Research graph
References from Galanin signaling in stress-induced brain–gut axis dysregulation: Receptor-specific mechanisms and context-dependent pharmacology. Local targets link to admitted publications; unresolved targets remain external evidence.
Stress and the brain-gut axis in functional and chronic-inflammatory gastrointestinal diseases: a transdisciplinary challenge
10.1016/j.psyneuen.2019.104501 · 2020 · External reference
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems
2015 · External reference
Review: occurrence and distribution of galanin in the physiological and inflammatory states in the mammalian gastrointestinal tract
10.3389/fimmu.2020.602070 · 2021 · External reference
Distribution of galanin-1, -2 and -3 receptor messenger RNAs in central and peripheral rat tissues
10.1016/s0306-4522(99)00407-8 · 2000 · External reference
Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus
10.1074/jbc.274.52.37041 · 1999 · External reference
Pharmacological and functional characterization of galanin-like peptide fragments as potent galanin receptor agonists
10.1016/j.npep.2004.12.015 · 2005 · External reference
Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III
10.1210/en.2013-2106 · 2014 · External reference
Hypothalamic Galanin-producing neurons regulate stress in zebrafish through a peptidergic, self-inhibitory loop
10.1016/j.cub.2022.02.011 · 2022 · External reference
Involvement of galanin receptors 1 and 2 in the modulation of mouse vagal afferent mechanosensitivity
10.1113/jphysiol.2007.135939 · 2007 · External reference
Galanin receptor 3 attenuates inflammation and influences the gut microbiota in an experimental murine colitis model
10.1038/s41598-020-79456-y · 2021 · External reference
The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders
10.1016/j.phrs.2021.105840 · 2021 · External reference
Brain–gut–microbiota axis in depression: A historical overview and future directions
10.1016/j.brainresbull.2022.02.004 · 2022 · External reference
Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome
10.3748/wjg.v28.i4.412 · 2022 · External reference
Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis
10.1016/j.pnpbp.2020.110209 · 2021 · External reference
The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective
10.1113/jp281951 · 2023 · External reference
Stress and the gut-brain axis: an inflammatory perspective
10.3389/fnmol.2024.1415567 · 2024 · External reference
Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis
10.1038/s41575-023-00890-0 · 2024 · External reference
Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro
10.1136/gut.2006.117549 · 2008 · External reference
Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism
10.1136/gutjnl-2013-305690 · 2014 · External reference
Inhibition of corticotropin-releasing hormone receptor 1 and activation of receptor 2 protect against colonic injury and promote epithelium repair
10.1038/srep46616 · 2017 · External reference
Corticotrophin-releasing factor, related peptides, and receptors in the normal and inflamed gastrointestinal tract
10.3389/fnins.2011.00054 · 2011 · External reference
Stress-induced norepinephrine release in the hypothalamic paraventricular nucleus and pituitary-adrenocortical and sympathoadrenal activity: in vivo microdialysis studies
10.1006/frne.1995.1004 · 1995 · External reference
Decreased nutrient blood flow during dopamine- and epinephrine-induced intestinal vasodilation
10.1016/s0022-3565(25)21396-9 · 1984 · External reference
Early effects of catecholamine therapy on mucosal integrity, intestinal blood flow, and oxygen metabolism in porcine endotoxin shock
10.1097/00000658-199808000-00014 · 1998 · External reference
Growth stimulation of intestinal commensal Escherichia coli by catecholamines: a possible contributory factor in trauma-induced sepsis
10.1097/00024382-200211000-00014 · 2002 · External reference
Differential effects of epinephrine, norepinephrine, and indole on Escherichia coli O157:H7 chemotaxis, colonization, and gene expression
