Research graph
References from Immune shielding of viral vectors via capsid engineering with genetically encoded zwitterionic peptides. Local targets link to admitted publications; unresolved targets remain external evidence.
Viral vector platforms within the gene therapy landscape
10.1038/s41392-021-00487-6 · 2021 · External reference
Lethal immunotoxicity in high-dose systemic AAV therapy
10.1016/j.ymthe.2023.10.015 · 2023 · External reference
Immune Responses to Viral Gene Therapy Vectors
10.1016/j.ymthe.2020.01.001 · 2020 · External reference
Interaction of adenovirus with antibodies, complement, and coagulation factors
10.1002/1873-3468.13649 · 2019 · External reference
Complement System Response to Adeno-Associated Virus Vector Gene Therapy
10.1089/hum.2023.194 · 2024 · External reference
Evading and overcoming AAV neutralization in gene therapy
10.1016/j.tibtech.2022.11.006 · 2023 · External reference
Immune Responses and Immunosuppressive Strategies for Adeno-Associated Virus-Based Gene Therapy for Treatment of Central Nervous System Disorders: Current Knowledge and Approaches
10.1089/hum.2022.138 · 2022 · External reference
Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant
10.1056/nejmoa1708538 · 2017 · External reference
Testing preexisting antibodies prior to AAV gene transfer therapy: rationale, lessons and future considerations
10.1016/j.omtm.2022.02.011 · 2022 · External reference
Infection Risk and Safety of Corticosteroid Use
10.1016/j.rdc.2015.08.004 · 2016 · External reference
Adenovirus Entry: From Infection to Immunity
10.1146/annurev-virology-092818-015550 · 2019 · External reference
Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade
10.1128/jvi.02702-13 · 2014 · External reference
Toll-like receptor 9 triggers an innate immune response to helper-dependent adenoviral vectors
10.1038/sj.mt.6300031 · 2007 · External reference
Multiple innate inflammatory responses induced after systemic adenovirus vector delivery depend on a functional complement system
10.1016/j.ymthe.2006.03.024 · 2006 · External reference
Coagulation factor X activates innate immunity to human species C adenovirus
10.1126/science.1226625 · 2012 · External reference
Adenovirus-Antibody Complexes Contributed to Lethal Systemic Inflammation in a Gene Therapy Trial
10.1016/j.ymthe.2020.01.006 · 2020 · External reference
Analysis of the Prevalence of Binding and Neutralizing Antibodies against 39 Human Adenovirus Types in Student Cohorts Reveals Low-Prevalence Types and a Decline in Binding Antibody Levels during the SARS-CoV-2 Pandemic
10.1128/jvi.01133-22 · 2022 · External reference
Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies
10.1038/sj.gt.3301389 · 2001 · External reference
Evaluation of polyethylene glycol modification of first-generation and helper-dependent adenoviral vectors to reduce innate immune responses
10.1016/j.ymthe.2004.09.015 · 2005 · External reference
PEGylation of adenovirus with retention of infectivity and protection from neutralizing antibody in vitro and in vivo
10.1089/10430349950018021 · 1999 · External reference
Substitution of blood coagulation factor X-binding to Ad5 by position-specific PEGylation: Preventing vector clearance and preserving infectivity
10.1016/j.jconrel.2016.06.022 · 2016 · External reference
Polyethylene glycol modification of adenovirus reduces platelet activation, endothelial cell activation, and thrombocytopenia
10.1089/hum.2007.0051 · 2007 · External reference
Albumin-binding adenoviruses circumvent pre-existing neutralizing antibodies upon systemic delivery
10.1016/j.jconrel.2016.07.004 · 2016 · External reference
Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control
10.1038/s41467-017-02707-6 · 2018 · External reference
Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia
10.1182/blood.2021013231 · 2021 · External reference
ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome
10.1126/sciadv.abl8213 · 2021 · External reference
Adenovirus type 34 and HVR1-deleted Adenovirus type 5 do not bind to PF4: clearing the path towards vectors without thrombosis risk
2022 · External reference
Ultra-low fouling peptide surfaces derived from natural amino acids
10.1016/j.biomaterials.2009.07.001 · 2009 · External reference
Hydration behaviors of nonfouling zwitterionic materials
10.1039/d3sc01977b · 2023 · External reference
Long circulating genetically encoded intrinsically disordered zwitterionic polypeptides for drug delivery
10.1016/j.biomaterials.2018.11.012 · 2019 · External reference
EKylation: Addition of an Alternating-Charge Peptide Stabilizes Proteins
10.1021/acs.biomac.5b01031 · 2015 · External reference
Zwitterionic Peptide Cloak Mimics Protein Surfaces for Protein Protection
10.1002/anie.202004995 · 2020 · External reference
Mitigating the Immunogenicity of AAV-Mediated Gene Therapy with an Immunosuppressive Phosphoserine-Containing Zwitterionic Peptide
10.1021/jacs.2c09484 · 2022 · External reference
Oncolytic adenovirus Ad657 for systemic virotherapy against prostate cancer
10.2147/ov.s155946 · 2018 · External reference
Hemocompatibility of zwitterionic interfaces and membranes
10.1038/pj.2014.46 · 2014 · External reference
Zwitterionic Polymers for Biomedical Applications: Antimicrobial and Antifouling Strategies toward Implantable Medical Devices and Drug Delivery
10.1021/acs.langmuir.4c02664 · 2024 · External reference
Elucidating Molecular Design Principles for Charge-Alternating Peptides
10.1021/acs.biomac.9b01191 · 2020 · External reference
Characterization of a permissive epitope insertion site in adenovirus hexon
