Research graph
References from PCBP2 facilitates miR-93-5p-mediated repression of GDF11 in HCC cell lines. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2018 · External reference
From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world
10.3748/wjg.v23.i29.5282 · 2017 · External reference
Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11
10.1038/10320 · 1999 · External reference
Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11
10.1002/ijc.32286 · 2019 · External reference
Clinical significance of growth differentiation factor 11 in colorectal cancer
2007 · External reference
GDF11 upregulation independently predicts shorter overall-survival of uveal melanoma
2019 · External reference
GDF11 restrains tumor growth by promoting apoptosis in pancreatic cancer
10.2147/ott.s181792 · 2018 · External reference
GDF11/BMP11 as a novel tumor marker for liver cancer
2018 · External reference
GDF11 exhibits tumor suppressive properties in hepatocellular carcinoma cells by restricting clonal expansion and invasion
10.1016/j.bbadis.2019.03.003 · 2019 · External reference
Regulation of microRNA biogenesis
10.1038/nrm3838 · 2014 · External reference
Metazoan MicroRNAs
10.1016/j.cell.2018.03.006 · 2018 · External reference
The role of MicroRNAs in human cancer
2016 · External reference
The Role of MicroRNAs in Hepatocellular Carcinoma
10.7150/jca.26350 · 2018 · External reference
MicroRNA-106b-5p promotes hepatocellular carcinoma development via modulating FOG2
10.2147/ott.s203382 · 2019 · External reference
miR-93 enhances hepatocellular carcinoma invasion and metastasis by EMT via targeting PDCD4
10.1007/s10529-017-2403-5 · 2017 · External reference
Over-expression of miR-106b promotes cell migration and metastasis in hepatocellular carcinoma by activating epithelial-mesenchymal transition process
10.1371/journal.pone.0057882 · 2013 · External reference
Erythroid cell-specific mRNA stability elements in the alpha 2-globin 3' nontranslated region
10.1128/mcb.15.5.2457 · 1995 · External reference
Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation
10.1242/jcs.02448 · 2005 · External reference
Overexpression of HnRNP A1 promotes tumor invasion through regulating CD44v6 and indicates poor prognosis for hepatocellular carcinoma
10.1002/ijc.27742 · 2013 · External reference
Characterisation of the nucleic-acid-binding activity of KH domains. Different properties of different domains
10.1111/j.1432-1033.1996.00425.x · 1996 · External reference
mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end
10.1016/s0092-8674(00)80241-x · 1997 · External reference
Requirement of poly(rC) binding protein 2 for translation of poliovirus RNA
10.1128/jvi.71.8.6243-6246.1997 · 1997 · External reference
The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms
10.1017/s1355838202024627 · 2002 · External reference
Overexpression of PCBP2 contributes to poor prognosis and enhanced cell growth in human hepatocellular carcinoma
10.3892/or.2016.5167 · 2016 · External reference
RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3
10.1172/jci61820 · 2013 · External reference
Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2',5'-oligoadenylate synthetase from prostate cancer cells
10.1093/nar/gkl968 · 2006 · External reference
Impact of poly(rC)-binding protein 2 (PCBP2) on the malignant phenotype of cholangiocarcinoma
10.1016/j.bcp.2026.117927 · 2026 · External reference
PCBP2 Posttranscriptional Modifications Induce Breast Cancer Progression via Upregulation of UFD1 and NT5E
10.1158/1541-7786.mcr-20-0390 · 2021 · External reference
Ribotrap analysis of proteins associated with FHL3 3'untranslated region in glioma cells
10.1016/s1001-9294(14)60032-8 · 2014 · External reference
RNA-binding proteins and exoribonucleases modulating miRNA in cancer: the enemy within
10.1038/s12276-024-01224-z · 2024 · External reference
Functional interactions between microRNAs and RNA binding proteins
10.2174/2211536611201010070 · 2012 · External reference
Cooperative interplay of let-7 mimic and HuR with MYC RNA
10.1080/15384101.2015.1069930 · 2015 · External reference
HuR recruits let-7/RISC to repress c-Myc expression
10.1101/gad.1812509 · 2009 · External reference
The regulatory impact of RNA-binding proteins on microRNA targeting
10.1038/s41467-021-25078-5 · 2021 · External reference
GDF11 inhibits the malignant progression of hepatocellular carcinoma via regulation of the mTORC1-autophagy axis