10.1128/iai.00630-07 · 2007 · External reference
Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT3 receptors in conscious rats
10.1152/ajpgi.00419.2006 · 2007 · External reference
Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice
10.1053/j.gastro.2013.01.047 · 2013 · External reference
Changes in Intestinal Motility and Gut Microbiota Composition in a Rat Stress Model
10.1159/000452364 · 2017 · External reference
Prebiotic and Probiotic Modulation of the Microbiota–Gut–Brain Axis in Depression
10.3390/nu15081880 · 2023 · External reference
Gut microbiota modulates neurotransmitter and gut-brain signaling
10.1016/j.micres.2024.127858 · 2024 · External reference
Methodological recommendations for human microbiota-gut-brain axis research
2024 · External reference
Principles and clinical implications of the brain-gut-enteric microbiota axis
10.1038/nrgastro.2009.35 · 2009 · External reference
Galanin family peptides: Molecular structure, expression and roles in the neuroendocrine axis and in the spinal cord
10.3389/fendo.2022.1019943 · 2022 · External reference
Galanin—a neuropeptide with inhibitory actions
10.1007/bf02071130 · 1995 · External reference
Galanin—10 years with a neuroendocrine peptide
10.1016/1357-2725(95)00008-d · 1995 · External reference
The galanin and galanin receptor subtypes, its regulatory role in the biological and pathological functions
10.33549/physiolres.933576 · 2017 · External reference
Galanin Receptors: G Protein-Dependent Signaling and Beyond
10.3390/biom16020236 · 2026 · External reference
Analysis of the contribution of galanin receptors 1 and 2 to the central actions of galanin-like peptide
10.1159/000079632 · 2004 · External reference
Galanin-like peptide stimulates vasopressin, oxytocin and adrenocorticotropic hormone release in rats
10.1097/00001756-200502280-00008 · 2005 · External reference
Identification of novel peptide hormones in the human proteome by hidden Markov model screening
10.1101/gr.5755407 · 2007 · External reference
Spexin enhances bowel movement through activating L-type voltage-dependent calcium channel via galanin receptor 2 in mice
2015 · External reference
Spexin as an anxiety regulator in mouse hippocampus: Mechanisms for transcriptional regulation of spexin gene expression by corticotropin releasing factor
10.1016/j.bbrc.2020.02.023 · 2020 · External reference
Coexistence of galanin-like immunoreactivity with catecholamines, 5-hydroxytryptamine, GABA and neuropeptides in the rat CNS
10.1523/jneurosci.06-12-03640.1986 · 1986 · External reference
T. Hökfelt, Ultrastructural studies on peptides in the dorsal horn of the spinal cord—I. Co-existence of galanin with other peptides in primary afferents in normal rats
10.1016/0306-4522(93)90069-r · 1993 · External reference
Galanin receptor antagonists: a potential novel pharmacological treatment for mood disorders
10.2165/00023210-200620080-00003 · 2006 · External reference
Human colonic epithelial cells express galanin-1 receptors, which when activated cause Cl- secretion, Am. J. Physiol
1999 · External reference
A novel long-galanin peptide from non-mammalian vertebrates mitigates the inflammatory response in IBD models via the biased GALR2/β-arrestin2 pathway
10.1038/s41467-025-66335-1 · 2025 · External reference
Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3
10.1046/j.1471-4159.1998.71062239.x · 1998 · External reference
Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
10.1038/s41467-022-29072-3 · 2022 · External reference
Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes
10.1021/bi9728405 · 1998 · External reference
Impairment of memory consolidation by galanin correlates with in vivo inhibition of both LTP and CREB phosphorylation
10.1016/j.nlm.2009.06.005 · 2009 · External reference
Galanin inhibition of voltage-dependent Ca²⁺ influx in rat cultured myenteric neurons is mediated by galanin receptor 1
10.1002/jnr.21923 · 2009 · External reference
10.1016/j.neuroscience.2005.02.042