10.1128/jvi.00256-06 · 2006 · External reference
High resolution solution structure of the 1.3S subunit of transcarboxylase from Propionibacterium shermanii
10.1021/bi9925367 · 2000 · External reference
Comparison of adenovirus fiber, protein IX, and hexon capsomeres as scaffolds for vector purification and cell targeting
10.1016/j.virol.2006.01.032 · 2006 · External reference
Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo
10.1073/pnas.0711757105 · 2008 · External reference
IIIa deleted adenovirus as a single-cycle genome replicating vector
10.1016/j.virol.2014.05.030 · 2014 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit
10.1016/j.chom.2009.11.006 · 2009 · External reference
Role of kinesins in directed adenovirus transport and cytoplasmic exploration
10.1371/journal.ppat.1007055 · 2018 · External reference
Nuclear import of adenovirus DNA involves direct interaction of hexon with an N-terminal domain of the nucleoporin Nup214
10.1128/jvi.02639-14 · 2015 · External reference
Rapid Kupffer cell death after intravenous injection of adenovirus vectors
10.1016/j.ymthe.2005.08.007 · 2006 · External reference
Circulating antibodies and macrophages as modulators of adenovirus pharmacology
10.1128/jvi.01392-12 · 2013 · External reference
Impact of Natural IgM Concentration on Gene Therapy with Adenovirus Type 5 Vectors
10.1128/jvi.03217-14 · 2015 · External reference
Adenovirus activates complement by distinctly different mechanisms in vitro and in vivo: indirect complement activation by virions in vivo
10.1128/jvi.00082-09 · 2009 · External reference
Clearance of adenovirus by Kupffer cells is mediated by scavenger receptors, natural antibodies, and complement
10.1128/jvi.01320-08 · 2008 · External reference
In vivo dose threshold effect of adenovirus-mediated factor VIII gene therapy in hemophiliac mice
10.1006/mthe.2000.0120 · 2000 · External reference
Characterization of human adenovirus serotypes 5, 6, 11, and 35 as anticancer agents
10.1016/j.virol.2009.08.038 · 2009 · External reference
Structure-derived insights from blood factors binding to the surfaces of different adenoviruses
10.1038/s41467-024-54049-9 · 2024 · External reference
Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity
10.1038/nature04721 · 2006 · External reference
Adenovirus serotype 5-specific neutralizing antibodies target multiple hexon hypervariable regions
10.1128/jvi.06165-11 · 2012 · External reference
Replacing adenoviral vector HVR1 with a malaria B cell epitope improves immunogenicity and circumvents preexisting immunity to adenovirus in mice
10.1172/jci39812 · 2010 · External reference
Systemic cancer therapy with engineered adenovirus that evades innate immunity
10.1126/scitranslmed.abc6659 · 2020 · External reference
Binding of adenovirus species C hexon to prothrombin and the influence of hexon on vector properties in vitro and in vivo
10.1371/journal.ppat.1010859 · 2022 · External reference
Conformational changes in the adenovirus hexon subunit responsible for regulating cytoplasmic dynein recruitment
10.1128/jvi.02889-14 · 2015 · External reference
Ebola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis
10.1128/jvi.03652-14 · 2015 · External reference
FastAd: A versatile toolkit for rapid generation of single adenoviruses or diverse adenoviral vector libraries
10.1016/j.omtm.2024.101356 · 2024 · External reference
Optimizing promoters for recombinant adeno-associated virus-mediated gene expression in the peripheral and central nervous system using self-complementary vectors
10.1089/hum.2010.245 · 2011 · External reference
Extracellular vesicles provide a capsid-free vector for oncolytic adenoviral DNA delivery
10.1080/20013078.2020.1747206 · 2020 · External reference
Adenovirus-associated virus vector-mediated gene transfer in hemophilia B
10.1056/nejmoa1108046 · 2011 · External reference
Motif-based zwitterionic peptides impact their structure and immunogenicity
10.1039/d2sc03519g · 2022 · External reference
Rapid construction of capsid-modified adenoviral vectors through bacteriophage lambda Red recombination
10.1089/hum.2004.15.1125 · 2004 · External reference
Quantifying adenovirus-neutralizing antibodies by luciferase transgene detection: addressing preexisting immunity to vaccine and gene therapy vectors
10.1128/jcm.41.11.5046-5052.2003 · 2003 · External reference
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
10.1038/nmeth.4169 · 2017 · External reference
Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes
10.1038/ncomms9843 · 2015 · External reference
Scipion: A software framework toward integration, reproducibility and validation in 3D electron microscopy
10.1016/j.jsb.2016.04.010 · 2016 · External reference
Localized reconstruction in Scipion expedites the analysis of symmetry mismatches in cryo-EM data
10.1016/j.pbiomolbio.2020.05.004 · 2021 · External reference
UCSF ChimeraX: Meeting modern challenges in visualization and analysis
10.1002/pro.3235 · 2018 · External reference
UCSF ChimeraX: Tools for structure building and analysis
10.1002/pro.4792 · 2023 · External reference
Coot: model-building tools for molecular graphics
10.1107/s0907444904019158 · 2004 · External reference
Features and development of Coot
10.1107/s0907444910007493 · 2010 · External reference
PHENIX: a comprehensive Python-based system for macromolecular structure solution
10.1107/s0907444909052925 · 2010 · External reference
Real-space refinement in PHENIX for cryo-EM and crystallography
10.1107/s2059798318006551 · 2018 · External reference
