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References from Targeted structural destabilization of flavonoids: A novel paradigm for metabolic reprogramming and anti-senescence to repair the alveolar-capillary barrier. Local targets link to admitted publications; unresolved targets remain external evidence.
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Mesenchymal stromal cell extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS
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Human placental mesenchymal stem cells transplantation repairs the alveolar epithelial barrier to alleviate lipopolysaccharides-induced acute lung injury
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SIRT1 and its SUMOylation attenuate hyperoxia-induced lung injury by improving mitochondrial biogenesis and fusion
10.1016/j.freeradbiomed.2025.05.400 · 2025 · External reference
From "metabolic storm" to "immune paralysis": the dynamic evolution of macrophages and metabolism reprogramming in ARDS
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Senescence of alveolar type 2 cells drives progressive pulmonary fibrosis
10.1164/rccm.202004-1274oc · 2021 · External reference
Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis
10.1038/s41556-020-0542-8 · 2020 · External reference
Therapeutic effects of flavonoids on pulmonary fibrosis: a preclinical meta-analysis
10.1016/j.phymed.2024.155807 · 2024 · External reference
Baicalein alleviates cisplatin-induced acute kidney injury by inhibiting ALOX12-dependent ferroptosis
10.1016/j.phymed.2024.155757 · 2024 · External reference
Resveratrol-loaded macrophage exosomes alleviate multiple sclerosis through targeting microglia
10.1016/j.jconrel.2022.12.026 · 2023 · External reference
Quercetin, a flavonoid with great pharmacological capacity
10.3390/molecules29051000 · 2024 · External reference
Kaempferol suppresses carbon tetrachloride-induced liver damage in rats via the MAPKs/NF-κB and AMPK/Nrf2 signaling pathways
2023 · External reference
Luteolin: a promising multifunctional natural flavonoid for human diseases
10.1002/ptr.8217 · 2024 · External reference
Apigenin ameliorates non-eosinophilic inflammation, dysregulated immune homeostasis and mitochondria-mediated airway epithelial cell apoptosis in chronic obese asthma via the ROS-ASK1-MAPK pathway
10.1016/j.phymed.2023.154646 · 2023 · External reference
Hesperetin attenuates ventilator-induced acute lung injury through inhibition of NF-κB-mediated inflammation
10.1016/j.ejphar.2015.11.038 · 2015 · External reference
Flavonoids as antidiabetic and anti-inflammatory agents: a review on structural activity relationship-based studies and meta-analysis
10.3390/ijms232012605 · 2022 · External reference
Updated resources for exploring experimentally-determined PDB structures and computed structure models at the RCSB protein data bank
10.1093/nar/gkae1091 · 2025 · External reference
Mitochondrial dysfunction and alveolar type II epithelial cell senescence: the destroyer and rescuer of idiopathic pulmonary fibrosis
2025 · External reference
Krebs cycle reborn in macrophage immunometabolism
10.1146/annurev-immunol-081619-104850 · 2020 · External reference
mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity
10.1126/science.1250684 · 2014 · External reference
MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage
10.1038/emm.2015.8 · 2015 · External reference
Advances in the role of STAT3 in macrophage polarization
10.3389/fimmu.2023.1160719 · 2023 · External reference
STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
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Succinate is an inflammatory signal that induces IL-1β through HIF-1α
10.1038/nature11986 · 2013 · External reference
Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages
10.1016/j.cell.2016.08.064 · 2016 · External reference
Melatonin alleviates acute respiratory distress syndrome by inhibiting alveolar macrophage NLRP3 inflammasomes through the ROS/HIF-1α/GLUT1 pathway
10.1016/j.labinv.2023.100266 · 2023 · External reference
Regulation of epithelial transitional states in murine and human pulmonary fibrosis
10.1172/jci165612 · 2023 · External reference
Unexpected role for adaptive αβTh17 cells in acute respiratory distress syndrome
10.4049/jimmunol.1500054 · 2015 · External reference