10.1016/j.neuroscience.2005.02.042 · 2005 · External reference
Activation of galanin receptor 1 inhibits locus coeruleus neurons via GIRK channels
10.1016/j.bbrc.2018.05.181 · 2018 · External reference
Galanin inhibition of enteric cholinergic neurotransmission: guanosine triphosphate-binding protein interactions with adenylate cyclase
1992 · External reference
Role of galanin receptor 1 in peristaltic activity in the guinea pig ileum
10.1016/j.neuroscience.2003.12.043 · 2004 · External reference
vivo interaction between serotonin and galanin receptors types 1 and 2 in the dorsal raphe: implication for limbic seizures
10.1111/j.1471-4159.2005.03498.x · 2005 · External reference
Cloned human and rat galanin GALR3 receptors
1998 · External reference
Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299
10.1073/pnas.0508970102 · 2005 · External reference
GalR3 mediates galanin proliferative effects on postnatal hippocampal precursors
10.1016/j.npep.2017.04.002 · 2017 · External reference
Effects of galanin on monoaminergic systems and HPA axis: Potential mechanisms underlying the effects of galanin on addiction- and stress-related behaviors
10.1016/j.brainres.2009.08.033 · 2010 · External reference
Galanin Inhibits Gut-Related Vagal Neurons in Rats
10.1152/jn.00869.2003 · 2004 · External reference
Differential galanin receptor-1 and galanin expression by 5-HT neurons in dorsal raphé nucleus of rat and mouse: evidence for species-dependent modulation of serotonin transmission
10.1046/j.1460-9568.2003.02471.x · 2003 · External reference
Differential role of galanin receptors in the regulation of depression-like behavior and monoamine/stress-related genes at the cell body level
10.1038/sj.npp.1301660 · 2008 · External reference
Depression-like behavior in rat: involvement of galanin receptor subtype 1 in the ventral periaqueductal gray
2016 · External reference
Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli
10.14814/phy2.14326 · 2020 · External reference
The galanin receptor type 2 initiates multiple signaling pathways in small cell lung cancer cells by coupling to Gq, Gi and G12 proteins
10.1038/sj.onc.1203777 · 2000 · External reference
Investigating the potential of GalR2 as a drug target for neuropathic pain
10.1016/j.npep.2022.102311 · 2023 · External reference
vitro toxicity of the galanin receptor 3 antagonist SNAP 37889
10.1016/j.npep.2015.12.003 · 2016 · External reference
Involvement of Novel Feeding-Related Peptides in Neuroendocrine Response to Stress
10.1177/153537020322801011 · 2003 · External reference
Galaninergic mechanisms are involved in the regulation of corticotropin and thyrotropin secretion in the rat
10.1210/endo-127-5-2281 · 1990 · External reference
Galanin inhibits insulin and corticosterone release after injection into the PVN
10.1016/0006-8993(90)90050-l · 1990 · External reference
The role of galanin system in modulating depression, anxiety, and addiction-like behaviors after chronic restraint stress
10.1016/j.neuroscience.2013.04.046 · 2013 · External reference
Galanin inhibits ACTH release in vitro and can be demonstrated immunocytochemically in dispersed corticotrophs
10.1006/excr.1996.0319 · 1996 · External reference
Evidence for a paracrine role of endogenous adrenomedullary galanin in the regulation of glucocorticoid secretion in the rat adrenal gland
2007 · External reference
Interplay Between Galanin and Leptin in the Hypothalamic Control of Feeding via Corticotropin-Releasing Hormone and Neuropeptide Y
10.2337/diabetes.50.12.2666 · 2001 · External reference
Galanin enhances corticosterone secretion from dispersed rat adrenocortical cells through the activation of GAL-R1 and GAL-R2 receptors coupled to the adenylate cyclase-dependent signaling cascade
2007 · External reference
D.A. Morilak, Modulatory Effects of Galanin in the Lateral Bed Nucleus of the Stria Terminalis on Behavioral and Neuroendocrine Responses to Acute Stress
10.1016/s0893-133x(01)00424-9 · 2002 · External reference
