Research graph
References from miRNA-34a-5p is a novel biomarker and modulator of the radioresponse in esophageal adenocarcinoma. Local targets link to admitted publications; unresolved targets remain external evidence.
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 · External reference
Obesity and gastrointestinal cancer: the interrelationship of adipose and tumour microenvironments
10.1038/s41575-018-0069-7 · 2018 · External reference
Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries
10.1016/s0140-6736(17)33326-3 · 2018 · External reference
Epidemiology and Outcomes of Young-Onset Esophageal Adenocarcinoma: An Analysis from a Population-Based Database
10.1158/1055-9965.epi-20-0944 · 2021 · External reference
Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial
10.1016/s1470-2045(15)00040-6 · 2015 · External reference
Long-term outcomes following neoadjuvant chemoradiotherapy for esophageal cancer
10.1097/01.sla.0000254367.15810.38 · 2007 · External reference
Esophageal carcinoma advances in treatment results for locally advanced disease: review
10.1093/annonc/mdr433 · 2012 · External reference
A microRNA in a multiple-turnover RNAi enzyme complex
10.1126/science.1073827 · 2002 · External reference
Prediction of mammalian microRNA targets
10.1016/s0092-8674(03)01018-3 · 2003 · External reference
p53-mediated activation of miRNA34 candidate tumor-suppressor genes
10.1016/j.cub.2007.06.068 · 2007 · External reference
Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
10.1016/j.molcel.2007.05.017 · 2007 · External reference
Myc-mediated repression of microRNA-34a promotes high-grade transformation of B-cell lymphoma by dysregulation of FoxP1
10.1182/blood-2010-10-312231 · 2011 · External reference
Role of miR-34 in gastric cancer: From bench to bedside
2019 · External reference
c-Myc Acts as a Competing Endogenous RNA to Sponge miR-34a, in the Upregulation of CD44, in Urothelial Carcinoma
10.3390/cancers11101457 · 2019 · External reference
miR-34a regulates cisplatin-induce gastric cancer cell death by modulating PI3K/AKT/survivin pathway
10.1007/s13277-013-1171-7 · 2014 · External reference
MiR-34a in age and tissue related radio-sensitivity and serum miR-34a as a novel indicator of radiation injury
10.7150/ijbs.7.221 · 2011 · External reference
Cellular responses to ionizing radiation damage
10.1016/s0360-3016(00)01524-8 · 2001 · External reference
Molecular mechanisms of chemo- and radiotherapy resistance and the potential implications for cancer treatment
10.1002/mco2.55 · 2020 · External reference
microRNA-34a promotes DNA damage and mitotic catastrophe
10.4161/cc.26459 · 2013 · External reference
Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest
10.1016/j.febslet.2008.03.057 · 2008 · External reference
The miR-34 family in cancer and apoptosis
10.1038/cdd.2009.56 · 2010 · External reference
MicroRNA-330-5p as a Putative Modulator of Neoadjuvant Chemoradiotherapy Sensitivity in Oesophageal Adenocarcinoma
10.1371/journal.pone.0134180 · 2015 · External reference
Low miR-187 expression promotes resistance to chemoradiation therapy in vitro and correlates with treatment failure in patients with esophageal adenocarcinoma
10.2119/molmed.2016.00020 · 2016 · External reference
MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma
10.1007/s00109-012-0924-x · 2012 · External reference
Alterations in DNA repair efficiency are involved in the radioresistance of esophageal adenocarcinoma
10.1667/rr2295.1 · 2010 · External reference
Novel metastatic models of esophageal adenocarcinoma derived from FLO-1 cells highlight the importance of E-cadherin in cancer metastasis
10.18632/oncotarget.13391 · 2016 · External reference
gammaH2AX: a sensitive molecular marker of DNA damage and repair
10.1038/leu.2010.6 · 2010 · External reference
Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma
10.1371/journal.pone.0100738 · 2014 · External reference
Classification of pathologic response to neoadjuvant therapy in esophageal and junctional cancer: assessment of existing measures and proposal of a novel 3-point standard
10.1097/sla.0b013e3182a66588 · 2013 · External reference
Cancer and radiation therapy: current advances and future directions
10.7150/ijms.3635 · 2012 · External reference
Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity
10.1016/0360-3016(79)90044-0 · 1979 · External reference
The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells
10.1038/onc.2009.106 · 2009 · External reference
Analysis of p53 and miRNA expression after irradiation of glioblastoma cell lines
2012 · External reference
Human serum miR-34a as an indicator of exposure to ionizing radiation
10.1007/s00411-016-0661-6 · 2016 · External reference
Quantitative assessment of miR34a as an independent prognostic marker in breast cancer
10.1038/bjc.2014.573 · 2015 · External reference
miR-34a and miR-21 as biomarkers in evaluating the response of chemo-radiotherapy in Egyptian breast cancer patients
2022 · External reference
Ectopic expression of miR-34a enhances radiosensitivity of non-small cell lung cancer cells, partly by suppressing the LyGDI signaling pathway
10.1093/jrr/rrs136 · 2013 · External reference
In Vivo Delivery of miR-34a Sensitizes Lung Tumors to Radiation Through RAD51 Regulation
10.1038/mtna.2015.47 · 2015 · External reference
MiR-34a reverses radiation resistance on ECA-109 cells by inhibiting PI3K/AKT/mTOR signal pathway through downregulating the expression of SIRT1
10.1080/09553002.2021.1866225 · 2021 · External reference
The DNA-damage response in human biology and disease
10.1038/nature08467 · 2009 · External reference
MiR-34s negatively regulate homologous recombination through targeting RAD51
10.1016/j.abb.2019.03.017 · 2019 · External reference
Preclinical testing of an Atr inhibitor demonstrates improved response to standard therapies for esophageal cancer
10.1016/j.radonc.2016.10.023 · 2016 · External reference
Role of cell cycle in mediating sensitivity to radiotherapy
10.1016/j.ijrobp.2004.03.005 · 2004 · External reference
Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres
10.1186/1471-2407-8-266 · 2008 · External reference
microRNA-34a is tumor suppressive in brain tumors and glioma stem cells
10.4161/cc.9.6.10987 · 2010 · External reference
Analyzing the G2/M checkpoint
2004 · External reference
X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells
10.2307/3572025 · 1966 · External reference
Cyclin E2 Promotes Whole Genome Doubling in Breast Cancer
2020 · External reference
Cyclin E2 overexpression is associated with endocrine resistance but not insensitivity to CDK2 inhibition in human breast cancer cells
10.1158/1535-7163.mct-11-0963 · 2012 · External reference
Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours
10.1038/s41416-020-0802-1 · 2020 · External reference
Clonogenic assay of cells in vitro
10.1038/nprot.2006.339 · 2006 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
10.1006/meth.2001.1262 · 2001 · External reference
Integrated genomic characterization of oesophageal carcinoma
10.1038/nature20805 · 2017 · External reference
Comprehensive molecular characterization of gastric adenocarcinoma
10.1038/nature13480 · 2014 · External reference
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
10.1158/2159-8290.cd-12-0095 · 2012 · External reference
Unresolved reference
2016 · External reference
Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlations
10.1002/1097-0142(19940601)73:11<2680::aid-cncr2820731105>3.0.co;2-c · 1994 · External reference
