Research graph
References from Breathing-phase selection for gated proton therapy in lung cancer towards temporally targeted ultra-high dose rate delivery. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2024 · External reference
Lung cancer in the Netherlands
10.1016/j.jtho.2020.10.012 · 2021 · External reference
Tumour movement in proton therapy: solutions and remaining questions: a review
10.3390/cancers7030829 · 2015 · External reference
Proton therapy of lung cancer patients–treatment strategies and clinical experience from a medical physicist’s perspective
10.1016/j.ejmp.2024.104890 · 2025 · External reference
Selection of patients for radiotherapy with protons aiming at reduction of side effects: the model-based approach
10.1016/j.radonc.2013.05.007 · 2013 · External reference
Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
10.1126/scitranslmed.3008973 · 2014 · External reference
Reinventing radiobiology in the light of FLASH radiotherapy
10.1146/annurev-cancerbio-061421-022217 · 2023 · External reference
FLASH irradiation spares lung progenitor cells and limits the incidence of radio-induced senescence
10.1158/1078-0432.ccr-19-1440 · 2020 · External reference
Characterization of radiation-induced lung fibrosis and mode of cell death using single and multi-pulsed proton flash irradiation
10.1016/j.ijrobp.2019.06.1033 · 2019 · External reference
FLASH radiotherapy: expectations, challenges, and current knowledge
10.3390/ijms25052546 · 2024 · External reference
Towards clinical translation of FLASH radiotherapy
10.1038/s41571-022-00697-z · 2022 · External reference
Mid-ventilation CT scan construction from four-dimensional respiration-correlated CT scans for radiotherapy planning of lung cancer patients
10.1016/j.ijrobp.2006.04.031 · 2006 · External reference
Physics controversies in proton therapy
10.1016/j.semradonc.2012.11.003 · 2013 · External reference
Investigating volumetric repainting to mitigate interplay effect on 4D robustly optimized lung cancer plans in pencil beam scanning proton therapy
10.1002/acm2.13183 · 2021 · External reference
How should we model and evaluate breathing interplay effects in IMPT?
10.1088/1361-6560/ac383f · 2021 · External reference
Precise and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy
10.1016/s0360-3016(02)02803-1 · 2002 · External reference
Unresolved reference
2017 · External reference
Robust proton treatment planning: physical and biological optimization
10.1016/j.semradonc.2017.11.005 · 2018 · External reference
Practical robustness evaluation in radiotherapy–a photon and proton-proof alternative to PTV-based plan evaluation
10.1016/j.radonc.2019.08.005 · 2019 · External reference
Unresolved reference
2021 · External reference
Comparison of different strategies to use four-dimensional computed tomography in treatment planning for lung cancer patients
10.1016/j.ijrobp.2007.11.042 · 2008 · External reference
A proof of concept treatment planning study of gated proton radiotherapy for cardiac soft tissue sarcoma
10.1016/j.phro.2021.06.001 · 2021 · External reference
Radiation pneumonitis as a function of mean lung dose: an analysis of pooled data of 540 patients
10.1016/s0360-3016(98)00196-5 · 1998 · External reference
Radiation dose–volume effects in the lung
10.1016/j.ijrobp.2009.06.091 · 2010 · External reference
Clinical dose–volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC)
10.1016/s0360-3016(99)00183-2 · 1999 · External reference
Cardiovascular complications of radiotherapy
10.1016/j.amjcard.2013.07.031 · 2013 · External reference
Cardiac events after radiation therapy: combined analysis of prospective multicenter trials for locally advanced non–small-cell lung cancer
10.1200/jco.2016.71.6142 · 2017 · External reference
Acute esophageal toxicity in non-small cell lung cancer patients after high dose conformal radiotherapy
10.1016/j.radonc.2005.03.021 · 2005 · External reference
Predictors of high-grade esophagitis after definitive three-dimensional conformal therapy, intensity-modulated radiation therapy, or proton beam therapy for non-small cell lung cancer
