Research graph
References from Segmented poly(A) tails with microRNA target sites confer tissue-specific regulation for mRNA therapeutics. Local targets link to admitted publications; unresolved targets remain external evidence.
mRNA vaccines for infectious diseases - advances, challenges and opportunities
10.1038/s41573-024-01042-y · 2024 · External reference
mRNA-based therapeutics: powerful and versatile tools to combat diseases
10.1038/s41392-022-01007-w · 2022 · External reference
mRNA-based cancer therapeutics
10.1038/s41568-023-00586-2 · 2023 · External reference
Cancer mRNA vaccines: clinical advances and future opportunities
10.1038/s41571-024-00902-1 · 2024 · External reference
mRNA vaccines: miRNA-based controlled biodistribution and directed adjuvantation
10.1016/j.it.2025.03.004 · 2025 · External reference
Strategies to reduce the risks of mRNA drug and vaccine toxicity
10.1038/s41573-023-00859-3 · 2024 · External reference
Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs
10.1038/s41578-022-00529-7 · 2023 · External reference
microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site
10.1038/s41467-018-05053-3 · 2018 · External reference
Targeting cancer with mRNA-lipid nanoparticles: key considerations and future prospects
10.1038/s41571-023-00811-9 · 2023 · External reference
Regulation by 3'-Untranslated Regions
10.1146/annurev-genet-120116-024704 · 2017 · External reference
A mammalian microRNA expression atlas based on small RNA library sequencing
10.1016/j.cell.2007.04.040 · 2007 · External reference
Distribution of miRNA expression across human tissues
10.1093/nar/gkw116 · 2016 · External reference
Life of RISC: Formation, action, and degradation of RNA-induced silencing complex
10.1016/j.molcel.2021.11.026 · 2022 · External reference
Reducing off-target expression of mRNA therapeutics and vaccines in the liver with microRNA binding sites
10.1016/j.omtm.2024.101402 · 2025 · External reference
miR-122--a key factor and therapeutic target in liver disease
10.1016/j.jhep.2014.10.004 · 2015 · External reference
miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities
10.3390/cells13010084 · 2023 · External reference
MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct
10.1089/nat.2018.0734 · 2018 · External reference
microRNA122-regulated transgene expression increases specificity of cardiac gene transfer upon intravenous delivery of AAV9 vectors
10.1038/gt.2010.141 · 2011 · External reference
Development and characterization of a miRNA-responsive circular RNA expression system with cell type specificity
10.1016/j.omtn.2025.102450 · 2025 · External reference
PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding
10.1038/nsmb.2309 · 2012 · External reference
Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression
10.1038/s41580-021-00417-y · 2022 · External reference
Segmented poly(A) tails significantly reduce recombination of plasmid DNA without affecting mRNA translation efficiency or half-life
10.1261/rna.069286.118 · 2019 · External reference
Branched chemically modified poly(A) tails enhance the translation capacity of mRNA
10.1038/s41587-024-02174-7 · 2025 · External reference
Cytidine-containing tails robustly enhance and prolong protein production of synthetic mRNA in cell and in vivo
10.1016/j.omtn.2022.10.003 · 2022 · External reference
Poly(A) variants supporting robust transmission stability in bacteria and high protein expression in animals for mRNA in vitro transcription
10.1016/j.omtn.2025.102809 · 2026 · External reference
Discovery of Ketal-Ester Ionizable Lipid Nanoparticle with Reduced Hepatotoxicity, Enhanced Spleen Tropism for mRNA Vaccine Delivery
10.1002/advs.202404684 · 2024 · External reference
Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment
10.1158/1078-0432.ccr-20-0472 · 2020 · External reference
What Are 3' UTRs Doing?
10.1101/cshperspect.a034728 · 2019 · External reference
Simplified Lipid Nanoparticles for Tissue- And Cell-Targeted mRNA Delivery Facilitate Precision Tumor Therapy in a Lung Metastasis Mouse Model
10.1002/adma.202409812 · 2024 · External reference