10.3892/etm.2024.12540 · 2024 · External reference
Predicting effective microRNA target sites in mammalian mRNAs
10.7554/elife.05005 · 2015 · External reference
The biochemical basis of microRNA targeting efficacy
10.1126/science.aav1741 · 2019 · External reference
Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data
10.1186/s13059-019-1629-z · 2019 · External reference
miRDB: an online database for prediction of functional microRNA targets
10.1093/nar/gkz757 · 2020 · External reference
Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles
10.1261/rna.2254110 · 2010 · External reference
miRNA profiling of cancer
10.1016/j.gde.2013.01.004 · 2013 · External reference
Oncomirs - microRNAs with a role in cancer
10.1038/nrc1840 · 2006 · External reference
Role of the miR-106b-25 microRNA cluster in hepatocellular carcinoma
10.1111/j.1349-7006.2009.01164.x · 2009 · External reference
Identification of PCBP2, a facilitator of IRES-mediated translation, as a novel constituent of stress granules and processing bodies
10.1261/rna.780708 · 2008 · External reference
Selective localization of PCBP2 to cytoplasmic processing bodies
10.1016/j.bbamcr.2009.02.002 · 2009 · External reference
Computational assessment of the cooperativity between RNA binding proteins and MicroRNAs in Transcript Decay
10.1371/journal.pcbi.1003075 · 2013 · External reference
microRNAs and RNA-binding proteins: a complex network of interactions and reciprocal regulations in cancer
10.4161/rna.24641 · 2013 · External reference
A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility
10.1038/ncb2105 · 2010 · External reference
Novel roles of the multi-functional CCR4-NOT complex in post-transcriptional regulation
10.3389/fgene.2014.00135 · 2014 · External reference
Advances and Breakthroughs in IRES-Directed Translation and Replication of Picornaviruses
10.1128/mbio.00358-23 · 2023 · External reference
Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug
10.1016/j.ymthe.2020.06.015 · 2020 · External reference
Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys
10.1089/nat.2016.0623 · 2016 · External reference
Eplontersen for Hereditary Transthyretin Amyloidosis With Polyneuropathy
10.1001/jama.2023.18688 · 2023 · External reference
Olezarsen, Acute Pancreatitis, and Familial Chylomicronemia Syndrome
10.1056/nejmoa2400201 · 2024 · External reference
Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy
10.1056/nejmoa1702752 · 2017 · External reference
RNA therapeutics: beyond RNA interference and antisense oligonucleotides
10.1038/nrd3625 · 2012 · External reference
Use of target protector morpholinos to analyze the physiological roles of specific miRNA-mRNA pairs in vivo
10.1038/nprot.2011.423 · 2011 · External reference
Disrupting miR-466l-3p and HuR Cooperation with Target Site Blockers Reveals a Therapeutic Strategy to Destabilize mRNA Transcripts
2026 · External reference
Physical traits of cancer
10.1126/science.aaz0868 · 2020 · External reference
Principles of nanoparticle design for overcoming biological barriers to drug delivery
10.1038/nbt.3330 · 2015 · External reference
Context-dependent control of alternative splicing by RNA-binding proteins
10.1038/nrg3778 · 2014 · External reference
Auto-regulatory feedback by RNA-binding proteins
10.1093/jmcb/mjz043 · 2019 · External reference
Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs
10.1093/nar/gkx1239 · 2018 · External reference
RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs
10.3390/cells9010137 · 2020 · External reference
mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues
10.1016/j.molcel.2014.08.028 · 2014 · External reference
Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in zebrafish
10.1126/science.1215704 · 2012 · External reference
MicroRNAs in cancer: biomarkers, functions and therapy
10.1016/j.molmed.2014.06.005 · 2014 · External reference
RNase-assisted RNA chromatography
10.1261/rna.2136010 · 2010 · External reference
DROSHA targets its own transcript to modulate alternative splicing
10.1261/rna.059808.116 · 2017 · External reference
An Amphiphilic Peptide Induces Apoptosis Through the miR29b-p53 Pathway in Cancer Cells
10.1038/mtna.2016.45 · 2016 · External reference
Slicer-independent mechanism drives small-RNA strand separation during human RISC assembly
10.1093/nar/gkv937 · 2015 · External reference
Detection of nonneutral substitution rates on mammalian phylogenies
10.1101/gr.097857.109 · 2010 · External reference