10.1016/j.ijrobp.2012.01.071 · 2012 · External reference
Simulation of dosimetric consequences of 4D-CT-based motion margin estimation for proton radiotherapy using patient tumor motion data
10.1088/0031-9155/59/4/853 · 2014 · External reference
Advanced pencil beam scanning Bragg peak FLASH-RT delivery technique can enhance lung cancer planning treatment outcomes compared to conventional multiple-energy proton PBS techniques
10.1016/j.radonc.2022.08.005 · 2022 · External reference
Implementation of a novel pencil beam scanning Bragg peak FLASH technique to a commercial treatment planning system
10.1002/mp.17876 · 2025 · External reference
A universal range shifter and range compensator can enable proton pencil beam scanning single-energy Bragg peak FLASH-RT treatment using current commercially available proton systems
10.1016/j.ijrobp.2022.01.009 · 2022 · External reference
Advancing proton FLASH radiation therapy: innovations, techniques, and clinical potentials
10.1016/j.ijrobp.2025.05.076 · 2025 · External reference
Requirements and study design for the next proton FLASH clinical trials: an international multidisciplinary Delphi consensus
10.1016/j.ijrobp.2025.03.047 · 2025 · External reference
Impact assessment of current knowledge gaps and mitigation strategies in clinical FLASH proton therapy through a systematic review
10.3389/fonc.2025.1550264 · 2025 · External reference
Bridging research and clinical practice in ultra-high dose rate proton therapy
10.1140/epjp/s13360-025-06532-5 · 2025 · External reference
Intra-and interfraction breathing variations during curative radiotherapy for lung cancer
10.1016/j.radonc.2007.05.026 · 2007 · External reference
Adaptive radiotherapy for lung cancer
10.1016/j.semradonc.2009.11.003 · 2010 · External reference
Respiratory gating for radiotherapy: main technical aspects and clinical benefits
2013 · External reference
Clinical accuracy of the respiratory tumor tracking system of the cyberknife: assessment by analysis of log files
10.1016/j.ijrobp.2008.12.041 · 2009 · External reference
Breathing adapted radiotherapy for breast cancer: comparison of free breathing gating with the breath-hold technique
10.1016/j.radonc.2005.07.009 · 2005 · External reference
Improved heart, lung and target dose with deep inspiration breath hold in a large clinical series of breast cancer patients
10.1016/j.radonc.2012.10.016 · 2013 · External reference
Dosimetric and clinical advantages of deep inspiration breath-hold (DIBH) during radiotherapy of breast cancer
10.1186/1756-9966-32-88 · 2013 · External reference
Contribution of respiratory gating techniques for optimization of breast cancer radiotherapy
10.3109/07357907.2012.657818 · 2012 · External reference
Geometric and dosimetric comparison of four intrafraction motion adaptation strategies for stereotactic liver radiotherapy
10.1088/1361-6560/aacdda · 2018 · External reference
Respiratory gating techniques for optimization of lung cancer radiotherapy
10.1097/jto.0b013e3182307ec2 · 2011 · External reference
Visually guided inspiration breath-hold facilitated with nasal high flow therapy in locally advanced lung cancer
10.1080/0284186x.2020.1856408 · 2021 · External reference
Combining rescanning and gating for a time-efficient treatment of mobile tumors using pencil beam scanning proton therapy
10.1016/j.radonc.2021.03.041 · 2021 · External reference
A systematic review of the influence of radiation-induced lymphopenia on survival outcomes in solid tumors
10.1016/j.critrevonc.2018.01.003 · 2018 · External reference
High dose rate and fractionation to reduce radiation-induced lymphopenia: in vivo derivation of lymphocyte radiosensitivity using patient-specific blood flow simulations
10.1016/j.ijrobp.2022.07.1797 · 2022 · External reference
FLASH radiotherapy sparing effect on the circulating lymphocytes in pencil beam scanning proton therapy: impact of hypofractionation and dose rate
10.1088/1361-6560/ad144e · 2024 · External reference
Improvement of CT-based treatment-planning models of abdominal targets using static exhale imaging
10.1016/s0360-3016(98)00130-8 · 1998 · External reference