Novel galanin receptor subtype specific ligands in feeding regulation
10.1016/j.neuint.2011.02.012 · 2011 · External reference
Galanin peptide family regulation of glucose metabolism
10.1016/j.yfrne.2019.100801 · 2020 · External reference
Role of Melatonin, Galanin, and RFamide Neuropeptides QRFP26 and QRFP43 in the Neuroendocrine Control of Pancreatic β-Cell Function
10.3389/fendo.2017.00143 · 2017 · External reference
Spexin and Galanin in Metabolic Functions and Social Behaviors With a Focus on Non-Mammalian Vertebrates
10.3389/fendo.2022.882772 · 2022 · External reference
Exploring the role of neuropeptides in depression and anxiety
10.1016/j.pnpbp.2021.110478 · 2022 · External reference
A vagus nerve dominant tetra-synaptic ascending pathway for gastric pain processing
10.1038/s41467-024-54056-w · 2024 · External reference
Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance
10.1016/j.cmet.2012.06.015 · 2012 · External reference
Arcuate Nucleus-Dependent Regulation of Metabolism-Pathways to Obesity and Diabetes Mellitus
10.1210/endrev/bnab025 · 2022 · External reference
Mechanistic relationship between the vagal afferent pathway, central nervous system and peripheral organs in appetite regulation
10.1111/jdi.12492 · 2016 · External reference
Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization
10.1016/j.bbrc.2010.02.078 · 2010 · External reference
Galanin (1–15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system
10.1007/s00429-015-1180-y · 2016 · External reference
Galanin subtype 1 and subtype 2 receptors mediate opposite anxiety-like effects in the rat dorsal raphe nucleus
10.1016/j.bbr.2016.08.007 · 2016 · External reference
Serotonin heteroreceptor complexes and their integration of signals in neurons and astroglia—relevance for mental diseases
10.3390/cells10081902 · 2021 · External reference
Galanin(1-15) Potentiates the Antidepressant-like Effects Induced by Escitalopram in a Rat Model of Depression
10.3390/ijms221910848 · 2021 · External reference
Effects of galanin on the opossum internal anal sphincter: structure-activity relationship
10.1016/0016-5085(91)80015-2 · 1991 · External reference
Role of galanin in the gastrointestinal sphincters
10.1111/j.1749-6632.1998.tb10691.x · 1998 · External reference
Interaction of NO and VIP in gastrointestinal smooth muscle relaxation
10.2174/1381612043383890 · 2004 · External reference
Influence of the regulatory peptide galanin on cytokine expression in human monocytes
10.1111/nyas.14111 · 2019 · External reference
Galanin modulates human and murine neutrophil activation in vitro
10.1111/apha.12444 · 2015 · External reference
Galanin is a potent modulator of cytokine and chemokine expression in human macrophages
10.1038/s41598-019-43704-7 · 2019 · External reference
The neuropeptide galanin modulates natural killer cell function
10.1016/j.npep.2016.11.002 · 2017 · External reference
Inferior vagal ganglion galaninergic response to gastric ulcers
10.1371/journal.pone.0242746 · 2020 · External reference
A galanin receptor subtype 1 specific agonist
10.1007/s10989-004-1717-z · 2005 · External reference
Binding of chimeric peptides M617 and M871 to galanin receptor type 3 reveals characteristics of galanin receptor–ligand interaction
10.1007/s10989-009-9197-9 · 2010 · External reference
Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors
10.1073/pnas.161293598 · 2001 · External reference
Galanin (2–11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes
10.1016/j.npep.2004.12.013 · 2005 · External reference
M871—A novel peptide antagonist selectively recognizing the galanin receptor type 2
10.1007/s10989-005-9008-x · 2006 · External reference
Development of spexin-based human galanin receptor type II-specific agonists with increased stability in serum and anxiolytic effect in mice
10.1038/srep21453 · 2016 · External reference
GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models
10.1073/pnas.1008986107 · 2010 · External reference
Structural insights into galanin receptor signaling
