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References from Impact of physical and chemical parameters on spinoculation for chimeric antigen receptor T cell manufacturing using a quality-by-design approach. Local targets link to admitted publications; unresolved targets remain external evidence.
Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia
10.1056/nejmoa1709866 · 2018 · External reference
EMA Review of Axicabtagene Ciloleucel (Yescarta) for the Treatment of Diffuse Large B-Cell Lymphoma
10.1634/theoncologist.2019-0646 · 2020 · External reference
Brexucabtagene Autoleucel for Relapsed or Refractory Mantle Cell Lymphoma in Standard-of-Care Practice: Results From the US Lymphoma CAR T Consortium
10.1200/jco.22.01797 · 2023 · External reference
New Approval for Drug Treating Large B-Cell Lymphoma
2022 · External reference
Gene therapy process change evaluation framework: Transient transfection and stable producer cell line comparison
10.1016/j.bej.2021.108202 · 2021 · External reference
Lentiviral vector bioprocess economics for cell and gene therapy commercialization
10.1016/j.bej.2020.107868 · 2021 · External reference
Quasi-perfusion studies for intensified lentiviral vector production using a continuous stable producer cell line
2024 · External reference
Continuous manufacturing of lentiviral vectors using a stable producer cell line in a fixed-bed bioreactor
2024 · External reference
Scalable manufacturing of gene-modified human mesenchymal stromal cells with microcarriers in spinner flasks
10.1007/s00253-023-12634-w · 2023 · External reference
Automated production of gene-modified chimeric antigen receptor T cells using the Cocoon Platform
10.1016/j.jcyt.2023.07.012 · 2023 · External reference
Decentralized manufacturing of anti CD19 CAR-T cells using CliniMACS Prodigy®: real-world experience and cost analysis in India
10.1038/s41409-022-01866-5 · 2023 · External reference
CAR-T Cell Production Using the Clinimacs® Prodigy System
10.1182/blood.v128.22.5724.5724 · 2016 · External reference
Viral and non-viral vectors in gene therapy: current state and clinical perspectives
10.1016/j.ebiom.2025.105834 · 2025 · External reference
An Efficient Low Cost Method for Gene Transfer to T Lymphocytes
10.1371/journal.pone.0060298 · 2013 · External reference
An Efficient Electroporation Protocol for the Genetic Modification of Mammalian Cells
2016 · External reference
Non-viral therapeutic cell engineering with the Sleeping Beauty transposon system
10.1016/j.gde.2018.06.003 · 2018 · External reference
Lentiviral Vectors for T Cell Engineering: Clinical Applications, Bioprocessing and Future Perspectives
10.3390/v13081528 · 2021 · External reference
Clinical use of lentiviral vectors
10.1038/s41375-018-0106-0 · 2018 · External reference
High-Efficiency Lentiviral Transduction of Human CD34+ Cells in High-Density Culture with Poloxamer and Prostaglandin E2
10.1016/j.omtm.2019.01.005 · 2019 · External reference
Vectofusin-1 Promotes RD114-TR-Pseudotyped Lentiviral Vector Transduction of Human HSPCs and T Lymphocytes
10.1016/j.omtm.2017.02.003 · 2017 · External reference
Lentiviral Transduction of P140K MGMT into Human CD34+ Hematopoietic Progenitors at Low Multiplicity of Infection Confers Significant Resistance to BG/BCNU and Allows Selection in Vitro
10.1006/mthe.2002.0571 · 2002 · External reference
Optimizing Lentiviral Transduction of Human Natural Killer Cells
10.1182/blood.v118.21.4714.4714 · 2011 · External reference
Centrifugal enhancement of retroviral mediated gene transfer
10.1016/0166-0934(95)00035-s · 1995 · External reference
Rapid manufacturing of non-activated potent CAR T cells
10.1038/s41551-021-00842-6 · 2022 · External reference
Human Immunodeficiency Virus Type 1 Spinoculation Enhances Infection through Virus Binding
10.1128/jvi.74.21.10074-10080.2000 · 2000 · External reference
Spinoculation Triggers Dynamic Actin and Cofilin Activity That Facilitates HIV-1 Infection of Transformed and Resting CD4 T Cells
10.1128/jvi.05170-11 · 2011 · External reference
Vectofusin-1 Improves Transduction of Primary Human Cells with Diverse Retroviral and Lentiviral Pseudotypes, Enabling Robust, Automated Closed-System Manufacturing
10.1089/hum.2019.157 · 2019 · External reference
Identification of a small molecule for enhancing lentiviral transduction of T cells
10.1016/j.omtm.2023.101113 · 2023 · External reference
The significance of chemical transfection/transduction enhancers in promoting the viral vectors-assisted gene delivery approaches: A focus on potentials for inherited retinal diseases
10.1016/j.ejbt.2024.07.005 · 2024 · External reference
A Nontoxic Transduction Enhancer Enables Highly Efficient Lentiviral Transduction of Primary Murine T Cells and Hematopoietic Stem Cells
10.1016/j.omtm.2018.08.002 · 2018 · External reference
Optimized Lentiviral Transduction Protocols by Use of a Poloxamer Enhancer, Spinoculation, and scFv-Antibody Fusions to VSV-G
10.1007/978-1-4939-3753-0_4 · 2016 · External reference
Human CD3+ T-Cells with the Anti-ERBB2 Chimeric Antigen Receptor Exhibit Efficient Targeting and Induce Apoptosis in ERBB2 Overexpressing Breast Cancer Cells
10.3390/ijms18091797 · 2017 · External reference
