Research graph
References from Thermal dose and thermobiophysical regulation of skeletal tissues: A context-dependent framework from molecular thermosensing to microenvironment remodeling. Local targets link to admitted publications; unresolved targets remain external evidence.
Chondrocyte viability and metabolic activity after treatment of bovine articular cartilage with bipolar radiofrequency: an in vitro study
10.1016/j.arthro.2004.03.018 · 2004 · External reference
The history of radiofrequency energy and Coblation in arthroscopy: a current concepts review of its application in chondroplasty of the knee
10.1186/s40634-018-0168-y · 2019 · External reference
Recombinant HSP70 and mild heat shock stimulate growth of aged mesenchymal stem cells
10.1007/s12192-016-0691-7 · 2016 · External reference
Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast
10.1074/jbc.m409332200 · 2005 · External reference
Cold exposure reduces trabecular and cortical bone mass in wildtype and Dio2-deficient mice
10.1210/endocr/bqag011 · 2026 · External reference
Thermotherapy for treatment of osteoarthritis
10.1002/14651858.cd004259 · 2003 · External reference
Crosstalk between ferroptosis and chondrocytes in osteoarthritis: a systematic review of in vivo and in vitro studies
2023 · External reference
Effect of nanoheat stimulation mediated by magnetic nanocomposite hydrogel on the osteogenic differentiation of mesenchymal stem cells
10.1007/s11427-017-9287-8 · 2018 · External reference
Extracellular heat shock protein 70 promotes osteogenesis of human mesenchymal stem cells through activation of the ERK signaling pathway
10.1016/j.febslet.2015.11.021 · 2015 · External reference
Periodic heat shock accelerated the chondrogenic differentiation of human mesenchymal stem cells in pellet culture
2014 · External reference
Enhanced osteogenesis of human mesenchymal stem cells by periodic heat shock in self-assembling peptide hydrogel
10.1089/ten.tea.2012.0070 · 2013 · External reference
Magnetoelectric 3D microenvironments for tissue engineering: a comprehensive review
2026 · External reference
Warmth prevents bone loss through the Gut Microbiota
10.1016/j.cmet.2020.08.012 · 2020 · External reference
Recovery of articular cartilage metabolism following thermal stress is facilitated by IGF-1 and JNK inhibitor
10.1177/0363546503260743 · 2004 · External reference
An asymmetric magnetic hydrogel with mild magnetothermal effect for safe and efficient bone repair
10.1002/adhm.71642 · 2026 · External reference
Response of preosteoblasts to thermal stress conditioning and osteoinductive growth factors
10.1007/s12192-011-0300-8 · 2012 · External reference
Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice
10.1002/art.27624 · 2010 · External reference
Short-term cryotherapy did not substantially reduce pain and had unclear effects on physical function and quality of life in people with knee osteoarthritis: a randomised trial
10.1016/j.jphys.2019.08.004 · 2019 · External reference
Cryotherapy in knee osteoarthritis: a systematic review with meta-analysis
10.1111/papr.70055 · 2025 · External reference
Heat-shock-induced cellular responses to temperature elevations occurring during orthopaedic cutting
10.1098/rsif.2012.0520 · 2012 · External reference
Thermally induced osteocyte damage initiates a remodelling signaling cascade
10.1371/journal.pone.0119652 · 2015 · External reference
Osteocyte apoptosis contributes to cold exposure-induced bone loss
10.3389/fbioe.2021.733582 · 2021 · External reference
Brown adipose tissue rescues bone loss induced by cold exposure
2021 · External reference
TRPV4 channel activation improves the tensile properties of self-assembled articular cartilage constructs
10.1016/j.actbio.2012.10.031 · 2013 · External reference
Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins
10.1038/nsmb.1610 · 2009 · External reference
Temperature-modulated diversity of TRPV4 channel gating: activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and -independent pathways
10.1074/jbc.m302517200 · 2003 · External reference
Magnetic hyperthermia in focus: emerging non-cancer applications of magnetic nanoparticles
10.1039/d5nr03329b · 2025 · External reference
Local cryotherapy improves adjuvant-induced arthritis through down-regulation of IL-6/IL-17 pathway but independently of TNFα
10.1371/journal.pone.0178668 · 2017 · External reference
Local ice cryotherapy decreases synovial interleukin 6, interleukin 1β, vascular endothelial growth factor, prostaglandin-E2, and nuclear factor kappa B p65 in human knee arthritis: a controlled study
10.1186/s13075-019-1965-0 · 2019 · External reference
Heat-evoked activation of the ion channel
10.1523/jneurosci.22-15-06408.2002 · 2002 · External reference
Photobiomodulation in promoting cartilage regeneration
10.3390/ijms26125580 · 2025 · External reference
A randomized controlled trial on the effect of focal thermal therapy at acupressure points treating osteoarthritis of the knee
10.1186/s13018-021-02398-2 · 2021 · External reference
Radiofrequency-Based chondroplasty creates a precise area of targeted chondrocyte death with minimal necrosis outside the target Zone: a systematic review
10.1016/j.asmr.2023.100754 · 2023 · External reference
The multifaceted functions of TRPV4 and calcium oscillations in tissue repair
2024 · External reference
The analysis of articular cartilage after thermal exposure: "is red really dead?"