10.1073/pnas.2121465119 · 2022 · External reference
Preferential activation by galanin 1–15 fragment of the GalR1 protomer of a GalR1–GalR2 heteroreceptor complex
10.1016/j.bbrc.2014.08.061 · 2014 · External reference
Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor
10.1038/s42003-018-0134-3 · 2018 · External reference
Spexin-GALR2-Gq axis as a biased signaling pathway for colitis therapy
2026 · External reference
Galanin inhibition of voltage-dependent Ca²⁺ influx in rat cultured myenteric neurons is mediated by galanin receptor 1
10.1002/jnr.21923 · ExternalCitation · doi-reference
Galanin inhibits ACTH release in vitro and can be demonstrated immunocytochemically in dispersed corticotrophs
10.1006/excr.1996.0319 · ExternalCitation · doi-reference
Stress-induced norepinephrine release in the hypothalamic paraventricular nucleus and pituitary-adrenocortical and sympathoadrenal activity: in vivo microdialysis studies
10.1006/frne.1995.1004 · ExternalCitation · doi-reference
Galanin—a neuropeptide with inhibitory actions
10.1007/bf02071130 · ExternalCitation · doi-reference
Galanin (1–15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system
10.1007/s00429-015-1180-y · ExternalCitation · doi-reference
A galanin receptor subtype 1 specific agonist
10.1007/s10989-004-1717-z · ExternalCitation · doi-reference
M871—A novel peptide antagonist selectively recognizing the galanin receptor type 2
10.1007/s10989-005-9008-x · ExternalCitation · doi-reference
Binding of chimeric peptides M617 and M871 to galanin receptor type 3 reveals characteristics of galanin receptor–ligand interaction
10.1007/s10989-009-9197-9 · ExternalCitation · doi-reference
Galanin inhibits insulin and corticosterone release after injection into the PVN
10.1016/0006-8993(90)90050-l · ExternalCitation · doi-reference
Effects of galanin on the opossum internal anal sphincter: structure-activity relationship
10.1016/0016-5085(91)80015-2 · ExternalCitation · doi-reference
T. Hökfelt, Ultrastructural studies on peptides in the dorsal horn of the spinal cord—I. Co-existence of galanin with other peptides in primary afferents in normal rats
10.1016/0306-4522(93)90069-r · ExternalCitation · doi-reference
Galanin—10 years with a neuroendocrine peptide
10.1016/1357-2725(95)00008-d · ExternalCitation · doi-reference
Galanin subtype 1 and subtype 2 receptors mediate opposite anxiety-like effects in the rat dorsal raphe nucleus
10.1016/j.bbr.2016.08.007 · ExternalCitation · doi-reference
Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization
10.1016/j.bbrc.2010.02.078 · ExternalCitation · doi-reference
Preferential activation by galanin 1–15 fragment of the GalR1 protomer of a GalR1–GalR2 heteroreceptor complex
10.1016/j.bbrc.2014.08.061 · ExternalCitation · doi-reference
Activation of galanin receptor 1 inhibits locus coeruleus neurons via GIRK channels
10.1016/j.bbrc.2018.05.181 · ExternalCitation · doi-reference
Spexin as an anxiety regulator in mouse hippocampus: Mechanisms for transcriptional regulation of spexin gene expression by corticotropin releasing factor
10.1016/j.bbrc.2020.02.023 · ExternalCitation · doi-reference
Effects of galanin on monoaminergic systems and HPA axis: Potential mechanisms underlying the effects of galanin on addiction- and stress-related behaviors
10.1016/j.brainres.2009.08.033 · ExternalCitation · doi-reference
Brain–gut–microbiota axis in depression: A historical overview and future directions
10.1016/j.brainresbull.2022.02.004 · ExternalCitation · doi-reference
Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance
10.1016/j.cmet.2012.06.015 · ExternalCitation · doi-reference
Hypothalamic Galanin-producing neurons regulate stress in zebrafish through a peptidergic, self-inhibitory loop
10.1016/j.cub.2022.02.011 · ExternalCitation · doi-reference
Gut microbiota modulates neurotransmitter and gut-brain signaling
10.1016/j.micres.2024.127858 · ExternalCitation · doi-reference
Novel galanin receptor subtype specific ligands in feeding regulation
