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References from Clinical development of tacrolimus-resistant regulatory T cells to enable simultaneous immunosuppression and immune regulation. Local targets link to admitted publications; unresolved targets remain external evidence.
Mycophenolic acid-mediated suppression of human CD4+ T cells: more than mere guanine nucleotide deprivation
10.1111/j.1600-6143.2010.03413.x · 2011 · External reference
Mycophenolate mofetil and its mechanisms of action
10.1016/s0162-3109(00)00188-0 · 2000 · External reference
Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naive T cells into cytokine-producing mature T cells
10.1371/journal.pone.0031465 · 2012 · External reference
Regulation by corticosteroids of Th1 and Th2 cytokine production in human CD4+ effector T cells generated from CD45RO- and CD45RO+ subsets
10.4049/jimmunol.155.7.3322 · 1995 · External reference
Glucocorticoids in T cell apoptosis and function
10.1007/s00018-005-5390-y · 2006 · External reference
CD25+CD4+ T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene
10.1016/j.exphem.2004.03.012 · 2004 · External reference
CD4+CD25+CD127 (low/-) T cells: a more specific Treg population in human peripheral blood
10.1007/s10753-012-9496-8 · 2012 · External reference
Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus
10.4049/jimmunol.1203473 · 2013 · External reference
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function
10.1186/1479-5876-7-89 · 2009 · External reference
The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-kappaB signaling
10.1371/journal.pone.0088318 · 2014 · External reference
DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells
10.1002/eji.200737594 · 2007 · External reference
DNA methylation controls Foxp3 gene expression
10.1002/eji.200838105 · 2008 · External reference
Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials
10.1016/s0140-6736(20)30167-7 · 2020 · External reference
Regulatory T cells for minimising immune suppression in kidney transplantation: phase I/IIa clinical trial
2020 · External reference
Permanent CNI treatment for prevention of renal allograft rejection in sensitized hosts can be replaced by regulatory T cells
10.1111/j.1600-6143.2012.04143.x · 2012 · External reference
Calcineurin inhibitors affect circulating regulatory T cells in stable renal transplant recipients
10.1016/j.transproceed.2006.08.081 · 2006 · External reference
CRISPR-Cas9-Edited Tacrolimus-Resistant Antiviral T Cells for Advanced Adoptive Immunotherapy in Transplant Recipients
10.1016/j.ymthe.2020.09.011 · 2020 · External reference
Tacrolimus-resistant SARS-CoV-2-specific T cell products to prevent and treat severe COVID-19 in immunosuppressed patients
10.1016/j.omtm.2022.02.012 · 2022 · External reference
Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
10.1093/intimm/dxm014 · 2007 · External reference
Signatures of human regulatory T cells: an encounter with old friends and new players
10.1186/gb-2006-7-7-r54 · 2006 · External reference
Effects of lactate on metabolism and differentiation of CD4(+)T cells
10.1016/j.molimm.2022.12.015 · 2023 · External reference
Immunometabolism and PI(3)K Signaling As a Link between IL-2, Foxp3 Expression, and Suppressor Function in Regulatory T Cells
10.3389/fimmu.2018.00069 · 2018 · External reference
The role of metabolism on regulatory T cell development and its impact in tumor and transplantation immunity
10.3389/fimmu.2022.1016670 · 2022 · External reference
T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses
10.1038/s42003-020-01122-w · 2020 · External reference
A bead-based western for high-throughput cellular signal transduction analyses
10.1038/ncomms12852 · 2016 · External reference
GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo
10.1080/2162402x.2015.1051297 · 2015 · External reference
LAG-3 expression defines a subset of CD4(+)CD25(high)Foxp3(+) regulatory T cells that are expanded at tumor sites
10.4049/jimmunol.0903879 · 2010 · External reference
The performance of homopolymer detection using dichromatic and tetrachromatic fluorogenic next-generation sequencing platforms
10.1186/s12864-024-10474-0 · 2024 · External reference
Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts
10.1136/jitc-2023-006783 · 2023 · External reference
Regulatory T-cell therapy approaches
10.1093/cei/uxac078 · 2023 · External reference
The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes
10.1172/jci.insight.147474 · 2021 · External reference
Adoptive transfer of ex vivo expanded regulatory T-cells improves immune cell engraftment and therapy-refractory chronic GvHD
10.1016/j.ymthe.2022.02.025 · 2022 · External reference
A Phase I Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants
10.1038/s41598-018-25574-7 · 2018 · External reference
Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants
10.1111/ajt.14415 · 2017 · External reference
Selective decrease of donor-reactive T(regs) after liver transplantation limits T(reg) therapy for promoting allograft tolerance in humans
10.1126/scitranslmed.abo2628 · 2022 · External reference
Clinical adoptive regulatory T Cell therapy: State of the art, challenges, and prospective
2022 · External reference
PharmGKB summary: cyclosporine and tacrolimus pathways
10.1097/fpc.0b013e328364db84 · 2013 · External reference
Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells
10.1073/pnas.2335979100 · 2003 · External reference
Natural product ligands of FKBP12: Immunosuppressive antifungal agents FK506, rapamycin, and beyond
10.1371/journal.ppat.1011056 · 2023 · External reference
Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin
10.4049/jimmunol.144.1.251 · 1990 · External reference
The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin
10.1128/mcb.22.21.7428-7438.2002 · 2002 · External reference
A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials
10.1016/j.omtm.2018.01.006 · 2018 · External reference
Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells
10.1182/blood-2007-06-094482 · 2008 · External reference
Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin
10.1371/journal.pone.0005994 · 2009 · External reference
Higher FOXP3-TSDR demethylation rates in adjacent normal tissues in patients with colon cancer were associated with worse survival
10.1186/1476-4598-13-153 · 2014 · External reference
Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells
10.1002/eji.200636435 · 2007 · External reference
Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function
10.1172/jci137712 · 2020 · External reference
Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function
10.3389/fcell.2021.751590 · 2021 · External reference
Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer
10.1111/ajt.12934 · 2014 · External reference
The Value of a Rapid Test of Human Regulatory T Cell Function Needs to be Revised
10.3389/fimmu.2019.00150 · 2019 · External reference
Natural regulatory T cells: mechanisms of suppression
10.1016/j.molmed.2007.01.003 · 2007 · External reference
Cas9-directed immune tolerance in humans-a model to evaluate regulatory T cells in gene therapy?
10.1038/s41434-021-00232-2 · 2021 · External reference
Comparative Study of Immunomodulatory Agents to Induce Human T Regulatory (Treg) Cells: Preferential Treg-Stimulatory Effect of Prednisolone and Rapamycin
10.1007/s00005-020-00582-6 · 2020 · External reference
Novel immunosuppressive effect of FK506 by upregulation of PD-L1 via FKBP51 in heart transplantation
10.1111/sji.13203 · 2022 · External reference
Human CD39(hi) regulatory T cells present stronger stability and function under inflammatory conditions
10.1038/cmi.2016.30 · 2017 · External reference
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
10.1126/science.1202947 · 2011 · External reference
Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
10.1016/s1074-7613(01)00259-x · 2002 · External reference
IL-2 can signal via chemokine receptors to promote regulatory T cells' suppressive function
10.1016/j.celrep.2023.112996 · 2023 · External reference
IL-2-based approaches to Treg enhancement
10.1093/cei/uxac105 · 2023 · External reference
Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential
10.1038/s41392-025-02326-4 · 2025 · External reference
IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
10.1084/jem.20050419 · 2005 · External reference
A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells
10.1038/s41591-018-0137-0 · 2018 · External reference
Effector memory-type regulatory T cells display phenotypic and functional instability
10.1126/sciadv.adn3470 · 2024 · External reference
Inference of CRISPR Edits from Sanger Trace Data
10.1089/crispr.2021.0113 · 2022 · External reference
Application of two-dimensional gel-based mass spectrometry to functionally dissect resistance to targeted cancer therapy
10.1002/prca.201300056 · 2013 · External reference
UNCOVERseq Enables Sensitive and Controlled Gene Editing Off-Target Nomination Across CRISPR-Cas Modalities and Systems
2025 · External reference
Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq
10.1016/j.stem.2021.02.002 · 2021 · External reference
T-CAST: An optimized CAST-Seq pipeline for TALEN confirms superior safety and efficacy of obligate-heterodimeric scaffolds
10.3389/fgeed.2023.1130736 · 2023 · External reference
CALITAS: A CRISPR-Cas-aware ALigner for In silico off-TArget Search
10.1089/crispr.2020.0036 · 2021 · External reference
CRISPAltRations: a validated cloud-based approach for interrogation of double-strand break repair mediated by CRISPR genome editing
10.1016/j.omtm.2021.03.024 · 2021 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
