart failure in the United Kingdom 2000-2017: population based cohort study
2019 · External reference
Hormones and hemodynamics in heart failure
10.1056/nejm199908193410806 · 1999 · External reference
Screening for primary aldosteronism in pregnancy
10.1016/j.preghy.2021.06.005 · 2021 · External reference
Relaxin family peptides and their receptors
10.1152/physrev.00001.2012 · 2013 · External reference
Effects of relaxin on arterial dilation, remodeling, and mechanical properties
10.1007/s11906-011-0231-x · 2011 · External reference
Effects of volenrelaxin in worsening heart failure with preserved ejection fraction: a phase 2 randomized trial
10.1038/s41591-025-03939-6 · 2025 · External reference
RXFP1, the relaxin receptor: Lost and found in translation
10.1016/j.drudis.2025.104483 · 2025 · External reference
Effects of serelaxin in patients with acute heart failure
10.1056/nejmoa1801291 · 2019 · External reference
Discovery of clinical candidate AZD5462, a selective oral allosteric RXFP1 agonist for treatment of heart failure
10.1021/acs.jmedchem.3c02184 · 2024 · External reference
Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes
10.1038/s41467-021-22331-9 · 2021 · External reference
Imaging characterization of myocardial function, fibrosis, and perfusion in a nonhuman primate model with heart failure-like features
2023 · External reference
Replacement substance P reduces cardiac fibrosis in monkeys with type 2 diabetes
10.1016/j.biopha.2023.114365 · 2023 · External reference
A pig BodyMap transcriptome reveals diverse tissue physiologies and evolutionary dynamics of transcription
10.1038/s41467-021-23560-8 · 2021 · External reference
Emerging role of relaxin in the maternal adaptations to normal pregnancy: implications for preeclampsia
10.1016/j.semnephrol.2010.10.003 · 2011 · External reference
Relaxin family peptide receptors--from orphans to therapeutic targets
10.1016/j.drudis.2008.04.002 · 2008 · External reference
Active plasma renin concentration throughout healthy and complicated pregnancy: a systematic review and meta-analysis
10.1186/s12958-024-01200-2 · 2024 · External reference
Targeting glomerular hemodynamics for kidney protection
10.1053/j.akdh.2022.12.003 · 2023 · External reference
Classical renin-angiotensin system in kidney physiology
10.1002/j.2040-4603.2014.tb00567.x · 2014 · External reference
Renal hemodynamic effects of serelaxin in patients with chronic heart failure: a randomized, placebo-controlled study
10.1161/circheartfailure.114.001536 · 2014 · External reference
MR extracellular volume mapping and non-contrast T1rho mapping allow early detection of myocardial fibrosis in diabetic monkeys
10.1007/s00330-018-5950-9 · 2019 · External reference
A novel long-acting relaxin-2 fusion, AZD3427, improves cardiac performance in non-human primates with cardiac dysfunction
10.1093/cvr/cvaf031 · 2025 · External reference
A randomized, double-blind, placebo-controlled, multicentre study to assess haemodynamic effects of serelaxin in patients with acute heart failure
10.1093/eurheartj/eht459 · 2014 · External reference
Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial
10.1016/s0140-6736(12)61855-8 · 2013 · External reference
Aged monkeys fed a high-fat/high-sugar diet recapitulate metabolic disorders and cardiac contractile dysfunction
10.1007/s12265-021-10105-z · 2021 · External reference