10.1016/j.neuint.2011.02.012 · ExternalCitation · doi-reference
Role of galanin receptor 1 in peristaltic activity in the guinea pig ileum
10.1016/j.neuroscience.2003.12.043 · ExternalCitation · doi-reference
10.1016/j.neuroscience.2005.02.042
10.1016/j.neuroscience.2005.02.042 · ExternalCitation · doi-reference
The role of galanin system in modulating depression, anxiety, and addiction-like behaviors after chronic restraint stress
10.1016/j.neuroscience.2013.04.046 · ExternalCitation · doi-reference
Impairment of memory consolidation by galanin correlates with in vivo inhibition of both LTP and CREB phosphorylation
10.1016/j.nlm.2009.06.005 · ExternalCitation · doi-reference
Galanin (2–11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes
10.1016/j.npep.2004.12.013 · ExternalCitation · doi-reference
Pharmacological and functional characterization of galanin-like peptide fragments as potent galanin receptor agonists
10.1016/j.npep.2004.12.015 · ExternalCitation · doi-reference
vitro toxicity of the galanin receptor 3 antagonist SNAP 37889
10.1016/j.npep.2015.12.003 · ExternalCitation · doi-reference
The neuropeptide galanin modulates natural killer cell function
10.1016/j.npep.2016.11.002 · ExternalCitation · doi-reference
GalR3 mediates galanin proliferative effects on postnatal hippocampal precursors
10.1016/j.npep.2017.04.002 · ExternalCitation · doi-reference
Investigating the potential of GalR2 as a drug target for neuropathic pain
10.1016/j.npep.2022.102311 · ExternalCitation · doi-reference
The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders
10.1016/j.phrs.2021.105840 · ExternalCitation · doi-reference
Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis
10.1016/j.pnpbp.2020.110209 · ExternalCitation · doi-reference
Exploring the role of neuropeptides in depression and anxiety
10.1016/j.pnpbp.2021.110478 · ExternalCitation · doi-reference
Stress and the brain-gut axis in functional and chronic-inflammatory gastrointestinal diseases: a transdisciplinary challenge
10.1016/j.psyneuen.2019.104501 · ExternalCitation · doi-reference
Galanin peptide family regulation of glucose metabolism
10.1016/j.yfrne.2019.100801 · ExternalCitation · doi-reference
Decreased nutrient blood flow during dopamine- and epinephrine-induced intestinal vasodilation
10.1016/s0022-3565(25)21396-9 · ExternalCitation · doi-reference
Distribution of galanin-1, -2 and -3 receptor messenger RNAs in central and peripheral rat tissues
10.1016/s0306-4522(99)00407-8 · ExternalCitation · doi-reference
D.A. Morilak, Modulatory Effects of Galanin in the Lateral Bed Nucleus of the Stria Terminalis on Behavioral and Neuroendocrine Responses to Acute Stress
10.1016/s0893-133x(01)00424-9 · ExternalCitation · doi-reference
Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes
10.1021/bi9728405 · ExternalCitation · doi-reference
Principles and clinical implications of the brain-gut-enteric microbiota axis
10.1038/nrgastro.2009.35 · ExternalCitation · doi-reference
Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
10.1038/s41467-022-29072-3 · ExternalCitation · doi-reference
A vagus nerve dominant tetra-synaptic ascending pathway for gastric pain processing
10.1038/s41467-024-54056-w · ExternalCitation · doi-reference
A novel long-galanin peptide from non-mammalian vertebrates mitigates the inflammatory response in IBD models via the biased GALR2/β-arrestin2 pathway
10.1038/s41467-025-66335-1 · ExternalCitation · doi-reference
Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis
10.1038/s41575-023-00890-0 · ExternalCitation · doi-reference
Galanin is a potent modulator of cytokine and chemokine expression in human macrophages
10.1038/s41598-019-43704-7 · ExternalCitation · doi-reference
Galanin receptor 3 attenuates inflammation and influences the gut microbiota in an experimental murine colitis model
10.1038/s41598-020-79456-y · ExternalCitation · doi-reference
Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor
10.1038/s42003-018-0134-3 · ExternalCitation · doi-reference