10.1053/jars.2003.50087 · 2003 · External reference
Application of heat and a home exercise program for pain and function levels in patients with knee osteoarthritis: a randomized controlled trial
10.1111/ijn.12772 · 2019 · External reference
Role of heat shock protein 27 in transforming growth factor-β-stimulated vascular endothelial growth factor release in osteoblasts
2011 · External reference
Heat-treated osteoblastic cell (ROS17/2.8)-conditioned medium induces the formation of osteoclast-like cells
10.1016/s0169-6009(08)80048-7 · 1993 · External reference
Cold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy
10.1186/s12951-024-02640-z · 2024 · External reference
TRPM8 modulates temperature regulation in a sex-dependent manner without affecting cold-induced bone loss
10.1371/journal.pone.0231060 · 2021 · External reference
How do cells respond to their thermal environment?
10.1080/02656730500307298 · 2005 · External reference
Downregulation of heat shock protein 70 impairs osteogenic and chondrogenic differentiation in human mesenchymal stem cells
10.1038/s41598-017-18541-1 · 2018 · External reference
Mild heat stress enhances angiogenesis in a co-culture system consisting of primary human osteoblasts and outgrowth endothelial cells
10.1089/ten.tec.2013.0087 · 2014 · External reference
Heat shock-induced necrosis and apoptosis in osteoblasts
10.1002/jor.1100170614 · 1999 · External reference
Linking thermodynamics and measurements of protein stability
10.1093/protein/gzab002 · 2021 · External reference
Hypothermia inhibits the proliferation of bone marrow-derived mesenchymal stem cells and increases tolerance to hypoxia by enhancing SUMOylation
2017 · External reference
Heat shock protein 70 protects PC12 cells against ischemia-hypoxia/reoxygenation by maintaining intracellular Ca(2+) homeostasis
10.4103/1673-5374.187051 · 2016 · External reference
The effects of radiofrequency on cartilage: a systematic review of preclinical evidence in animals and humans
10.1002/jeo2.70297 · 2025 · External reference
Stress relief: emerging methods to mitigate dissociation-induced artefacts
10.1016/j.tcb.2021.05.004 · 2021 · External reference
Quantification of laser-induced cartilage injury by confocal microscopy in an ex vivo model
10.2106/00004623-200104000-00012 · 2001 · External reference
The thermal effects of skeletal fixation-pin insertion in bone
10.2106/00004623-198466070-00015 · 1984 · External reference
Temperatures measured in human cortical bone when drilling
10.2106/00004623-197254020-00008 · 1972 · External reference
Multistep mechanism of substrate binding determines chaperone activity of Hsp70
10.1038/76819 · 2000 · External reference
Repeat mild heat shock increases dermal fibroblast activity and collagen production
10.1089/rej.2008.0683 · 2008 · External reference
TRPV4 as a therapeutic target for joint diseases
10.1007/s00210-014-1078-x · 2015 · External reference
Cooperation of Hsp70 and Hsp100 chaperone machines in protein disaggregation
10.3389/fmolb.2015.00022 · 2015 · External reference
Effectiveness of home-based conventional exercise and cryotherapy on daily living activities in patients with knee osteoarthritis: a randomized controlled clinical trial
2023 · External reference
Cadaveric Study of bone tissue temperature during pin site drilling using fluoroptic thermography
10.1097/bot.0000000000001191 · 2018 · External reference
Thermal adaptation of heat shock proteins
10.2174/138920308786733903 · 2008 · External reference
Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation
10.1074/jbc.m706158200 · 2007 · External reference
Temperature evolution following joint loading promotes chondrogenesis by synergistic cues via calcium signaling
10.7554/elife.72068 · 2022 · External reference
Cold exposure stimulates lipid metabolism, induces inflammatory response in the adipose tissue of mice and promotes the osteogenic differentiation of BMMSCs via the p38 MAPK pathway in vitro
2015 · External reference
TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading
10.1073/pnas.1319569111 · 2014 · External reference
Cartilage-Specific knockout of the mechanosensory ion channel TRPV4 decreases age-related osteoarthritis
2016 · External reference
Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses
10.1186/s13059-019-1830-0 · 2019 · External reference
Treating arthritis with locally applied heat or cold
10.1016/s0049-0172(05)80002-2 · 1994 · External reference
Hypothermia inhibits osteoblast differentiation and bone formation but stimulates osteoclastogenesis
10.1016/j.yexcr.2012.06.021 · 2012 · External reference
Effects of local cryotherapy on systemic endothelial activation, dysfunction, and vascular inflammation in adjuvant-induced arthritis (AIA) rats
10.1186/s13075-022-02774-1 · 2022 · External reference