Understanding the complexity of p53 in a new era of tumor suppression
10.1016/j.ccell.2024.04.009 · 2024 · External reference
Senescent cells promote tissue NAD(+) decline during ageing via the activation of CD38(+) macrophages
10.1038/s42255-020-00305-3 · 2020 · External reference
Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis
10.1038/s41588-025-02080-x · 2025 · External reference
Temporo-spatial cellular atlas of the regenerating alveolar niche in idiopathic pulmonary fibrosis
10.1038/s41467-025-61880-1 · 2025 · External reference
Flavonoids as modulators of metabolic enzymes and drug transporters
10.1111/nyas.13384 · 2017 · External reference
Binding affinity determination in drug design: insights from lock and key, induced fit, conformational selection, and inhibitor trapping models
10.3390/ijms25137124 · 2024 · External reference
Future directions in therapies for acute respiratory distress syndrome
10.1016/j.ccm.2024.08.014 · 2024 · External reference
Molecular mechanisms and emerging therapeutics in pulmonary fibrosis: a recent update
10.1016/j.ejphar.2025.178159 · 2025 · External reference
From single drug targets to synergistic network pharmacology in ischemic stroke
10.1073/pnas.1820799116 · 2019 · External reference
Unveiling the therapeutic mechanisms of Chinese herbs in heart failure: integrating network pharmacology, molecular docking, and simulation analysis
10.3390/ph18111648 · 2025 · External reference
Effect of flavonoids on the destabilization of α-synuclein fibrils and their conversion to amorphous aggregate: a molecular dynamics simulation and experimental study
10.1016/j.bbapap.2023.140951 · 2023 · External reference
Advances in molecular dynamics simulations and enhanced sampling methods for the study of protein systems
10.3390/ijms21176339 · 2020 · External reference
Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features
10.1002/bip.360221211 · 1983 · External reference
Pre-molten, wet, and dry molten globules en route to the functional state of proteins
10.3390/ijms24032424 · 2023 · External reference
The molten globule state of a globular protein in a cell is more or less frequent case rather than an exception
10.3390/molecules27144361 · 2022 · External reference
The client protein p53 adopts a molten globule-like state in the presence of Hsp90
10.1038/nsmb.2045 · 2011 · External reference
Novel STAT3 inhibitors targeting STAT3 dimerization by binding to the STAT3 SH2 domain
10.3389/fphar.2022.836724 · 2022 · External reference
Conformational landscape of cytochrome c folding studied by microsecond-resolved small-angle x-ray scattering
10.1073/pnas.012458999 · 2002 · External reference
Destabilisation of Alzheimer's amyloid-β protofibrils by baicalein: mechanistic insights from all-atom molecular dynamics simulations
10.1007/s11030-024-11001-9 · 2025 · External reference
The burial of solvent-accessible surface area is a predictor of polypeptide folding and misfolding as a function of chain elongation
10.1021/ja0560682 · 2005 · External reference
Flavonoids: overview of biosynthesis, biological activity, and current extraction techniques
10.3390/plants12142732 · 2023 · External reference
Role of plant-derived compounds in the molecular pathways related to inflammation
10.3390/ijms24054666 · 2023 · External reference
Understanding mechanisms of antioxidant action in health and disease
10.1038/s41580-023-00645-4 · 2024 · External reference
Macrophage heterogeneity and plasticity: mechanism and therapeutics
10.1016/j.tips.2026.02.002 · 2026 · External reference
HIF1α and metabolic reprogramming in inflammation
10.1172/jci84431 · 2016 · External reference
Baicalein suppresses lipopolysaccharide-induced acute lung injury by regulating Drp1-dependent mitochondrial fission of macrophages
10.1016/j.biopha.2021.112408 · 2022 · External reference
Quercetin-driven M2 polarization of macrophages via ALOX5 inhibition in kupffer cells: a strategy for mouse liver fibrosis treatment
10.1016/j.gene.2026.150143 · 2026 · External reference
Fatty acid oxidation-glycolysis metabolic transition affects ECM homeostasis in silica-induced pulmonary fibrosis
2025 · External reference
Baicalein suppresses inflammation and attenuates acute lung injury by inhibiting glycolysis via HIF‑1α signaling
2025 · External reference