Optimization of the Transductional Efficiency of Lentiviral Vectors: Effect of Sera and Polycations
10.1007/s12033-012-9528-5 · 2013 · External reference
Improvement of K562 Cell Line Transduction by FBS Mediated Attachment to the Cell Culture Plate
10.1155/2019/9540702 · 2019 · External reference
Simplified production and concentration of lentiviral vectors to achieve high transduction in primary human T cells
10.1186/1472-6750-13-98 · 2013 · External reference
Quality cell therapy manufacturing by design
10.1038/nbt.3525 · 2016 · External reference
A quality-by-design approach to improve process understanding and optimise the production and quality of CAR-T cells in automated stirred-tank bioreactors
10.3389/fimmu.2024.1335932 · 2024 · External reference
Establishing a scalable perfusion strategy for the manufacture of CAR -T cells in stirred-tank bioreactors using a quality-by-design approach
10.1002/btm2.10753 · 2025 · External reference
Quantitative analysis of T cell homeostatic proliferation
10.1016/j.cellimm.2008.01.003 · 2007 · External reference
Effector and memory T-cell differentiation: implications for vaccine development
10.1038/nri778 · 2002 · External reference
First decade of clinical trials and published studies with mesenchymal stromal cells from umbilical cord tissue
10.2217/rme-2018-0171 · 2019 · External reference
The first decade of advanced cell therapy clinical trials using perinatal cells (2005–2015)
10.2217/rme-2017-0066 · 2017 · External reference
A Dozen Years of Clinical Trials Performing Advanced Cell Therapy with Perinatal Cells
10.4155/fsoa-2018-0085 · 2018 · External reference
The Landscape of Early Clinical Gene Therapies outside of Oncology
10.1016/j.ymthe.2019.09.002 · 2019 · External reference
Gene therapy clinical trials, where do we go? An overview
10.1016/j.biopha.2022.113324 · 2022 · External reference
Generating suspension-adapted human mesenchymal stromal cells (S-hMSCs) for the scalable manufacture of extracellular vesicles
10.1016/j.jcyt.2024.06.011 · 2024 · External reference
Spinoculation and retronectin highly enhance the gene transduction efficiency of Mucin-1-specific chimeric antigen receptor (CAR) in human primary T cells
10.1186/s12860-021-00397-z · 2021 · External reference
Optimized conditions for gene transduction into primary immune cells using viral vectors
2023 · External reference
Closed and automated CAR T cell lentiviral transduction by spinoculation
10.1016/j.jcyt.2020.03.387 · 2020 · External reference
High efficiency closed-system gene transfer using automated spinoculation
10.1186/s12967-021-03126-4 · 2021 · External reference
Clinical-scale Lentiviral Vector Transduction of PBL for TCR Gene Therapy and Potential for Expression in Less-differentiated Cells
10.1097/cji.0b013e31818817c5 · 2008 · External reference
Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding
10.1128/jvi.74.21.10074-10080.2000 · 2000 · External reference
Efficient lentiviral transduction method to gene modify cord blood CD8+ T cells for cancer therapy applications
10.1016/j.omtm.2021.03.015 · 2021 · External reference
Towards a Clinically Relevant Lentiviral Transduction Protocol for Primary Human CD34+ Hematopoietic Stem/Progenitor Cells
10.1371/journal.pone.0006461 · 2009 · External reference
Understanding the impact of bioactive coating materials for human mesenchymal stromal cells and implications for manufacturing
10.1007/s10529-023-03369-9 · 2023 · External reference
Biological differences between adult and perinatal human mesenchymal stromal cells and their impact on the manufacturing processes
10.1016/j.jcyt.2024.05.020 · 2024 · External reference
High-Efficiency Transduction of Primary Human Hematopoietic Stem/Progenitor Cells by AAV6 Vectors: Strategies for Overcoming Donor-Variation and Implications in Genome Editing
10.1038/srep35495 · 2016 · External reference
Demonstrating the manufacture of human car-t cells in an automated stirred-tank bioreactor
10.1002/biot.202000177 · 2020 · External reference
Optimising and adapting perfusion feeds in serum-free medium to intensify CAR-T cell expansion in stirred-tank bioreactors
10.3389/fbioe.2025.1593895 · 2025 · External reference
Impact of serum/Xeno-free medium and cytokine supplementation on CAR-T cell therapy manufacturing in stirred tank bioreactors
10.1002/biot.70114 · 2025 · External reference
Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts
10.1038/s41598-020-65193-9 · 2020 · External reference
Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
10.1038/s41467-020-15543-y · 2020 · External reference
A New Method for Transduction of Mesenchymal Stem Cells Using Mechanical Agitation
10.1007/s10059-009-0146-4 · 2009 · External reference
A Microfluidic Device to Enhance Viral Transduction Efficiency During Manufacture of Engineered Cellular Therapies
10.1038/s41598-019-50981-9 · 2019 · External reference
Establishing the scalable manufacture of primary human T-cells in an automated stirred-tank bioreactor
10.1002/bit.27088 · 2019 · External reference
Detection and quantification of integrated vector copy number by multiplex droplet digital PCR in dual-transduced CAR T cells
10.1016/j.omtm.2023.07.003 · 2023 · External reference
