Research graph
References from Sequence-based artificial intelligence-guided inhibitory peptides to counteract AAV neutralizing antibodies in gene therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Prevalence of Anti-Adeno-Associated Virus Immune Responses in International Cohorts of Healthy Donors
10.1016/j.omtm.2019.05.014 · 2019 · External reference
Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity
10.1016/j.omtm.2020.06.003 · 2020 · External reference
Advances of adeno-associated virus applied in gene therapy to hemophilia from bench work to the clinical use
10.1097/bs9.0000000000000030 · 2019 · External reference
Safety and activity of an engineered, liver-tropic adeno-associated virus vector expressing a hyperactive Padua factor IX administered with prophylactic glucocorticoids in patients with haemophilia B: a single-centre, single-arm, phase 1, pilot trial
10.1016/s2352-3026(22)00113-2 · 2022 · External reference
Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant
10.1056/nejmoa1708538 · 2017 · External reference
AAV5-Factor VIII Gene Transfer in Severe Hemophilia A
10.1056/nejmoa1708483 · 2017 · External reference
Safety and Efficacy of DTX401, an AAV8-Mediated Liver-Directed Gene Therapy, in Adults With Glycogen Storage Disease Type I a (GSDIa)
10.1002/jimd.70014 · 2025 · External reference
Death after High-Dose rAAV9 Gene Therapy in a Patient with Duchenne's Muscular Dystrophy
10.1056/nejmoa2307798 · 2023 · External reference
Relationship Between Neutralizing Antibodies Against Adeno-Associated Virus in the Vitreous and Serum: Effects on Retinal Gene Therapy
10.1167/tvst.8.2.14 · 2019 · External reference
AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial
10.1016/s0140-6736(23)02874-x · 2024 · External reference
Long-Term Follow-Up of the First in Human Intravascular Delivery of AAV for Gene Transfer: AAV2-hFIX16 for Severe Hemophilia B
10.1016/j.ymthe.2020.06.001 · 2020 · External reference
Repeated Systemic Dosing of Adeno-Associated Virus Vectors in Immunocompetent Mice After Blockade of T Cell Costimulatory Pathways
10.1089/hum.2021.129 · 2022 · External reference
Overcoming preexisting humoral immunity to AAV using capsid decoys
10.1126/scitranslmed.3005795 · 2013 · External reference
IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies
10.1038/s41591-020-0911-7 · 2020 · External reference
The combination of rAAV pseudo-lipid nanoparticle and triamcinolone acetonide enables multi-administration to liver
10.1016/j.omtm.2024.101399 · 2025 · External reference
Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice
10.1016/j.jaut.2024.103205 · 2024 · External reference
The DWEYS peptide in systemic lupus erythematosus
10.1016/j.molmed.2012.01.008 · 2012 · External reference
Neutralizing capacity of monoclonal antibodies that recognize peptide sequences underlying the carbohydrates on gp41 of simian immunodeficiency virus
10.1128/jvi.01959-12 · 2012 · External reference
A new strategy: identification of specific antibodies for neutralizing epitope on SARS-CoV-2 S protein by LC-MS/MS combined with immune repertoire
10.1186/s43556-022-00085-0 · 2022 · External reference
Broadly neutralizing antibodies target the coronavirus fusion peptide
10.1126/science.abq3773 · 2022 · External reference
The language of proteins: NLP, machine learning & protein sequences
10.1016/j.csbj.2021.03.022 · 2021 · External reference
Learning meaningful representations of protein sequences
10.1038/s41467-022-29443-w · 2022 · External reference
Accurate prediction of virus-host protein-protein interactions via a siamese neural network using deep protein sequence embeddings
10.1016/j.patter.2022.100551 · 2022 · External reference
Expanding functional protein sequence spaces using generative adversarial networks
10.1038/s42256-021-00310-5 · 2021 · External reference
Evaluating Protein Transfer Learning with TAPE
2019 · External reference
NetTCR-2.0 enables accurate prediction of TCR-peptide binding by using paired TCRalpha and beta sequence data
10.1038/s42003-021-02610-3 · 2021 · External reference
Deep learning-based prediction of the T cell receptor-antigen binding specificity
10.1038/s42256-021-00383-2 · 2021 · External reference
Deciphering interaction fingerprints from protein molecular surfaces using geometric deep learning
10.1038/s41592-019-0666-6 · 2020 · External reference
Evading and overcoming AAV neutralization in gene therapy
10.1016/j.tibtech.2022.11.006 · 2023 · External reference
Global seroprevalence of neutralizing antibodies against adeno-associated virus serotypes used for human gene therapies
10.1016/j.omtm.2024.101273 · 2024 · External reference
Use of plasmapheresis to lower anti-AAV antibodies in nonhuman primates with pre-existing immunity to AAVrh74
10.1016/j.omtm.2024.101195 · 2024 · External reference
A simple method for displaying the hydropathic character of a protein
10.1016/0022-2836(82)90515-0 · 1982 · External reference
CD-HIT: accelerated for clustering the next-generation sequencing data
10.1093/bioinformatics/bts565 · 2012 · External reference
Fixing weight decay regularization in Adam
2018 · External reference
Reducing the risk of adeno-associated virus (AAV) vector mobilization with AAV type 5 vectors
10.1128/jvi.02466-08 · 2009 · External reference
An investigation of the immune epitopes of adeno-associated virus capsid-derived peptides among hemophilia patients