Quercetin attenuates sepsis-induced acute lung injury via suppressing oxidative stress-mediated ER stress through activation of SIRT1/AMPK pathways
10.1016/j.cellsig.2022.110363 · 2022 · External reference
Metabolic effects of quercetin on inflammatory and autoimmune responses in rheumatoid arthritis are mediated through the inhibition of JAK1/STAT3/HIF-1α signaling
10.1186/s10020-024-00929-1 · 2024 · External reference
Resveratrol ameliorates LPS-induced acute lung injury via NLRP3 inflammasome modulation
10.1016/j.biopha.2016.09.020 · 2016 · External reference
STAT3 and NF-κB are common targets for kaempferol-mediated attenuation of COX-2 expression in IL-6-induced macrophages and carrageenan-induced mouse paw edema
2017 · External reference
Macrophages: redefining extracellular matrix architecture through phenotypic switches as therapeutic targets
10.1016/j.biomaterials.2026.124063 · 2026 · External reference
Mitochondrial metabolism mediated macrophage polarization in chronic lung diseases
10.1016/j.pharmthera.2022.108208 · 2022 · External reference
The multifaceted roles of natural products in mitochondrial dysfunction
2023 · External reference
Interfacial coordination-engineered emulgel modulates the osteo-immune microenvironment in periodontitis treatment via HIF1 signaling pathway-induced metabolic reprogramming
10.1002/advs.202509998 · 2025 · External reference
Quercetin alleviates ferroptosis accompanied by reducing M1 macrophage polarization during neutrophilic airway inflammation
10.1016/j.ejphar.2022.175407 · 2023 · External reference
Baicalein disrupts the KEAP1-NRF2 interaction to alleviate oxidative stress injury by inhibiting M1 macrophage polarization
10.1016/j.freeradbiomed.2024.12.036 · 2025 · External reference
Alveolar type 2 progenitor cells for lung injury repair
10.1038/s41420-019-0147-9 · 2019 · External reference
p53 governs an AT1 differentiation programme in lung cancer suppression
10.1038/s41586-023-06253-8 · 2023 · External reference
CSP7 protects alveolar epithelial cells by targeting p53-fibrinolytic pathways during lung injuries
10.1165/rcmb.2023-0453oc · 2025 · External reference
JinLiDa granules alleviates cardiac hypertrophy and inflammation in diabetic cardiomyopathy by regulating TP53
10.1016/j.phymed.2024.155659 · 2024 · External reference
YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis
10.1038/s12276-024-01277-0 · 2024 · External reference
PAI-1 regulation of TGF-β1-induced alveolar type II cell senescence, SASP secretion, and SASP-mediated activation of alveolar macrophages
10.1165/rcmb.2019-0071oc · 2020 · External reference
Determinants of p53 DNA binding, gene regulation, and cell fate decisions
10.1038/s41418-024-01326-1 · 2024 · External reference
Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expression
10.1080/13880209.2022.2160767 · 2023 · External reference
Quercetin influences intestinal dysbacteriosis and delays alveolar epithelial cell senescence by regulating PTEN/PI3K/AKT signaling in pulmonary fibrosis
10.1007/s00210-023-02913-8 · 2024 · External reference
Alveolar macrophages: guardians of the alveolar lipid galaxy
10.1097/mol.0000000000000987 · 2025 · External reference
Molecular mechanisms of alveolar epithelial cell senescence and idiopathic pulmonary fibrosis: a narrative review
10.21037/jtd-22-886 · 2023 · External reference
Dynamic personalities of proteins
10.1038/nature06522 · 2007 · External reference
Allostery in disease and in drug discovery
10.1016/j.cell.2013.03.034 · 2013 · External reference
Conformational selection in protein binding and function
10.1002/pro.2539 · 2014 · External reference
Inhibition of dipeptidyl peptidase-4 by flavonoids: structure-activity relationship, kinetics and interaction mechanism
10.3389/fnut.2022.892426 · 2022 · External reference
Spatial and phenotypic heterogeneity of resident and monocyte-derived macrophages during inflammatory exacerbations leading to pulmonary fibrosis
10.3389/fimmu.2024.1425466 · 2024 · External reference
Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy
10.1016/j.ejmech.2023.115774 · 2023 · External reference
Exploring the current advancements of quercetin nanoformulations alleviating respiratory diseases
10.1080/17568919.2024.2347067 · 2024 · External reference
Alveolar biomarker profiles in subphenotypes of the acute respiratory distress syndrome
10.1097/ccm.0000000000005704 · 2023 · External reference