Research graph
References from Spatial mapping of barcoded, brain-tropic AAVs using multiplexed RNA in situ hybridization. Local targets link to admitted publications; unresolved targets remain external evidence.
Viral Strategies for Targeting the Central and Peripheral Nervous Systems
10.1146/annurev-neuro-080317-062048 · 2018 · External reference
Adeno-Associated Virus Technologies and Methods for Targeted Neuronal Manipulation
10.3389/fnana.2019.00093 · 2019 · External reference
Gene Therapy for Neurodegenerative Diseases: Slowing Down the Ticking Clock
10.3389/fnins.2020.580179 · 2020 · External reference
Trends and challenges of AAV-delivered gene editing therapeutics for CNS disorders: Implications for neurodegenerative disease
10.1016/j.omtn.2025.102635 · 2025 · External reference
Addressing high dose AAV toxicity – ‘one and done’ or ‘slower and lower
10.1080/14712598.2022.2060737 · 2022 · External reference
Natural Adeno-Associated Virus Serotypes and Engineered Adeno-Associated Virus Capsid Variants: Tropism Differences and Mechanistic Insights
10.3390/v16030442 · 2024 · External reference
Adeno-Associated Virus (AAV) Vectors in the CNS
10.2174/156652311795684759 · 2011 · External reference
Capsid-Engineering for Central Nervous System-Directed Gene Therapy with Adeno-Associated Virus Vectors
10.1089/hum.2021.169 · 2021 · External reference
Advances in AAV capsid engineering: Integrating rational design, directed evolution and machine learning
10.1016/j.ymthe.2025.03.056 · 2025 · External reference
Boosters for adeno-associated virus (AAV) vector (r)evolution
10.1016/j.jcyt.2022.07.005 · 2023 · External reference
Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain
10.1038/nbt.3440 · 2016 · External reference
Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types
10.1038/s41592-020-0799-7 · 2020 · External reference
Rapid evolution of blood-brain-barrier-penetrating AAV capsids by RNA-driven biopanning
10.1016/j.omtm.2020.12.006 · 2021 · External reference
Selection of an Efficient AAV Vector for Robust CNS Transgene Expression
10.1016/j.omtm.2019.10.007 · 2019 · External reference
A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism
10.1073/pnas.1910061116 · 2019 · External reference
Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors
10.1038/nbt856 · 2003 · External reference
In vitro selection of viral vectors with modified tropism: the adeno-associated virus display
10.1016/s1525-0016(03)00123-0 · 2003 · External reference
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset
10.1038/s41593-021-00969-4 · 2022 · External reference
A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases
10.15252/emmm.201506078 · 2016 · External reference
New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets
10.1016/j.isci.2024.109777 · 2024 · External reference
Pulmonary Targeting of Adeno-associated Viral Vectors by Next-generation Sequencing-guided Screening of Random Capsid Displayed Peptide Libraries
10.1038/mt.2016.62 · 2016 · External reference
Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species
10.1016/j.cell.2021.08.028 · 2021 · External reference
Adeno-Associated Virus-Induced Dorsal Root Ganglion Pathology
10.1089/hum.2020.167 · 2020 · External reference
Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems
10.1038/nn.4593 · 2017 · External reference
A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency
10.1093/brain/awy126 · 2018 · External reference
Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain
10.1016/j.neulet.2017.11.049 · 2018 · External reference
The Neurotropic Properties of AAV-PHP.B Are Limited to C57BL/6J Mice
10.1016/j.ymthe.2018.01.018 · 2018 · External reference
Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants
10.1038/s41467-020-19230-w · 2020 · External reference
High-Throughput Quantification of In Vivo Adeno-Associated Virus Transduction with Barcoded Non-Coding RNAs
10.1089/hum.2018.253 · 2019 · External reference
Deep Parallel Characterization of AAV Tropism and AAV-Mediated Transcriptional Changes via Single-Cell RNA Sequencing
10.3389/fimmu.2021.730825 · 2021 · External reference
scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution
10.7554/elife.64175 · 2021 · External reference
Spatial transcriptomics in neuroscience
10.1038/s12276-023-01093-y · 2023 · External reference
The expanding vistas of spatial transcriptomics
10.1038/s41587-022-01448-2 · 2023 · External reference
Spatial Transcriptomics: Technical Aspects of Recent Developments and Their Applications in Neuroscience and Cancer Research
10.1002/advs.202206939 · 2023 · External reference
Spatial genomics of AAV vectors reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo
10.1038/s41587-025-02565-4 · 2026 · External reference
Spatial transcriptomics for profiling the tropism of viral vectors in tissues
10.1038/s41587-022-01648-w · 2023 · External reference
Identification of the Galactose Binding Domain of the Adeno-Associated Virus Serotype 9 Capsid
10.1128/jvi.00448-12 · 2012 · External reference
Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids
10.1371/journal.pone.0225206 · 2019 · External reference
The GPI-Linked Protein LY6A Drives AAV-PHP.B Transport across the Blood-Brain Barrier
10.1016/j.ymthe.2019.02.013 · 2019 · External reference
A comprehensive study of AAV tropism across C57BL/6 mice, BALB/c mice, and crab-eating macaques
10.1016/j.omtm.2025.101434 · 2025 · External reference
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
10.1016/j.cell.2021.04.021 · 2021 · External reference
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
10.1038/s41586-023-06812-z · 2023 · External reference
Hierarchical organization of cortical and thalamic connectivity
10.1038/s41586-019-1716-z · 2019 · External reference
Heterogeneity within classical cell types is the rule: lessons from hippocampal pyramidal neurons
10.1038/s41583-019-0125-5 · 2019 · External reference
Specific AAV2/PHP.eB-mediated gene transduction of CA2 pyramidal cells via injection into the lateral ventricle
10.1038/s41598-022-27372-8 · 2023 · External reference
Characterization of brain transduction capability of a BBB-penetrant AAV vector in mice, rats and macaques reveals differences in expression profiles
10.1038/s41434-024-00466-w · 2024 · External reference
Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood–brain barrier in rodents and primates
10.1038/s41551-022-00938-7 · 2022 · External reference
Enhanced CNS transduction from AAV.PHP.eB infusion into the cisterna magna of older adult rats compared to AAV9
10.1038/s41434-021-00244-y · 2022 · External reference
CNS Transduction Benefits of AAV-PHP.eB over AAV9 Are Dependent on Administration Route and Mouse Strain
10.1016/j.omtm.2020.10.011 · 2020 · External reference
Optimization of adeno-associated viral vector-mediated transduction of the corticospinal tract: comparison of four promoters
10.1038/s41434-020-0169-1 · 2021 · External reference
Gene therapy decreases seizures in a model of Incontinentia pigmenti
10.1002/ana.24981 · 2017 · External reference
A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant
10.1016/j.omtm.2023.02.016 · 2023 · External reference
Every little bit helps: A single-residue switch in a vascular AAV enables blood-brain barrier penetration
10.1016/j.omtm.2023.04.007 · 2023 · External reference
Application of spatial transcriptomics across organoids: a high-resolution spatial whole-transcriptome benchmarking dataset
2025 · External reference
Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain
10.1016/j.omtm.2020.05.028 · 2020 · External reference
Standardized, Scalable, and Timely Flexible Adeno-Associated Virus Vector Production Using Frozen High-Density HEK-293 Cell Stocks and CELLdiscs
10.1089/hgtb.2018.228 · 2019 · External reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · 2024 · External reference
