Research graph
References from Systemic clinical-grade recombinant decorin reduces disease burden and fibrosis in advanced recessive dystrophic epidermolysis bullosa. Local targets link to admitted publications; unresolved targets remain external evidence.
Epidermolysis bullosa
10.1038/s41572-020-0210-0 · 2020 · External reference
Dystrophic Epidermolysis Bullosa - from biochemistry to interventions
10.1016/j.matbio.2025.02.001 · 2025 · External reference
Phase I/II open-label trial of intravenous allogeneic mesenchymal stromal cell therapy in adults with recessive dystrophic epidermolysis bullosa
10.1016/j.jaad.2019.11.038 · 2020 · External reference
Safety and tolerability of losartan to treat recessive dystrophic epidermolysis bullosa in children (REFLECT): an open-label, single-arm, phase 1/2 trial
10.1016/j.eclinm.2024.102900 · 2024 · External reference
Efficacy and safety of Oleogel-S10 (birch triterpenes) for epidermolysis bullosa: results from the phase III randomized double-blind phase of the EASE study
10.1093/bjd/ljac001 · 2023 · External reference
Trial of Beremagene Geperpavec (B-VEC) for Dystrophic Epidermolysis Bullosa
10.1056/nejmoa2206663 · 2022 · External reference
Safety and Wound Outcomes Following Genetically Corrected Autologous Epidermal Grafts in Patients With Recessive Dystrophic Epidermolysis Bullosa
10.1001/jama.2016.15588 · 2016 · External reference
Type VII Collagen Deficiency in the Oncogenesis of Cutaneous Squamous Cell Carcinoma in Dystrophic Epidermolysis Bullosa
10.1016/j.jid.2023.05.024 · 2023 · External reference
Stopping a runaway train: targeting fibrosis in recessive dystrophic epidermolysis bullosa
10.1093/bjd/ljae300 · 2024 · External reference
Decorin counteracts disease progression in mice with recessive dystrophic epidermolysis bullosa
10.1016/j.matbio.2018.12.001 · 2019 · External reference
Monozygotic twins discordant for recessive dystrophic epidermolysis bullosa phenotype highlight the role of TGF-β signalling in modifying disease severity
10.1093/hmg/ddu102 · 2014 · External reference
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
10.1016/j.matbio.2015.02.003 · 2015 · External reference
Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility
10.1083/jcb.136.3.729 · 1997 · External reference
Congenital Stromal Dystrophy of the Cornea Caused by a Mutation in the Decorin Gene
10.1167/iovs.04-0804 · 2005 · External reference
Decorin interacting network: A comprehensive analysis of decorin-binding partners and their versatile functions
10.1016/j.matbio.2016.09.009 · 2016 · External reference
Decorin: a guardian from the matrix
10.1016/j.ajpath.2012.04.029 · 2012 · External reference
Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease
10.1038/360361a0 · 1992 · External reference
Oncosuppressive roles of decorin through regulation of multiple receptors and diverse signaling pathways
10.1152/ajpcell.00016.2022 · 2022 · External reference
Systemically Administered, Target-Specific, Multi-Functional Therapeutic Recombinant Proteins in Regenerative Medicine
10.3390/nano10020226 · 2020 · External reference
Negative regulation of transforming growth factor-beta by the proteoglycan decorin
10.1038/346281a0 · 1990 · External reference
Absence of Decorin Adversely Influences Tubulointerstitial Fibrosis of the Obstructed Kidney by Enhanced Apoptosis and Increased Inflammatory Reaction
10.1016/s0002-9440(10)64937-1 · 2002 · External reference
Regulation of Fibrillin-1 by Biglycan and Decorin Is Important for Tissue Preservation in the Kidney During Pressure-Induced Injury
10.1016/s0002-9440(10)63305-6 · 2004 · External reference
Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins
10.1101/cshperspect.a021907 · 2016 · External reference
Exposed CendR Domain in Homing Peptide Yields Skin-Targeted Therapeutic in Epidermolysis Bullosa
10.1016/j.ymthe.2020.05.017 · 2020 · External reference
Age-dependent alterations of decorin glycosaminoglycans in human skin
10.1038/srep02422 · 2013 · External reference
The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis
10.1111/j.1742-4658.2007.05951.x · 2007 · External reference
Decorin: A Growth Factor Antagonist for Tumor Growth Inhibition
10.1155/2015/654765 · 2015 · External reference
Decorin core protein secretion is regulated by N-linked oligosaccharide and glycosaminoglycan additions
10.1074/jbc.m511531200 · 2005 · External reference
Recombinant decorin glycoforms. Purification and structure
10.1074/jbc.271.32.19578 · 1996 · External reference
Unresolved reference
2022 · External reference
Systemic Collagen VII Replacement Therapy for Advanced Recessive Dystrophic Epidermolysis Bullosa
10.1016/j.jid.2021.09.008 · 2022 · External reference
Decorin Antagonizes Met Receptor Activity and Down-regulates β-Catenin and Myc Levels
10.1074/jbc.m110.172841 · 2010 · External reference
Pro-inflammatory immunity supports fibrosis advancement in epidermolysis bullosa: intervention with Ang-(1-7)
10.15252/emmm.202114392 · 2021 · External reference
Ex Vivo Transepithelial Collagen Cross-linking in Porcine and Human Corneas Using Human Decorin Core Protein
10.3928/1081597x-20160428-08 · 2016 · External reference
Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor
10.1016/s0021-9258(17)35235-3 · 1991 · External reference
Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan
10.1073/pnas.0402976101 · 2004 · External reference
The concave face of decorin mediates reversible dimerization and collagen binding
10.1074/jbc.m113.504530 · 2013 · External reference
Differential interactions of decorin and decorin mutants with type I and type VI collagens
10.1111/j.1432-1033.2004.04273.x · 2004 · External reference
Decorin the antifibrotic proteoglycan and its progression in therapy
10.1152/ajpcell.01075.2024 · 2025 · External reference
Pharmacokinetics and disposition characteristics of recombinant decorin after intravenous injection into mice
10.1016/s0304-4165(98)00163-9 · 1999 · External reference
Target-seeking antifibrotic compound enhances wound healing and suppresses scar formation in mice
10.1073/pnas.1016233107 · 2010 · External reference
A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy
10.1172/jci34292 · 2008 · External reference
Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin
10.1016/j.jid.2016.03.036 · 2016 · External reference
Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms
10.15252/emmm.201505061 · 2015 · External reference
Histone deacetylase inhibition mitigates fibrosis-driven disease progression in recessive dystrophic epidermolysis bullosa
10.1093/bjd/ljae225 · 2024 · External reference
Lung collagen cross-links in rats with experimentally induced pulmonary fibrosis
10.1016/0925-4439(96)00019-1 · 1996 · External reference
The type of collagen cross-link determines the reversibility of experimental skin fibrosis
10.1016/j.bbadis.2005.02.007 · 2005 · External reference
Dipeptidyl Peptidase-4-Mediated Fibronectin Processing Evokes a Profibrotic Extracellular Matrix
10.1016/j.jid.2024.03.020 · 2024 · External reference
Pro-Inflammatory Chemokines and Cytokines Dominate the Blister Fluid Molecular Signature in Patients with Epidermolysis Bullosa and Affect Leukocyte and Stem Cell Migration
10.1016/j.jid.2017.07.002 · 2017 · External reference
Knockout of IL-1R1 Reduced Inflammation and Improved Survival in a Mouse Model of Recessive Dystrophic Epidermolysis Bullosa
10.1016/j.jid.2025.01.010 · 2025 · External reference
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21
10.1126/scisignal.2001868 · 2011 · External reference
Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases
10.1369/0022155420930303 · 2020 · External reference
Fibrillin-1 regulates the bioavailability of TGFβ1
10.1083/jcb.200608167 · 2007 · External reference
Diversity of Mechanisms Underlying Latent TGF-β Activation in Recessive Dystrophic Epidermolysis Bullosa
10.1016/j.jid.2020.10.024 · 2021 · External reference
Decorin is a biological ligand for the epidermal growth factor receptor
10.1074/jbc.274.8.4489 · 1999 · External reference
Decorin is a novel antagonistic ligand of the Met receptor
10.1083/jcb.200901129 · 2009 · External reference
Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression
10.1073/pnas.2317760121 · 2024 · External reference
Synergetic roles of TGF-β signaling in tissue engineering
10.1016/j.cyto.2018.12.010 · 2019 · External reference
Decorin core protein fragment Leu155-Val260 interacts with TGF-beta but does not compete for decorin binding to type I collagen
10.1006/abbi.1998.0720 · 1998 · External reference
Alpha-smooth muscle actin expression upregulates fibroblast contractile activity
10.1091/mbc.12.9.2730 · 2001 · External reference
The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship
10.1016/j.matbio.2015.05.006 · 2015 · External reference
The regulation of tenascin expression by tissue microenvironments
10.1016/j.bbamcr.2008.12.012 · 2009 · External reference
Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix
10.1016/s0021-9258(17)35666-1 · 1986 · External reference
Long-Term Safety and Tolerability of Beremagene Geperpavec-svdt (B-VEC) in an Open-Label Extension Study of Patients with Dystrophic Epidermolysis Bullosa
10.1007/s40257-025-00942-y · 2025 · External reference
Glycosaminoglycan Modification of Decorin Depends on MMP14 Activity and Regulates Collagen Assembly
10.3390/cells9122646 · 2020 · External reference
Ageing-associated endothelial decorin induction and the impact of non-glycanated decorin on cardiac inflammation
10.1093/cvr/cvaf128 · 2025 · External reference
Non-glycanated ΔDCN isoform in muscle invasive bladder cancer mediates cancer stemness and gemcitabine resistance
10.1007/s13402-024-00998-8 · 2024 · External reference
Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation
10.1074/jbc.m602853200 · 2006 · External reference
Decorin Protein Core Affects the Global Gene Expression Profile of the Tumor Microenvironment in a Triple-Negative Orthotopic Breast Carcinoma Xenograft Model
10.1371/journal.pone.0045559 · 2012 · External reference
Decorin suppresses neurocan, brevican, phosphacan and NG2 expression and promotes axon growth across adult rat spinal cord injuries
10.1111/j.1460-9568.2004.03184.x · 2004 · External reference
Absence of the dermatan sulfate chain of decorin does not affect mouse development
10.1186/s12952-017-0074-3 · 2017 · External reference
Injury-Driven Stiffening of the Dermis Expedites Skin Carcinoma Progression
10.1158/0008-5472.can-15-1348 · 2016 · External reference
Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma?
10.1016/j.matbio.2005.07.002 · 2005 · External reference
