Research graph
References from Interrogating the dependency of AAV capsids on AAVR for retinal transduction. Local targets link to admitted publications; unresolved targets remain external evidence.
Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous
10.1038/mt.2009.181 · 2009 · External reference
The internal limiting membrane: Roles in retinal development and implications for emerging ocular therapies
10.1016/j.exer.2021.108545 · 2021 · External reference
Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020
10.1167/tvst.10.4.3 · 2021 · External reference
Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients
10.1167/iovs.17-22494 · 2018 · External reference
Analysis of immune deviation elicited by antigens injected into the subretinal space
1998 · External reference
A deviant immune response to viral proteins and transgene product is generated on subretinal administration of adenovirus and adeno-associated virus
10.1006/mthe.2002.0525 · 2002 · External reference
An Alternate Route for Adeno-associated Virus (AAV) Entry Independent of AAV Receptor
10.1128/jvi.02213-17 · 2018 · External reference
An essential receptor for adeno-associated virus infection
10.1038/nature16465 · 2016 · External reference
The Dyslexia-associated gene
10.1387/ijdb.230052pm · 2023 · External reference
Embryonic disruption of the candidate dyslexia susceptibility gene homolog Kiaa0319-like results in neuronal migration disorders
10.1016/j.neuroscience.2013.06.056 · 2013 · External reference
The KIAA0319-like (KIAA0319L) gene on chromosome 1p34 as a candidate for reading disabilities
10.1080/01677060802354328 · 2008 · External reference
Structural and cellular biology of adeno-associated virus attachment and entry
10.1016/bs.aivir.2020.01.002 · 2020 · External reference
Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression
10.1038/s41592-023-01896-x · 2023 · External reference
Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system
10.1016/j.ymthe.2004.05.024 · 2004 · External reference
Intravitreal Injection of AAV2 Transduces Macaque Inner Retina
10.1167/iovs.10-6250 · 2011 · External reference
A Comprehensive Review of Clinically Applied Adeno-Associated Virus-Based Gene Therapies for Ocular Disease
10.1089/hum.2024.252 · 2025 · External reference
Evaluation of Dose and Safety of AAV7m8 and AAV8BP2 in the Non-Human Primate Retina
10.1089/hum.2016.111 · 2017 · External reference
Heparan Sulfate Binding Promotes Accumulation of Intravitreally Delivered Adeno-associated Viral Vectors at the Retina for Enhanced Transduction but Weakly Influences Tropism
10.1128/jvi.01568-16 · 2016 · External reference
Impact of Heparan Sulfate Binding on Transduction of Retina by Recombinant Adeno-Associated Virus Vectors
10.1128/jvi.00200-16 · 2016 · External reference
The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9
10.1128/jvi.00878-06 · 2006 · External reference
Terminal N-linked galactose is the primary receptor for adeno-associated virus 9
10.1074/jbc.m110.210922 · 2011 · External reference
Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors
10.1073/pnas.0508214103 · 2006 · External reference
Light-driven cone arrestin translocation in cones of postnatal guanylate cyclase-1 knockout mouse retina treated with AAV-GC1
10.1167/iovs.06-0086 · 2006 · External reference
Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes
10.1128/jvi.01288-06 · 2006 · External reference
Rationally designed AAV2 and AAVrh8R capsids provide improved transduction in the retina and brain
10.1038/s41434-018-0017-8 · 2018 · External reference
Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6
10.1128/jvi.00895-06 · 2006 · External reference
Differential adeno-associated virus serotype-specific interaction patterns with synthetic heparins and other glycans
10.1128/jvi.03371-13 · 2014 · External reference
An alternate receptor for adeno-associated viruses
10.1016/j.cell.2025.06.026 · 2025 · External reference
Clades of Adeno-associated viruses are widely disseminated in human tissues
10.1128/jvi.78.12.6381-6388.2004 · 2004 · External reference
Adeno-associated Virus (AAV) Serotypes Have Distinctive Interactions with Domains of the Cellular AAV Receptor
10.1128/jvi.00391-17 · 2017 · External reference
Divergent engagements between adeno-associated viruses with their cellular receptor AAVR
10.1038/s41467-019-11668-x · 2019 · External reference
Adeno-associated virus 2 bound to its cellular receptor AAVR
10.1038/s41564-018-0356-7 · 2019 · External reference
Comprehensive biophysical characterization of AAV-AAVR interaction uncovers serotype- and pH-dependent interaction
10.1016/j.jpba.2023.115562 · 2023 · External reference
Safety and efficacy of ATSN-101 in patients with Leber congenital amaurosis caused by biallelic mutations in GUCY2D: a phase 1/2, multicentre, open-label, unilateral dose escalation study
10.1016/s0140-6736(24)01447-8 · 2024 · External reference
Phase 1/2 AAV5-hRKp.RPGR (Botaretigene Sparoparvovec) Gene Therapy: Safety and Efficacy in RPGR-Associated X-Linked Retinitis Pigmentosa
10.1016/j.ajo.2024.05.034 · 2024 · External reference
AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells
2025 · External reference
Serotype survey of AAV gene delivery via subconjunctival injection in mice
10.1038/s41434-018-0035-6 · 2018 · External reference
Single Cell Portal: an interactive home for single-cell genomics data
2023 · External reference
Comprehensive single-cell atlas of the mouse retina
2024 · External reference
Spectacle: An interactive resource for ocular single-cell RNA sequencing data analysis
10.1016/j.exer.2020.108204 · 2020 · External reference
A single-cell transcriptome atlas of the adult human retina
10.15252/embj.2018100811 · 2019 · External reference
Single-cell multiome of the human retina and deep learning nominate causal variants in complex eye diseases
2022 · External reference
Single-nuclei RNA-seq on human retinal tissue provides improved transcriptome profiling
10.1038/s41467-019-12917-9 · 2019 · External reference
Effect of adeno-associated virus serotype and genomic structure on liver transduction and biodistribution in mice of both genders
10.1089/hum.2009.031 · 2009 · External reference
Differential Identification of Females and Males with Reading Difficulties: A Meta-Analysis
10.1007/s11145-018-9827-8 · 2018 · External reference
Predicted deleterious variants in the human genome relevant to gene therapy with adeno-associated virus vectors
10.1016/j.omtm.2023.101136 · 2023 · External reference
Consequences of Human Genetic Variations of the Adeno-Associated Virus Receptor (AAVR) Gene (KIAA0319L) on AAV-Mediated Gene Transfer
2024 · External reference
Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors
10.1016/s1046-2023(02)00220-7 · 2002 · External reference
Effects of Altering HSPG Binding and Capsid Hydrophilicity on Retinal Transduction by AAV
10.1128/jvi.02440-20 · 2021 · External reference
Characterization of a mutation in the lens-specific CP49 in the 129 strain of mouse
10.1167/iovs.03-0677 · 2004 · External reference
Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors
10.1371/annotation/99ee1789-a658-4fb0-8593-40a40e9f344a · 2013 · External reference
Subretinal injections in rodent eyes: effects on electrophysiology and histology of rat retina
2001 · External reference
Novel AAV44.9-Based Vectors Display Exceptional Characteristics for Retinal Gene Therapy
10.1016/j.ymthe.2020.04.002 · 2020 · External reference