10.1016/j.omtm.2024.101245 · 2024 · External reference
Safety and Efficacy of DTX401, an AAV8-Mediated Liver-Directed Gene Therapy, in Adults With Glycogen Storage Disease Type I a (GSDIa)
10.1002/jimd.70014 · ExternalCitation · doi-reference
A simple method for displaying the hydropathic character of a protein
10.1016/0022-2836(82)90515-0 · ExternalCitation · doi-reference
The language of proteins: NLP, machine learning & protein sequences
10.1016/j.csbj.2021.03.022 · ExternalCitation · doi-reference
Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice
10.1016/j.jaut.2024.103205 · ExternalCitation · doi-reference
The DWEYS peptide in systemic lupus erythematosus
10.1016/j.molmed.2012.01.008 · ExternalCitation · doi-reference
Prevalence of Anti-Adeno-Associated Virus Immune Responses in International Cohorts of Healthy Donors
10.1016/j.omtm.2019.05.014 · ExternalCitation · doi-reference
Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity
10.1016/j.omtm.2020.06.003 · ExternalCitation · doi-reference
Use of plasmapheresis to lower anti-AAV antibodies in nonhuman primates with pre-existing immunity to AAVrh74
10.1016/j.omtm.2024.101195 · ExternalCitation · doi-reference
An investigation of the immune epitopes of adeno-associated virus capsid-derived peptides among hemophilia patients
10.1016/j.omtm.2024.101245 · ExternalCitation · doi-reference
Global seroprevalence of neutralizing antibodies against adeno-associated virus serotypes used for human gene therapies
10.1016/j.omtm.2024.101273 · ExternalCitation · doi-reference
The combination of rAAV pseudo-lipid nanoparticle and triamcinolone acetonide enables multi-administration to liver
10.1016/j.omtm.2024.101399 · ExternalCitation · doi-reference
Accurate prediction of virus-host protein-protein interactions via a siamese neural network using deep protein sequence embeddings
10.1016/j.patter.2022.100551 · ExternalCitation · doi-reference
Evading and overcoming AAV neutralization in gene therapy
10.1016/j.tibtech.2022.11.006 · ExternalCitation · doi-reference
Long-Term Follow-Up of the First in Human Intravascular Delivery of AAV for Gene Transfer: AAV2-hFIX16 for Severe Hemophilia B
10.1016/j.ymthe.2020.06.001 · ExternalCitation · doi-reference
AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial
10.1016/s0140-6736(23)02874-x · ExternalCitation · doi-reference
Safety and activity of an engineered, liver-tropic adeno-associated virus vector expressing a hyperactive Padua factor IX administered with prophylactic glucocorticoids in patients with haemophilia B: a single-centre, single-arm, phase 1, pilot trial
10.1016/s2352-3026(22)00113-2 · ExternalCitation · doi-reference
Learning meaningful representations of protein sequences
10.1038/s41467-022-29443-w · ExternalCitation · doi-reference
IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies
10.1038/s41591-020-0911-7 · ExternalCitation · doi-reference
Deciphering interaction fingerprints from protein molecular surfaces using geometric deep learning
10.1038/s41592-019-0666-6 · ExternalCitation · doi-reference
NetTCR-2.0 enables accurate prediction of TCR-peptide binding by using paired TCRalpha and beta sequence data
10.1038/s42003-021-02610-3 · ExternalCitation · doi-reference
Expanding functional protein sequence spaces using generative adversarial networks
10.1038/s42256-021-00310-5 · ExternalCitation · doi-reference
Deep learning-based prediction of the T cell receptor-antigen binding specificity
10.1038/s42256-021-00383-2 · ExternalCitation · doi-reference
AAV5-Factor VIII Gene Transfer in Severe Hemophilia A
10.1056/nejmoa1708483 · ExternalCitation · doi-reference
Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant
10.1056/nejmoa1708538 · ExternalCitation · doi-reference
Death after High-Dose rAAV9 Gene Therapy in a Patient with Duchenne's Muscular Dystrophy
10.1056/nejmoa2307798 · ExternalCitation · doi-reference
Repeated Systemic Dosing of Adeno-Associated Virus Vectors in Immunocompetent Mice After Blockade of T Cell Costimulatory Pathways
10.1089/hum.2021.129 · ExternalCitation · doi-reference
CD-HIT: accelerated for clustering the next-generation sequencing data
10.1093/bioinformatics/bts565 · ExternalCitation · doi-reference
Advances of adeno-associated virus applied in gene therapy to hemophilia from bench work to the clinical use
10.1097/bs9.0000000000000030 · ExternalCitation · doi-reference
Broadly neutralizing antibodies target the coronavirus fusion peptide
10.1126/science.abq3773 · ExternalCitation · doi-reference
Overcoming preexisting humoral immunity to AAV using capsid decoys
10.1126/scitranslmed.3005795 · ExternalCitation · doi-reference
Neutralizing capacity of monoclonal antibodies that recognize peptide sequences underlying the carbohydrates on gp41 of simian immunodeficiency virus
10.1128/jvi.01959-12 · ExternalCitation · doi-reference
Reducing the risk of adeno-associated virus (AAV) vector mobilization with AAV type 5 vectors
10.1128/jvi.02466-08 · ExternalCitation · doi-reference
Relationship Between Neutralizing Antibodies Against Adeno-Associated Virus in the Vitreous and Serum: Effects on Retinal Gene Therapy
10.1167/tvst.8.2.14 · ExternalCitation · doi-reference
A new strategy: identification of specific antibodies for neutralizing epitope on SARS-CoV-2 S protein by LC-MS/MS combined with immune repertoire
10.1186/s43556-022-00085-0 · ExternalCitation · doi-reference