Thermomechanobiology as a new research field in soft tissues
10.3389/fmede.2024.1491942 · 2024 · External reference
Deep heating therapy via microwave diathermy relieves pain and improves physical function in patients with knee osteoarthritis: a double-blind randomized clinical trial
2012 · External reference
Hypothermia promotes cell-protective and chondroprotective effects after blunt cartilage trauma
10.1177/0363546517736051 · 2018 · External reference
Low temperature decreases bone mass in mice: implications for humans
10.1002/ajpa.23684 · 2018 · External reference
Thermal damage in orthopaedics
10.5435/jaaos-d-23-00838 · 2024 · External reference
The effects of radiofrequency energy treatment on chondrocytes and matrix of fibrillated articular cartilage
10.1177/03635465030310031001 · 2003 · External reference
Heat shock protein 70 negatively regulates TGF-β-Stimulated VEGF synthesis via p38 MAP kinase in osteoblasts
10.1159/000485418 · 2017 · External reference
Thermal dose determination in cancer therapy
10.1016/0360-3016(84)90379-1 · 1984 · External reference
Infrared thermography for the evaluation of inflammatory and degenerative joint diseases: a systematic review
10.1177/19476035211063862 · 2021 · External reference
Environmental temperature impact on bone and cartilage growth
10.1002/j.2040-4603.2014.tb00556.x · 2014 · External reference
Mild heat shock induces proliferation, alkaline phosphatase activity, and mineralization in human bone marrow stromal cells and Mg-63 cells in vitro
10.1359/jbmr.2001.16.4.731 · 2001 · External reference
Temperature changes during implant osteotomy preparations in fresh human cadaver tibiae, comparing straight with tapered drills
10.3390/ma15072369 · 2022 · External reference
Mimicking loading-induced cartilage self-heating in vitro promotes matrix Formation in Chondrocyte-Laden constructs with different mechanical properties
10.1021/acsbiomaterials.2c00723 · 2023 · External reference
Hyperthermia for the treatment of articular cartilage with osteoarthritis
10.3109/02656730903107519 · 2009 · External reference
Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: an update from the bone marrow adiposity society (BMAS)
2025 · External reference
Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant
10.1016/j.biomaterials.2018.12.008 · 2019 · External reference
Effects of heat stimulation via microwave applicator on cartilage matrix gene and HSP70 expression in the rabbit knee joint
10.1002/jor.20421 · 2008 · External reference
Bone marrow adiposity and the hematopoietic niche: a historical perspective of reciprocity, heterogeneity, and lineage commitment
10.1016/j.beem.2021.101564 · 2021 · External reference
Effects of thermal energy on chondrocyte viability
10.2460/ajvr.67.10.1708 · 2006 · External reference
Transient receptor potential channels in chondrocyte homeostasis and pathophysiology: from molecular mechanisms to translational therapeutics
10.1016/j.ijbiomac.2025.149035 · 2025 · External reference
Calcium-cell cycle regulator, differentiator, killer, chemopreventor, and maybe, tumor promoter
10.1002/jcb.240590811 · 1995 · External reference
Low intensity thermal stimulation to enhance early osteointegration in implants: a preclinical Study in rabbits
10.1002/cre2.70223 · 2025 · External reference
Type H blood vessels in coupling angiogenesis-osteogenesis and its application in bone tissue engineering
10.1002/jbm.b.35243 · 2023 · External reference
Bone modelling and remodelling in cold environment
10.3390/biom15040564 · 2025 · External reference
Vitamin C alleviates heat-stress-induced damages in pig thoracic vertebral chondrocytes via the ubiquitin-mediated proteolysis pathway
10.3390/antiox13111341 · 2024 · External reference
The effect of heat application on pain, stiffness, physical function and quality of life in patients with knee osteoarthritis
10.1111/j.1365-2702.2009.03070.x · 2010 · External reference
Effects of thermal environment on bone microenvironment: a narrative review
10.3390/ijms26083501 · 2025 · External reference
Environmental high temperature (heat stroke) causes articular cartilage damage in vivo and in vitro
10.1016/j.ecoenv.2024.117535 · 2025 · External reference
Mid-IR laser ablation of articular and fibro-cartilage: a wavelength dependence study of thermal injury and crater morphology
10.1002/lsm.20288 · 2006 · External reference
Osteoclastogenesis, bone resorption, and osteoclast-based therapeutics
10.1359/jbmr.2003.18.4.599 · 2003 · External reference
Neural network methodology for real-time modelling of bio-heat transfer during thermo-therapeutic applications
10.1016/j.artmed.2019.101728 · 2019 · External reference
Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases
10.1126/scitranslmed.aaw6143 · 2020 · External reference