Differential role of galanin receptors in the regulation of depression-like behavior and monoamine/stress-related genes at the cell body level
10.1038/sj.npp.1301660 · ExternalCitation · doi-reference
The galanin receptor type 2 initiates multiple signaling pathways in small cell lung cancer cells by coupling to Gq, Gi and G12 proteins
10.1038/sj.onc.1203777 · ExternalCitation · doi-reference
Development of spexin-based human galanin receptor type II-specific agonists with increased stability in serum and anxiolytic effect in mice
10.1038/srep21453 · ExternalCitation · doi-reference
Inhibition of corticotropin-releasing hormone receptor 1 and activation of receptor 2 protect against colonic injury and promote epithelium repair
10.1038/srep46616 · ExternalCitation · doi-reference
Differential galanin receptor-1 and galanin expression by 5-HT neurons in dorsal raphé nucleus of rat and mouse: evidence for species-dependent modulation of serotonin transmission
10.1046/j.1460-9568.2003.02471.x · ExternalCitation · doi-reference
Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3
10.1046/j.1471-4159.1998.71062239.x · ExternalCitation · doi-reference
Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice
10.1053/j.gastro.2013.01.047 · ExternalCitation · doi-reference
Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299
10.1073/pnas.0508970102 · ExternalCitation · doi-reference
GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models
10.1073/pnas.1008986107 · ExternalCitation · doi-reference
Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors
10.1073/pnas.161293598 · ExternalCitation · doi-reference
Structural insights into galanin receptor signaling
10.1073/pnas.2121465119 · ExternalCitation · doi-reference
Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus
10.1074/jbc.274.52.37041 · ExternalCitation · doi-reference
Early effects of catecholamine therapy on mucosal integrity, intestinal blood flow, and oxygen metabolism in porcine endotoxin shock
10.1097/00000658-199808000-00014 · ExternalCitation · doi-reference
Galanin-like peptide stimulates vasopressin, oxytocin and adrenocorticotropic hormone release in rats
10.1097/00001756-200502280-00008 · ExternalCitation · doi-reference
Growth stimulation of intestinal commensal Escherichia coli by catecholamines: a possible contributory factor in trauma-induced sepsis
10.1097/00024382-200211000-00014 · ExternalCitation · doi-reference
Identification of novel peptide hormones in the human proteome by hidden Markov model screening
10.1101/gr.5755407 · ExternalCitation · doi-reference
Galanin modulates human and murine neutrophil activation in vitro
10.1111/apha.12444 · ExternalCitation · doi-reference
vivo interaction between serotonin and galanin receptors types 1 and 2 in the dorsal raphe: implication for limbic seizures
10.1111/j.1471-4159.2005.03498.x · ExternalCitation · doi-reference
Role of galanin in the gastrointestinal sphincters
10.1111/j.1749-6632.1998.tb10691.x · ExternalCitation · doi-reference
Mechanistic relationship between the vagal afferent pathway, central nervous system and peripheral organs in appetite regulation
10.1111/jdi.12492 · ExternalCitation · doi-reference
Influence of the regulatory peptide galanin on cytokine expression in human monocytes
10.1111/nyas.14111 · ExternalCitation · doi-reference
The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective
10.1113/jp281951 · ExternalCitation · doi-reference
Involvement of galanin receptors 1 and 2 in the modulation of mouse vagal afferent mechanosensitivity
10.1113/jphysiol.2007.135939 · ExternalCitation · doi-reference
Differential effects of epinephrine, norepinephrine, and indole on Escherichia coli O157:H7 chemotaxis, colonization, and gene expression
10.1128/iai.00630-07 · ExternalCitation · doi-reference
Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro
10.1136/gut.2006.117549 · ExternalCitation · doi-reference
Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism
10.1136/gutjnl-2013-305690 · ExternalCitation · doi-reference
Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT3 receptors in conscious rats
10.1152/ajpgi.00419.2006 · ExternalCitation · doi-reference
Galanin Inhibits Gut-Related Vagal Neurons in Rats
10.1152/jn.00869.2003 · ExternalCitation · doi-reference
Analysis of the contribution of galanin receptors 1 and 2 to the central actions of galanin-like peptide
10.1159/000079632 · ExternalCitation · doi-reference
Changes in Intestinal Motility and Gut Microbiota Composition in a Rat Stress Model
10.1159/000452364 · ExternalCitation · doi-reference
Involvement of Novel Feeding-Related Peptides in Neuroendocrine Response to Stress
10.1177/153537020322801011 · ExternalCitation · doi-reference
Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III
10.1210/en.2013-2106 · ExternalCitation · doi-reference
Galaninergic mechanisms are involved in the regulation of corticotropin and thyrotropin secretion in the rat
10.1210/endo-127-5-2281 · ExternalCitation · doi-reference
Arcuate Nucleus-Dependent Regulation of Metabolism-Pathways to Obesity and Diabetes Mellitus
10.1210/endrev/bnab025 · ExternalCitation · doi-reference
Inferior vagal ganglion galaninergic response to gastric ulcers
10.1371/journal.pone.0242746 · ExternalCitation · doi-reference
Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli
10.14814/phy2.14326 · ExternalCitation · doi-reference
Coexistence of galanin-like immunoreactivity with catecholamines, 5-hydroxytryptamine, GABA and neuropeptides in the rat CNS
10.1523/jneurosci.06-12-03640.1986 · ExternalCitation · doi-reference
Galanin receptor antagonists: a potential novel pharmacological treatment for mood disorders
10.2165/00023210-200620080-00003 · ExternalCitation · doi-reference
Interaction of NO and VIP in gastrointestinal smooth muscle relaxation
10.2174/1381612043383890 · ExternalCitation · doi-reference
Interplay Between Galanin and Leptin in the Hypothalamic Control of Feeding via Corticotropin-Releasing Hormone and Neuropeptide Y
10.2337/diabetes.50.12.2666 · ExternalCitation · doi-reference
The galanin and galanin receptor subtypes, its regulatory role in the biological and pathological functions
10.33549/physiolres.933576 · ExternalCitation · doi-reference
Role of Melatonin, Galanin, and RFamide Neuropeptides QRFP26 and QRFP43 in the Neuroendocrine Control of Pancreatic β-Cell Function
10.3389/fendo.2017.00143 · ExternalCitation · doi-reference
Galanin family peptides: Molecular structure, expression and roles in the neuroendocrine axis and in the spinal cord
10.3389/fendo.2022.1019943 · ExternalCitation · doi-reference
Spexin and Galanin in Metabolic Functions and Social Behaviors With a Focus on Non-Mammalian Vertebrates
10.3389/fendo.2022.882772 · ExternalCitation · doi-reference
Review: occurrence and distribution of galanin in the physiological and inflammatory states in the mammalian gastrointestinal tract
10.3389/fimmu.2020.602070 · ExternalCitation · doi-reference
Corticotrophin-releasing factor, related peptides, and receptors in the normal and inflamed gastrointestinal tract
10.3389/fnins.2011.00054 · ExternalCitation · doi-reference
Stress and the gut-brain axis: an inflammatory perspective
10.3389/fnmol.2024.1415567 · ExternalCitation · doi-reference
Galanin Receptors: G Protein-Dependent Signaling and Beyond
10.3390/biom16020236 · ExternalCitation · doi-reference
Serotonin heteroreceptor complexes and their integration of signals in neurons and astroglia—relevance for mental diseases
10.3390/cells10081902 · ExternalCitation · doi-reference
Galanin(1-15) Potentiates the Antidepressant-like Effects Induced by Escitalopram in a Rat Model of Depression
10.3390/ijms221910848 · ExternalCitation · doi-reference
Prebiotic and Probiotic Modulation of the Microbiota–Gut–Brain Axis in Depression
10.3390/nu15081880 · ExternalCitation · doi-reference
Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome
10.3748/wjg.v28.i4.412 · ExternalCitation · doi-reference